@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix ke-wp: <https://molaop-builder.vhp4safety.nl/vocab#> .
@prefix mapping: <https://molaop-builder.vhp4safety.nl/mappings/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

mapping:00c68fec-ca92-4eae-87af-e45f5d7fd129 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-03-16T14:13:58.705415"^^xsd:dateTime ;
    dcterms:identifier "00c68fec-ca92-4eae-87af-e45f5d7fd129" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 178" ;
    ke-wp:keyEventName "Mitochondrial electron transport chain, disrupted" ;
    ke-wp:pathwayId "WP111" ;
    ke-wp:pathwayTitle "Electron transport chain: OXPHOS system in mitochondria" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:01264711-7889-4b3f-b038-6f8432f07ec5 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:48:53.116910"^^xsd:dateTime ;
    dcterms:identifier "01264711-7889-4b3f-b038-6f8432f07ec5" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 836" ;
    ke-wp:keyEventName "Occurrence, Cytoplasmic vacuolization (Bile duct cell)" ;
    ke-wp:pathwayId "WP4923" ;
    ke-wp:pathwayTitle "Autophagy" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:0138f004-96d7-40ba-97c7-a1e74eb5cccb a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2025-09-25T13:19:49"^^xsd:dateTime ;
    dcterms:identifier "0138f004-96d7-40ba-97c7-a1e74eb5cccb" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 468" ;
    ke-wp:keyEventName "Inhibition, PPAR alpha" ;
    ke-wp:pathwayId "WP2878" ;
    ke-wp:pathwayTitle "PPAR-alpha pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:013ffa6b-1232-47f5-8485-49fb3547957f a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:23:51.674075"^^xsd:dateTime ;
    dcterms:identifier "013ffa6b-1232-47f5-8485-49fb3547957f" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1172" ;
    ke-wp:keyEventName "Increased activation, Nuclear factor kappa B (NF-kB)" ;
    ke-wp:pathwayId "WP3656" ;
    ke-wp:pathwayTitle "Interleukin-1 induced activation of NF-kB" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:01d10bb4-abda-4ce4-a348-cc7d6f6bd2a5 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:57:52.310443"^^xsd:dateTime ;
    dcterms:identifier "01d10bb4-abda-4ce4-a348-cc7d6f6bd2a5" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2115" ;
    ke-wp:keyEventName "Altered, cholesterol metabolism" ;
    ke-wp:pathwayId "WP197" ;
    ke-wp:pathwayTitle "Cholesterol biosynthesis pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:01e32369-e81d-487d-b083-6b7d2e2658f3 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-04-12T16:59:59.791602"^^xsd:dateTime ;
    dcterms:identifier "01e32369-e81d-487d-b083-6b7d2e2658f3" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 898" ;
    ke-wp:keyEventName "Disruption, Lysosome" ;
    ke-wp:pathwayId "WP4923" ;
    ke-wp:pathwayTitle "Autophagy" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:02aa0594-f1db-49cc-b940-afc5cb08a8bf a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-04-12T21:39:22.801171"^^xsd:dateTime ;
    dcterms:identifier "02aa0594-f1db-49cc-b940-afc5cb08a8bf" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1493" ;
    ke-wp:keyEventName "Increased Pro-inflammatory mediators" ;
    ke-wp:pathwayId "WP453" ;
    ke-wp:pathwayTitle "Inflammatory response pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:03a9d9c5-a93f-4738-b51e-563b43e845ec a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:48:10.130628"^^xsd:dateTime ;
    dcterms:identifier "03a9d9c5-a93f-4738-b51e-563b43e845ec" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 851" ;
    ke-wp:keyEventName "Decrease of GABAergic interneurons" ;
    ke-wp:pathwayId "WP4159" ;
    ke-wp:pathwayTitle "GABA receptor signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:041aae19-97d4-419f-b9fd-c33a037c5872 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:44:54.722810"^^xsd:dateTime ;
    dcterms:identifier "041aae19-97d4-419f-b9fd-c33a037c5872" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 155" ;
    ke-wp:keyEventName "Inadequate DNA repair" ;
    ke-wp:pathwayId "WP4946" ;
    ke-wp:pathwayTitle "Genes and complexes involved in the DNA repair pathways" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:04416c7f-efc8-4457-a610-8b9f11f991d1 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.931274"^^xsd:dateTime ;
    dcterms:identifier "04416c7f-efc8-4457-a610-8b9f11f991d1" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 291" ;
    ke-wp:keyEventName "Accumulation, Triglyceride" ;
    ke-wp:pathwayId "WP5323" ;
    ke-wp:pathwayTitle "Fatty acid and lipoprotein transport in hepatocytes" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:048c2e50-d18d-4dd0-beba-81e7fcf61ba4 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:48:03.932535"^^xsd:dateTime ;
    dcterms:identifier "048c2e50-d18d-4dd0-beba-81e7fcf61ba4" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 875" ;
    ke-wp:keyEventName "Binding of agonist, Ionotropic glutamate receptors" ;
    ke-wp:pathwayId "WP5083" ;
    ke-wp:pathwayTitle "Neuroinflammation and glutamatergic signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:04ac87f4-63bf-497a-b769-bf30ec13471d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-03-16T14:15:29.509837"^^xsd:dateTime ;
    dcterms:identifier "04ac87f4-63bf-497a-b769-bf30ec13471d" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 122" ;
    ke-wp:keyEventName "Increase, Glucocorticoid receptor activation" ;
    ke-wp:pathwayId "WP2880" ;
    ke-wp:pathwayTitle "Glucocorticoid receptor pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:05781ae1-f9fe-48f9-80df-0c37783f9f6e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:47:00.457933"^^xsd:dateTime ;
    dcterms:identifier "05781ae1-f9fe-48f9-80df-0c37783f9f6e" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1493" ;
    ke-wp:keyEventName "Increased Pro-inflammatory mediators" ;
    ke-wp:pathwayId "WP5095" ;
    ke-wp:pathwayTitle "Overview of proinflammatory and profibrotic mediators" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:059a1c15-b17b-486a-9a3d-ebd7d2dc55c6 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-03-16T14:14:35.064635"^^xsd:dateTime ;
    dcterms:identifier "059a1c15-b17b-486a-9a3d-ebd7d2dc55c6" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 664" ;
    ke-wp:keyEventName "Overwhelmed, Mitochondrial DNA repair mechanisms" ;
    ke-wp:pathwayId "WP4946" ;
    ke-wp:pathwayTitle "DNA repair pathways, full network" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:05d3d7c1-d98a-4a94-803a-c065afcf2c14 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T11:16:41.021312"^^xsd:dateTime ;
    dcterms:identifier "05d3d7c1-d98a-4a94-803a-c065afcf2c14" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1270" ;
    ke-wp:keyEventName "Inactivation of PPARγ" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:07796e78-dd0f-4f3a-8cf3-b15689158332 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:49:25.408278"^^xsd:dateTime ;
    dcterms:identifier "07796e78-dd0f-4f3a-8cf3-b15689158332" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 794" ;
    ke-wp:keyEventName "Increase, Cytotoxicity (urothelial cells)" ;
    ke-wp:pathwayId "WP1772" ;
    ke-wp:pathwayTitle "Apoptosis modulation and signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:079c9c1b-9a9e-4067-9cc3-dc429ae011e0 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:52.850414"^^xsd:dateTime ;
    dcterms:identifier "079c9c1b-9a9e-4067-9cc3-dc429ae011e0" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 458" ;
    ke-wp:keyEventName "Increased, De Novo FA synthesis" ;
    ke-wp:pathwayId "WP357" ;
    ke-wp:pathwayTitle "Fatty acid biosynthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:081fd464-efbf-4a29-8cc8-a250d30996b8 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2026-03-03T08:48:52.213466"^^xsd:dateTime ;
    dcterms:identifier "081fd464-efbf-4a29-8cc8-a250d30996b8" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1392" ;
    ke-wp:keyEventName "Increase, Oxidative Stress" ;
    ke-wp:pathwayId "WP5477" ;
    ke-wp:pathwayTitle "Molecular pathway for oxidative stress" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:08b926ea-a36f-48b8-911e-b868d47c4c9a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.931048"^^xsd:dateTime ;
    dcterms:identifier "08b926ea-a36f-48b8-911e-b868d47c4c9a" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 327" ;
    ke-wp:keyEventName "Accumulation, Fatty acid" ;
    ke-wp:pathwayId "WP5061" ;
    ke-wp:pathwayTitle "Fatty acid transporters" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:08b96b2d-2a37-4843-b82a-1ecace48de91 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:54:06.535521"^^xsd:dateTime ;
    dcterms:identifier "08b96b2d-2a37-4843-b82a-1ecace48de91" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1900" ;
    ke-wp:keyEventName "increased platelet surface TLR9 expression" ;
    ke-wp:pathwayId "WP1449" ;
    ke-wp:pathwayTitle "Regulation of toll-like receptor signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:09734018-fb5c-4412-952e-06620ee15d79 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:19:20.121306"^^xsd:dateTime ;
    dcterms:identifier "09734018-fb5c-4412-952e-06620ee15d79" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1635" ;
    ke-wp:keyEventName "Increase, DNA strand breaks" ;
    ke-wp:pathwayId "WP3959" ;
    ke-wp:pathwayTitle "DNA IR-double strand breaks and cellular response via ATM" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:09ecf784-e5e7-40f3-acee-a05f7561f749 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:10.114823"^^xsd:dateTime ;
    dcterms:identifier "09ecf784-e5e7-40f3-acee-a05f7561f749" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 902" ;
    ke-wp:keyEventName "Inflammation, Liver" ;
    ke-wp:pathwayId "WP530" ;
    ke-wp:pathwayTitle "Cytokines and inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:0a9e95d7-7625-4969-b921-791a3791611b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:49:28.773707"^^xsd:dateTime ;
    dcterms:identifier "0a9e95d7-7625-4969-b921-791a3791611b" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 716" ;
    ke-wp:keyEventName "Increase, cell proliferation (hepatocytes)" ;
    ke-wp:pathwayId "WP179" ;
    ke-wp:pathwayTitle "Cell cycle" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:0b2bbce5-21b2-444c-9e0c-f83379970b36 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-23T09:05:48.120759"^^xsd:dateTime ;
    dcterms:identifier "0b2bbce5-21b2-444c-9e0c-f83379970b36" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1825" ;
    ke-wp:keyEventName "Increase, Cell death" ;
    ke-wp:pathwayId "WP4923" ;
    ke-wp:pathwayTitle "Autophagy" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:0b762d88-b15f-4409-930c-de8b059ff13c a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:13:30.259267"^^xsd:dateTime ;
    dcterms:identifier "0b762d88-b15f-4409-930c-de8b059ff13c" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1738" ;
    ke-wp:keyEventName "SARS-CoV-2 cell entry" ;
    ke-wp:pathwayId "WP4846" ;
    ke-wp:pathwayTitle "SARS-CoV-2 and COVID-19 pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:0b8e0188-4a6d-4808-a9a2-9b0d0177f741 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2026-02-07T19:40:47"^^xsd:dateTime ;
    dcterms:identifier "0b8e0188-4a6d-4808-a9a2-9b0d0177f741" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 889" ;
    ke-wp:keyEventName "Proteostasis, impaired" ;
    ke-wp:pathwayId "WP4918" ;
    ke-wp:pathwayTitle "Cellular proteostasis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:0bad2bc9-8022-4a21-943e-60bce8096e80 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-04-12T21:39:43.862998"^^xsd:dateTime ;
    dcterms:identifier "0bad2bc9-8022-4a21-943e-60bce8096e80" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 465" ;
    ke-wp:keyEventName "Increased, Fatty acid influx" ;
    ke-wp:pathwayId "WP5061" ;
    ke-wp:pathwayTitle "Fatty acid transporters" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:0cd4cbce-334a-4696-8571-f6105340127c a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:10:30.877493"^^xsd:dateTime ;
    dcterms:identifier "0cd4cbce-334a-4696-8571-f6105340127c" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1770" ;
    ke-wp:keyEventName "Decrease, Mitochondrial membrane potential" ;
    ke-wp:pathwayId "WP111" ;
    ke-wp:pathwayTitle "Electron transport chain: OXPHOS system in mitochondria" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:0d0b1f8b-ac1a-4ad3-af7f-9ba1e8580d22 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:42:46.884445"^^xsd:dateTime ;
    dcterms:identifier "0d0b1f8b-ac1a-4ad3-af7f-9ba1e8580d22" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 2086" ;
    ke-wp:keyEventName "Airway inflammation" ;
    ke-wp:pathwayId "WP3624" ;
    ke-wp:pathwayTitle "Lung fibrosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:0e07f67c-dce6-4659-b383-7b183f6b54e9 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.932367"^^xsd:dateTime ;
    dcterms:identifier "0e07f67c-dce6-4659-b383-7b183f6b54e9" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 167" ;
    ke-wp:keyEventName "Activation, LXR" ;
    ke-wp:pathwayId "WP2874" ;
    ke-wp:pathwayTitle "Liver X receptor pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:0e69f220-e4d0-4a30-8439-f19851a8c7fc a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:45:59.439565"^^xsd:dateTime ;
    dcterms:identifier "0e69f220-e4d0-4a30-8439-f19851a8c7fc" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 425" ;
    ke-wp:keyEventName "Decrease of Thyroidal iodide" ;
    ke-wp:pathwayId "WP1981" ;
    ke-wp:pathwayTitle "Thyroxine (thyroid hormone) production" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:0f36d8b0-30e5-417e-97bc-8fd8e7595262 a ke-wp:KeyEventPathwayMapping ;
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mapping:0ff2fcb5-4140-4242-8b9b-0d3b185065c8 a ke-wp:KeyEventPathwayMapping ;
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mapping:103f9312-a5db-4d28-b6f1-9c46cf1ac8e8 a ke-wp:KeyEventPathwayMapping ;
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mapping:10e9fcc2-6622-4e8c-8628-a5b4fe59d87c a ke-wp:KeyEventPathwayMapping ;
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mapping:11062e7c-7b73-46ec-ba4e-e88f74686de5 a ke-wp:KeyEventPathwayMapping ;
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mapping:118b8f8e-4528-4114-96c2-d1f721b786fc a ke-wp:KeyEventPathwayMapping ;
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mapping:11a62a45-ade0-4ea9-92dd-3ff8599c8749 a ke-wp:KeyEventPathwayMapping ;
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mapping:11d306d0-8f83-44e2-a514-afdeb998e65f a ke-wp:KeyEventPathwayMapping ;
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mapping:12700823-f3fb-4e89-abc4-22e268a28b4a a ke-wp:KeyEventPathwayMapping ;
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mapping:139dd362-87e5-44dc-90b0-a592b583fa60 a ke-wp:KeyEventPathwayMapping ;
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mapping:13a0f780-8710-47ea-bef7-71e377264d4c a ke-wp:KeyEventPathwayMapping ;
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mapping:142fe8a3-2cd0-48d1-98b9-c3f891a2e0b8 a ke-wp:KeyEventPathwayMapping ;
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mapping:14929bcf-8df9-4685-a372-f941487abf37 a ke-wp:KeyEventPathwayMapping ;
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mapping:14ca81e5-7454-4927-99e5-333ae3688fc0 a ke-wp:KeyEventPathwayMapping ;
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mapping:15f4ca44-0c72-4450-afa8-ac271af3e256 a ke-wp:KeyEventPathwayMapping ;
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mapping:15f6790a-073f-4ed3-ba07-020dcbc9f6aa a ke-wp:KeyEventPathwayMapping ;
