https://molaop-builder.vhp4safety.nl/mappings/00c68fec-ca92-4eae-87af-e45f5d7fd129
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-03-16T14:13:58.705415
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 178
key event name: Mitochondrial electron transport chain, disrupted
pathway id: WP111
pathway title: Electron transport chain: OXPHOS system in mitochondria
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/01264711-7889-4b3f-b038-6f8432f07ec5
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:53.116910
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 836
key event name: Occurrence, Cytoplasmic vacuolization (Bile duct cell)
pathway id: WP4923
pathway title: Autophagy
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/0138f004-96d7-40ba-97c7-a1e74eb5cccb
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-09-25T13:19:49
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 468
key event name: Inhibition, PPAR alpha
pathway id: WP2878
pathway title: PPAR-alpha pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/013ffa6b-1232-47f5-8485-49fb3547957f
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:23:51.674075
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1172
key event name: Increased activation, Nuclear factor kappa B (NF-kB)
pathway id: WP3656
pathway title: Interleukin-1 induced activation of NF-kB
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/01d10bb4-abda-4ce4-a348-cc7d6f6bd2a5
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:57:52.310443
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2115
key event name: Altered, cholesterol metabolism
pathway id: WP197
pathway title: Cholesterol biosynthesis pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/01e32369-e81d-487d-b083-6b7d2e2658f3
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:59:59.791602
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 898
key event name: Disruption, Lysosome
pathway id: WP4923
pathway title: Autophagy
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/02aa0594-f1db-49cc-b940-afc5cb08a8bf
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:39:22.801171
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1493
key event name: Increased Pro-inflammatory mediators
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/03a9d9c5-a93f-4738-b51e-563b43e845ec
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:48:10.130628
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 851
key event name: Decrease of GABAergic interneurons
pathway id: WP4159
pathway title: GABA receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/041aae19-97d4-419f-b9fd-c33a037c5872
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:44:54.722810
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 155
key event name: Inadequate DNA repair
pathway id: WP4946
pathway title: Genes and complexes involved in the DNA repair pathways
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/04416c7f-efc8-4457-a610-8b9f11f991d1
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931274
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 291
key event name: Accumulation, Triglyceride
pathway id: WP5323
pathway title: Fatty acid and lipoprotein transport in hepatocytes
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/048c2e50-d18d-4dd0-beba-81e7fcf61ba4
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:48:03.932535
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 875
key event name: Binding of agonist, Ionotropic glutamate receptors
pathway id: WP5083
pathway title: Neuroinflammation and glutamatergic signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/04ac87f4-63bf-497a-b769-bf30ec13471d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-03-16T14:15:29.509837
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 122
key event name: Increase, Glucocorticoid receptor activation
pathway id: WP2880
pathway title: Glucocorticoid receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/05781ae1-f9fe-48f9-80df-0c37783f9f6e
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:00.457933
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1493
key event name: Increased Pro-inflammatory mediators
pathway id: WP5095
pathway title: Overview of proinflammatory and profibrotic mediators
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/059a1c15-b17b-486a-9a3d-ebd7d2dc55c6
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-03-16T14:14:35.064635
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 664
key event name: Overwhelmed, Mitochondrial DNA repair mechanisms
pathway id: WP4946
pathway title: DNA repair pathways, full network
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/05d3d7c1-d98a-4a94-803a-c065afcf2c14
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:16:41.021312
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1270
key event name: Inactivation of PPARγ
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/07796e78-dd0f-4f3a-8cf3-b15689158332
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:49:25.408278
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 794
key event name: Increase, Cytotoxicity (urothelial cells)
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/079c9c1b-9a9e-4067-9cc3-dc429ae011e0
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:52.850414
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 458
key event name: Increased, De Novo FA synthesis
pathway id: WP357
pathway title: Fatty acid biosynthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/081fd464-efbf-4a29-8cc8-a250d30996b8
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-03T08:48:52.213466
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1392
key event name: Increase, Oxidative Stress
pathway id: WP5477
pathway title: Molecular pathway for oxidative stress
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/08b926ea-a36f-48b8-911e-b868d47c4c9a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931048
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 327
key event name: Accumulation, Fatty acid
pathway id: WP5061
pathway title: Fatty acid transporters
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/08b96b2d-2a37-4843-b82a-1ecace48de91
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:54:06.535521
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1900
key event name: increased platelet surface TLR9 expression
pathway id: WP1449
pathway title: Regulation of toll-like receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/09734018-fb5c-4412-952e-06620ee15d79
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:19:20.121306
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1635
key event name: Increase, DNA strand breaks
pathway id: WP3959
pathway title: DNA IR-double strand breaks and cellular response via ATM
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/09ecf784-e5e7-40f3-acee-a05f7561f749
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:10.114823
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 902
key event name: Inflammation, Liver
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/0a9e95d7-7625-4969-b921-791a3791611b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:28.773707
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 716
key event name: Increase, cell proliferation (hepatocytes)
pathway id: WP179
pathway title: Cell cycle
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/0b2bbce5-21b2-444c-9e0c-f83379970b36
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-23T09:05:48.120759
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1825
key event name: Increase, Cell death
pathway id: WP4923
pathway title: Autophagy
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/0b762d88-b15f-4409-930c-de8b059ff13c
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:13:30.259267
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1738
key event name: SARS-CoV-2 cell entry
pathway id: WP4846
pathway title: SARS-CoV-2 and COVID-19 pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/0b8e0188-4a6d-4808-a9a2-9b0d0177f741
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-07T19:40:47
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 889
key event name: Proteostasis, impaired
pathway id: WP4918
pathway title: Cellular proteostasis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/0bad2bc9-8022-4a21-943e-60bce8096e80
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:39:43.862998
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 465
key event name: Increased, Fatty acid influx
pathway id: WP5061
pathway title: Fatty acid transporters
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/0cd4cbce-334a-4696-8571-f6105340127c
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:10:30.877493
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1770
key event name: Decrease, Mitochondrial membrane potential
pathway id: WP111
pathway title: Electron transport chain: OXPHOS system in mitochondria
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/0d0b1f8b-ac1a-4ad3-af7f-9ba1e8580d22
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:42:46.884445
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2086
key event name: Airway inflammation
pathway id: WP3624
pathway title: Lung fibrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/0e07f67c-dce6-4659-b383-7b183f6b54e9
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932367
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 167
key event name: Activation, LXR
pathway id: WP2874
pathway title: Liver X receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/0e69f220-e4d0-4a30-8439-f19851a8c7fc
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:45:59.439565
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 425
key event name: Decrease of Thyroidal iodide
pathway id: WP1981
pathway title: Thyroxine (thyroid hormone) production
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/0f36d8b0-30e5-417e-97bc-8fd8e7595262
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:17:45.723826
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1995
key event name: Abnormal lipid metabolism
pathway id: WP299
pathway title: Nuclear receptors in lipid metabolism and toxicity
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/0ff2fcb5-4140-4242-8b9b-0d3b185065c8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:42.259629
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 484
key event name: Activation, AKT2
pathway id: WP4172
pathway title: PI3K-Akt signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/103f9312-a5db-4d28-b6f1-9c46cf1ac8e8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-05-10T11:13:32.167453
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 474
key event name: Down Regulation, HMGCS2
pathway id: WP4718
pathway title: Cholesterol metabolism with Bloch and Kandutsch-Russell pathways
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/10e9fcc2-6622-4e8c-8628-a5b4fe59d87c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934095
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 214
key event name: Bile accumulation, Pathological condition
pathway id: WP5396
pathway title: Enterohepatic circulation of bile acids
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/11062e7c-7b73-46ec-ba4e-e88f74686de5
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:50.246329
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 459
key event name: Increased, Liver Steatosis
pathway id: WP5323
pathway title: Fatty acid and lipoprotein transport in hepatocytes
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/118b8f8e-4528-4114-96c2-d1f721b786fc
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:11:54.058691
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1750
key event name: Increased inflammatory immune responses
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/11a62a45-ade0-4ea9-92dd-3ff8599c8749
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:29:45.949817
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 768
key event name: Increase, Cytotoxicity
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/11d306d0-8f83-44e2-a514-afdeb998e65f
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-08-25T09:45:55
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 87
key event name: Release, Cytokine
