Mitochondrial electron transport chain, disrupted
Electron transport chain: OXPHOS system in mitochondria
Occurrence, Cytoplasmic vacuolization (Bile duct cell)
Increased activation, Nuclear factor kappa B (NF-kB)
Interleukin-1 induced activation of NF-kB
Genes and complexes involved in the DNA repair pathways
Fatty acid and lipoprotein transport in hepatocytes
Binding of agonist, Ionotropic glutamate receptors
Neuroinflammation and glutamatergic signaling
Increase, Glucocorticoid receptor activation
Overview of proinflammatory and profibrotic mediators
Overwhelmed, Mitochondrial DNA repair mechanisms
Increase, Cytotoxicity (urothelial cells)
increased platelet surface TLR9 expression
Regulation of toll-like receptor signaling
DNA IR-double strand breaks and cellular response via ATM
Increase, cell proliferation (hepatocytes)
Decrease, Mitochondrial membrane potential
Nuclear receptors in lipid metabolism and toxicity
Cholesterol metabolism with Bloch and Kandutsch-Russell pathways
Bile accumulation, Pathological condition
Increase, Clonal Expansion of Altered Hepatic Foci
Hallmark of cancer: sustaining proliferative signaling
Suppression, Constitutive androstane receptor, NR1l3
Constitutive androstane receptor pathway
modulation, Extracellular Matrix Composition
Type I collagen synthesis in the context of osteogenesis imperfecta
GABA and glutamate signalling in epileptogenesis
Hepatitis C and hepatocellular carcinoma
Altered gene expression, NRF2 dependent antioxidant pathway
Transcriptional activation by NRF2 in response to phytochemicals
Decreased, Mitochondrial Fatty Acid Beta Oxidation
Increase, Regenerative cell proliferation (tubular epithelial cells)
Dysregulation, ACE2 expression and activity
Occurrence, A paroxysmal depolarizing shift
systemic inflammation leading to hepatic steatosis
Cells and molecules involved in local acute inflammatory response
Antagonism, Glucocorticoid hormone receptor
Increase, Hyperplasia (tubular epithelial cells)
Sterol regulatory element-binding proteins (SREBP) signaling
Inhibition, Mitochondrial Electron Transport Chain Complexes
protein-coupled estrogen receptor 1 (GPER) activation
Increased, Clearance of thyroxine from serum
Thyroid hormones production and peripheral downstream signaling effects
Reduced, Presynaptic release of glutamate
Increase, Preneoplastic foci (hepatocytes)
Increased, Reactive metabolites production
Metapathway biotransformation Phase I and II
Altered gene expression, P53 dependent apoptosis pathway
Degeneration of dopaminergic neurons of the nigrostriatal pathway
Involvement of δ-secretase in neurodegenerative diseases
Hepatocyte growth factor receptor signaling
Wnt signaling in adult hippocampal neurogenesis
Aberrant, synaptic formation and plasticity
Hippocampal synaptogenesis and neurogenesis
Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
Activation of metabotropic glutamate receptor
GPCRs, class C metabotropic glutamate, pheromone
Decreased, oligodendrocyte differentiation
Oligodendrocyte specification and differentiation, leading to myelin components for CNS
Complement system in neuronal development and plasticity
Activation, Long term AHR receptor driven direct and indirect gene expression changes
Nanoparticle triggered regulated necrosis
Increase, hepatocellular adenomas and carcinomas
Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
Fibroblast proliferation and differentiation
Binding of antagonist to glucocorticoid hormone receptor
Binding at picrotoxin site, iGABAR chloride channel
Altered, Thyroid hormone-dependent gene expression
Opening of calcium channel, Calcium influx
Increase, Cytotoxicity (epithelial cells)
Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
Mitochondrial carrier deficiency associated with shuttle disturbances
Binding of antagonist to thyroid hormone receptor
Disrupted binding, laminin-beta1-integrin receptors with laminin
Inhibition, Mitochondrial fatty acid beta-oxidation
Mitochondrial long chain fatty acid beta-oxidation
Increased, Induced Mutations in Critical Genes
Primary focal segmental glomerulosclerosis (FSGS)
Increased, Uptake of thyroxine into tissue
Releasing, Apoptosis-Inducing Factor (AIF)
Disruption of postsynaptic signaling by CNV
Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
Mitochondrial complex I assembly model OXPHOS system
Toll-like receptor signaling related to MyD88
Renin-angiotensin-aldosterone system (RAAS)
ncRNAs in Wnt signaling in hepatocellular carcinoma
Increase, Hyperplasia (renal tubular cells)