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mapping:1627d16b-b42d-4664-a24b-f3742bc72e1b a ke-wp:KeyEventPathwayMapping ;
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mapping:16ca6fa9-3ae0-4cfc-ba1e-69e5deb03e4f a ke-wp:KeyEventPathwayMapping ;
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mapping:16f5e55a-24a9-4fa1-88aa-be9d79de0eb5 a ke-wp:KeyEventPathwayMapping ;
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mapping:1a2ee3f1-4fe1-4ceb-890c-e69af2e00305 a ke-wp:KeyEventPathwayMapping ;
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mapping:1ad6f717-ea94-49c6-b2dd-7b66b3934fd7 a ke-wp:KeyEventPathwayMapping ;
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mapping:1bcb003c-069b-4331-b00e-67b6736cfebc a ke-wp:KeyEventPathwayMapping ;
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mapping:1d684103-3b34-4c33-8f75-b8da09746ac1 a ke-wp:KeyEventPathwayMapping ;
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mapping:1f7a1503-18c9-4c5b-8ef4-5baf364aedec a ke-wp:KeyEventPathwayMapping ;
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mapping:1f886fc4-9dcb-4c24-9e34-435e52bd757e a ke-wp:KeyEventPathwayMapping ;
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mapping:201589e0-c5a4-4a9e-a81b-f7b97437151f a ke-wp:KeyEventPathwayMapping ;
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mapping:202ac787-d051-4932-96ec-4d48485d9fcf a ke-wp:KeyEventPathwayMapping ;
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mapping:206d7731-d26d-4b94-b350-b86b50dc31e7 a ke-wp:KeyEventPathwayMapping ;
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mapping:2176c3c7-7951-4669-8de0-f070cb9d76b8 a ke-wp:KeyEventPathwayMapping ;
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mapping:21deba79-e0c2-4a01-beb0-7680d85e964f a ke-wp:KeyEventPathwayMapping ;
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mapping:21f40e2d-5f36-4336-a62e-dc2dafdef26a a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayTitle "PPAR-alpha pathway" ;
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mapping:21f99235-bf4a-4046-b775-bb98b368157d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-04-12T16:58:26.778742"^^xsd:dateTime ;
    dcterms:identifier "21f99235-bf4a-4046-b775-bb98b368157d" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 459" ;
    ke-wp:keyEventName "Increased, Liver Steatosis" ;
    ke-wp:pathwayId "WP3965" ;
    ke-wp:pathwayTitle "Lipid metabolism pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:225b0930-b885-485e-9b9a-ed50cb55cfa5 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T12:13:26.543744"^^xsd:dateTime ;
    dcterms:identifier "225b0930-b885-485e-9b9a-ed50cb55cfa5" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1854" ;
    ke-wp:keyEventName "Dysregulation, ACE2 expression and activity" ;
    ke-wp:pathwayId "WP5036" ;
    ke-wp:pathwayTitle "Angiotensin II receptor type 1 pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:22ec95fd-d875-4c4f-8ec5-a01bae32992d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-13T12:29:23.909048"^^xsd:dateTime ;
    dcterms:identifier "22ec95fd-d875-4c4f-8ec5-a01bae32992d" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 616" ;
    ke-wp:keyEventName "Occurrence, A paroxysmal depolarizing shift" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:235b4e2c-e933-4396-b4be-33e2b1652709 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:40:47.735462"^^xsd:dateTime ;
    dcterms:identifier "235b4e2c-e933-4396-b4be-33e2b1652709" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1391" ;
    ke-wp:keyEventName "Activation of Cyp2E1" ;
    ke-wp:pathwayId "WP43" ;
    ke-wp:pathwayTitle "Oxidation by cytochrome P450" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:24280d84-ecff-46dc-bf6b-36a6d8f0c066 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:49:35.778503"^^xsd:dateTime ;
    dcterms:identifier "24280d84-ecff-46dc-bf6b-36a6d8f0c066" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 486" ;
    ke-wp:keyEventName "systemic inflammation leading to hepatic steatosis" ;
    ke-wp:pathwayId "WP530" ;
    ke-wp:pathwayTitle "Cytokines and inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:24d0ea58-ba89-4cca-bdb6-2dbe0517f4ec a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:46:58.063923"^^xsd:dateTime ;
    dcterms:identifier "24d0ea58-ba89-4cca-bdb6-2dbe0517f4ec" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1494" ;
    ke-wp:keyEventName "Leukocyte recruitment/activation" ;
    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:24f67e89-97dc-448f-bf60-afaf45990158 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:01:56.663113"^^xsd:dateTime ;
    dcterms:identifier "24f67e89-97dc-448f-bf60-afaf45990158" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2220" ;
    ke-wp:keyEventName "Antagonism, Glucocorticoid hormone receptor" ;
    ke-wp:pathwayId "WP2880" ;
    ke-wp:pathwayTitle "Glucocorticoid receptor pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:25e0091f-d106-4d43-961f-d2b950af84d8 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:49:53.740842"^^xsd:dateTime ;
    dcterms:identifier "25e0091f-d106-4d43-961f-d2b950af84d8" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1014" ;
    ke-wp:keyEventName "Induction, Somatic muscle paralysis" ;
    ke-wp:pathwayId "WP383" ;
    ke-wp:pathwayTitle "Striated muscle contraction pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:265c4b94-9d05-4c41-991d-966ab46bc691 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:49:31.969712"^^xsd:dateTime ;
    dcterms:identifier "265c4b94-9d05-4c41-991d-966ab46bc691" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 784" ;
    ke-wp:keyEventName "Increase, Hyperplasia (tubular epithelial cells)" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:26f543ed-3073-428c-8c6c-06c9facbf57b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:48:02.388119"^^xsd:dateTime ;
    dcterms:identifier "26f543ed-3073-428c-8c6c-06c9facbf57b" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1944" ;
    ke-wp:keyEventName "Synaptic dysfunction" ;
    ke-wp:pathwayId "WP2267" ;
    ke-wp:pathwayTitle "Synaptic vesicle pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:27251b4b-6ea5-46c6-81cf-96a544f25ece a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T17:31:14.686628"^^xsd:dateTime ;
    dcterms:identifier "27251b4b-6ea5-46c6-81cf-96a544f25ece" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2336" ;
    ke-wp:keyEventName "Increase, SREBF1" ;
    ke-wp:pathwayId "WP1982" ;
    ke-wp:pathwayTitle "Sterol regulatory element-binding proteins (SREBP) signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:27373650-58e1-4f1a-aaba-c75f4ecf9fdb a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2026-03-01T12:25:21.759903"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 105" ;
    ke-wp:keyEventName "Inhibition, Mitochondrial Electron Transport Chain Complexes" ;
    ke-wp:pathwayId "WP111" ;
    ke-wp:pathwayTitle "Electron transport chain: OXPHOS system in mitochondria" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:2894b6c7-d16b-4edc-bd95-c53bb56a0370 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:16:50.792166"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2029" ;
    ke-wp:keyEventName "protein-coupled estrogen receptor 1 (GPER) activation" ;
    ke-wp:pathwayId "WP712" ;
    ke-wp:pathwayTitle "Estrogen signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:29b0617d-1ccd-4403-8f6c-d8e9cafff210 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1015" ;
    ke-wp:keyEventName "Increased, Neuronal synaptic inhibition" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:29d718ff-8fac-43b2-aa64-1d0a05a9f41c a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:08:25.675370"^^xsd:dateTime ;
    dcterms:identifier "29d718ff-8fac-43b2-aa64-1d0a05a9f41c" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1812" ;
    ke-wp:keyEventName "Increase, Cytochrome c release" ;
    ke-wp:pathwayId "WP254" ;
    ke-wp:pathwayTitle "Apoptosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:2c6fac33-0002-407a-99e6-2bfc17bd24c4 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-04-13T08:08:39.435051"^^xsd:dateTime ;
    dcterms:identifier "2c6fac33-0002-407a-99e6-2bfc17bd24c4" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 2408" ;
    ke-wp:keyEventName "Increase, Adipose lipolysis" ;
    ke-wp:pathwayId "WP236" ;
    ke-wp:pathwayTitle "Adipogenesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:2c7a3d92-886e-428b-a7cd-0148ef18e73b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 961" ;
    ke-wp:keyEventName "Increased, Clearance of thyroxine from serum" ;
    ke-wp:pathwayId "WP4746" ;
    ke-wp:pathwayTitle "Thyroid hormones production and peripheral downstream signaling effects" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:2ed421ff-9747-4071-83a3-c15ea6391123 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1284" ;
    ke-wp:keyEventName "Up Regulation, SREBF2" ;
    ke-wp:pathwayId "WP1982" ;
    ke-wp:pathwayTitle "Sterol regulatory element-binding proteins (SREBP) signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:2f465814-5838-45cd-a966-4b1daaf1b7d6 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 383" ;
    ke-wp:keyEventName "Reduced, Presynaptic release of glutamate" ;
    ke-wp:pathwayId "WP5083" ;
    ke-wp:pathwayTitle "Neuroinflammation and glutamatergic signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:2fdf35f3-52dc-4f43-a1c9-3d3d433f6c68 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1909" ;
    ke-wp:keyEventName "Mucociliary Clearance, Decreased" ;
    ke-wp:pathwayId "WP4803" ;
    ke-wp:pathwayTitle "Ciliopathies" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:3087be9d-ec92-4601-a82e-1f3ed6899823 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 774" ;
    ke-wp:keyEventName "Increase, Preneoplastic foci (hepatocytes)" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:30df6e30-5d2c-4b0a-801a-608c89acf6f2 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1922" ;
    ke-wp:keyEventName "Increased, Reactive metabolites production" ;
    ke-wp:pathwayId "WP702" ;
    ke-wp:pathwayTitle "Metapathway biotransformation Phase I and II" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:317384b4-2c21-45b6-8058-d784160a0e32 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1923" ;
    ke-wp:keyEventName "Altered gene expression, P53 dependent apoptosis pathway" ;
    ke-wp:pathwayId "WP4963" ;
    ke-wp:pathwayTitle "p53 transcriptional gene network" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:31fc8aa3-2ea3-4552-bb06-4ec80b878f16 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 890" ;
    ke-wp:keyEventName "Degeneration of dopaminergic neurons of the nigrostriatal pathway" ;
    ke-wp:pathwayId "WP5372" ;
    ke-wp:pathwayTitle "Involvement of δ-secretase in neurodegenerative diseases" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:342f57b2-6a1b-4163-8e72-afbfbebf3e2a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 55" ;
    ke-wp:keyEventName "Increase, Cell injury/death" ;
    ke-wp:pathwayId "WP254" ;
    ke-wp:pathwayTitle "Apoptosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:35280d2a-0c7f-48c1-8887-e663b7437277 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:keyEventName "Promotion, Hepatocelluar carcinoma" ;
    ke-wp:pathwayId "WP313" ;
    ke-wp:pathwayTitle "Hepatocyte growth factor receptor signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:35dd7a66-0adc-40d1-8ef3-50869b2bbf5f a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:keyEventId "KE 1670" ;
    ke-wp:keyEventName "Lung cancer" ;
    ke-wp:pathwayId "WP4255" ;
    ke-wp:pathwayTitle "Non-small cell lung cancer" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:3686f554-0627-4a82-85df-65f01cd6cc22 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Hippocampal anatomy, Altered" ;
    ke-wp:pathwayId "WP5536" ;
    ke-wp:pathwayTitle "Wnt signaling in adult hippocampal neurogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:374b033d-63a4-4fbf-9139-a9f3190bf36b a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 68" ;
    ke-wp:keyEventName "Accumulation, Collagen" ;
    ke-wp:pathwayId "WP5312" ;
    ke-wp:pathwayTitle "Metabolic pathways of fibroblasts" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:376fba0c-4479-4239-9935-c76484eb12cd a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 18" ;
    ke-wp:keyEventName "Activation, AhR" ;
    ke-wp:pathwayId "WP2873" ;
    ke-wp:pathwayTitle "Aryl hydrocarbon receptor pathway" ;
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mapping:3802c6c7-62c6-477b-9226-a876c431bfbd a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:keyEventId "KE 2208" ;
    ke-wp:keyEventName "Aberrant, synaptic formation and plasticity" ;
    ke-wp:pathwayId "WP5231" ;
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mapping:38705c21-ae84-4678-b59e-e6405de3b187 a ke-wp:KeyEventPathwayMapping ;
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mapping:389e54aa-fc7f-4eb0-9b1c-9fcc99319d01 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)" ;
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mapping:39928d1c-c27c-46e4-baa4-1eaa957848e3 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Activation, Stellate cells" ;
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mapping:3a18e3b0-bf86-45ef-8f4b-0779f300567d a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP501" ;
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mapping:3a5f0733-8a18-4b21-8f74-ccb7671ecf98 a ke-wp:KeyEventPathwayMapping ;
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mapping:3ac9fd94-1b94-4783-9cec-30b0f772be9b a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP4545" ;
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mapping:3acb794f-7ca9-43ea-a33d-6523007b0534 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 1395" ;
    ke-wp:keyEventName "Liver Cancer" ;
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    ke-wp:pathwayTitle "Hepatitis C and hepatocellular carcinoma" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:3ae3a33a-002e-4f8b-b6e5-bb27984b724c a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 2116" ;
    ke-wp:keyEventName "Decreased, oligodendrocyte differentiation" ;
    ke-wp:pathwayId "WP4304" ;
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mapping:3b8c4edd-b798-467b-bf87-0689cd206896 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 1669" ;
    ke-wp:keyEventName "Increased, DNA damage and mutation" ;
    ke-wp:pathwayId "WP4946" ;
    ke-wp:pathwayTitle "Genes and complexes involved in the DNA repair pathways" ;
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mapping:3ba22c33-cf54-4653-9881-c915c32be955 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Hippocampal Physiology, Altered" ;
    ke-wp:pathwayId "WP5090" ;
    ke-wp:pathwayTitle "Complement system in neuronal development and plasticity" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:3bb6873b-b4f4-4346-80a7-52b12bc3a2e9 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:keyEventName "Activation, Caspase 8 pathway" ;
    ke-wp:pathwayId "WP254" ;
    ke-wp:pathwayTitle "Apoptosis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:3bd9947e-f807-4d55-9b52-02b9c756b187 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 1115" ;
    ke-wp:keyEventName "Increase, Reactive oxygen species" ;
    ke-wp:pathwayId "WP5477" ;
    ke-wp:pathwayTitle "Molecular pathway for oxidative stress" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:3c43d2e0-2ad1-4491-a130-29ac337e3d74 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:keyEventName "Proteostasis, impaired" ;