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/12700823-f3fb-4e89-abc4-22e268a28b4a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:07.143350
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1171
key event name: Increase, Clonal Expansion of Altered Hepatic Foci
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/139dd362-87e5-44dc-90b0-a592b583fa60
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T09:59:57.259678
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2233
key event name: Decreased, ERαβ heterodimers
pathway id: WP2881
pathway title: Estrogen receptor pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/13a0f780-8710-47ea-bef7-71e377264d4c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:57.938639
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 456
key event name: Suppression, Constitutive androstane receptor, NR1l3
pathway id: WP2875
pathway title: Constitutive androstane receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/142fe8a3-2cd0-48d1-98b9-c3f891a2e0b8
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-03T09:38:28.259004
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1365
key event name: Increase, Apoptosis
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/14929bcf-8df9-4685-a372-f941487abf37
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-13T08:09:18.273157
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1195
key event name: modulation, Extracellular Matrix Composition
pathway id: WP5382
pathway title: TGFB / Smad signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/14ca81e5-7454-4927-99e5-333ae3688fc0
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:32.498671
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1285
key event name: Up Regulation, Unsaturated fatty acid
pathway id: WP357
pathway title: Fatty acid biosynthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/15f4ca44-0c72-4450-afa8-ac271af3e256
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932694
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 68
key event name: Accumulation, Collagen
pathway id: WP4786
pathway title: Type I collagen synthesis in the context of osteogenesis imperfecta
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/15f6790a-073f-4ed3-ba07-020dcbc9f6aa
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:18:28.513835
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1355
key event name: Activated, membrane depolarization
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/1627d16b-b42d-4664-a24b-f3742bc72e1b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:50:12.516922
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1275
key event name: Collagen Deposition
pathway id: WP4786
pathway title: Type I collagen synthesis in the context of osteogenesis imperfecta
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/16ca6fa9-3ae0-4cfc-ba1e-69e5deb03e4f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-28T13:10:21.631614
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 378
key event name: Tumorigenesis, Hepatocellular carcinoma
pathway id: WP3646
pathway title: Hepatitis C and hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/16f5e55a-24a9-4fa1-88aa-be9d79de0eb5
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:00:25.668859
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2232
key event name: Antagonism, Retinoic acid receptors
pathway id: WP5397
pathway title: Vitamin A1 and A5/X pathways
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/1a2ee3f1-4fe1-4ceb-890c-e69af2e00305
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:11:13.817206
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1349
key event name: Activated, presynaptic neuron 1
pathway id: WP2267
pathway title: Synaptic vesicle pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/1ad6f717-ea94-49c6-b2dd-7b66b3934fd7
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:43:46.733175
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 50
key event name: Increase, Ca++ (intracellular)
pathway id: WP536
pathway title: Calcium regulation in cardiac cells
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/1bcb003c-069b-4331-b00e-67b6736cfebc
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:50:43.638936
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1488
key event name: Glutamate dyshomeostasis
pathway id: WP5083
pathway title: Neuroinflammation and glutamatergic signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/1d684103-3b34-4c33-8f75-b8da09746ac1
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.930753
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 344
key event name: N/A, Liver fibrosis
pathway id: WP4786
pathway title: Type I collagen synthesis in the context of osteogenesis imperfecta
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/1f7a1503-18c9-4c5b-8ef4-5baf364aedec
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:14.598867
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1633
key event name: Increase in inflammation
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/1f886fc4-9dcb-4c24-9e34-435e52bd757e
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:35.154467
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2225
key event name: Disrupted Lipid Storage
pathway id: WP5323
pathway title: Fatty acid and lipoprotein transport in hepatocytes
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/201589e0-c5a4-4a9e-a81b-f7b97437151f
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:50:18.094850
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1917
key event name: Altered gene expression, NRF2 dependent antioxidant pathway
pathway id: WP3
pathway title: Transcriptional activation by NRF2 in response to phytochemicals
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/202ac787-d051-4932-96ec-4d48485d9fcf
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:23.066160
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 860
key event name: Decreased, Mitochondrial Fatty Acid Beta Oxidation
pathway id: WP143
pathway title: Fatty acid beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/206d7731-d26d-4b94-b350-b86b50dc31e7
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:56:54.234886
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2265
key event name: Oligodendrocyte death, increased
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/2176c3c7-7951-4669-8de0-f070cb9d76b8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:47:26.954980
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 710
key event name: Increase, Regenerative cell proliferation (tubular epithelial cells)
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/21deba79-e0c2-4a01-beb0-7680d85e964f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-05-10T11:13:43.598526
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 115
key event name: Increase, FA Influx
pathway id: WP5061
pathway title: Fatty acid transporters
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/21f40e2d-5f36-4336-a62e-dc2dafdef26a
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-23T10:06:21.147901
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 227
key event name: Activation, PPARα
pathway id: WP2878
pathway title: PPAR-alpha pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/21f99235-bf4a-4046-b775-bb98b368157d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:58:26.778742
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 459
key event name: Increased, Liver Steatosis
pathway id: WP3965
pathway title: Lipid metabolism pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/225b0930-b885-485e-9b9a-ed50cb55cfa5
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:13:26.543744
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1854
key event name: Dysregulation, ACE2 expression and activity
pathway id: WP5036
pathway title: Angiotensin II receptor type 1 pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/22ec95fd-d875-4c4f-8ec5-a01bae32992d
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:29:23.909048
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 616
key event name: Occurrence, A paroxysmal depolarizing shift
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/235b4e2c-e933-4396-b4be-33e2b1652709
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:40:47.735462
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1391
key event name: Activation of Cyp2E1
pathway id: WP43
pathway title: Oxidation by cytochrome P450
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/24280d84-ecff-46dc-bf6b-36a6d8f0c066
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:35.778503
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 486
key event name: systemic inflammation leading to hepatic steatosis
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/24d0ea58-ba89-4cca-bdb6-2dbe0517f4ec
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:46:58.063923
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1494
key event name: Leukocyte recruitment/activation
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/24f67e89-97dc-448f-bf60-afaf45990158
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:01:56.663113
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2220
key event name: Antagonism, Glucocorticoid hormone receptor
pathway id: WP2880
pathway title: Glucocorticoid receptor pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/25e0091f-d106-4d43-961f-d2b950af84d8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:49:53.740842
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1014
key event name: Induction, Somatic muscle paralysis
pathway id: WP383
pathway title: Striated muscle contraction pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/265c4b94-9d05-4c41-991d-966ab46bc691
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:49:31.969712
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 784
key event name: Increase, Hyperplasia (tubular epithelial cells)
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/26f543ed-3073-428c-8c6c-06c9facbf57b
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:48:02.388119
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1944
key event name: Synaptic dysfunction
pathway id: WP2267
pathway title: Synaptic vesicle pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/27251b4b-6ea5-46c6-81cf-96a544f25ece
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:31:14.686628
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2336
key event name: Increase, SREBF1
pathway id: WP1982
pathway title: Sterol regulatory element-binding proteins (SREBP) signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/27373650-58e1-4f1a-aaba-c75f4ecf9fdb
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-01T12:25:21.759903
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 105
key event name: Inhibition, Mitochondrial Electron Transport Chain Complexes
pathway id: WP111
pathway title: Electron transport chain: OXPHOS system in mitochondria
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/2894b6c7-d16b-4edc-bd95-c53bb56a0370
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:50.792166
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2029
key event name: protein-coupled estrogen receptor 1 (GPER) activation
pathway id: WP712
pathway title: Estrogen signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/29b0617d-1ccd-4403-8f6c-d8e9cafff210
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:20:05.691252
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1015
key event name: Increased, Neuronal synaptic inhibition
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/29d718ff-8fac-43b2-aa64-1d0a05a9f41c
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:08:25.675370
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1812
key event name: Increase, Cytochrome c release
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/2c6fac33-0002-407a-99e6-2bfc17bd24c4
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-13T08:08:39.435051
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 2408
key event name: Increase, Adipose lipolysis
pathway id: WP236
pathway title: Adipogenesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/2c7a3d92-886e-428b-a7cd-0148ef18e73b
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:30:12.944455
