Getting Started

Welcome to the Molecular AOP Builder documentation. This application helps researchers map Key Events from AOP-Wiki to WikiPathways, creating valuable connections between adverse outcome pathways and biological pathways.

What is Molecular AOP Builder?

The Molecular AOP Builder enables you to:

  • Map Key Events (KEs) from AOP-Wiki to WikiPathways
  • Map Key Events to Gene Ontology Biological Process (GO BP) terms using gene-based and semantic scoring
  • Assess mapping confidence using a structured 4-question workflow
  • Explore existing mappings created by the community
  • Download mapping data in multiple formats
  • Propose changes to existing mappings

Quick Start

  1. Optional: Login with GitHub - Required only if you want to submit new mappings or propose changes. Workshop participants can use a guest access code instead.
  2. Navigate to Mapping - Go to the main mapping interface
  3. Select a Key Event - A details panel shows the KE description, biological level, and AOP-Wiki link; a context panel loads AOP membership and any existing WP/GO mappings
  4. Select Pathway or GO Term - Use the KE-WP Mapping tab (Suggested / Search / Browse All sub-tabs) or the KE-GO Mapping tab for GO BP terms
  5. Complete Confidence Assessment - Answer 4 questions to determine mapping quality
  6. Submit Mapping - Your mapping is saved to the database
Note: This application is part of the VHP4Safety project, integrating data from AOP-Wiki and WikiPathways to support toxicology research.

System Requirements

  • Modern web browser (Chrome, Firefox, Safari, Edge)
  • GitHub account (optional, for submitting mappings)
  • Internet connection (for SPARQL queries to AOP-Wiki and WikiPathways)