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Confidence

KE ID	KE Title	WikiPathways ID	WikiPathways Title	Confidence Level	Proposer	Curator	Last updated	AOP context	Actions

KE ID	KE Title	GO ID	GO Name	Connection Type	Confidence Level	Proposer	Last updated	AOP context	Actions
KE 1115	Increase, Reactive oxygen species	GO:0072593	reactive oxygen species metabolic process	describes	high	marvinm2	2026-07-18	AOP 186, AOP 207, AOP 213, AOP 26, AOP 27, AOP 273, AOP 282, AOP 298, AOP 299, AOP 303, AOP 311, AOP 319, AOP 324, AOP 325, AOP 326, AOP 327, AOP 328, AOP 329, AOP 330, AOP 331, AOP 332, AOP 333, AOP 382, AOP 383, AOP 384, AOP 386, AOP 387, AOP 396, AOP 409, AOP 413, AOP 416, AOP 418, AOP 423, AOP 451, AOP 462, AOP 476, AOP 481, AOP 488, AOP 492, AOP 497, AOP 500, AOP 505, AOP 511, AOP 513, AOP 521, AOP 534, AOP 540, AOP 569, AOP 595, AOP 596, AOP 598, AOP 599, AOP 600, AOP 601, AOP 602, AOP 603, AOP 608, AOP 613, AOP 622, AOP 472
KE 1392	Oxidative Stress	GO:0006979	response to oxidative stress	describes	high	marvinm2	2026-07-18	AOP 138, AOP 17, AOP 171, AOP 177, AOP 186, AOP 200, AOP 220, AOP 26, AOP 260, AOP 284, AOP 31, AOP 324, AOP 325, AOP 326, AOP 331, AOP 332, AOP 333, AOP 377, AOP 396, AOP 411, AOP 424, AOP 425, AOP 429, AOP 437, AOP 444, AOP 447, AOP 450, AOP 452, AOP 457, AOP 459, AOP 462, AOP 464, AOP 470, AOP 471, AOP 476, AOP 478, AOP 479, AOP 481, AOP 482, AOP 483, AOP 488, AOP 497, AOP 501, AOP 505, AOP 507, AOP 509, AOP 510, AOP 511, AOP 521, AOP 534, AOP 535, AOP 538, AOP 540, AOP 595, AOP 596, AOP 598, AOP 599, AOP 600, AOP 601, AOP 602, AOP 603, AOP 608, AOP 616, AOP 622, AOP 624, AOP 625, AOP 626, AOP 472
KE 1097	Occurrence, renal proximal tubular necrosis	GO:0097300	programmed necrotic cell death	describes	medium	marvinm2	2026-07-18	AOP 138, AOP 177, AOP 186, AOP 447, AOP 472
KE 177	Mitochondrial dysfunction	GO:0007005	mitochondrion organization	involves	medium	marvinm2	2026-07-18	AOP 130, AOP 144, AOP 178, AOP 200, AOP 205, AOP 207, AOP 256, AOP 258, AOP 273, AOP 3, AOP 335, AOP 34, AOP 362, AOP 377, AOP 423, AOP 437, AOP 447, AOP 464, AOP 476, AOP 479, AOP 48, AOP 480, AOP 481, AOP 497, AOP 500, AOP 509, AOP 511, AOP 530, AOP 587, AOP 588, AOP 589, AOP 595, AOP 622, AOP 624, AOP 625, AOP 626, AOP 77, AOP 78, AOP 79, AOP 80, AOP 87, AOP 472
KE 57	Proliferation, Cell proliferation in the absence of cytotoxicity	GO:0051301	cell division	describes	medium	SidraAdil	2026-05-10	AOP 1
KE 142	Hyperplasia, Hyperplasia	GO:0014738	regulation of muscle hyperplasia	describes	high	SidraAdil	2026-05-10	AOP 1
KE 334	Promotion, Hepatocelluar carcinoma	GO:2000345	regulation of hepatocyte proliferation	involves	medium	SidraAdil	2026-05-10	AOP 1
KE 214	Bile accumulation, Pathological condition	GO:0015721	bile acid and bile salt transport	describes	medium	SidraAdil	2026-05-10	AOP 27
KE 55	Increase, Cell injury/death	GO:0043525	positive regulation of neuron apoptotic process	describes	high	-	2026-02-23	AOP 12, AOP 13, AOP 144, AOP 17, AOP 264, AOP 265, AOP 266, AOP 268, AOP 273, AOP 278, AOP 281, AOP 324, AOP 331, AOP 377, AOP 38, AOP 479, AOP 48, AOP 490, AOP 494, AOP 530, AOP 596, AOP 599, AOP 624, AOP 625, AOP 626, AOP 627, AOP 628, AOP 629
KE 55	Increase, Cell injury/death	GO:0006915	apoptotic process	describes	medium	-	2026-02-07	AOP 12, AOP 13, AOP 144, AOP 17, AOP 264, AOP 265, AOP 266, AOP 268, AOP 273, AOP 278, AOP 281, AOP 324, AOP 331, AOP 377, AOP 38, AOP 479, AOP 48, AOP 490, AOP 494, AOP 530, AOP 596, AOP 599, AOP 624, AOP 625, AOP 626, AOP 627, AOP 628, AOP 629