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 961
key event name: Increased, Clearance of thyroxine from serum
pathway id: WP4746
pathway title: Thyroid hormones production and peripheral downstream signaling effects
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/2ed421ff-9747-4071-83a3-c15ea6391123
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:39.944638
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1284
key event name: Up Regulation, SREBF2
pathway id: WP1982
pathway title: Sterol regulatory element-binding proteins (SREBP) signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/2f465814-5838-45cd-a966-4b1daaf1b7d6
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:59:59.917675
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 383
key event name: Reduced, Presynaptic release of glutamate
pathway id: WP5083
pathway title: Neuroinflammation and glutamatergic signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/2fdf35f3-52dc-4f43-a1c9-3d3d433f6c68
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:53:24.151374
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1909
key event name: Mucociliary Clearance, Decreased
pathway id: WP4803
pathway title: Ciliopathies
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3087be9d-ec92-4601-a82e-1f3ed6899823
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:09.153652
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 774
key event name: Increase, Preneoplastic foci (hepatocytes)
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/30df6e30-5d2c-4b0a-801a-608c89acf6f2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:13:20.421714
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1922
key event name: Increased, Reactive metabolites production
pathway id: WP702
pathway title: Metapathway biotransformation Phase I and II
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/317384b4-2c21-45b6-8058-d784160a0e32
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:48:33.092613
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1923
key event name: Altered gene expression, P53 dependent apoptosis pathway
pathway id: WP4963
pathway title: p53 transcriptional gene network
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/31fc8aa3-2ea3-4552-bb06-4ec80b878f16
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:21:56.355673
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 890
key event name: Degeneration of dopaminergic neurons of the nigrostriatal pathway
pathway id: WP5372
pathway title: Involvement of δ-secretase in neurodegenerative diseases
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/342f57b2-6a1b-4163-8e72-afbfbebf3e2a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-15T12:10:28.246844
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 55
key event name: Increase, Cell injury/death
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/35280d2a-0c7f-48c1-8887-e663b7437277
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.930976
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 334
key event name: Promotion, Hepatocelluar carcinoma
pathway id: WP313
pathway title: Hepatocyte growth factor receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/35dd7a66-0adc-40d1-8ef3-50869b2bbf5f
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:16:00.110167
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1670
key event name: Lung cancer
pathway id: WP4255
pathway title: Non-small cell lung cancer
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3686f554-0627-4a82-85df-65f01cd6cc22
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:47:11.296475
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 757
key event name: Hippocampal anatomy, Altered
pathway id: WP5536
pathway title: Wnt signaling in adult hippocampal neurogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/374b033d-63a4-4fbf-9139-a9f3190bf36b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932618
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 68
key event name: Accumulation, Collagen
pathway id: WP5312
pathway title: Metabolic pathways of fibroblasts
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/376fba0c-4479-4239-9935-c76484eb12cd
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:58:05.530964
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 18
key event name: Activation, AhR
pathway id: WP2873
pathway title: Aryl hydrocarbon receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/3802c6c7-62c6-477b-9226-a876c431bfbd
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:03:37.057878
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2208
key event name: Aberrant, synaptic formation and plasticity
pathway id: WP5231
pathway title: Hippocampal synaptogenesis and neurogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/38705c21-ae84-4678-b59e-e6405de3b187
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-08-14T06:51:54
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 28
key event name: Reduction, Angiogenesis
pathway id: WP1539
pathway title: Angiogenesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/389e54aa-fc7f-4eb0-9b1c-9fcc99319d01
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931928
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 216
key event name: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
pathway id: WP534
pathway title: Glycolysis and gluconeogenesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/39928d1c-c27c-46e4-baa4-1eaa957848e3
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:45:02.447433
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 265
key event name: Activation, Stellate cells
pathway id: WP560
pathway title: TGF-beta receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/3a18e3b0-bf86-45ef-8f4b-0779f300567d
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:05:51.757481
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2036
key event name: Activation of metabotropic glutamate receptor
pathway id: WP501
pathway title: GPCRs, class C metabotropic glutamate, pheromone
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3a5f0733-8a18-4b21-8f74-ccb7671ecf98
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:21:40.879516
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1556
key event name: Increase, lung cancer
pathway id: WP4658
pathway title: Small cell lung cancer
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3ac9fd94-1b94-4783-9cec-30b0f772be9b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:57:49.638772
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2115
key event name: Altered, cholesterol metabolism
pathway id: WP4545
pathway title: Oxysterols derived from cholesterol
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3acb794f-7ca9-43ea-a33d-6523007b0534
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:44:56.825418
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1395
key event name: Liver Cancer
pathway id: WP3646
pathway title: Hepatitis C and hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/3ae3a33a-002e-4f8b-b6e5-bb27984b724c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:57:43.963745
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2116
key event name: Decreased, oligodendrocyte differentiation
pathway id: WP4304
pathway title: Oligodendrocyte specification and differentiation, leading to myelin components for CNS
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3b8c4edd-b798-467b-bf87-0689cd206896
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:16:36.889327
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1669
key event name: Increased, DNA damage and mutation
pathway id: WP4946
pathway title: Genes and complexes involved in the DNA repair pathways
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3ba22c33-cf54-4653-9881-c915c32be955
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:47:07.271097
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 758
key event name: Hippocampal Physiology, Altered
pathway id: WP5090
pathway title: Complement system in neuronal development and plasticity
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3bb6873b-b4f4-4346-80a7-52b12bc3a2e9
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:37.015479
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1575
key event name: Activation, Caspase 8 pathway
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/3bd9947e-f807-4d55-9b52-02b9c756b187
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-03T08:48:46.883531
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1115
key event name: Increase, Reactive oxygen species
pathway id: WP5477
pathway title: Molecular pathway for oxidative stress
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/3c43d2e0-2ad1-4491-a130-29ac337e3d74
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:46:03.615649
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 889
key event name: Proteostasis, impaired
pathway id: WP183
pathway title: Proteasome degradation
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3cbd2aee-253f-4c71-baed-dae19f96ddb2
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-03T11:59:00.133709
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1194
key event name: Increase, DNA damage
pathway id: WP707
pathway title: DNA damage response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/3d531c8d-ece1-4c50-bf5e-2e20264c4d12
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932455
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 165
key event name: Activation, Long term AHR receptor driven direct and indirect gene expression changes
pathway id: WP2873
pathway title: Aryl hydrocarbon receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/3d8511d8-824a-4acc-8894-0c0d105e1b43
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:46:57.939346
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 758
key event name: Hippocampal Physiology, Altered
pathway id: WP5231
pathway title: Hippocampal synaptogenesis and neurogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3dd12e28-4991-49a2-a95a-59958558322a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:48:23.927708
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 850
key event name: Induction, CYP1A2/CYP1A5
pathway id: WP43
pathway title: Oxidation by cytochrome P450
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3e8e5fea-52f5-4f71-911f-c6609a885012
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:13:10.743040
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1750
key event name: Increased inflammatory immune responses
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3e9ccbea-7bc6-41a7-ab1b-ed0596d4aed2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:15:13.496068
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1339
key event name: Increase, intracellular calcium
pathway id: WP536
pathway title: Calcium regulation in cardiac cells
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/3ebc04c0-20b8-4139-8ea9-32ddd36d310c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:43.899837
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1548
key event name: Necrotic Tissue
pathway id: WP2513
pathway title: Nanoparticle triggered regulated necrosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/3f7129ad-98a5-4699-8b52-0d38d6a90bf5
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:20.104869
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 719
key event name: Increase, hepatocellular adenomas and carcinomas
pathway id: WP3646
pathway title: Hepatitis C and hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/40838948-42b5-49ce-acef-8bd45cd08ff6
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:38:43.255042
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1262
key event name: Apoptosis
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/413c7311-b688-4f3c-ae3a-b1df32a18fc7
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-10-21T06:41:17
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 111
key event name: Agonism, Estrogen receptor
pathway id: WP2881
pathway title: Estrogen receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/417d9348-ac9e-4538-af74-1bcacd9dea99
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:20:50.170293
