Connecting Key Events to Molecular Pathways and Processes

A curated, FAIR database linking AOP Key Events to WikiPathways and Reactome pathways and to Gene Ontology biological processes — enabling gene-set enrichment and mechanistic network analysis in toxicology.

451
KE–WikiPathways mappings
355
KE–Gene Ontology mappings
13
KE–Reactome mappings
819
Total Mappings
WikiPathways: 2026-08-10 Reactome: v97 GO: 2026-06-15 AOP-Wiki: 2026-08-23
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How it works

  1. 1
    Pick a Key Event Browse AOP Key Events retrieved from the AOP-Wiki knowledge base.
  2. 2
    Review AI-ranked suggestions BioBERT semantic similarity ranks candidates across all three resources — WikiPathways and Reactome for curated pathway models, Gene Ontology for the underlying biological process.
  3. 3
    Propose a mapping Submit and justify your chosen connection — curators approve, and the mapping enters the FAIR database.