    ke-wp:pathwayId "WP183" ;
    ke-wp:pathwayTitle "Proteasome degradation" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:3cbd2aee-253f-4c71-baed-dae19f96ddb2 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 1194" ;
    ke-wp:keyEventName "Increase, DNA damage" ;
    ke-wp:pathwayId "WP707" ;
    ke-wp:pathwayTitle "DNA damage response" ;
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mapping:3d531c8d-ece1-4c50-bf5e-2e20264c4d12 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Activation, Long term AHR receptor driven direct and indirect gene expression changes" ;
    ke-wp:pathwayId "WP2873" ;
    ke-wp:pathwayTitle "Aryl hydrocarbon receptor pathway" ;
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mapping:3d8511d8-824a-4acc-8894-0c0d105e1b43 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Hippocampal Physiology, Altered" ;
    ke-wp:pathwayId "WP5231" ;
    ke-wp:pathwayTitle "Hippocampal synaptogenesis and neurogenesis" ;
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mapping:3dd12e28-4991-49a2-a95a-59958558322a a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayTitle "Oxidation by cytochrome P450" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:3e8e5fea-52f5-4f71-911f-c6609a885012 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increased inflammatory immune responses" ;
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mapping:3e9ccbea-7bc6-41a7-ab1b-ed0596d4aed2 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP536" ;
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mapping:3ebc04c0-20b8-4139-8ea9-32ddd36d310c a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Necrotic Tissue" ;
    ke-wp:pathwayId "WP2513" ;
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mapping:3f7129ad-98a5-4699-8b52-0d38d6a90bf5 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, hepatocellular adenomas and carcinomas" ;
    ke-wp:pathwayId "WP3646" ;
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mapping:40838948-42b5-49ce-acef-8bd45cd08ff6 a ke-wp:KeyEventPathwayMapping ;
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mapping:413c7311-b688-4f3c-ae3a-b1df32a18fc7 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayTitle "Estrogen receptor pathway" ;
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mapping:417d9348-ac9e-4538-af74-1bcacd9dea99 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP2513" ;
    ke-wp:pathwayTitle "Nanoparticle triggered regulated necrosis" ;
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mapping:4210b35d-db00-4f75-a62a-1aea38254531 a ke-wp:KeyEventPathwayMapping ;
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mapping:426acb0b-05bc-42f6-801a-52e07862f6ed a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
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mapping:427e6bb4-caa2-450d-ba19-4ea90c85907d a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP4925" ;
    ke-wp:pathwayTitle "Unfolded protein response" ;
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mapping:4285c015-ad24-46ea-b3b2-76087d42e682 a ke-wp:KeyEventPathwayMapping ;
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mapping:42a8d85c-5d7a-4bfb-bbc1-cac7aac22ca0 a ke-wp:KeyEventPathwayMapping ;
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mapping:4328b6f0-edc4-4d5a-ad46-3e5316b303ad a ke-wp:KeyEventPathwayMapping ;
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mapping:43e4ffdf-68ac-40b0-9321-c04f3f915235 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP100" ;
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mapping:43f211cc-d837-45b6-a3d8-65d2bcb22dad a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-13T12:07:08.781628"^^xsd:dateTime ;
    dcterms:identifier "43f211cc-d837-45b6-a3d8-65d2bcb22dad" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "low" ;
    ke-wp:keyEventId "KE 2012" ;
    ke-wp:keyEventName "Fibroblast proliferation and differentiation" ;
    ke-wp:pathwayId "WP3624" ;
    ke-wp:pathwayTitle "Lung fibrosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:44357349-2883-42ae-beae-c6c457929bc3 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:02:16.562950"^^xsd:dateTime ;
    dcterms:identifier "44357349-2883-42ae-beae-c6c457929bc3" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2217" ;
    ke-wp:keyEventName "Binding of antagonist to glucocorticoid hormone receptor" ;
    ke-wp:pathwayId "WP2880" ;
    ke-wp:pathwayTitle "Glucocorticoid receptor pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:466f9241-b03d-48dc-9d48-3e6ce0b4573e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:48:05.814488"^^xsd:dateTime ;
    dcterms:identifier "466f9241-b03d-48dc-9d48-3e6ce0b4573e" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1300" ;
    ke-wp:keyEventName "Activation, mTORC1" ;
    ke-wp:pathwayId "WP1471" ;
    ke-wp:pathwayTitle "Target of rapamycin signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:468515f6-3799-43c3-9cc4-2892ed266990 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-03-16T14:14:55.641134"^^xsd:dateTime ;
    dcterms:identifier "468515f6-3799-43c3-9cc4-2892ed266990" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 40" ;
    ke-wp:keyEventName "Mitochondrial ATP production, decreased" ;
    ke-wp:pathwayId "WP5241" ;
    ke-wp:pathwayTitle "Mitochondrial beta-oxidation" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:468e2b24-db43-4348-906c-a9d95dcc8f67 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.933589"^^xsd:dateTime ;
    dcterms:identifier "468e2b24-db43-4348-906c-a9d95dcc8f67" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 493" ;
    ke-wp:keyEventName "Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts" ;
    ke-wp:pathwayId "WP4753" ;
    ke-wp:pathwayTitle "Nucleotide excision repair" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:469c7e46-d209-478e-8d88-ae06b7712b8f a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-13T12:28:18.665829"^^xsd:dateTime ;
    dcterms:identifier "469c7e46-d209-478e-8d88-ae06b7712b8f" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 667" ;
    ke-wp:keyEventName "Binding at picrotoxin site, iGABAR chloride channel" ;
    ke-wp:pathwayId "WP4159" ;
    ke-wp:pathwayTitle "GABA receptor signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:47a1ee61-a7ab-4be9-b974-91565cb2277e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:05:52.754548"^^xsd:dateTime ;
    dcterms:identifier "47a1ee61-a7ab-4be9-b974-91565cb2277e" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1829" ;
    ke-wp:keyEventName "Altered, Thyroid hormone-dependent gene expression" ;
    ke-wp:pathwayId "WP4746" ;
    ke-wp:pathwayTitle "Thyroid hormones production and peripheral downstream signaling effects" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:47a98ef6-02c4-492c-acba-4e1cd5a16279 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:50:22.522470"^^xsd:dateTime ;
    dcterms:identifier "47a98ef6-02c4-492c-acba-4e1cd5a16279" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1218" ;
    ke-wp:keyEventName "Opening of calcium channel, Calcium influx" ;
    ke-wp:pathwayId "WP536" ;
    ke-wp:pathwayTitle "Calcium regulation in cardiac cells" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:48731973-7147-4f20-9c5a-7c4e2b4bb541 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:29:09.047459"^^xsd:dateTime ;
    dcterms:identifier "48731973-7147-4f20-9c5a-7c4e2b4bb541" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 780" ;
    ke-wp:keyEventName "Increase, Cytotoxicity (epithelial cells)" ;
    ke-wp:pathwayId "WP1772" ;
    ke-wp:pathwayTitle "Apoptosis modulation and signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:48b354a6-3e6c-46ae-af8f-f8873770c180 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T12:05:03.378804"^^xsd:dateTime ;
    dcterms:identifier "48b354a6-3e6c-46ae-af8f-f8873770c180" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 272" ;
    ke-wp:keyEventName "Activation/Proliferation, T-cells" ;
    ke-wp:pathwayId "WP69" ;
    ke-wp:pathwayTitle "T-cell receptor signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:49458423-10d4-4f5d-97fe-7f5993e50f77 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:48:16.183092"^^xsd:dateTime ;
    dcterms:identifier "49458423-10d4-4f5d-97fe-7f5993e50f77" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1933" ;
    ke-wp:keyEventName "Increased, Interleukin-6 production" ;
    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:4946b5df-38b9-465d-8dc4-0aa3ae021f3b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:49:38.324622"^^xsd:dateTime ;
    dcterms:identifier "4946b5df-38b9-465d-8dc4-0aa3ae021f3b" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 486" ;
    ke-wp:keyEventName "systemic inflammation leading to hepatic steatosis" ;
    ke-wp:pathwayId "WP453" ;
    ke-wp:pathwayTitle "Inflammatory response pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:4967e507-23a7-456c-bd1a-9222418b254e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    dcterms:identifier "4967e507-23a7-456c-bd1a-9222418b254e" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1818" ;
    ke-wp:keyEventName "Immune cell activation" ;
    ke-wp:pathwayId "WP69" ;
    ke-wp:pathwayTitle "T-cell receptor signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:4a500613-39c8-4067-8946-651f568a8c3e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T17:31:28.855312"^^xsd:dateTime ;
    dcterms:identifier "4a500613-39c8-4067-8946-651f568a8c3e" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 654" ;
    ke-wp:keyEventName "Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists" ;
    ke-wp:pathwayId "WP5393" ;
    ke-wp:pathwayTitle "Androgen biosynthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:4a98519c-1b33-4a65-9955-f3d946014787 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:21:49.280027"^^xsd:dateTime ;
    dcterms:identifier "4a98519c-1b33-4a65-9955-f3d946014787" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1556" ;
    ke-wp:keyEventName "Increase, lung cancer" ;
    ke-wp:pathwayId "WP4255" ;
    ke-wp:pathwayTitle "Non-small cell lung cancer" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:4ac6be90-26fe-4789-a7fc-bf1a67ee53fd a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1740" ;
    ke-wp:keyEventName "Induced dysregulation of ACE2" ;
    ke-wp:pathwayId "WP554" ;
    ke-wp:pathwayTitle "ACE inhibitor pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:4bc9372a-3b46-4fe9-82d3-685e3c05620b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 177" ;
    ke-wp:keyEventName "Increase, Mitochondrial dysfunction" ;
    ke-wp:pathwayId "WP5507" ;
    ke-wp:pathwayTitle "Mitochondrial carrier deficiency associated with shuttle disturbances" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:4d80e5f7-7a7d-4d63-be36-56af9762834a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 757" ;
    ke-wp:keyEventName "Hippocampal anatomy, Altered" ;
    ke-wp:pathwayId "WP5231" ;
    ke-wp:pathwayTitle "Hippocampal synaptogenesis and neurogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:4f2ca984-f4f1-44f7-8513-9587ca39c010 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2216" ;
    ke-wp:keyEventName "Binding of antagonist to thyroid hormone receptor" ;
    ke-wp:pathwayId "WP4746" ;
    ke-wp:pathwayTitle "Thyroid hormones production and peripheral downstream signaling effects" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:4f78f4fb-e5db-43ae-84dc-29ac03b27c14 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1306" ;
    ke-wp:keyEventName "Increase, De novo lipogenesis" ;
    ke-wp:pathwayId "WP3965" ;
    ke-wp:pathwayTitle "Lipid metabolism pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:4f98ca00-860c-404a-9cea-7e1b0cbae208 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 454" ;
    ke-wp:keyEventName "Increased, Triglyceride formation" ;
    ke-wp:pathwayId "WP325" ;
    ke-wp:pathwayTitle "Triacylglyceride synthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:4fea7294-ff85-45fb-8756-b3a5aaffcf8a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:keyEventId "KE 2039" ;
    ke-wp:keyEventName "Inhibition GABAA receptor" ;
    ke-wp:pathwayId "WP4159" ;
    ke-wp:pathwayTitle "GABA receptor signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:501369d9-4380-407a-b4fc-337cde0a3fd5 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2110" ;
    ke-wp:keyEventName "Disrupted binding, laminin-beta1-integrin receptors with laminin" ;
    ke-wp:pathwayId "WP185" ;
    ke-wp:pathwayTitle "Integrin-mediated cell adhesion" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:5020b87c-7f90-420d-a747-91f0d4744134 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 761" ;
    ke-wp:keyEventName "Increased, Chloride conductance" ;
    ke-wp:pathwayId "WP4159" ;
    ke-wp:pathwayTitle "GABA receptor signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:50933917-0690-4401-9a66-4b8cfc3899c5 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1413" ;
    ke-wp:keyEventName "Reduced, presynaptic neuron 2 activity" ;
    ke-wp:pathwayId "WP2267" ;
    ke-wp:pathwayTitle "Synaptic vesicle pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:51635510-27ce-4bd9-a2ae-f6c20a6139f0 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:46:38.938392"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 383" ;
    ke-wp:keyEventName "Reduced, Presynaptic release of glutamate" ;
    ke-wp:pathwayId "WP2267" ;
    ke-wp:pathwayTitle "Synaptic vesicle pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:519041c6-a531-4842-9bfa-ebc7a96ff5ce a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1350" ;
    ke-wp:keyEventName "Increased, glutamate" ;
    ke-wp:pathwayId "WP5083" ;
    ke-wp:pathwayTitle "Neuroinflammation and glutamatergic signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:51fbfd4e-a95e-46a3-8ac4-6a1439782354 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 2009" ;
    ke-wp:keyEventName "Activation of inflammation pathway" ;
    ke-wp:pathwayId "WP530" ;
    ke-wp:pathwayTitle "Cytokines and inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:529c0637-5996-46a5-8581-b8d2bf2b9c7e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1841" ;
    ke-wp:keyEventName "Encephalitis" ;
    ke-wp:pathwayId "WP4919" ;
    ke-wp:pathwayTitle "Neuroinflammation" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:535d741b-8f8c-4201-ae06-ea6cd06bdafa a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 269" ;
    ke-wp:keyEventName "Induction, Sustained Cell Proliferation" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:54a188fb-08d1-4c68-9c7e-b68b0391b8f8 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "low" ;
    ke-wp:keyEventId "KE 1511" ;
    ke-wp:keyEventName "Lipid Peroxidation" ;
    ke-wp:pathwayId "WP4313" ;
    ke-wp:pathwayTitle "Ferroptosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:54afbdb4-9841-4b0f-b1ae-b1f32c819cee a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:20:18.697620"^^xsd:dateTime ;
    dcterms:identifier "54afbdb4-9841-4b0f-b1ae-b1f32c819cee" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1607" ;
    ke-wp:keyEventName "Increase, Necrosis" ;
    ke-wp:pathwayId "WP4313" ;
    ke-wp:pathwayTitle "Ferroptosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:54e68995-3db6-4f4f-9878-60fd8fcccd0a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-19T12:08:59.796963"^^xsd:dateTime ;
    dcterms:identifier "54e68995-3db6-4f4f-9878-60fd8fcccd0a" ;
    ke-wp:aopWikiSnapshotDate "2026-08-13"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2221" ;
    ke-wp:keyEventName "Altered Liver X receptor activity" ;
    ke-wp:pathwayId "WP2874" ;
    ke-wp:pathwayTitle "Liver X receptor pathway" ;
    ke-wp:wpReleaseDate "2026-08-10"^^xsd:date .