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1607
key event name: Increase, Necrosis
pathway id: WP2513
pathway title: Nanoparticle triggered regulated necrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/4210b35d-db00-4f75-a62a-1aea38254531
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:00.607721
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1310
key event name: Activation, PI3K
pathway id: WP4172
pathway title: PI3K-Akt signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/426acb0b-05bc-42f6-801a-52e07862f6ed
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:42:07.273800
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1363
key event name: Increased, epilepsy
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/427e6bb4-caa2-450d-ba19-4ea90c85907d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-13T08:08:22.099238
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1815
key event name: Increase, Endoplasmic reticulum stress
pathway id: WP4925
pathway title: Unfolded protein response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4285c015-ad24-46ea-b3b2-76087d42e682
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:21:14.400803
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1513
key event name: General Apoptosis
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/42a8d85c-5d7a-4bfb-bbc1-cac7aac22ca0
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933367
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 493
key event name: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
pathway id: WP4946
pathway title: Genes and complexes involved in the DNA repair pathways
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4328b6f0-edc4-4d5a-ad46-3e5316b303ad
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T17:00:45.616529
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1493
key event name: Increased Pro-inflammatory mediators
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/43e4ffdf-68ac-40b0-9321-c04f3f915235
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-24T14:26:32.728605
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1287
key event name: Glutathione synthesis
pathway id: WP100
pathway title: Glutathione metabolism
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/43f211cc-d837-45b6-a3d8-65d2bcb22dad
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:07:08.781628
aop wiki snapshot date: 2026-08-06
confidence level: low
key event id: KE 2012
key event name: Fibroblast proliferation and differentiation
pathway id: WP3624
pathway title: Lung fibrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/44357349-2883-42ae-beae-c6c457929bc3
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:02:16.562950
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2217
key event name: Binding of antagonist to glucocorticoid hormone receptor
pathway id: WP2880
pathway title: Glucocorticoid receptor pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/466f9241-b03d-48dc-9d48-3e6ce0b4573e
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:05.814488
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1300
key event name: Activation, mTORC1
pathway id: WP1471
pathway title: Target of rapamycin signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/468515f6-3799-43c3-9cc4-2892ed266990
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-03-16T14:14:55.641134
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 40
key event name: Mitochondrial ATP production, decreased
pathway id: WP5241
pathway title: Mitochondrial beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/468e2b24-db43-4348-906c-a9d95dcc8f67
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933589
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 493
key event name: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
pathway id: WP4753
pathway title: Nucleotide excision repair
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/469c7e46-d209-478e-8d88-ae06b7712b8f
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:28:18.665829
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 667
key event name: Binding at picrotoxin site, iGABAR chloride channel
pathway id: WP4159
pathway title: GABA receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/47a1ee61-a7ab-4be9-b974-91565cb2277e
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:05:52.754548
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1829
key event name: Altered, Thyroid hormone-dependent gene expression
pathway id: WP4746
pathway title: Thyroid hormones production and peripheral downstream signaling effects
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/47a98ef6-02c4-492c-acba-4e1cd5a16279
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:50:22.522470
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1218
key event name: Opening of calcium channel, Calcium influx
pathway id: WP536
pathway title: Calcium regulation in cardiac cells
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/48731973-7147-4f20-9c5a-7c4e2b4bb541
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:29:09.047459
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 780
key event name: Increase, Cytotoxicity (epithelial cells)
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/48b354a6-3e6c-46ae-af8f-f8873770c180
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T12:05:03.378804
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 272
key event name: Activation/Proliferation, T-cells
pathway id: WP69
pathway title: T-cell receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/49458423-10d4-4f5d-97fe-7f5993e50f77
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:48:16.183092
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1933
key event name: Increased, Interleukin-6 production
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/4946b5df-38b9-465d-8dc4-0aa3ae021f3b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:38.324622
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 486
key event name: systemic inflammation leading to hepatic steatosis
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4967e507-23a7-456c-bd1a-9222418b254e
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:02.122820
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1818
key event name: Immune cell activation
pathway id: WP69
pathway title: T-cell receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4a500613-39c8-4067-8946-651f568a8c3e
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:31:28.855312
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 654
key event name: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
pathway id: WP5393
pathway title: Androgen biosynthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4a98519c-1b33-4a65-9955-f3d946014787
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:21:49.280027
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1556
key event name: Increase, lung cancer
pathway id: WP4255
pathway title: Non-small cell lung cancer
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/4ac6be90-26fe-4789-a7fc-bf1a67ee53fd
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:58:47.951073
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1740
key event name: Induced dysregulation of ACE2
pathway id: WP554
pathway title: ACE inhibitor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4bc9372a-3b46-4fe9-82d3-685e3c05620b
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-01T12:25:08.715823
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 177
key event name: Increase, Mitochondrial dysfunction
pathway id: WP5507
pathway title: Mitochondrial carrier deficiency associated with shuttle disturbances
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4d80e5f7-7a7d-4d63-be36-56af9762834a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:47:13.295827
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 757
key event name: Hippocampal anatomy, Altered
pathway id: WP5231
pathway title: Hippocampal synaptogenesis and neurogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/4f2ca984-f4f1-44f7-8513-9587ca39c010
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:02:26.929147
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2216
key event name: Binding of antagonist to thyroid hormone receptor
pathway id: WP4746
pathway title: Thyroid hormones production and peripheral downstream signaling effects
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/4f78f4fb-e5db-43ae-84dc-29ac03b27c14
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-13T08:08:18.788438
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1306
key event name: Increase, De novo lipogenesis
pathway id: WP3965
pathway title: Lipid metabolism pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4f98ca00-860c-404a-9cea-7e1b0cbae208
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:59.732885
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 454
key event name: Increased, Triglyceride formation
pathway id: WP325
pathway title: Triacylglyceride synthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/4fea7294-ff85-45fb-8756-b3a5aaffcf8a
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:43:03.435437
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2039
key event name: Inhibition GABAA receptor
pathway id: WP4159
pathway title: GABA receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/501369d9-4380-407a-b4fc-337cde0a3fd5
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:08:53.178135
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2110
key event name: Disrupted binding, laminin-beta1-integrin receptors with laminin
pathway id: WP185
pathway title: Integrin-mediated cell adhesion
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/5020b87c-7f90-420d-a747-91f0d4744134
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:26:13.128082
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 761
key event name: Increased, Chloride conductance
pathway id: WP4159
pathway title: GABA receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/50933917-0690-4401-9a66-4b8cfc3899c5
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:39:32.322990
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1413
key event name: Reduced, presynaptic neuron 2 activity
pathway id: WP2267
pathway title: Synaptic vesicle pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/51635510-27ce-4bd9-a2ae-f6c20a6139f0
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:46:38.938392
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 383
key event name: Reduced, Presynaptic release of glutamate
pathway id: WP2267
pathway title: Synaptic vesicle pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/519041c6-a531-4842-9bfa-ebc7a96ff5ce
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:15:08.624514
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1350
key event name: Increased, glutamate
pathway id: WP5083
pathway title: Neuroinflammation and glutamatergic signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/51fbfd4e-a95e-46a3-8ac4-6a1439782354
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:57.805039
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 2009
key event name: Activation of inflammation pathway
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/529c0637-5996-46a5-8581-b8d2bf2b9c7e
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:05:34.673262
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1841
key event name: Encephalitis
pathway id: WP4919
pathway title: Neuroinflammation
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/535d741b-8f8c-4201-ae06-ea6cd06bdafa
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-23T10:05:07.498816
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 269
key event name: Induction, Sustained Cell Proliferation
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/54a188fb-08d1-4c68-9c7e-b68b0391b8f8
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:10:01.056225
aop wiki snapshot date: 2026-08-06
confidence level: low
key event id: KE 1511
key event name: Lipid Peroxidation
pathway id: WP4313
pathway title: Ferroptosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/54afbdb4-9841-4b0f-b1ae-b1f32c819cee
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:20:18.697620
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1607