Increased, Inhibitory postsynaptic potential
Decreased protection against oxidative stress
Increase, Hepatic intracellular active glucocorticoids
Binding, Thiol/seleno-proteins involved in protection against oxidative stress
Induction, Upregulation of glucuronyltransferase activity
Activation of specific nuclear receptors, Transcriptional change
Inhibition, Nuclear factor kappa B (NF-kB)
Synaptic signaling associated with autism spectrum disorder
TCA cycle (aka Krebs or citric acid cycle)
Altered neurotransmission in development
Occurrence, renal proximal tubular necrosis
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
Mitochondrial fatty acid oxidation disorders
Alterations, Cellular proliferation / hyperplasia
Activation, Transforming Growth Factor beta pathway
Increased, hippocampal hyperdepolarization
Induction, persistent proliferation/sustained proliferation
Binding of (ant)agonist to liver X receptor
Increase, Cytotoxicity (tubular epithelial cells)
Regucalcin in proximal tubule epithelial kidney cells
Brain-derived neurotrophic factor (BDNF) signaling
Increase, Differentiation of fibroblasts
Decreased, Ionotropic GABA receptor chloride channel conductance
Platelet-neutrophil interactions, Increased
Platelet-mediated interactions with vascular and circulating cells
Genes related to primary cilium development (based on CRISPR)
Aryl hydrocarbon receptor response to main mediators PAH and TCDD
Altered gene expression specific to CAR activation, Hepatocytes
Formation, Hepatocellular and Bile duct tumors
Oxidation, Glutathione (To be considered with MIE)
Leukocyte-intrinsic Hippo pathway functions
Disrupted PPAR isoform nuclear signaling
Thrombosis and Disseminated Intravascular Coagulation
Serotonin receptor 2 and ELK-SRF/GATA4 signaling
Decreased, Neuronal network function in adult brain
Canonical and non-canonical TGF-B signaling
Proliferation, Cell proliferation in the absence of cytotoxicity
Changes/Inhibition, Cellular Homeostasis and Apoptosis
Increase, proinflammatory mediators (TNFalpha)
Generation, Amplified excitatory postsynaptic potential (EPSP)
Inhibition, Bile Salt Export Pump (ABCB11)
Disorders of bile acid synthesis and biliary transport
SREBF and miR33 in cholesterol and lipid homeostasis
Dysregulation of transcriptional expression within PPAR signaling network
Increased, secretion of proinflammatory mediators
KE 17 - Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway
Occurrence, Ballooning degeneration (hepatocyte)
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Increased, recruitment of inflammatory cells
Disturbance in microtubule dynamic instability
Androgen receptor network in prostate cancer
Activation, ionotropic GABA Receptor chloride channel
Decreased, Prostaglandin F2alpha concentration, plasma
mRNA vaccine activation of dendritic cell and induction of IFN-1
Increase, Regenerative cell proliferation (hepatocytes)
Disruption of sodium channel gating kinetics
Increased, extracellular matrix deposition
Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
Activation, Latent Transforming Growth Factor Beta 1
Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway
Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity
peroxisome proliferator activated receptor promoter demethylation
Decreased, neural progenitor cell adhesion to laminin
Increase, Regenerative cell proliferation (urothelial cells)
Eicosanoid metabolism via cyclooxygenases (COX)
Increase, Cytotoxicity (renal tubular cell)
Diminished protective oxidative stress response
Interferon-I antiviral response, antagonized by SARS-CoV-2
Type I interferon induction and signaling during SARS-CoV-2 infection
Host-pathogen interaction of human coronaviruses - apoptosis
Increased, blood uric acid concentration
Th17 cell migration and inflammation induction
Bile acid synthesis and enterohepatic circulation
ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
Increase in reactive oxygen and nitrogen species (RONS)
Arsenic metabolism and reactive oxygen species generation
Mammalian disorder of sexual development
Increase, Extracellular matrix deposition
Reduction, Ionotropic GABA receptor chloride channel conductance
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Disorders of mitochondrial homeostatis, dynamics, protein import, and quality control
Renin Angiotensin System and Bradykinin pathways in COVID-19
Increase, Transforming growth factor-beta signaling
Occurrence, Cytoplasmic vacuolization (kupffer cell)
Latent Transforming growth Factor beta expression