mapping:5529072e-22cb-4632-b80b-e080b41d4625 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.926471"^^xsd:dateTime ;
    dcterms:identifier "5529072e-22cb-4632-b80b-e080b41d4625" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 451" ;
    ke-wp:keyEventName "Inhibition, Mitochondrial fatty acid beta-oxidation" ;
    ke-wp:pathwayId "WP368" ;
    ke-wp:pathwayTitle "Mitochondrial long chain fatty acid beta-oxidation" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:5638fba3-f3bd-43c0-8308-f17f7cf2e1e0 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:16:10.450811"^^xsd:dateTime ;
    dcterms:identifier "5638fba3-f3bd-43c0-8308-f17f7cf2e1e0" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 2094" ;
    ke-wp:keyEventName "Abnormal, neuroblast migration" ;
    ke-wp:pathwayId "WP5289" ;
    ke-wp:pathwayTitle "Axon guidance" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:56e4bdbc-33e9-46cd-a71a-d71253b8d1b8 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.933660"^^xsd:dateTime ;
    dcterms:identifier "56e4bdbc-33e9-46cd-a71a-d71253b8d1b8" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 376" ;
    ke-wp:keyEventName "Increased, Induced Mutations in Critical Genes" ;
    ke-wp:pathwayId "WP4946" ;
    ke-wp:pathwayTitle "Genes and complexes involved in the DNA repair pathways" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:58039853-ac17-419f-8372-d658072d19c6 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:17:58.036983"^^xsd:dateTime ;
    dcterms:identifier "58039853-ac17-419f-8372-d658072d19c6" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1819" ;
    ke-wp:keyEventName "IFNγ signaling" ;
    ke-wp:pathwayId "WP619" ;
    ke-wp:pathwayTitle "Type II interferon signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:58256fa2-9403-4dc6-9474-0092a4ecc42c a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:14.762343"^^xsd:dateTime ;
    dcterms:identifier "58256fa2-9403-4dc6-9474-0092a4ecc42c" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 902" ;
    ke-wp:keyEventName "Inflammation, Liver" ;
    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:58a8c278-8efe-4f81-bf80-1fae402460ce a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2026-03-01T12:25:15.125934"^^xsd:dateTime ;
    dcterms:identifier "58a8c278-8efe-4f81-bf80-1fae402460ce" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 819" ;
    ke-wp:keyEventName "Decreased, Glomerular filtration" ;
    ke-wp:pathwayId "WP2572" ;
    ke-wp:pathwayTitle "Primary focal segmental glomerulosclerosis (FSGS)" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:58d250b6-dc0a-4c98-bf90-e683f9db94fd a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:29:22.993863"^^xsd:dateTime ;
    dcterms:identifier "58d250b6-dc0a-4c98-bf90-e683f9db94fd" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 771" ;
    ke-wp:keyEventName "Decrease, Serum thyroid hormone (T4/T3)" ;
    ke-wp:pathwayId "WP1981" ;
    ke-wp:pathwayTitle "Thyroxine (thyroid hormone) production" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:59d15e8b-f7af-4a88-bed3-daca8648e3c7 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:49:44.790635"^^xsd:dateTime ;
    dcterms:identifier "59d15e8b-f7af-4a88-bed3-daca8648e3c7" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1263" ;
    ke-wp:keyEventName "Necrosis" ;
    ke-wp:pathwayId "WP2513" ;
    ke-wp:pathwayTitle "Nanoparticle triggered regulated necrosis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:59d61db8-749b-4f33-a346-2f50bd05477e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T11:44:54.590083"^^xsd:dateTime ;
    dcterms:identifier "59d61db8-749b-4f33-a346-2f50bd05477e" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 960" ;
    ke-wp:keyEventName "Increased, Uptake of thyroxine into tissue" ;
    ke-wp:pathwayId "WP4746" ;
    ke-wp:pathwayTitle "Thyroid hormones production and peripheral downstream signaling effects" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:5a5f44e0-3137-4495-8c05-7771b65e4f76 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    dcterms:identifier "5a5f44e0-3137-4495-8c05-7771b65e4f76" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1422" ;
    ke-wp:keyEventName "Reduced, PPARalpha" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:5af8a926-c3b0-49a8-8be8-e173a54a4f06 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:16:47.977610"^^xsd:dateTime ;
    dcterms:identifier "5af8a926-c3b0-49a8-8be8-e173a54a4f06" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2031" ;
    ke-wp:keyEventName "Releasing, Apoptosis-Inducing Factor (AIF)" ;
    ke-wp:pathwayId "WP1772" ;
    ke-wp:pathwayTitle "Apoptosis modulation and signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:5b95718d-edb7-4017-8f2c-d95708da060f a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:47:07.781262"^^xsd:dateTime ;
    dcterms:identifier "5b95718d-edb7-4017-8f2c-d95708da060f" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1489" ;
    ke-wp:keyEventName "N/A, Steatohepatisis" ;
    ke-wp:pathwayId "WP4396" ;
    ke-wp:pathwayTitle "Nonalcoholic fatty liver disease" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:5cc6d938-cd92-45fb-b66c-d9478dfa9699 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.931560"^^xsd:dateTime ;
    dcterms:identifier "5cc6d938-cd92-45fb-b66c-d9478dfa9699" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 233" ;
    ke-wp:keyEventName "Decreased, PPAR-gamma activation" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:5d26d2f4-7640-4e9f-ba6d-af3a4764ae9a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:16:37.189856"^^xsd:dateTime ;
    dcterms:identifier "5d26d2f4-7640-4e9f-ba6d-af3a4764ae9a" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2225" ;
    ke-wp:keyEventName "Disrupted Lipid Storage" ;
    ke-wp:pathwayId "WP3965" ;
    ke-wp:pathwayTitle "Lipid metabolism pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:5d640dfa-990b-4110-8ba7-41b7973a2986 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:03:53.576286"^^xsd:dateTime ;
    dcterms:identifier "5d640dfa-990b-4110-8ba7-41b7973a2986" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2208" ;
    ke-wp:keyEventName "Aberrant, synaptic formation and plasticity" ;
    ke-wp:pathwayId "WP4875" ;
    ke-wp:pathwayTitle "Disruption of postsynaptic signaling by CNV" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:5f5f1b9a-adf3-4728-988a-921c11d894a8 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 450" ;
    ke-wp:keyEventName "Suppression, VLDL secretion" ;
    ke-wp:pathwayId "WP5323" ;
    ke-wp:pathwayTitle "Fatty acid and lipoprotein transport in hepatocytes" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:5fd09ce1-9d89-4f2e-b93d-eb4bb48d1bc4 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 491" ;
    ke-wp:keyEventName "Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:60051014-a31f-427c-bcc7-5317a6a6c403 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:44:49.558899"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 178" ;
    ke-wp:keyEventName "Mitochondrial electron transport chain, disrupted" ;
    ke-wp:pathwayId "WP4324" ;
    ke-wp:pathwayTitle "Mitochondrial complex I assembly model OXPHOS system" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:60478fe8-eebc-4371-8b7d-d84c4ea36037 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    dcterms:identifier "60478fe8-eebc-4371-8b7d-d84c4ea36037" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 177" ;
    ke-wp:keyEventName "Mitochondrial dysfunction" ;
    ke-wp:pathwayId "WP111" ;
    ke-wp:pathwayTitle "Electron transport chain: OXPHOS system in mitochondria" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:60e2f282-42e4-48f6-a9c7-db2aa47d11a6 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1848" ;
    ke-wp:keyEventName "Toll Like Receptor (TLR) Dysregulation" ;
    ke-wp:pathwayId "WP3858" ;
    ke-wp:pathwayTitle "Toll-like receptor signaling related to MyD88" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:618c2abc-12a9-4091-ade3-4376740f7836 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-04-12T16:58:56.163068"^^xsd:dateTime ;
    dcterms:identifier "618c2abc-12a9-4091-ade3-4376740f7836" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1743" ;
    ke-wp:keyEventName "Increase plasma Ang II" ;
    ke-wp:pathwayId "WP4756" ;
    ke-wp:pathwayTitle "Renin-angiotensin-aldosterone system (RAAS)" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:61b17d69-6ecd-4a7c-8952-3041c0a232cb a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    dcterms:identifier "61b17d69-6ecd-4a7c-8952-3041c0a232cb" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 378" ;
    ke-wp:keyEventName "Tumorigenesis, Hepatocellular carcinoma" ;
    ke-wp:pathwayId "WP4336" ;
    ke-wp:pathwayTitle "ncRNAs in Wnt signaling in hepatocellular carcinoma" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:61e8e9b2-5ebb-4e69-b65e-76e41a9ef420 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:31:06.694475"^^xsd:dateTime ;
    dcterms:identifier "61e8e9b2-5ebb-4e69-b65e-76e41a9ef420" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 767" ;
    ke-wp:keyEventName "Increase, Hyperplasia (renal tubular cells)" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:6299240d-1cc1-4f15-bd42-45ccf8238db7 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1853" ;
    ke-wp:keyEventName "Hyperactivation of ACE/Ang-II/AT1R axis" ;
    ke-wp:pathwayId "WP5036" ;
    ke-wp:pathwayTitle "Angiotensin II receptor type 1 pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:629c9049-414c-488c-a381-d280c7ade0eb a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    dcterms:identifier "629c9049-414c-488c-a381-d280c7ade0eb" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1012" ;
    ke-wp:keyEventName "Increased, Inhibitory postsynaptic potential" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:62bd589e-249a-4985-8405-6f7f7f8e31e5 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 291" ;
    ke-wp:keyEventName "Accumulation, Triglyceride" ;
    ke-wp:pathwayId "WP325" ;
    ke-wp:pathwayTitle "Triacylglyceride synthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:637fd9e7-ba5c-4820-bcfe-ed50cef508b0 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:44:35.715675"^^xsd:dateTime ;
    dcterms:identifier "637fd9e7-ba5c-4820-bcfe-ed50cef508b0" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 239" ;
    ke-wp:keyEventName "Activation, Pregnane-X receptor, NR1I2" ;
    ke-wp:pathwayId "WP2876" ;
    ke-wp:pathwayTitle "Pregnane X receptor pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:64719024-334b-4a16-9b26-423887bfa82b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:22:13.332232"^^xsd:dateTime ;
    dcterms:identifier "64719024-334b-4a16-9b26-423887bfa82b" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1538" ;
    ke-wp:keyEventName "Decreased protection against oxidative stress" ;
    ke-wp:pathwayId "WP408" ;
    ke-wp:pathwayTitle "Oxidative stress response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:66ff7c41-d4c0-4555-8ac2-6e96f8941d6d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-04-13T08:08:25.346790"^^xsd:dateTime ;
    dcterms:identifier "66ff7c41-d4c0-4555-8ac2-6e96f8941d6d" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2412" ;
    ke-wp:keyEventName "Increase, Hepatic intracellular active glucocorticoids" ;
    ke-wp:pathwayId "WP5280" ;
    ke-wp:pathwayTitle "Glucocorticoid biosynthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:688077d8-d53f-4e18-ae9b-86b03b557bbd a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:36:31.991467"^^xsd:dateTime ;
    dcterms:identifier "688077d8-d53f-4e18-ae9b-86b03b557bbd" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1487" ;
    ke-wp:keyEventName "Binding, Thiol/seleno-proteins involved in protection against oxidative stress" ;
    ke-wp:pathwayId "WP408" ;
    ke-wp:pathwayTitle "Oxidative stress response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:691d739b-ef13-48f7-83a6-23b2e146c92c a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:02:48.910256"^^xsd:dateTime ;
    dcterms:identifier "691d739b-ef13-48f7-83a6-23b2e146c92c" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1844" ;
    ke-wp:keyEventName "systemic inflammatory response syndrome" ;
    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:696bf0d2-dd9c-4b76-91fd-85df06899380 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T12:03:40.763986"^^xsd:dateTime ;
    dcterms:identifier "696bf0d2-dd9c-4b76-91fd-85df06899380" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 295" ;
    ke-wp:keyEventName "Induction, Upregulation of glucuronyltransferase activity" ;
    ke-wp:pathwayId "WP698" ;
    ke-wp:pathwayTitle "Glucuronidation" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:697dbaad-3c66-4939-ba72-e6b9d8209f4c a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.934025"^^xsd:dateTime ;
    dcterms:identifier "697dbaad-3c66-4939-ba72-e6b9d8209f4c" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 288" ;
    ke-wp:keyEventName "Activation of specific nuclear receptors, Transcriptional change" ;
    ke-wp:pathwayId "WP2882" ;
    ke-wp:pathwayTitle "Nuclear receptors meta-pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:69bab8f7-7c3d-4e6c-8c5d-2d33b2d843ad a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:45:08.475288"^^xsd:dateTime ;
    dcterms:identifier "69bab8f7-7c3d-4e6c-8c5d-2d33b2d843ad" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "low" ;
    ke-wp:keyEventId "KE 68" ;
    ke-wp:keyEventName "Increase, Collagen accumulation" ;
    ke-wp:pathwayId "WP3624" ;
    ke-wp:pathwayTitle "Lung fibrosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:69f63176-899e-41a5-a334-8087223e6af3 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:45:06.004097"^^xsd:dateTime ;
    dcterms:identifier "69f63176-899e-41a5-a334-8087223e6af3" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 202" ;
    ke-wp:keyEventName "Inhibition, Nuclear factor kappa B (NF-kB)" ;
    ke-wp:pathwayId "WP3656" ;
    ke-wp:pathwayTitle "Interleukin-1 induced activation of NF-kB" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:6baabf6a-835e-49e2-bb18-03ea081d5f88 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-15T12:03:53.681538"^^xsd:dateTime ;
    dcterms:identifier "6baabf6a-835e-49e2-bb18-03ea081d5f88" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 386" ;
    ke-wp:keyEventName "Decrease of neuronal network function" ;
    ke-wp:pathwayId "WP4539" ;
    ke-wp:pathwayTitle "Synaptic signaling associated with autism spectrum disorder" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:6bb30d07-942e-45e0-a8be-113b8c4a1ee7 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-05-11T18:32:08.534730"^^xsd:dateTime ;
    dcterms:identifier "6bb30d07-942e-45e0-a8be-113b8c4a1ee7" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 177" ;
    ke-wp:keyEventName "Increase, Mitochondrial dysfunction" ;
    ke-wp:pathwayId "WP78" ;
    ke-wp:pathwayTitle "TCA cycle (aka Krebs or citric acid cycle)" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:6bed8438-62b1-4adb-bab2-04187f927b92 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:54:20.351116"^^xsd:dateTime ;
    dcterms:identifier "6bed8438-62b1-4adb-bab2-04187f927b92" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1897" ;
    ke-wp:keyEventName "increased MyD88 activation" ;
    ke-wp:pathwayId "WP3877" ;
    ke-wp:pathwayTitle "MYD88 distinct input-output pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:6c09bce6-b0a3-4eec-9a3c-cdc29e340a27 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-05-11T18:16:47.739924"^^xsd:dateTime ;
    dcterms:identifier "6c09bce6-b0a3-4eec-9a3c-cdc29e340a27" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1825" ;
    ke-wp:keyEventName "Increase, Cell death" ;
    ke-wp:pathwayId "WP1772" ;
    ke-wp:pathwayTitle "Apoptosis modulation and signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:6c1ea844-60c6-420f-a2a0-265bdcfa0dac a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:43.247964"^^xsd:dateTime ;
    dcterms:identifier "6c1ea844-60c6-420f-a2a0-265bdcfa0dac" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 478" ;
    ke-wp:keyEventName "Activation, NRF2" ;
    ke-wp:pathwayId "WP4357" ;
    ke-wp:pathwayTitle "NRF2-ARE regulation" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:6cece2e6-5541-4155-b77d-46770c526ee1 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:18:23.366688"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1605" ;
    ke-wp:keyEventName "Accumulation of misfolded proteins" ;
    ke-wp:pathwayId "WP4925" ;
    ke-wp:pathwayTitle "Unfolded protein response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:6d2afdda-b83b-4d5b-8ea5-6d0f2a499f30 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:09:38.887353"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1788" ;
    ke-wp:keyEventName "Status epilepticus" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:6f156dd6-6c3a-4269-ade6-8ffe755979d7 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:47:15.016463"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2005" ;
    ke-wp:keyEventName "Altered neurotransmission in development" ;
    ke-wp:pathwayId "WP2267" ;
    ke-wp:pathwayTitle "Synaptic vesicle pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:6f212609-255d-44cf-887f-f0d8d4045722 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T09:52:56.192650"^^xsd:dateTime ;
    dcterms:identifier "6f212609-255d-44cf-887f-f0d8d4045722" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2300" ;
    ke-wp:keyEventName "Disruption, Glucolipid metabolism" ;
    ke-wp:pathwayId "WP3965" ;
    ke-wp:pathwayTitle "Lipid metabolism pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:6f36c7a5-1624-4209-b71b-63999f5db7ea a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:00:10.334832"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 2232" ;
    ke-wp:keyEventName "Antagonism, Retinoic acid receptors" ;
    ke-wp:pathwayId "WP716" ;
    ke-wp:pathwayTitle "Vitamin A and carotenoid metabolism" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:6f493927-5e8e-437d-b246-9909821e759e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    dcterms:identifier "6f493927-5e8e-437d-b246-9909821e759e" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1097" ;
    ke-wp:keyEventName "Occurrence, renal proximal tubular necrosis" ;
    ke-wp:pathwayId "WP4313" ;
    ke-wp:pathwayTitle "Ferroptosis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:6f79bc69-d518-4a43-bbf3-7d709729882b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.933954"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 288" ;
    ke-wp:keyEventName "Activation of specific nuclear receptors, Transcriptional change" ;
    ke-wp:pathwayId "WP299" ;
    ke-wp:pathwayTitle "Nuclear receptors in lipid metabolism and toxicity" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:6faf6930-6e6b-408e-b1ed-170c5646fb5b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1527" ;
    ke-wp:keyEventName "Increase, Cell membrane depolarization" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:702df415-f531-48f3-94f0-2e64f6e2fc4b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 486" ;
    ke-wp:keyEventName "systemic inflammation leading to hepatic steatosis" ;
    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:724dcf2c-a9e9-478d-b4fb-a653392fedc6 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1285" ;
    ke-wp:keyEventName "Up Regulation, Unsaturated fatty acid" ;
    ke-wp:pathwayId "WP4724" ;
    ke-wp:pathwayTitle "Omega-9 fatty acid synthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:740b563f-ff84-4c41-b39a-92778cee452e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1851" ;
    ke-wp:keyEventName "Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)" ;
    ke-wp:pathwayId "WP5036" ;
    ke-wp:pathwayTitle "Angiotensin II receptor type 1 pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:742b5962-500e-405b-ac14-240b7a6f666e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
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    dcterms:identifier "742b5962-500e-405b-ac14-240b7a6f666e" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 188" ;
    ke-wp:keyEventName "Neuroinflammation" ;
    ke-wp:pathwayId "WP4919" ;
    ke-wp:pathwayTitle "Neuroinflammation" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:74916ac5-2e1d-439e-bf35-abb2815fb29b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-13"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 941" ;
    ke-wp:keyEventName "Activation, EGFR" ;
    ke-wp:pathwayId "WP437" ;
    ke-wp:pathwayTitle "EGF/EGFR signaling" ;
    ke-wp:wpReleaseDate "2026-08-10"^^xsd:date .