key event name: Increase, Necrosis
pathway id: WP4313
pathway title: Ferroptosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/54e68995-3db6-4f4f-9878-60fd8fcccd0a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-19T12:08:59.796963
aop wiki snapshot date: 2026-08-13
confidence level: high
key event id: KE 2221
key event name: Altered Liver X receptor activity
pathway id: WP2874
pathway title: Liver X receptor pathway
wp release date: 2026-08-10

https://molaop-builder.vhp4safety.nl/mappings/5529072e-22cb-4632-b80b-e080b41d4625
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.926471
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 451
key event name: Inhibition, Mitochondrial fatty acid beta-oxidation
pathway id: WP368
pathway title: Mitochondrial long chain fatty acid beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/5638fba3-f3bd-43c0-8308-f17f7cf2e1e0
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:16:10.450811
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2094
key event name: Abnormal, neuroblast migration
pathway id: WP5289
pathway title: Axon guidance
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/56e4bdbc-33e9-46cd-a71a-d71253b8d1b8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933660
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 376
key event name: Increased, Induced Mutations in Critical Genes
pathway id: WP4946
pathway title: Genes and complexes involved in the DNA repair pathways
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/58039853-ac17-419f-8372-d658072d19c6
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:17:58.036983
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1819
key event name: IFNγ signaling
pathway id: WP619
pathway title: Type II interferon signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/58256fa2-9403-4dc6-9474-0092a4ecc42c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:14.762343
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 902
key event name: Inflammation, Liver
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/58a8c278-8efe-4f81-bf80-1fae402460ce
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-01T12:25:15.125934
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 819
key event name: Decreased, Glomerular filtration
pathway id: WP2572
pathway title: Primary focal segmental glomerulosclerosis (FSGS)
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/58d250b6-dc0a-4c98-bf90-e683f9db94fd
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:29:22.993863
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 771
key event name: Decrease, Serum thyroid hormone (T4/T3)
pathway id: WP1981
pathway title: Thyroxine (thyroid hormone) production
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/59d15e8b-f7af-4a88-bed3-daca8648e3c7
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:44.790635
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1263
key event name: Necrosis
pathway id: WP2513
pathway title: Nanoparticle triggered regulated necrosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/59d61db8-749b-4f33-a346-2f50bd05477e
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:44:54.590083
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 960
key event name: Increased, Uptake of thyroxine into tissue
pathway id: WP4746
pathway title: Thyroid hormones production and peripheral downstream signaling effects
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/5a5f44e0-3137-4495-8c05-7771b65e4f76
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:12.818060
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1422
key event name: Reduced, PPARalpha
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/5af8a926-c3b0-49a8-8be8-e173a54a4f06
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:47.977610
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2031
key event name: Releasing, Apoptosis-Inducing Factor (AIF)
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/5b95718d-edb7-4017-8f2c-d95708da060f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:07.781262
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1489
key event name: N/A, Steatohepatisis
pathway id: WP4396
pathway title: Nonalcoholic fatty liver disease
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/5cc6d938-cd92-45fb-b66c-d9478dfa9699
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931560
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 233
key event name: Decreased, PPAR-gamma activation
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/5d26d2f4-7640-4e9f-ba6d-af3a4764ae9a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:37.189856
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2225
key event name: Disrupted Lipid Storage
pathway id: WP3965
pathway title: Lipid metabolism pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/5d640dfa-990b-4110-8ba7-41b7973a2986
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:03:53.576286
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2208
key event name: Aberrant, synaptic formation and plasticity
pathway id: WP4875
pathway title: Disruption of postsynaptic signaling by CNV
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/5f5f1b9a-adf3-4728-988a-921c11d894a8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.930398
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 450
key event name: Suppression, VLDL secretion
pathway id: WP5323
pathway title: Fatty acid and lipoprotein transport in hepatocytes
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/5fd09ce1-9d89-4f2e-b93d-eb4bb48d1bc4
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933289
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 491
key event name: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/60051014-a31f-427c-bcc7-5317a6a6c403
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:44:49.558899
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 178
key event name: Mitochondrial electron transport chain, disrupted
pathway id: WP4324
pathway title: Mitochondrial complex I assembly model OXPHOS system
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/60478fe8-eebc-4371-8b7d-d84c4ea36037
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932272
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 177
key event name: Mitochondrial dysfunction
pathway id: WP111
pathway title: Electron transport chain: OXPHOS system in mitochondria
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/60e2f282-42e4-48f6-a9c7-db2aa47d11a6
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:13:49.097393
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1848
key event name: Toll Like Receptor (TLR) Dysregulation
pathway id: WP3858
pathway title: Toll-like receptor signaling related to MyD88
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/618c2abc-12a9-4091-ade3-4376740f7836
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:58:56.163068
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1743
key event name: Increase plasma Ang II
pathway id: WP4756
pathway title: Renin-angiotensin-aldosterone system (RAAS)
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/61b17d69-6ecd-4a7c-8952-3041c0a232cb
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932998
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 378
key event name: Tumorigenesis, Hepatocellular carcinoma
pathway id: WP4336
pathway title: ncRNAs in Wnt signaling in hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/61e8e9b2-5ebb-4e69-b65e-76e41a9ef420
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:31:06.694475
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 767
key event name: Increase, Hyperplasia (renal tubular cells)
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/6299240d-1cc1-4f15-bd42-45ccf8238db7
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:57:31.655455
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1853
key event name: Hyperactivation of ACE/Ang-II/AT1R axis
pathway id: WP5036
pathway title: Angiotensin II receptor type 1 pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/629c9049-414c-488c-a381-d280c7ade0eb
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:20:13.657748
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1012
key event name: Increased, Inhibitory postsynaptic potential
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/62bd589e-249a-4985-8405-6f7f7f8e31e5
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931348
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 291
key event name: Accumulation, Triglyceride
pathway id: WP325
pathway title: Triacylglyceride synthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/637fd9e7-ba5c-4820-bcfe-ed50cef508b0
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:44:35.715675
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 239
key event name: Activation, Pregnane-X receptor, NR1I2
pathway id: WP2876
pathway title: Pregnane X receptor pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/64719024-334b-4a16-9b26-423887bfa82b
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:22:13.332232
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1538
key event name: Decreased protection against oxidative stress
pathway id: WP408
pathway title: Oxidative stress response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/66ff7c41-d4c0-4555-8ac2-6e96f8941d6d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-13T08:08:25.346790
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2412
key event name: Increase, Hepatic intracellular active glucocorticoids
pathway id: WP5280
pathway title: Glucocorticoid biosynthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/688077d8-d53f-4e18-ae9b-86b03b557bbd
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:36:31.991467
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1487
key event name: Binding, Thiol/seleno-proteins involved in protection against oxidative stress
pathway id: WP408
pathway title: Oxidative stress response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/691d739b-ef13-48f7-83a6-23b2e146c92c
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:02:48.910256
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1844
key event name: systemic inflammatory response syndrome
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/696bf0d2-dd9c-4b76-91fd-85df06899380
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T12:03:40.763986
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 295
key event name: Induction, Upregulation of glucuronyltransferase activity
pathway id: WP698
pathway title: Glucuronidation
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/697dbaad-3c66-4939-ba72-e6b9d8209f4c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934025
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 288
key event name: Activation of specific nuclear receptors, Transcriptional change
pathway id: WP2882
pathway title: Nuclear receptors meta-pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/69bab8f7-7c3d-4e6c-8c5d-2d33b2d843ad
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:45:08.475288
aop wiki snapshot date: 2026-08-06
confidence level: low
key event id: KE 68
key event name: Increase, Collagen accumulation
pathway id: WP3624
pathway title: Lung fibrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/69f63176-899e-41a5-a334-8087223e6af3
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:45:06.004097
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 202
key event name: Inhibition, Nuclear factor kappa B (NF-kB)
pathway id: WP3656
pathway title: Interleukin-1 induced activation of NF-kB
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/6baabf6a-835e-49e2-bb18-03ea081d5f88
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-15T12:03:53.681538
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 386
key event name: Decrease of neuronal network function
pathway id: WP4539
pathway title: Synaptic signaling associated with autism spectrum disorder
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/6bb30d07-942e-45e0-a8be-113b8c4a1ee7
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-05-11T18:32:08.534730
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 177
key event name: Increase, Mitochondrial dysfunction
pathway id: WP78
pathway title: TCA cycle (aka Krebs or citric acid cycle)
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/6bed8438-62b1-4adb-bab2-04187f927b92
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:54:20.351116
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1897
key event name: increased MyD88 activation
pathway id: WP3877
pathway title: MYD88 distinct input-output pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/6c09bce6-b0a3-4eec-9a3c-cdc29e340a27
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-05-11T18:16:47.739924
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1825
key event name: Increase, Cell death
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/6c1ea844-60c6-420f-a2a0-265bdcfa0dac
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:43.247964
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 478
key event name: Activation, NRF2
pathway id: WP4357
pathway title: NRF2-ARE regulation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/6cece2e6-5541-4155-b77d-46770c526ee1
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:23.366688
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1605
key event name: Accumulation of misfolded proteins
pathway id: WP4925
pathway title: Unfolded protein response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/6d2afdda-b83b-4d5b-8ea5-6d0f2a499f30
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:09:38.887353
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1788
key event name: Status epilepticus
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/6f156dd6-6c3a-4269-ade6-8ffe755979d7
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:47:15.016463
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2005
key event name: Altered neurotransmission in development
pathway id: WP2267
pathway title: Synaptic vesicle pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/6f212609-255d-44cf-887f-f0d8d4045722
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T09:52:56.192650
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2300
key event name: Disruption, Glucolipid metabolism
pathway id: WP3965
pathway title: Lipid metabolism pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/6f36c7a5-1624-4209-b71b-63999f5db7ea
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:00:10.334832
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2232
key event name: Antagonism, Retinoic acid receptors
pathway id: WP716
pathway title: Vitamin A and carotenoid metabolism
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/6f493927-5e8e-437d-b246-9909821e759e
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:45:01.594063
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1097
key event name: Occurrence, renal proximal tubular necrosis
pathway id: WP4313
pathway title: Ferroptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/6f79bc69-d518-4a43-bbf3-7d709729882b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933954
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 288
key event name: Activation of specific nuclear receptors, Transcriptional change
pathway id: WP299
pathway title: Nuclear receptors in lipid metabolism and toxicity
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/6faf6930-6e6b-408e-b1ed-170c5646fb5b
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:08:47.565841
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1527
key event name: Increase, Cell membrane depolarization
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/702df415-f531-48f3-94f0-2e64f6e2fc4b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:40.080981
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 486
key event name: systemic inflammation leading to hepatic steatosis
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/724dcf2c-a9e9-478d-b4fb-a653392fedc6
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:28.574685
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1285
key event name: Up Regulation, Unsaturated fatty acid
pathway id: WP4724
pathway title: Omega-9 fatty acid synthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/740b563f-ff84-4c41-b39a-92778cee452e
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:58:01.316290
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1851
key event name: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
pathway id: WP5036
pathway title: Angiotensin II receptor type 1 pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/742b5962-500e-405b-ac14-240b7a6f666e
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-12T10:40:08
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 188
key event name: Neuroinflammation
pathway id: WP4919
pathway title: Neuroinflammation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/74916ac5-2e1d-439e-bf35-abb2815fb29b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-19T12:09:06.954870
aop wiki snapshot date: 2026-08-13
confidence level: high
key event id: KE 941
key event name: Activation, EGFR
pathway id: WP437
pathway title: EGF/EGFR signaling
wp release date: 2026-08-10

https://molaop-builder.vhp4safety.nl/mappings/7495d57d-13cb-4932-b5b4-4ced54d25d0c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:43.332339
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 840
key event name: Formation, Liver fibrosis
pathway id: WP4786
pathway title: Type I collagen synthesis in the context of osteogenesis imperfecta
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/75a5d197-39d0-4632-aeab-db0876622a8f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931490
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 245
key event name: Activation, PXR/SXR
pathway id: WP2876
pathway title: Pregnane X receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/76baaea0-2e1a-4629-b782-d80e41fb760d
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:40:44.407153
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2093
key event name: Brain thyroid hormone (T4/T3) decreased
pathway id: WP4746
pathway title: Thyroid hormones production and peripheral downstream signaling effects
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/772e8aa1-85ff-41ba-a3da-ce139f3adc5b
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-03T11:59:04.831564
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1392
key event name: Oxidative Stress
pathway id: WP408
pathway title: Oxidative stress response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/776ec9ad-30ac-469b-9b16-8b451f082237
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:46.262962
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 838
key event name: Induction, Microvesicular fat
pathway id: WP5123
pathway title: Mitochondrial fatty acid oxidation disorders
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/777a19c2-8f05-47bc-9ff7-0436ce390ada
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:29.048159
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 854
key event name: Alterations, Cellular proliferation / hyperplasia
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/7823acd2-12b4-439a-b3c2-37ff868458f3
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:05:48.415608
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2151
key event name: Disruption, neurotransmitter release
pathway id: WP2267
pathway title: Synaptic vesicle pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/79ad02a0-a157-4746-aa8d-070f4db8240e
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-08-13T05:42:58
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 25
key event name: KE 25 - Agonism, Androgen receptor
pathway id: WP138
pathway title: Androgen receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/79fb565c-7139-479f-accd-b38ffaefe95e
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:45:32.068658
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 896
key event name: Parkinsonian motor deficits
pathway id: WP2371
pathway title: Parkinson's disease pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/7bc40c84-b209-4596-a7e1-da040fdbf7a8
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:36:43.726994
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1469
key event name: Activation, Transforming Growth Factor beta pathway
pathway id: WP560
pathway title: TGF-beta receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/7bde7550-36cb-44db-9d7a-62dfd9f66558
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:15:02.233571
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1352
key event name: Activated, voltage-gated sodium channel
pathway id: WP5598
pathway title: Sodium channel in epilepsy
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/7c024a14-81a3-4204-a0a6-ba5a61110bc2
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:29:34.337080
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 770
key event name: Increase, Cytotoxicity (club cells)
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/8042d055-eb6b-400a-ad1b-5c55a89303ac
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:46:55.724107
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2010
key event name: Pulmonary inflammation
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/8128c066-9546-411e-a998-26fec560c68c
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:15:49.703426
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1670
key event name: Lung cancer
pathway id: WP4658
pathway title: Small cell lung cancer
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/817a33e0-2427-4e97-a8cc-7248eae68113
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:05:54.841741
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2116
key event name: Decreased, oligodendrocyte differentiation
pathway id: WP5574
pathway title: Oligodendrocyte development
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/8249103b-49f2-44ab-a0b3-3b0582848879
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:11.092763
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1633
key event name: Increase in inflammation
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/824ce1d6-18ad-447f-9ba0-0c95ab17a356
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:17:44.650586
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1362
key event name: Increased, hippocampal hyperdepolarization
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/82e0e0d8-0e1e-481a-8542-bc863dc09ee4
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:48.824448
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1394
key event name: Induction, persistent proliferation/sustained proliferation
pathway id: WP179
pathway title: Cell cycle
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8494eb60-cc8f-4e3c-95b4-470e3d27d367
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:02:04.526182
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2218
key event name: Binding of (ant)agonist to liver X receptor
pathway id: WP2874
pathway title: Liver X receptor pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/84d82d9f-6e85-415e-a1ef-f6175b0d3af4
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:25:01.826515
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 783
key event name: Increase, Cytotoxicity (tubular epithelial cells)
pathway id: WP4838
pathway title: Regucalcin in proximal tubule epithelial kidney cells
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/8507e5b8-1f00-4a12-8f06-7e9577963da0
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T12:00:44.769587
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 381
key event name: Reduced levels of BDNF
pathway id: WP2380
pathway title: Brain-derived neurotrophic factor (BDNF) signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/8564e2e8-5f88-4def-881d-07339de606fb
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:51:00.958734
aop wiki snapshot date: 2026-08-06
confidence level: low
key event id: KE 1456
key event name: Increase, Differentiation of fibroblasts
pathway id: WP3624
pathway title: Lung fibrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/85ff536f-3d8a-4842-99eb-9e42f7938a23
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:51:13.301114
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1623
key event name: Occurrence, Focal Seizure
pathway id: WP5598
pathway title: Sodium channel in epilepsy