mapping:7495d57d-13cb-4932-b5b4-4ced54d25d0c a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 840" ;
    ke-wp:keyEventName "Formation, Liver fibrosis" ;
    ke-wp:pathwayId "WP4786" ;
    ke-wp:pathwayTitle "Type I collagen synthesis in the context of osteogenesis imperfecta" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:75a5d197-39d0-4632-aeab-db0876622a8f a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 245" ;
    ke-wp:keyEventName "Activation, PXR/SXR" ;
    ke-wp:pathwayId "WP2876" ;
    ke-wp:pathwayTitle "Pregnane X receptor pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:76baaea0-2e1a-4629-b782-d80e41fb760d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:40:44.407153"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 2093" ;
    ke-wp:keyEventName "Brain thyroid hormone (T4/T3) decreased" ;
    ke-wp:pathwayId "WP4746" ;
    ke-wp:pathwayTitle "Thyroid hormones production and peripheral downstream signaling effects" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:772e8aa1-85ff-41ba-a3da-ce139f3adc5b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
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    dcterms:identifier "772e8aa1-85ff-41ba-a3da-ce139f3adc5b" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1392" ;
    ke-wp:keyEventName "Oxidative Stress" ;
    ke-wp:pathwayId "WP408" ;
    ke-wp:pathwayTitle "Oxidative stress response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:776ec9ad-30ac-469b-9b16-8b451f082237 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    dcterms:identifier "776ec9ad-30ac-469b-9b16-8b451f082237" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 838" ;
    ke-wp:keyEventName "Induction, Microvesicular fat" ;
    ke-wp:pathwayId "WP5123" ;
    ke-wp:pathwayTitle "Mitochondrial fatty acid oxidation disorders" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:777a19c2-8f05-47bc-9ff7-0436ce390ada a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:29.048159"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 854" ;
    ke-wp:keyEventName "Alterations, Cellular proliferation / hyperplasia" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:7823acd2-12b4-439a-b3c2-37ff868458f3 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:05:48.415608"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2151" ;
    ke-wp:keyEventName "Disruption, neurotransmitter release" ;
    ke-wp:pathwayId "WP2267" ;
    ke-wp:pathwayTitle "Synaptic vesicle pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:79ad02a0-a157-4746-aa8d-070f4db8240e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2025-08-13T05:42:58"^^xsd:dateTime ;
    dcterms:identifier "79ad02a0-a157-4746-aa8d-070f4db8240e" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 25" ;
    ke-wp:keyEventName "KE 25 - Agonism, Androgen receptor" ;
    ke-wp:pathwayId "WP138" ;
    ke-wp:pathwayTitle "Androgen receptor signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:79fb565c-7139-479f-accd-b38ffaefe95e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T11:45:32.068658"^^xsd:dateTime ;
    dcterms:identifier "79fb565c-7139-479f-accd-b38ffaefe95e" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 896" ;
    ke-wp:keyEventName "Parkinsonian motor deficits" ;
    ke-wp:pathwayId "WP2371" ;
    ke-wp:pathwayTitle "Parkinson's disease pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:7bc40c84-b209-4596-a7e1-da040fdbf7a8 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:36:43.726994"^^xsd:dateTime ;
    dcterms:identifier "7bc40c84-b209-4596-a7e1-da040fdbf7a8" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1469" ;
    ke-wp:keyEventName "Activation, Transforming Growth Factor beta pathway" ;
    ke-wp:pathwayId "WP560" ;
    ke-wp:pathwayTitle "TGF-beta receptor signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:7bde7550-36cb-44db-9d7a-62dfd9f66558 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T12:15:02.233571"^^xsd:dateTime ;
    dcterms:identifier "7bde7550-36cb-44db-9d7a-62dfd9f66558" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1352" ;
    ke-wp:keyEventName "Activated, voltage-gated sodium channel" ;
    ke-wp:pathwayId "WP5598" ;
    ke-wp:pathwayTitle "Sodium channel in epilepsy" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:7c024a14-81a3-4204-a0a6-ba5a61110bc2 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:29:34.337080"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 770" ;
    ke-wp:keyEventName "Increase, Cytotoxicity (club cells)" ;
    ke-wp:pathwayId "WP1772" ;
    ke-wp:pathwayTitle "Apoptosis modulation and signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:8042d055-eb6b-400a-ad1b-5c55a89303ac a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:46:55.724107"^^xsd:dateTime ;
    dcterms:identifier "8042d055-eb6b-400a-ad1b-5c55a89303ac" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 2010" ;
    ke-wp:keyEventName "Pulmonary inflammation" ;
    ke-wp:pathwayId "WP453" ;
    ke-wp:pathwayTitle "Inflammatory response pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:8128c066-9546-411e-a998-26fec560c68c a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:15:49.703426"^^xsd:dateTime ;
    dcterms:identifier "8128c066-9546-411e-a998-26fec560c68c" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1670" ;
    ke-wp:keyEventName "Lung cancer" ;
    ke-wp:pathwayId "WP4658" ;
    ke-wp:pathwayTitle "Small cell lung cancer" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:817a33e0-2427-4e97-a8cc-7248eae68113 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:05:54.841741"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2116" ;
    ke-wp:keyEventName "Decreased, oligodendrocyte differentiation" ;
    ke-wp:pathwayId "WP5574" ;
    ke-wp:pathwayTitle "Oligodendrocyte development" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:8249103b-49f2-44ab-a0b3-3b0582848879 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:18:11.092763"^^xsd:dateTime ;
    dcterms:identifier "8249103b-49f2-44ab-a0b3-3b0582848879" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1633" ;
    ke-wp:keyEventName "Increase in inflammation" ;
    ke-wp:pathwayId "WP530" ;
    ke-wp:pathwayTitle "Cytokines and inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:824ce1d6-18ad-447f-9ba0-0c95ab17a356 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-13T12:17:44.650586"^^xsd:dateTime ;
    dcterms:identifier "824ce1d6-18ad-447f-9ba0-0c95ab17a356" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1362" ;
    ke-wp:keyEventName "Increased, hippocampal hyperdepolarization" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:82e0e0d8-0e1e-481a-8542-bc863dc09ee4 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:47:48.824448"^^xsd:dateTime ;
    dcterms:identifier "82e0e0d8-0e1e-481a-8542-bc863dc09ee4" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1394" ;
    ke-wp:keyEventName "Induction, persistent proliferation/sustained proliferation" ;
    ke-wp:pathwayId "WP179" ;
    ke-wp:pathwayTitle "Cell cycle" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8494eb60-cc8f-4e3c-95b4-470e3d27d367 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:02:04.526182"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2218" ;
    ke-wp:keyEventName "Binding of (ant)agonist to liver X receptor" ;
    ke-wp:pathwayId "WP2874" ;
    ke-wp:pathwayTitle "Liver X receptor pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:84d82d9f-6e85-415e-a1ef-f6175b0d3af4 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-13T12:25:01.826515"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 783" ;
    ke-wp:keyEventName "Increase, Cytotoxicity (tubular epithelial cells)" ;
    ke-wp:pathwayId "WP4838" ;
    ke-wp:pathwayTitle "Regucalcin in proximal tubule epithelial kidney cells" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:8507e5b8-1f00-4a12-8f06-7e9577963da0 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T12:00:44.769587"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 381" ;
    ke-wp:keyEventName "Reduced levels of BDNF" ;
    ke-wp:pathwayId "WP2380" ;
    ke-wp:pathwayTitle "Brain-derived neurotrophic factor (BDNF) signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:8564e2e8-5f88-4def-881d-07339de606fb a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:51:00.958734"^^xsd:dateTime ;
    dcterms:identifier "8564e2e8-5f88-4def-881d-07339de606fb" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "low" ;
    ke-wp:keyEventId "KE 1456" ;
    ke-wp:keyEventName "Increase, Differentiation of fibroblasts" ;
    ke-wp:pathwayId "WP3624" ;
    ke-wp:pathwayTitle "Lung fibrosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:85ff536f-3d8a-4842-99eb-9e42f7938a23 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:51:13.301114"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1623" ;
    ke-wp:keyEventName "Occurrence, Focal Seizure" ;
    ke-wp:pathwayId "WP5598" ;
    ke-wp:pathwayTitle "Sodium channel in epilepsy" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:87c3f4d4-5e19-4aa1-b309-bdab8451fed0 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:21:59.543518"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1177" ;
    ke-wp:keyEventName "Decreased, Ionotropic GABA receptor chloride channel conductance" ;
    ke-wp:pathwayId "WP4159" ;
    ke-wp:pathwayTitle "GABA receptor signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:88ac9b15-c441-4376-966f-2a34012ec3e9 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:55:16.417677"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1857" ;
    ke-wp:keyEventName "Platelet-neutrophil interactions, Increased" ;
    ke-wp:pathwayId "WP4462" ;
    ke-wp:pathwayTitle "Platelet-mediated interactions with vascular and circulating cells" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:88bdcbd8-9dbe-4947-acb1-710b8134e04a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-13"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 179" ;
    ke-wp:keyEventName "Decrease, Fatty acid beta-oxidation" ;
    ke-wp:pathwayId "WP143" ;
    ke-wp:pathwayTitle "Fatty acid beta-oxidation" ;
    ke-wp:wpReleaseDate "2026-08-10"^^xsd:date .

mapping:88ce5205-8f30-41cf-b46c-a99c6cd2179b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1541" ;
    ke-wp:keyEventName "Mitochondrial Complex I inhibition" ;
    ke-wp:pathwayId "WP4324" ;
    ke-wp:pathwayTitle "Mitochondrial complex I assembly model OXPHOS system" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:88dd86d9-b6a3-4179-8664-1d947f5dd186 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 186" ;
    ke-wp:keyEventName "Altered, Neuroanatomy" ;
    ke-wp:pathwayId "WP5231" ;
    ke-wp:pathwayTitle "Hippocampal synaptogenesis and neurogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:89870f0a-a071-44c3-a8f7-aca76e0f48e4 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 716" ;
    ke-wp:keyEventName "Increase, cell proliferation (hepatocytes)" ;
    ke-wp:pathwayId "WP313" ;
    ke-wp:pathwayTitle "Hepatocyte growth factor receptor signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8a951aed-8624-4c37-ad4c-2a192b80e710 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1422" ;
    ke-wp:keyEventName "Reduced, PPARalpha" ;
    ke-wp:pathwayId "WP2878" ;
    ke-wp:pathwayTitle "PPAR-alpha pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8aba0b0c-1d85-4ba8-8dab-dc1bd303b33a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 1283" ;
    ke-wp:keyEventName "Activation, TGF-beta pathway" ;
    ke-wp:pathwayId "WP560" ;
    ke-wp:pathwayTitle "TGF-beta receptor signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8c6b2d57-e547-4573-9f3b-5aa50585b635 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 870" ;
    ke-wp:keyEventName "Increase, Cell Proliferation" ;
    ke-wp:pathwayId "WP179" ;
    ke-wp:pathwayTitle "Cell cycle" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8cc61567-5358-4810-a978-fbad69c62320 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 881" ;
    ke-wp:keyEventName "Increased, Triglyceride" ;
    ke-wp:pathwayId "WP5323" ;
    ke-wp:pathwayTitle "Fatty acid and lipoprotein transport in hepatocytes" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8e02b782-6c64-4874-afb7-0b955c6f3b53 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 831" ;
    ke-wp:keyEventName "Disturbance, Lysosomal function" ;
    ke-wp:pathwayId "WP4923" ;
    ke-wp:pathwayTitle "Autophagy" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8e1cf23e-380f-444d-a921-00ac2b4eb5e2 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1912" ;
    ke-wp:keyEventName "Motile Cilia Number/Length, Decreased" ;
    ke-wp:pathwayId "WP4536" ;
    ke-wp:pathwayTitle "Genes related to primary cilium development (based on CRISPR)" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:8e2c714a-819b-4fa4-81d4-4009b12e6664 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.931201"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 327" ;
    ke-wp:keyEventName "Accumulation, Fatty acid" ;
    ke-wp:pathwayId "WP143" ;
    ke-wp:pathwayTitle "Fatty acid beta-oxidation" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8ebdf99b-6e06-4328-9696-181cd0994209 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 165" ;
    ke-wp:keyEventName "Activation, Long term AHR receptor driven direct and indirect gene expression changes" ;
    ke-wp:pathwayId "WP2586" ;
    ke-wp:pathwayTitle "Aryl hydrocarbon receptor response to main mediators PAH and TCDD" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:8ed559b0-17d9-4538-99f3-8ff91f90beaa a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1214" ;
    ke-wp:keyEventName "Altered gene expression specific to CAR activation, Hepatocytes" ;
    ke-wp:pathwayId "WP2875" ;
    ke-wp:pathwayTitle "Constitutive androstane receptor pathway" ;
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mapping:9067f7af-d5e5-415a-afdf-f6ce15bfeb85 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 850" ;
    ke-wp:keyEventName "Induction, CYP1A2/CYP1A5" ;
    ke-wp:pathwayId "WP2586" ;
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mapping:915c2c4a-2ac5-4a31-8523-1fa4ebc5b1ce a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 1458" ;
    ke-wp:keyEventName "Pulmonary fibrosis" ;
    ke-wp:pathwayId "WP3624" ;
    ke-wp:pathwayTitle "Lung fibrosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:923fb92c-75f1-4e41-94a7-b4a9d9474b53 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Oxidative Stress" ;
    ke-wp:pathwayId "WP3941" ;
    ke-wp:pathwayTitle "Oxidative damage response" ;
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mapping:92a1425c-c8ab-457e-9675-ddab3f0f5155 a ke-wp:KeyEventPathwayMapping ;
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mapping:935eb43f-3226-4cf1-abce-d38cbe9f91c2 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Mitochondrial dysfunction" ;
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    ke-wp:pathwayTitle "Oxidative phosphorylation" ;
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mapping:93ed848b-4b26-4e95-814c-0b253551ccd5 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Collagen Deposition" ;
    ke-wp:pathwayId "WP5312" ;
    ke-wp:pathwayTitle "Metabolic pathways of fibroblasts" ;
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mapping:93fce828-81cd-4305-b7ba-1b36ca0650f5 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 926" ;
    ke-wp:keyEventName "Oxidation, Glutathione (To be considered with MIE)" ;
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mapping:94bdac0c-dbd6-4680-b6ed-f52a9fccad74 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 1494" ;
    ke-wp:keyEventName "Leukocyte recruitment/activation" ;
    ke-wp:pathwayId "WP4542" ;
    ke-wp:pathwayTitle "Leukocyte-intrinsic Hippo pathway functions" ;
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mapping:95e9d3a7-c450-4e69-be30-d828220e93de a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Peptide Oxidation" ;
    ke-wp:pathwayId "WP408" ;
    ke-wp:pathwayTitle "Oxidative stress response" ;
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mapping:97b1ad41-4095-4b1c-a226-78de4a2c8f56 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Reduced number of oligodendrocytes" ;
    ke-wp:pathwayId "WP5574" ;
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mapping:97e56fdd-c416-46a5-86bd-02df2ef90cc9 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 839" ;
    ke-wp:keyEventName "Formation, Mallory body" ;
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    ke-wp:pathwayTitle "Proteasome degradation" ;
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mapping:98189a63-5c9c-4b47-835b-dceb0c6e8871 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Inhibition, SREBP1c" ;
    ke-wp:pathwayId "WP1982" ;
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mapping:992d5d01-bc59-4caa-bb36-41b1bf5fa3b1 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 1847" ;
    ke-wp:keyEventName "Increased SARS-CoV-2 production" ;
    ke-wp:pathwayId "WP4846" ;
    ke-wp:pathwayTitle "SARS-CoV-2 and COVID-19 pathway" ;
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mapping:99c31115-54ec-416a-b723-e6d8004313c0 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 1365" ;
    ke-wp:keyEventName "Increase, Apoptosis" ;
    ke-wp:pathwayId "WP1772" ;
    ke-wp:pathwayTitle "Apoptosis modulation and signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:9c09469b-c9d4-44f7-8e15-2455762ae121 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
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    ke-wp:keyEventName "Airway remodeling" ;
    ke-wp:pathwayId "WP3624" ;
    ke-wp:pathwayTitle "Lung fibrosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:9c80084f-a261-4e3d-9424-08ac9fad7ecc a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
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    ke-wp:keyEventName "Airway inflammation" ;
    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:9d722c70-9b86-4d16-82ad-1938198c69d9 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 373" ;
    ke-wp:keyEventName "Formation, Pro-mutagenic DNA Adducts" ;
    ke-wp:pathwayId "WP4753" ;