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/87c3f4d4-5e19-4aa1-b309-bdab8451fed0
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:21:59.543518
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1177
key event name: Decreased, Ionotropic GABA receptor chloride channel conductance
pathway id: WP4159
pathway title: GABA receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/88ac9b15-c441-4376-966f-2a34012ec3e9
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:55:16.417677
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1857
key event name: Platelet-neutrophil interactions, Increased
pathway id: WP4462
pathway title: Platelet-mediated interactions with vascular and circulating cells
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/88bdcbd8-9dbe-4947-acb1-710b8134e04a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-19T12:09:03.634121
aop wiki snapshot date: 2026-08-13
confidence level: high
key event id: KE 179
key event name: Decrease, Fatty acid beta-oxidation
pathway id: WP143
pathway title: Fatty acid beta-oxidation
wp release date: 2026-08-10

https://molaop-builder.vhp4safety.nl/mappings/88ce5205-8f30-41cf-b46c-a99c6cd2179b
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:22:03.113130
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1541
key event name: Mitochondrial Complex I inhibition
pathway id: WP4324
pathway title: Mitochondrial complex I assembly model OXPHOS system
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/88dd86d9-b6a3-4179-8664-1d947f5dd186
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:44:43.390981
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 186
key event name: Altered, Neuroanatomy
pathway id: WP5231
pathway title: Hippocampal synaptogenesis and neurogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/89870f0a-a071-44c3-a8f7-aca76e0f48e4
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:26.448273
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 716
key event name: Increase, cell proliferation (hepatocytes)
pathway id: WP313
pathway title: Hepatocyte growth factor receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8a951aed-8624-4c37-ad4c-2a192b80e710
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:14.259794
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1422
key event name: Reduced, PPARalpha
pathway id: WP2878
pathway title: PPAR-alpha pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8aba0b0c-1d85-4ba8-8dab-dc1bd303b33a
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-24T13:29:57.881637
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1283
key event name: Activation, TGF-beta pathway
pathway id: WP560
pathway title: TGF-beta receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8c6b2d57-e547-4573-9f3b-5aa50585b635
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:38:30.437906
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 870
key event name: Increase, Cell Proliferation
pathway id: WP179
pathway title: Cell cycle
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8cc61567-5358-4810-a978-fbad69c62320
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:17.476057
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 881
key event name: Increased, Triglyceride
pathway id: WP5323
pathway title: Fatty acid and lipoprotein transport in hepatocytes
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8e02b782-6c64-4874-afb7-0b955c6f3b53
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:44:57.665034
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 831
key event name: Disturbance, Lysosomal function
pathway id: WP4923
pathway title: Autophagy
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8e1cf23e-380f-444d-a921-00ac2b4eb5e2
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:51:59.922267
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1912
key event name: Motile Cilia Number/Length, Decreased
pathway id: WP4536
pathway title: Genes related to primary cilium development (based on CRISPR)
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/8e2c714a-819b-4fa4-81d4-4009b12e6664
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931201
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 327
key event name: Accumulation, Fatty acid
pathway id: WP143
pathway title: Fatty acid beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8ebdf99b-6e06-4328-9696-181cd0994209
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932539
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 165
key event name: Activation, Long term AHR receptor driven direct and indirect gene expression changes
pathway id: WP2586
pathway title: Aryl hydrocarbon receptor response to main mediators PAH and TCDD
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/8ed559b0-17d9-4538-99f3-8ff91f90beaa
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:02.114229
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1214
key event name: Altered gene expression specific to CAR activation, Hepatocytes
pathway id: WP2875
pathway title: Constitutive androstane receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/9067f7af-d5e5-415a-afdf-f6ce15bfeb85
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:24:08.186131
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 850
key event name: Induction, CYP1A2/CYP1A5
pathway id: WP2586
pathway title: Aryl hydrocarbon receptor response to main mediators PAH and TCDD
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/915c2c4a-2ac5-4a31-8523-1fa4ebc5b1ce
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:37:44.713444
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1458
key event name: Pulmonary fibrosis
pathway id: WP3624
pathway title: Lung fibrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/923fb92c-75f1-4e41-94a7-b4a9d9474b53
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:55.081287
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1392
key event name: Oxidative Stress
pathway id: WP3941
pathway title: Oxidative damage response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/92a1425c-c8ab-457e-9675-ddab3f0f5155
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:26.601649
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 856
key event name: Formation, Hepatocellular and Bile duct tumors
pathway id: WP4336
pathway title: ncRNAs in Wnt signaling in hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/935eb43f-3226-4cf1-abce-d38cbe9f91c2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-23T09:05:45.158003
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 177
key event name: Increase, Mitochondrial dysfunction
pathway id: WP623
pathway title: Oxidative phosphorylation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/93ed848b-4b26-4e95-814c-0b253551ccd5
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:50:07.359975
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1275
key event name: Collagen Deposition
pathway id: WP5312
pathway title: Metabolic pathways of fibroblasts
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/93fce828-81cd-4305-b7ba-1b36ca0650f5
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-01T12:25:30.831620
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 926
key event name: Oxidation, Glutathione (To be considered with MIE)
pathway id: WP100
pathway title: Glutathione metabolism
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/94bdac0c-dbd6-4680-b6ed-f52a9fccad74
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:44:55.995086
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1494
key event name: Leukocyte recruitment/activation
pathway id: WP4542
pathway title: Leukocyte-intrinsic Hippo pathway functions
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/95e9d3a7-c450-4e69-be30-d828220e93de
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934460
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 209
key event name: Peptide Oxidation
pathway id: WP408
pathway title: Oxidative stress response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/97b1ad41-4095-4b1c-a226-78de4a2c8f56
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:00:53.580018
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2223
key event name: Reduced number of oligodendrocytes
pathway id: WP5574
pathway title: Oligodendrocyte development
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/97e56fdd-c416-46a5-86bd-02df2ef90cc9
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:40:09.684399
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 839
key event name: Formation, Mallory body
pathway id: WP183
pathway title: Proteasome degradation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/98189a63-5c9c-4b47-835b-dceb0c6e8871
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:20.554930
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 878
key event name: Inhibition, SREBP1c
pathway id: WP1982
pathway title: Sterol regulatory element-binding proteins (SREBP) signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/992d5d01-bc59-4caa-bb36-41b1bf5fa3b1
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:01:21.620080
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1847
key event name: Increased SARS-CoV-2 production
pathway id: WP4846
pathway title: SARS-CoV-2 and COVID-19 pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/99c31115-54ec-416a-b723-e6d8004313c0
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:40:54.781322
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1365
key event name: Increase, Apoptosis
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/9c09469b-c9d4-44f7-8e15-2455762ae121
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:45:32.620329
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2013
key event name: Airway remodeling
pathway id: WP3624
pathway title: Lung fibrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/9c80084f-a261-4e3d-9424-08ac9fad7ecc
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:16:24.528047
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2086
key event name: Airway inflammation
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/9d722c70-9b86-4d16-82ad-1938198c69d9
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933738
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 373
key event name: Formation, Pro-mutagenic DNA Adducts
pathway id: WP4753
pathway title: Nucleotide excision repair
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/9dcb63b9-afc2-4351-80b5-40750a925c8f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:29.306513
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2227
key event name: Disrupted PPAR isoform nuclear signaling
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/9e3bc5f4-7243-41fd-afd6-f70cf049e801
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:58:20.827052
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1489
key event name: N/A, Steatohepatisis
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/9f064b32-a4ab-4c50-8f64-4db70aea6f7b
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-01-13T13:14:59
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 55
key event name: Increase, Cell injury/death
pathway id: WP2507
pathway title: Nanomaterial induced apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/9f24fa69-dbe8-49a0-b41c-0d6505f6adcd
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:47:17.464664
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 756
key event name: Hippocampal gene expression, Altered
pathway id: WP5231
pathway title: Hippocampal synaptogenesis and neurogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/9f7f0d83-5da6-489d-a87b-91601ae8edef
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:02:34.455060
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1846
key event name: Thrombosis and Disseminated Intravascular Coagulation
pathway id: WP272
pathway title: Blood clotting cascade
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/9f80d9ef-808c-4859-8f80-f084fd7e995b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:32:16.121667
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 9
key event name: Activation, 5HT2c
pathway id: WP732
pathway title: Serotonin receptor 2 and ELK-SRF/GATA4 signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/9f8e5303-ca8e-4ff5-8344-f07156eb14a4
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:58:37.834680