    ke-wp:pathwayTitle "Nucleotide excision repair" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:9dcb63b9-afc2-4351-80b5-40750a925c8f a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 2227" ;
    ke-wp:keyEventName "Disrupted PPAR isoform nuclear signaling" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:9e3bc5f4-7243-41fd-afd6-f70cf049e801 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:keyEventId "KE 1489" ;
    ke-wp:keyEventName "N/A, Steatohepatisis" ;
    ke-wp:pathwayId "WP453" ;
    ke-wp:pathwayTitle "Inflammatory response pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:9f064b32-a4ab-4c50-8f64-4db70aea6f7b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
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    ke-wp:keyEventId "KE 55" ;
    ke-wp:keyEventName "Increase, Cell injury/death" ;
    ke-wp:pathwayId "WP2507" ;
    ke-wp:pathwayTitle "Nanomaterial induced apoptosis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:9f24fa69-dbe8-49a0-b41c-0d6505f6adcd a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 756" ;
    ke-wp:keyEventName "Hippocampal gene expression, Altered" ;
    ke-wp:pathwayId "WP5231" ;
    ke-wp:pathwayTitle "Hippocampal synaptogenesis and neurogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:9f7f0d83-5da6-489d-a87b-91601ae8edef a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Thrombosis and Disseminated Intravascular Coagulation" ;
    ke-wp:pathwayId "WP272" ;
    ke-wp:pathwayTitle "Blood clotting cascade" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:9f80d9ef-808c-4859-8f80-f084fd7e995b a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Activation, 5HT2c" ;
    ke-wp:pathwayId "WP732" ;
    ke-wp:pathwayTitle "Serotonin receptor 2 and ELK-SRF/GATA4 signaling" ;
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mapping:9f8e5303-ca8e-4ff5-8344-f07156eb14a4 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Decrease of synaptogenesis" ;
    ke-wp:pathwayId "WP5231" ;
    ke-wp:pathwayTitle "Hippocampal synaptogenesis and neurogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:9fe2bd77-5347-46fd-9eeb-8b87771d3b05 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Hypomyelination" ;
    ke-wp:pathwayId "WP4304" ;
    ke-wp:pathwayTitle "Oligodendrocyte specification and differentiation, leading to myelin components for CNS" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a08472d6-8b80-43b8-96dc-f74131782c19 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Fibroproliferative airway lesions" ;
    ke-wp:pathwayId "WP3624" ;
    ke-wp:pathwayTitle "Lung fibrosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a1deff2c-95be-4f5b-b431-3e3424ca920c a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)" ;
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    ke-wp:pathwayTitle "Renin-angiotensin-aldosterone system (RAAS)" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a1e7b45c-891a-4307-97d3-adb33dc415cb a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:keyEventName "Decreased, Neuronal network function in adult brain" ;
    ke-wp:pathwayId "WP5083" ;
    ke-wp:pathwayTitle "Neuroinflammation and glutamatergic signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a20a7421-7dea-47d1-a9b0-8a3ce2b1bcdb a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increased Pro-inflammatory mediators" ;
    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:a28dd624-1171-4780-bc8c-1c17fd83004d a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Hepatocellular lipotoxicity" ;
    ke-wp:pathwayId "WP5323" ;
    ke-wp:pathwayTitle "Fatty acid and lipoprotein transport in hepatocytes" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:a374232d-d164-4ca5-bcb7-80a388144774 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Activation, TGF-beta pathway" ;
    ke-wp:pathwayId "WP3874" ;
    ke-wp:pathwayTitle "Canonical and non-canonical TGF-B signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a572404e-ec3e-4e92-afbb-a7de2c22a6fe a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2300" ;
    ke-wp:keyEventName "Disruption, Glucolipid metabolism" ;
    ke-wp:pathwayId "WP534" ;
    ke-wp:pathwayTitle "Glycolysis and gluconeogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a59b2893-5f85-4e82-83c5-9536bab503de a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 188" ;
    ke-wp:keyEventName "Neuroinflammation" ;
    ke-wp:pathwayId "WP5083" ;
    ke-wp:pathwayTitle "Neuroinflammation and glutamatergic signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a5c102fa-7b60-48fa-90e3-b7b811e583af a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1825" ;
    ke-wp:keyEventName "Increase, Cell death" ;
    ke-wp:pathwayId "WP254" ;
    ke-wp:pathwayTitle "Apoptosis" ;
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mapping:a5c68378-62e6-4549-9a4e-5c443d3f1cd3 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventName "Proliferation, Cell proliferation in the absence of cytotoxicity" ;
    ke-wp:pathwayId "WP179" ;
    ke-wp:pathwayTitle "Cell cycle" ;
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mapping:a6129677-ccf8-4044-aa25-b9963dbf7ac3 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 853" ;
    ke-wp:keyEventName "Changes/Inhibition, Cellular Homeostasis and Apoptosis" ;
    ke-wp:pathwayId "WP254" ;
    ke-wp:pathwayTitle "Apoptosis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:a61ac802-bc0f-4067-b6e6-8bca6e94ca4d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 1417" ;
    ke-wp:keyEventName "NFE2/Nrf2 repression" ;
    ke-wp:pathwayId "WP4357" ;
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mapping:a6638a2b-0e38-4d4f-9e09-89b36b530398 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 40" ;
    ke-wp:keyEventName "Mitochondrial ATP production, decreased" ;
    ke-wp:pathwayId "WP391" ;
    ke-wp:pathwayTitle "Mitochondrial gene expression" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:a729c940-c492-4161-a76f-eab6af7d8ce1 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 1852" ;
    ke-wp:keyEventName "Increased Ang II type 1 receptor (AT1R)" ;
    ke-wp:pathwayId "WP5036" ;
    ke-wp:pathwayTitle "Angiotensin II receptor type 1 pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:a73e634e-cfe2-4e67-969a-1d58e21000c9 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 881" ;
    ke-wp:keyEventName "Increased, Triglyceride" ;
    ke-wp:pathwayId "WP325" ;
    ke-wp:pathwayTitle "Triacylglyceride synthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:a78f2667-6a29-4c3f-afbc-6e79786cd7f4 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 2188" ;
    ke-wp:keyEventName "Activation, caspases" ;
    ke-wp:pathwayId "WP254" ;
    ke-wp:pathwayTitle "Apoptosis" ;
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mapping:a7f286e7-0afc-49f9-8cc0-50c6c18a0f20 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventName "Increase, Kupffer cell activation" ;
    ke-wp:pathwayId "WP530" ;
    ke-wp:pathwayTitle "Cytokines and inflammatory response" ;
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mapping:a8060df8-4dff-437a-9da7-5b5a791c4628 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 2031" ;
    ke-wp:keyEventName "Releasing, Apoptosis-Inducing Factor (AIF)" ;
    ke-wp:pathwayId "WP2507" ;
    ke-wp:pathwayTitle "Nanomaterial induced apoptosis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:a9336c38-aa97-43b2-a82c-43dad852368b a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
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    ke-wp:keyEventId "KE 1579" ;
    ke-wp:keyEventName "Increase, proinflammatory mediators (TNFalpha)" ;
    ke-wp:pathwayId "WP5095" ;
    ke-wp:pathwayTitle "Overview of proinflammatory and profibrotic mediators" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:a95cb0c2-284e-4a2c-a8af-0986ff41f1e1 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 352" ;
    ke-wp:keyEventName "N/A, Neurodegeneration" ;
    ke-wp:pathwayId "WP5372" ;
    ke-wp:pathwayTitle "Involvement of δ-secretase in neurodegenerative diseases" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a977caef-89f2-4dc7-914f-432924357bd6 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 682" ;
    ke-wp:keyEventName "Generation, Amplified excitatory postsynaptic potential (EPSP)" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:a9a24f8b-0174-4590-ac72-6321baeeb0df a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 716" ;
    ke-wp:keyEventName "Increase, cell proliferation (hepatocytes)" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:aa362328-b2d1-42f3-9820-2810a4d5fa31 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 41" ;
    ke-wp:keyEventName "Inhibition, Bile Salt Export Pump (ABCB11)" ;
    ke-wp:pathwayId "WP5176" ;
    ke-wp:pathwayTitle "Disorders of bile acid synthesis and biliary transport" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:ab8f0b1c-b460-42fd-9f84-87836b2ba7e6 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 87" ;
    ke-wp:keyEventName "Release, Cytokine" ;
    ke-wp:pathwayId "WP5473" ;
    ke-wp:pathwayTitle "Cytokine-cytokine receptor interaction" ;
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mapping:ac6e7d32-0072-4629-8ab0-704c5841e750 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Up Regulation, SREBF2" ;
    ke-wp:pathwayId "WP2011" ;
    ke-wp:pathwayTitle "SREBF and miR33 in cholesterol and lipid homeostasis" ;
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mapping:acbe3abe-1692-4d0c-ad78-5c55b9795de4 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Altered, Redox Homeostasis" ;
    ke-wp:pathwayId "WP408" ;
    ke-wp:pathwayTitle "Oxidative stress response" ;
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mapping:acc43298-853d-4ac5-968b-a08a147a15d4 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Perturbation of cholesterol" ;
    ke-wp:pathwayId "WP197" ;
    ke-wp:pathwayTitle "Cholesterol biosynthesis pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:ad0eae30-1335-46c4-a9cd-59eb52118b1e a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "NFE2/Nrf2 repression" ;
    ke-wp:pathwayId "WP2884" ;
    ke-wp:pathwayTitle "NRF2 pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:ad8e72c7-cab3-42af-8855-4a5c2ab4e1f2 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:confidenceLevel "high" ;
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    ke-wp:keyEventName "Dysregulation of transcriptional expression within PPAR signaling network" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:adf9941e-23d8-45c9-8044-7fa2a5b7d40c a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Inhibition, FoxA2" ;
    ke-wp:pathwayId "WP5066" ;
    ke-wp:pathwayTitle "FOXA2 pathway" ;
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mapping:affc3bd7-b0e5-4e1c-b94e-927a45f0d5b4 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increased, Liver Steatosis" ;
    ke-wp:pathwayId "WP143" ;
    ke-wp:pathwayTitle "Fatty acid beta-oxidation" ;
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mapping:b0521ec4-05e5-4372-b945-88c6b0aff09e a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Apoptotic cell death" ;
    ke-wp:pathwayId "WP1772" ;
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mapping:b1415e96-09e8-4068-a80b-f7bca1e86da5 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Oxidative metabolism" ;
    ke-wp:pathwayId "WP623" ;
    ke-wp:pathwayTitle "Oxidative phosphorylation" ;
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mapping:b18926cd-899c-4fa9-885e-958475540f0f a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP5176" ;
    ke-wp:pathwayTitle "Disorders of bile acid synthesis and biliary transport" ;
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mapping:b1cd5927-bdfc-4ae7-8fad-1a5c33c7da4d a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Altered expression of cell cycle genes" ;
    ke-wp:pathwayId "WP179" ;
    ke-wp:pathwayTitle "Cell cycle" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:b21ac548-dd63-480b-9199-7f9391587af8 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP530" ;
    ke-wp:pathwayTitle "Cytokines and inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:b2a9a055-feeb-4fb9-9119-656ed2b72d4e a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:keyEventName "Reduction, Neuronal synaptic inhibition" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
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mapping:b2d2da42-2a9a-45b0-b5fe-1accf323796f a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Cell injury/death" ;
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mapping:b4a4e3ff-f944-43ba-be34-3f35006c219f a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increased, secretion of proinflammatory mediators" ;
    ke-wp:pathwayId "WP5095" ;
    ke-wp:pathwayTitle "Overview of proinflammatory and profibrotic mediators" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:b53d61ea-d3d8-45ea-b44c-309247dc7d28 a ke-wp:KeyEventPathwayMapping ;
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mapping:b684145d-c10c-45cd-bcd2-d92eb80479e3 a ke-wp:KeyEventPathwayMapping ;
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mapping:b6bf69b1-7de6-4a51-919b-29fced13d641 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP111" ;
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mapping:b6c2ac14-406f-4115-a3a5-cb3143173753 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Decreased, PPAR-alpha activation" ;
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    ke-wp:pathwayTitle "PPAR signaling" ;
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mapping:b6edd972-4d6e-4157-8333-53e6d8e9afa0 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
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mapping:b766fed5-d9c9-44ca-91d8-304a2b62f101 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Pro-Inflammatory Mediators" ;
    ke-wp:pathwayId "WP5095" ;
    ke-wp:pathwayTitle "Overview of proinflammatory and profibrotic mediators" ;
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mapping:b812ffae-2a8a-4aa4-8eb4-757f709ddc3b a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP4746" ;
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mapping:b825a39b-4cd7-4c4c-8359-408d0596bf0d a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Necrotic Tissue" ;
    ke-wp:pathwayId "WP254" ;
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mapping:b8decd6a-e53e-4101-b8d1-e15dd9f0dc61 a ke-wp:KeyEventPathwayMapping ;
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mapping:b8eeaa97-12cc-466d-b735-2fdfb03d3e22 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "KE 25 - Agonism, Androgen receptor" ;
    ke-wp:pathwayId "WP2263" ;
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mapping:b930e45f-98de-452c-a295-e81353f13fe2 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Activation, ionotropic GABA Receptor chloride channel" ;
    ke-wp:pathwayId "WP4159" ;
    ke-wp:pathwayTitle "GABA receptor signaling" ;
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mapping:baf27503-2a2d-4d54-a8b6-a564ad005658 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Apoptotic cell death" ;
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    ke-wp:pathwayTitle "Apoptosis" ;
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mapping:bb7b4563-1c93-4822-a3dc-3f77b1f509e1 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Decreased, Prostaglandin F2alpha concentration, plasma" ;
    ke-wp:pathwayId "WP98" ;
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mapping:bc2b4468-103b-4012-a06a-9dcd29bc1cff a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Activation, Dendritic Cells" ;
    ke-wp:pathwayId "WP5187" ;
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mapping:bc61c5f7-1634-4110-80dc-9afa7bb338b8 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP2011" ;
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mapping:bcb9009c-0096-44e9-8ee5-edc6c44914ea a ke-wp:KeyEventPathwayMapping ;
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mapping:be0733b8-1452-4f0c-b79f-7bbc4e90e11c a ke-wp:KeyEventPathwayMapping ;
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mapping:be8e0812-0e81-4af2-a584-d280b04f8a19 a ke-wp:KeyEventPathwayMapping ;
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mapping:c07b904a-6f45-49ca-b49c-8dafd9979e4c a ke-wp:KeyEventPathwayMapping ;
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mapping:c11425fd-d781-4f36-815d-d8931a5d5c8c a ke-wp:KeyEventPathwayMapping ;
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mapping:c22f212d-7fcb-42fe-be87-920ad5c25d3a a ke-wp:KeyEventPathwayMapping ;
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mapping:c2c192fb-179d-4e1a-b36e-938c134a6cd2 a ke-wp:KeyEventPathwayMapping ;
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mapping:c2c3a715-900f-496d-aa4c-722ac0a8ce99 a ke-wp:KeyEventPathwayMapping ;
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mapping:c46697c2-0a08-4f9b-bd38-d63653c81217 a ke-wp:KeyEventPathwayMapping ;
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mapping:c4afe1c4-6ba7-4bbb-bebc-e76706f11d35 a ke-wp:KeyEventPathwayMapping ;
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mapping:c4b296c4-0762-4456-91e6-b19d1e6c879a a ke-wp:KeyEventPathwayMapping ;
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mapping:c4c66b60-8087-4852-ad28-6cd02bb80c26 a ke-wp:KeyEventPathwayMapping ;
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mapping:c4d5693f-11de-4bdc-94e5-53339c6ce250 a ke-wp:KeyEventPathwayMapping ;
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mapping:c62826a9-3e1c-49c8-aa9c-1d25e71263c2 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Inhibition, Bile Salt Export Pump (ABCB11)" ;
    ke-wp:pathwayId "WP5396" ;
    ke-wp:pathwayTitle "Enterohepatic circulation of bile acids" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:c63f005f-980e-472c-8b77-5a753872dbfb a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-13T12:17:41.043424"^^xsd:dateTime ;
    dcterms:identifier "c63f005f-980e-472c-8b77-5a753872dbfb" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "low" ;
    ke-wp:keyEventId "KE 1445" ;
    ke-wp:keyEventName "Increase, Lipid peroxidation" ;
    ke-wp:pathwayId "WP4313" ;
    ke-wp:pathwayTitle "Ferroptosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:c701ae5c-50f4-483f-88a8-f0fadebc0487 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T11:49:57.676354"^^xsd:dateTime ;
    dcterms:identifier "c701ae5c-50f4-483f-88a8-f0fadebc0487" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 17" ;
    ke-wp:keyEventName "Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway" ;
    ke-wp:pathwayId "WP2873" ;
    ke-wp:pathwayTitle "Aryl hydrocarbon receptor pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:c75463d3-2a7c-4000-b542-58cf82da1fc8 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T17:32:12.662914"^^xsd:dateTime ;
    dcterms:identifier "c75463d3-2a7c-4000-b542-58cf82da1fc8" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 12" ;
    ke-wp:keyEventName "Acetylcholinesterase (AchE) Inhibition" ;
    ke-wp:pathwayId "WP550" ;
    ke-wp:pathwayTitle "Biogenic amine synthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:c843f1b7-61d2-4ee6-9e1a-eea2631c6012 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-04-13T08:09:11.297665"^^xsd:dateTime ;
    dcterms:identifier "c843f1b7-61d2-4ee6-9e1a-eea2631c6012" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "low" ;
    ke-wp:keyEventId "KE 2410" ;
    ke-wp:keyEventName "Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity" ;
    ke-wp:pathwayId "WP2880" ;
    ke-wp:pathwayTitle "Glucocorticoid receptor pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:c85eefc9-977b-4bee-a654-f2ac96a7b1cc a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-13T12:32:00.095228"^^xsd:dateTime ;
    dcterms:identifier "c85eefc9-977b-4bee-a654-f2ac96a7b1cc" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 40" ;
    ke-wp:keyEventName "Mitochondrial ATP production, decreased" ;
    ke-wp:pathwayId "WP1403" ;
    ke-wp:pathwayTitle "AMP-activated protein kinase signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:c97a47c0-da19-439c-806f-4ca2b4ad5303 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T07:47:39.937104"^^xsd:dateTime ;
    dcterms:identifier "c97a47c0-da19-439c-806f-4ca2b4ad5303" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1945" ;
    ke-wp:keyEventName "Dysfunctional Autophagy" ;
    ke-wp:pathwayId "WP4923" ;
    ke-wp:pathwayTitle "Autophagy" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:c9869477-7ba5-4ddf-8888-c6b6ed5d9251 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:48:17.810806"^^xsd:dateTime ;
    dcterms:identifier "c9869477-7ba5-4ddf-8888-c6b6ed5d9251" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1289" ;
    ke-wp:keyEventName "Perturbation of cholesterol" ;
    ke-wp:pathwayId "WP5304" ;
    ke-wp:pathwayTitle "Cholesterol metabolism" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:c9e640ae-8843-41d9-a641-8b874d084502 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.931857"^^xsd:dateTime ;
    dcterms:identifier "c9e640ae-8843-41d9-a641-8b874d084502" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 228" ;
    ke-wp:keyEventName "peroxisome proliferator activated receptor promoter demethylation" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:ca311e87-a33b-41a5-b210-15dfd81d87a6 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:48:40.749628"^^xsd:dateTime ;
    dcterms:identifier "ca311e87-a33b-41a5-b210-15dfd81d87a6" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 821" ;
    ke-wp:keyEventName "Decreased, Sodium reabsorption" ;
    ke-wp:pathwayId "WP4917" ;
    ke-wp:pathwayTitle "Proximal tubule transport" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:cafe9d03-1b66-4241-8d09-5ec0fc0bbccc a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.933071"^^xsd:dateTime ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 491" ;
    ke-wp:keyEventName "Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)" ;
    ke-wp:pathwayId "WP313" ;
    ke-wp:pathwayTitle "Hepatocyte growth factor receptor signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:cb21d4fd-e591-472f-8640-a06d155ae02a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:16:07.101413"^^xsd:dateTime ;
    dcterms:identifier "cb21d4fd-e591-472f-8640-a06d155ae02a" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1669" ;
    ke-wp:keyEventName "Increased, DNA damage and mutation" ;
    ke-wp:pathwayId "WP707" ;
    ke-wp:pathwayTitle "DNA damage response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:cb58db28-269c-4fa6-abcc-b03561fca305 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T11:58:01.538397"^^xsd:dateTime ;
    dcterms:identifier "cb58db28-269c-4fa6-abcc-b03561fca305" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2111" ;
    ke-wp:keyEventName "Decreased, neural progenitor cell adhesion to laminin" ;
    ke-wp:pathwayId "WP185" ;
    ke-wp:pathwayTitle "Integrin-mediated cell adhesion" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:cc85af9e-ede8-4b7f-9118-c862686480c0 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2017" ;
    ke-wp:keyEventName "Endoplasmic reticulum stress" ;
    ke-wp:pathwayId "WP4925" ;
    ke-wp:pathwayTitle "Unfolded protein response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:cd182a2c-877b-4566-99e4-cf2927379632 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:45.551751"^^xsd:dateTime ;
    dcterms:identifier "cd182a2c-877b-4566-99e4-cf2927379632" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 478" ;
    ke-wp:keyEventName "Activation, NRF2" ;
    ke-wp:pathwayId "WP2884" ;
    ke-wp:pathwayTitle "NRF2 pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:ceb41bb5-d6bb-46a9-957a-b2f1629da547 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1635" ;
    ke-wp:keyEventName "Increase, DNA strand breaks" ;
    ke-wp:pathwayId "WP4946" ;
    ke-wp:pathwayTitle "Genes and complexes involved in the DNA repair pathways" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:ced7c569-aea1-4a72-b06b-223957a874d9 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 149" ;
    ke-wp:keyEventName "Increase, Inflammation" ;
    ke-wp:pathwayId "WP453" ;
    ke-wp:pathwayTitle "Inflammatory response pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:cf0e5998-d9f0-46c2-a6c1-ef6bd580de60 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    dcterms:identifier "cf0e5998-d9f0-46c2-a6c1-ef6bd580de60" ;
    ke-wp:aopWikiSnapshotDate "2026-08-13"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1512" ;
    ke-wp:keyEventName "Unfolded Protein Response" ;
    ke-wp:pathwayId "WP4925" ;
    ke-wp:pathwayTitle "Unfolded protein response" ;
    ke-wp:wpReleaseDate "2026-08-10"^^xsd:date .

mapping:cf9384c8-2c3e-4380-a51c-86b5b49c55b2 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 795" ;
    ke-wp:keyEventName "Increase, Regenerative cell proliferation (urothelial cells)" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:d03eb198-e060-4046-9349-038d809dcaea a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2025-10-01T16:38:58"^^xsd:dateTime ;
    dcterms:identifier "d03eb198-e060-4046-9349-038d809dcaea" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 79" ;
    ke-wp:keyEventName "Inhibition, Cyclooxygenase activity" ;
    ke-wp:pathwayId "WP4719" ;
    ke-wp:pathwayTitle "Eicosanoid metabolism via cyclooxygenases (COX)" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d04d0c5b-6581-4514-bf08-f320bf09827b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 613" ;
    ke-wp:keyEventName "Occurrence, Epileptic seizure" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:d1f67cbc-e3f0-40e8-88cf-a2f4865f0717 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1820" ;
    ke-wp:keyEventName "Immune mediated hepatitis" ;
    ke-wp:pathwayId "WP530" ;
    ke-wp:pathwayTitle "Cytokines and inflammatory response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d40838f6-05d2-47ce-959e-b2d366de5bd2 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1853" ;
    ke-wp:keyEventName "Hyperactivation of ACE/Ang-II/AT1R axis" ;
    ke-wp:pathwayId "WP4756" ;
    ke-wp:pathwayTitle "Renin-angiotensin-aldosterone system (RAAS)" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:d43548d9-7453-4d95-ab88-22c8c3fe9328 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    dcterms:identifier "d43548d9-7453-4d95-ab88-22c8c3fe9328" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 719" ;
    ke-wp:keyEventName "Increase, hepatocellular adenomas and carcinomas" ;
    ke-wp:pathwayId "WP4336" ;
    ke-wp:pathwayTitle "ncRNAs in Wnt signaling in hepatocellular carcinoma" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d458df4e-9359-43b6-ad37-a598c82ce577 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 357" ;
    ke-wp:keyEventName "Cholestasis, Pathology" ;
    ke-wp:pathwayId "WP5238" ;
    ke-wp:pathwayTitle "Cholestasis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d4b29dcb-1157-491c-8b25-aa5ba74b9c6b a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 709" ;
    ke-wp:keyEventName "Increase, Cytotoxicity (renal tubular cell)" ;
    ke-wp:pathwayId "WP1772" ;
    ke-wp:pathwayTitle "Apoptosis modulation and signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:d52b38c6-4c5d-4727-9dac-127fddfc7ae3 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 345" ;
    ke-wp:keyEventName "N/A, Liver Steatosis" ;
    ke-wp:pathwayId "WP4396" ;
    ke-wp:pathwayTitle "Nonalcoholic fatty liver disease" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d538e92b-1285-4436-a2a3-d973b7b9388a a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1394" ;
    ke-wp:keyEventName "Induction, persistent proliferation/sustained proliferation" ;
    ke-wp:pathwayId "WP313" ;
    ke-wp:pathwayTitle "Hepatocyte growth factor receptor signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d5e142c1-3c7b-4a81-9d44-4836b6495da6 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1869" ;
    ke-wp:keyEventName "Diminished protective oxidative stress response" ;
    ke-wp:pathwayId "WP408" ;
    ke-wp:pathwayTitle "Oxidative stress response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:d62063c3-549f-4ae7-9337-d3ca2d21a8ff a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
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    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1995" ;
    ke-wp:keyEventName "Abnormal lipid metabolism" ;
    ke-wp:pathwayId "WP3965" ;
    ke-wp:pathwayTitle "Lipid metabolism pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d6469dc4-f63f-4bba-a630-c87cd770e7cf a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1901" ;
    ke-wp:keyEventName "Interferon-I antiviral response, antagonized by SARS-CoV-2" ;
    ke-wp:pathwayId "WP4868" ;
    ke-wp:pathwayTitle "Type I interferon induction and signaling during SARS-CoV-2 infection" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:d67dbe34-4a26-4d0c-92f5-8458d3385807 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
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    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1197" ;
    ke-wp:keyEventName "Activation, Fibroblasts" ;
    ke-wp:pathwayId "WP3624" ;
    ke-wp:pathwayTitle "Lung fibrosis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:d68607e9-5b52-4ee7-80c3-a21885bdb06b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:39.947637"^^xsd:dateTime ;
    dcterms:identifier "d68607e9-5b52-4ee7-80c3-a21885bdb06b" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 483" ;
    ke-wp:keyEventName "Activation, LXR alpha" ;
    ke-wp:pathwayId "WP2874" ;
    ke-wp:pathwayTitle "Liver X receptor pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d6d3f689-00ab-4f9a-8c49-e3a1e35a1547 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2026-03-03T08:48:33.834124"^^xsd:dateTime ;
    dcterms:identifier "d6d3f689-00ab-4f9a-8c49-e3a1e35a1547" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 281" ;
    ke-wp:keyEventName "Thyroxine (T4) in serum, Decreased" ;
    ke-wp:pathwayId "WP1981" ;
    ke-wp:pathwayTitle "Thyroxine (thyroid hormone) production" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:d7dc11b2-d7c0-4e2f-8a65-8d817d405ccd a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-13T12:19:26.048390"^^xsd:dateTime ;
    dcterms:identifier "d7dc11b2-d7c0-4e2f-8a65-8d817d405ccd" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1177" ;
    ke-wp:keyEventName "Decreased, Ionotropic GABA receptor chloride channel conductance" ;
    ke-wp:pathwayId "WP5600" ;
    ke-wp:pathwayTitle "GABA and glutamate signalling in epileptogenesis" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:d7e9b570-013c-460e-83ae-d47f6eed499f a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:48:30.042117"^^xsd:dateTime ;
    dcterms:identifier "d7e9b570-013c-460e-83ae-d47f6eed499f" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1285" ;
    ke-wp:keyEventName "Up Regulation, Unsaturated fatty acid" ;
    ke-wp:pathwayId "WP4723" ;
    ke-wp:pathwayTitle "Omega-3 / omega-6 fatty acid synthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:dab85f99-fb90-498f-b3ba-3833063fe3ff a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:21:16.601463"^^xsd:dateTime ;
    dcterms:identifier "dab85f99-fb90-498f-b3ba-3833063fe3ff" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1585" ;
    ke-wp:keyEventName "Proteasomal dysfunction" ;
    ke-wp:pathwayId "WP183" ;
    ke-wp:pathwayTitle "Proteasome degradation" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:db828dc6-9737-4e63-ba87-c6d45ad4ae8d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2026-02-25T12:29:07.474042"^^xsd:dateTime ;
    dcterms:identifier "db828dc6-9737-4e63-ba87-c6d45ad4ae8d" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 709" ;
    ke-wp:keyEventName "Increase, Cytotoxicity (renal tubular cell)" ;
    ke-wp:pathwayId "WP4864" ;
    ke-wp:pathwayTitle "Host-pathogen interaction of human coronaviruses - apoptosis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:dbfd4847-7998-47e3-83e3-f1e170f868cf a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-08-11T12:14:55.429969"^^xsd:dateTime ;
    dcterms:identifier "dbfd4847-7998-47e3-83e3-f1e170f868cf" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1353" ;
    ke-wp:keyEventName "Binding to voltage-gated sodium channel" ;
    ke-wp:pathwayId "WP5598" ;
    ke-wp:pathwayTitle "Sodium channel in epilepsy" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:dc0c9c08-ea06-4841-83e4-c807f64e5108 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:55.608155"^^xsd:dateTime ;
    dcterms:identifier "dc0c9c08-ea06-4841-83e4-c807f64e5108" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 457" ;
    ke-wp:keyEventName "Activation, SREBF1" ;
    ke-wp:pathwayId "WP1982" ;
    ke-wp:pathwayTitle "Sterol regulatory element-binding proteins (SREBP) signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:dc7b7289-517d-45dc-9f1f-88976fb11f35 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2026-02-18T08:08:41"^^xsd:dateTime ;
    dcterms:identifier "dc7b7289-517d-45dc-9f1f-88976fb11f35" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1528" ;
    ke-wp:keyEventName "Fatty Acid Beta Oxidation, Decreased" ;
    ke-wp:pathwayId "WP143" ;
    ke-wp:pathwayTitle "Fatty acid beta-oxidation" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:dce50cc0-e125-4b3e-afa1-b977dfcc0bc0 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:47:01.110088"^^xsd:dateTime ;
    dcterms:identifier "dce50cc0-e125-4b3e-afa1-b977dfcc0bc0" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 202" ;
    ke-wp:keyEventName "Inhibition, Nuclear factor kappa B (NF-kB)" ;
    ke-wp:pathwayId "WP231" ;
    ke-wp:pathwayTitle "TNF-alpha signaling" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:dd0ff531-228c-4517-9157-3ed8c2611517 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.933445"^^xsd:dateTime ;
    dcterms:identifier "dd0ff531-228c-4517-9157-3ed8c2611517" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1115" ;
    ke-wp:keyEventName "Increase, Reactive oxygen species" ;
    ke-wp:pathwayId "WP408" ;
    ke-wp:pathwayTitle "Oxidative stress response" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:dd25eb43-5329-41a4-aa48-7061f0c2cc45 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:48:12.479948"^^xsd:dateTime ;
    dcterms:identifier "dd25eb43-5329-41a4-aa48-7061f0c2cc45" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1299" ;
    ke-wp:keyEventName "Activation, AKT" ;
    ke-wp:pathwayId "WP4172" ;
    ke-wp:pathwayTitle "PI3K-Akt signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:ddf497e1-e1e9-42b3-a2f3-9f6c2a4345d3 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T10:39:01.003333"^^xsd:dateTime ;
    dcterms:identifier "ddf497e1-e1e9-42b3-a2f3-9f6c2a4345d3" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1414" ;
    ke-wp:keyEventName "Decreased, GABA" ;
    ke-wp:pathwayId "WP4157" ;
    ke-wp:pathwayTitle "GABA metabolism (aka GHB)" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:df514a68-d0c8-4b08-8523-0d9fce3ac24f a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.931641"^^xsd:dateTime ;
    dcterms:identifier "df514a68-d0c8-4b08-8523-0d9fce3ac24f" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 232" ;
    ke-wp:keyEventName "Decreased, PPAR-beta activation" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:df81b858-2c52-4950-a128-bd4fefc8885d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.931787"^^xsd:dateTime ;
    dcterms:identifier "df81b858-2c52-4950-a128-bd4fefc8885d" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 231" ;
    ke-wp:keyEventName "Decreased, PPAR-alpha activation" ;
    ke-wp:pathwayId "WP2878" ;
    ke-wp:pathwayTitle "PPAR-alpha pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:df850130-029c-4f22-9d28-5e288de77448 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:47:57.812667"^^xsd:dateTime ;
    dcterms:identifier "df850130-029c-4f22-9d28-5e288de77448" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1310" ;
    ke-wp:keyEventName "Activation, PI3K" ;
    ke-wp:pathwayId "WP5472" ;
    ke-wp:pathwayTitle "Phosphoinositide 3-kinase (PI3K) family" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:dfa95510-459e-4f2c-8ce9-d8183aee3e00 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-05-10T11:13:49.668075"^^xsd:dateTime ;
    dcterms:identifier "dfa95510-459e-4f2c-8ce9-d8183aee3e00" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 89" ;
    ke-wp:keyEventName "Synthesis, De Novo Fatty Acid (FA)" ;
    ke-wp:pathwayId "WP357" ;
    ke-wp:pathwayTitle "Fatty acid biosynthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:dfb0b5c9-2a67-447c-b95e-c23b3d2d5816 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:25:30.139947"^^xsd:dateTime ;
    dcterms:identifier "dfb0b5c9-2a67-447c-b95e-c23b3d2d5816" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1096" ;
    ke-wp:keyEventName "Increased, blood uric acid concentration" ;
    ke-wp:pathwayId "WP4224" ;
    ke-wp:pathwayTitle "Purine metabolism and related disorders" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:dfb291ad-7dc0-45d2-971d-fa479cb8d070 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:39:52.772623"^^xsd:dateTime ;
    dcterms:identifier "dfb291ad-7dc0-45d2-971d-fa479cb8d070" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 385" ;
    ke-wp:keyEventName "Decrease of synaptogenesis" ;
    ke-wp:pathwayId "WP4875" ;
    ke-wp:pathwayTitle "Disruption of postsynaptic signaling by CNV" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:dfb6c1f3-4b23-4ab2-81a2-c3650824cd80 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-11T12:35:22.894943"^^xsd:dateTime ;
    dcterms:identifier "dfb6c1f3-4b23-4ab2-81a2-c3650824cd80" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 767" ;
    ke-wp:keyEventName "Increase, Hyperplasia (renal tubular cells)" ;
    ke-wp:pathwayId "WP4838" ;
    ke-wp:pathwayTitle "Regucalcin in proximal tubule epithelial kidney cells" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:e0539278-f0f4-4ddf-8e88-f7b12c089e9b a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.934388"^^xsd:dateTime ;
    dcterms:identifier "e0539278-f0f4-4ddf-8e88-f7b12c089e9b" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 209" ;
    ke-wp:keyEventName "Peptide Oxidation" ;
    ke-wp:pathwayId "WP5477" ;
    ke-wp:pathwayTitle "Molecular pathway for oxidative stress" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e236ffe8-0043-4e83-9d24-9e756aacaf6d a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.931128"^^xsd:dateTime ;
    dcterms:identifier "e236ffe8-0043-4e83-9d24-9e756aacaf6d" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 327" ;
    ke-wp:keyEventName "Accumulation, Fatty acid" ;
    ke-wp:pathwayId "WP357" ;
    ke-wp:pathwayTitle "Fatty acid biosynthesis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e2f8ad31-eec4-41ac-833a-f61c200b53f1 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.930903"^^xsd:dateTime ;
    dcterms:identifier "e2f8ad31-eec4-41ac-833a-f61c200b53f1" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 334" ;
    ke-wp:keyEventName "Promotion, Hepatocelluar carcinoma" ;
    ke-wp:pathwayId "WP4336" ;
    ke-wp:pathwayTitle "ncRNAs in Wnt signaling in hepatocellular carcinoma" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e3c8c56d-5490-43a8-8be9-ad7d6cd3b301 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.933518"^^xsd:dateTime ;
    dcterms:identifier "e3c8c56d-5490-43a8-8be9-ad7d6cd3b301" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 493" ;
    ke-wp:keyEventName "Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts" ;
    ke-wp:pathwayId "WP4752" ;
    ke-wp:pathwayTitle "Base excision repair" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e48630a6-1691-4cb3-8269-4613a6950df9 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:16:32.432695"^^xsd:dateTime ;
    dcterms:identifier "e48630a6-1691-4cb3-8269-4613a6950df9" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 2226" ;
    ke-wp:keyEventName "Stressor binding PPAR isoforms" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e504e8f9-7f6c-455d-9274-9620de30cc50 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T08:13:59.804422"^^xsd:dateTime ;
    dcterms:identifier "e504e8f9-7f6c-455d-9274-9620de30cc50" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 1708" ;
    ke-wp:keyEventName "Th17 cell migration and inflammation induction" ;
    ke-wp:pathwayId "WP5130" ;
    ke-wp:pathwayTitle "Th17 cell differentiation pathway" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:e5598c00-469a-4fbe-bd65-953a08897484 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:32.839555"^^xsd:dateTime ;
    dcterms:identifier "e5598c00-469a-4fbe-bd65-953a08897484" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 854" ;
    ke-wp:keyEventName "Alterations, Cellular proliferation / hyperplasia" ;
    ke-wp:pathwayId "WP179" ;
    ke-wp:pathwayTitle "Cell cycle" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e56c4319-04a4-4515-b099-4e804ec94b8f a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:50:47.586125"^^xsd:dateTime ;
    dcterms:identifier "e56c4319-04a4-4515-b099-4e804ec94b8f" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 468" ;
    ke-wp:keyEventName "Inhibition, PPAR alpha" ;
    ke-wp:pathwayId "WP3942" ;
    ke-wp:pathwayTitle "PPAR signaling" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e603bbce-6354-40ff-bcd4-672859312be8 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:marvinm2" ;
    dcterms:date "2026-07-29T16:51:24.934246"^^xsd:dateTime ;
    dcterms:identifier "e603bbce-6354-40ff-bcd4-672859312be8" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 214" ;
    ke-wp:keyEventName "Bile accumulation, Pathological condition" ;
    ke-wp:pathwayId "WP4389" ;
    ke-wp:pathwayTitle "Bile acid synthesis and enterohepatic circulation" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e762a290-66f0-4db1-8f1a-8380420e9bde a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "marvinm2" ;
    dcterms:date "2026-03-03T08:48:42.278147"^^xsd:dateTime ;
    dcterms:identifier "e762a290-66f0-4db1-8f1a-8380420e9bde" ;
    ke-wp:aopWikiSnapshotDate "2026-05-06"^^xsd:date ;
    ke-wp:confidenceLevel "medium" ;
    ke-wp:keyEventId "KE 1103" ;
    ke-wp:keyEventName "Inhibition, Cyclooxygenase 1 activity" ;
    ke-wp:pathwayId "WP4719" ;
    ke-wp:pathwayTitle "Eicosanoid metabolism via cyclooxygenases (COX)" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:e7df0c38-390d-42c9-97ff-90a5b214f501 a ke-wp:KeyEventPathwayMapping ;
    dcterms:creator "github:SidraAdil" ;
    dcterms:date "2026-08-10T12:03:55.616057"^^xsd:dateTime ;
    dcterms:identifier "e7df0c38-390d-42c9-97ff-90a5b214f501" ;
    ke-wp:aopWikiSnapshotDate "2026-08-06"^^xsd:date ;
    ke-wp:confidenceLevel "high" ;
    ke-wp:keyEventId "KE 277" ;
    ke-wp:keyEventName "Thyroid hormone synthesis, Decreased" ;
    ke-wp:pathwayId "WP1981" ;
    ke-wp:pathwayTitle "Thyroxine (thyroid hormone) production" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:ea4eac1c-302d-4950-abe1-35207db42480 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Promotion, Hepatocelluar carcinoma" ;
    ke-wp:pathwayId "WP4337" ;
    ke-wp:pathwayTitle "ncRNAs involved in STAT3 signaling in hepatocellular carcinoma" ;
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mapping:ea99d510-dd40-4206-884f-0b3654db8702 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Activation, Macrophages" ;
    ke-wp:pathwayId "WP4493" ;
    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
    ke-wp:wpReleaseDate "2026-07-10"^^xsd:date .

mapping:eaf79af8-3e17-42b5-97a6-57696106913b a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Altered, Neurophysiology" ;
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    ke-wp:pathwayTitle "Hippocampal synaptogenesis and neurogenesis" ;
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mapping:eb957e5f-b3dc-4c1e-9be9-33cd17989f49 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "CYP2E1 Activation" ;
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mapping:ebe94629-c5aa-44a8-86fb-6da0f48ce9b6 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase in reactive oxygen and nitrogen species (RONS)" ;
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mapping:ec1bdb66-e23d-4493-9d64-83d4186af1aa a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Hyperinflammation" ;
    ke-wp:pathwayId "WP5095" ;
    ke-wp:pathwayTitle "Overview of proinflammatory and profibrotic mediators" ;
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mapping:ec62ae9d-98ef-46ac-b724-3d2060916e80 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Inflammation, Liver" ;
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    ke-wp:pathwayTitle "Inflammatory response pathway" ;
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mapping:ed25d939-b504-4377-8a00-a45f061c26ec a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Neuroinflammation" ;
    ke-wp:pathwayId "WP5485" ;
    ke-wp:pathwayTitle "Post-COVID neuroinflammation" ;
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mapping:ed70e647-51c4-48c7-9ea9-132c243bb562 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increased, Differentiation to Testis" ;
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mapping:ee3080d6-845b-48a6-8348-2f786753a3a6 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Decreased, Mitochondrial Fatty Acid Beta Oxidation" ;
    ke-wp:pathwayId "WP368" ;
    ke-wp:pathwayTitle "Mitochondrial long chain fatty acid beta-oxidation" ;
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mapping:eeaafd26-1839-4f8d-ad45-e25d812e16cc a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Changes/Inhibition, Cellular Homeostasis and Apoptosis" ;
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mapping:f102739b-644c-409d-bb5a-3cac34aceb12 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Tumorigenesis, Hepatocellular carcinoma" ;
    ke-wp:pathwayId "WP4337" ;
    ke-wp:pathwayTitle "ncRNAs involved in STAT3 signaling in hepatocellular carcinoma" ;
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mapping:f149001c-5fb1-423a-9411-e5e9e57d1bad a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Inhibition, Mitochondrial fatty acid beta-oxidation" ;
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mapping:f1709f6c-b259-4f45-8d9b-1e22f35121f8 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Induction, persistent proliferation/sustained proliferation" ;
    ke-wp:pathwayId "WP5475" ;
    ke-wp:pathwayTitle "Hallmark of cancer: sustaining proliferative signaling" ;
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mapping:f2878706-a7de-4265-98a1-ef6823e2521c a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventId "KE 214" ;
    ke-wp:keyEventName "Bile accumulation, Pathological condition" ;
    ke-wp:pathwayId "WP2289" ;
    ke-wp:pathwayTitle "Drug induction of bile acid pathway" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:f2ecea3e-2881-4389-a0b5-ec5e2ccc5ad8 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Cell death" ;
    ke-wp:pathwayId "WP2513" ;
    ke-wp:pathwayTitle "Nanoparticle triggered regulated necrosis" ;
    ke-wp:wpReleaseDate "2026-05-10"^^xsd:date .

mapping:f3030700-5c99-48c2-bb43-236389aaf7f4 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP5312" ;
    ke-wp:pathwayTitle "Metabolic pathways of fibroblasts" ;
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mapping:f3ad91c0-5551-4d5a-8ce4-a6b4db9f7151 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Reduction, Ionotropic GABA receptor chloride channel conductance" ;
    ke-wp:pathwayId "WP4159" ;
    ke-wp:pathwayTitle "GABA receptor signaling" ;
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mapping:f3d36837-8f9b-48c0-be57-b89f90a077a2 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Glutathione homeostasis" ;
    ke-wp:pathwayId "WP100" ;
    ke-wp:pathwayTitle "Glutathione metabolism" ;
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mapping:f4632f88-67a2-47e5-97fb-601bd8456ace a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "N/A, Liver Steatosis" ;
    ke-wp:pathwayId "WP5323" ;
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mapping:f48d8413-3d7c-4c9f-acf8-1cbcc021a56c a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Insulin resistance" ;
    ke-wp:pathwayId "WP481" ;
    ke-wp:pathwayTitle "Insulin signaling" ;
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mapping:f5410fcd-5287-4519-b2f0-15d62a8a1544 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP5241" ;
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mapping:f6e918fc-193c-423a-8420-182f288a3af8 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayTitle "Mitochondrial complex I assembly model OXPHOS system" ;
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mapping:f85fc763-04b3-420d-8049-83ef77f9cfbd a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP4746" ;
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mapping:f888d6bc-d54c-48af-abcc-0613c58a7a18 a ke-wp:KeyEventPathwayMapping ;
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mapping:f8bcab2f-ff2a-47eb-a007-cbcb0c585aa3 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Systemic acute phase response" ;
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    ke-wp:pathwayTitle "Cells and molecules involved in local acute inflammatory response" ;
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mapping:f973d660-527b-4181-8ae1-b9c355801645 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayId "WP382" ;
    ke-wp:pathwayTitle "MAPK signaling" ;
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mapping:f986ecb0-fd86-4afb-bce4-3a8fa6947789 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Mitochondrial dysfunction EMPTY" ;
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    ke-wp:pathwayTitle "Disorders of mitochondrial homeostatis, dynamics, protein import, and quality control" ;
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mapping:f9a821c4-c0ac-4751-9a51-64219f310370 a ke-wp:KeyEventPathwayMapping ;
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mapping:f9bd1580-7dc1-43da-abf0-b9b26db2982e a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Frustrated phagocytosis" ;
    ke-wp:pathwayId "WP3937" ;
    ke-wp:pathwayTitle "Microglia pathogen phagocytosis pathway" ;
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mapping:fa12d400-ac9c-471c-b344-4ebdb9fe0fcb a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Accumulation, Damaged mitochondrial DNA" ;
    ke-wp:pathwayId "WP4946" ;
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mapping:fa9c36da-b698-44e0-8365-e30a7933c243 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Transforming growth factor-beta signaling" ;
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    ke-wp:pathwayTitle "TGF-beta receptor signaling" ;
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mapping:fb46738b-1edd-4f60-9bec-0108685860e5 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Motile Cilia Number/Length, Decreased" ;
    ke-wp:pathwayId "WP4803" ;
    ke-wp:pathwayTitle "Ciliopathies" ;
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mapping:fb6bd845-35c0-4800-a5de-01d32a2d7ffd a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Th17 cell migration and inflammation induction" ;
    ke-wp:pathwayId "WP2112" ;
    ke-wp:pathwayTitle "IL17 signaling" ;
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mapping:fbbeec70-e0e0-40bb-9534-191f96e0c3dc a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Activation of inflammation pathway" ;
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    ke-wp:pathwayTitle "Inflammatory response pathway" ;
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mapping:fbc66184-224b-4fde-9fab-4132f3eb3f4d a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Occurrence, Cytoplasmic vacuolization (kupffer cell)" ;
    ke-wp:pathwayId "WP4923" ;
    ke-wp:pathwayTitle "Autophagy" ;
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mapping:fbca0fba-3aa3-45be-b081-92e962543299 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Cilia Beat Frequency, Decreased" ;
    ke-wp:pathwayId "WP4803" ;
    ke-wp:pathwayTitle "Ciliopathies" ;
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mapping:fbd2ffe6-02ed-4d71-97e1-729807ba60a1 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Cytotoxicity (tubular epithelial cells)" ;
    ke-wp:pathwayId "WP1772" ;
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mapping:fbf7ceb9-b466-44e6-a7d9-9e2ba2be03b2 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Regenerative cell proliferation (hepatocytes)" ;
    ke-wp:pathwayId "WP179" ;
    ke-wp:pathwayTitle "Cell cycle" ;
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mapping:fc3dd7f8-778e-40fb-ae9e-10b4637cef93 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increased, Liver Steatosis" ;
    ke-wp:pathwayId "WP5061" ;
    ke-wp:pathwayTitle "Fatty acid transporters" ;
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mapping:fd099dec-4739-47af-889b-86f5ec62d1c6 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Latent Transforming growth Factor beta expression" ;
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mapping:fd513d6e-4ca9-467a-aade-3632e6c75548 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Prolonged TLR9 activation" ;
    ke-wp:pathwayId "WP1449" ;
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mapping:fd605d6a-deb5-4656-866a-0665634cc36d a ke-wp:KeyEventPathwayMapping ;
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mapping:fda5c1f7-15f5-4516-84ad-0411df22c532 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Hepatocytotoxicity" ;
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mapping:ff0901bc-7781-46ab-9cdd-6585f72f444c a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayTitle "Matrix metalloproteinases" ;
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mapping:ff4e4513-24d7-49f9-8e32-1faaf9d959ec a ke-wp:KeyEventPathwayMapping ;
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mapping:ff5f81d7-cda3-4441-90b4-eb3f26c71d5d a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:keyEventName "Increase, Abnormal Neural Remodeling" ;
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mapping:ff784cdd-b8a1-4245-84af-6db3decdba23 a ke-wp:KeyEventPathwayMapping ;
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    ke-wp:pathwayTitle "TGFB / Smad signaling" ;
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