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 385
key event name: Decrease of synaptogenesis
pathway id: WP5231
pathway title: Hippocampal synaptogenesis and neurogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/9fe2bd77-5347-46fd-9eeb-8b87771d3b05
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:58:07.654049
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2107
key event name: Hypomyelination
pathway id: WP4304
pathway title: Oligodendrocyte specification and differentiation, leading to myelin components for CNS
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a08472d6-8b80-43b8-96dc-f74131782c19
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:21:09.518185
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1587
key event name: Fibroproliferative airway lesions
pathway id: WP3624
pathway title: Lung fibrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a1deff2c-95be-4f5b-b431-3e3424ca920c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:13:42.926537
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1851
key event name: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
pathway id: WP4756
pathway title: Renin-angiotensin-aldosterone system (RAAS)
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a1e7b45c-891a-4307-97d3-adb33dc415cb
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:39:10.445157
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 618
key event name: Decreased, Neuronal network function in adult brain
pathway id: WP5083
pathway title: Neuroinflammation and glutamatergic signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a20a7421-7dea-47d1-a9b0-8a3ce2b1bcdb
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:04.169772
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1493
key event name: Increased Pro-inflammatory mediators
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a28dd624-1171-4780-bc8c-1c17fd83004d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:44:44.603599
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 2405
key event name: Increase, Hepatocellular lipotoxicity
pathway id: WP5323
pathway title: Fatty acid and lipoprotein transport in hepatocytes
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a374232d-d164-4ca5-bcb7-80a388144774
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:15:59.657895
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1283
key event name: Activation, TGF-beta pathway
pathway id: WP3874
pathway title: Canonical and non-canonical TGF-B signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a572404e-ec3e-4e92-afbb-a7de2c22a6fe
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T09:52:29.550927
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2300
key event name: Disruption, Glucolipid metabolism
pathway id: WP534
pathway title: Glycolysis and gluconeogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a59b2893-5f85-4e82-83c5-9536bab503de
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:44:36.620106
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 188
key event name: Neuroinflammation
pathway id: WP5083
pathway title: Neuroinflammation and glutamatergic signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a5c102fa-7b60-48fa-90e3-b7b811e583af
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-23T09:05:46.678943
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1825
key event name: Increase, Cell death
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a5c68378-62e6-4549-9a4e-5c443d3f1cd3
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932769
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 57
key event name: Proliferation, Cell proliferation in the absence of cytotoxicity
pathway id: WP179
pathway title: Cell cycle
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a6129677-ccf8-4044-aa25-b9963dbf7ac3
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:35.553445
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 853
key event name: Changes/Inhibition, Cellular Homeostasis and Apoptosis
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a61ac802-bc0f-4067-b6e6-8bca6e94ca4d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:18.469001
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1417
key event name: NFE2/Nrf2 repression
pathway id: WP4357
pathway title: NRF2-ARE regulation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a6638a2b-0e38-4d4f-9e09-89b36b530398
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-25T12:29:33.602913
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 40
key event name: Mitochondrial ATP production, decreased
pathway id: WP391
pathway title: Mitochondrial gene expression
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a729c940-c492-4161-a76f-eab6af7d8ce1
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:58:42.977046
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1852
key event name: Increased Ang II type 1 receptor (AT1R)
pathway id: WP5036
pathway title: Angiotensin II receptor type 1 pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a73e634e-cfe2-4e67-969a-1d58e21000c9
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:18.936749
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 881
key event name: Increased, Triglyceride
pathway id: WP325
pathway title: Triacylglyceride synthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a78f2667-6a29-4c3f-afbc-6e79786cd7f4
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:05:38.206990
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2188
key event name: Activation, caspases
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a7f286e7-0afc-49f9-8cc0-50c6c18a0f20
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:40:05.470862
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 134
key event name: Increase, Kupffer cell activation
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a8060df8-4dff-437a-9da7-5b5a791c4628
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:43.480081
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 2031
key event name: Releasing, Apoptosis-Inducing Factor (AIF)
pathway id: WP2507
pathway title: Nanomaterial induced apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a9336c38-aa97-43b2-a82c-43dad852368b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:29.555624
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1579
key event name: Increase, proinflammatory mediators (TNFalpha)
pathway id: WP5095
pathway title: Overview of proinflammatory and profibrotic mediators
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/a95cb0c2-284e-4a2c-a8af-0986ff41f1e1
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:42:38.002069
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 352
key event name: N/A, Neurodegeneration
pathway id: WP5372
pathway title: Involvement of δ-secretase in neurodegenerative diseases
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a977caef-89f2-4dc7-914f-432924357bd6
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:28:01.514598
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 682
key event name: Generation, Amplified excitatory postsynaptic potential (EPSP)
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/a9a24f8b-0174-4590-ac72-6321baeeb0df
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:23.193975
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 716
key event name: Increase, cell proliferation (hepatocytes)
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/aa362328-b2d1-42f3-9820-2810a4d5fa31
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934670
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 41
key event name: Inhibition, Bile Salt Export Pump (ABCB11)
pathway id: WP5176
pathway title: Disorders of bile acid synthesis and biliary transport
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ab8f0b1c-b460-42fd-9f84-87836b2ba7e6
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934530
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 87
key event name: Release, Cytokine
pathway id: WP5473
pathway title: Cytokine-cytokine receptor interaction
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ac6e7d32-0072-4629-8ab0-704c5841e750
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:34.940126
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1284
key event name: Up Regulation, SREBF2
pathway id: WP2011
pathway title: SREBF and miR33 in cholesterol and lipid homeostasis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/acbe3abe-1692-4d0c-ad78-5c55b9795de4
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T09:54:04.974852
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2299
key event name: Altered, Redox Homeostasis
pathway id: WP408
pathway title: Oxidative stress response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/acc43298-853d-4ac5-968b-a08a147a15d4
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:25.480093
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1289
key event name: Perturbation of cholesterol
pathway id: WP197
pathway title: Cholesterol biosynthesis pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ad0eae30-1335-46c4-a9cd-59eb52118b1e
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:19.775071
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1417
key event name: NFE2/Nrf2 repression
pathway id: WP2884
pathway title: NRF2 pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ad8e72c7-cab3-42af-8855-4a5c2ab4e1f2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:39.424626
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2224
key event name: Dysregulation of transcriptional expression within PPAR signaling network
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/adf9941e-23d8-45c9-8044-7fa2a5b7d40c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-05-10T11:13:37.747859
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 471
key event name: Inhibition, FoxA2
pathway id: WP5066
pathway title: FOXA2 pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/affc3bd7-b0e5-4e1c-b94e-927a45f0d5b4
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:58:52.473186
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 459
key event name: Increased, Liver Steatosis
pathway id: WP143
pathway title: Fatty acid beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b0521ec4-05e5-4372-b945-88c6b0aff09e
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:06.561834
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1817
key event name: Apoptotic cell death
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b1415e96-09e8-4068-a80b-f7bca1e86da5
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:12.345888
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 769
key event name: Increase, Oxidative metabolism
pathway id: WP623
pathway title: Oxidative phosphorylation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b18926cd-899c-4fa9-885e-958475540f0f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933810
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 357
key event name: Cholestasis, Pathology
pathway id: WP5176
pathway title: Disorders of bile acid synthesis and biliary transport
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b1cd5927-bdfc-4ae7-8fad-1a5c33c7da4d
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:04:01.238390
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2202
key event name: Altered expression of cell cycle genes
pathway id: WP179
pathway title: Cell cycle
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/b21ac548-dd63-480b-9199-7f9391587af8
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-03T11:59:13.592007
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 149
key event name: Increase, Inflammation
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b2a9a055-feeb-4fb9-9119-656ed2b72d4e
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:37:45.039604
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 669
key event name: Reduction, Neuronal synaptic inhibition
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/b2d2da42-2a9a-45b0-b5fe-1accf323796f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932844
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 55
key event name: Increase, Cell injury/death
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b4a4e3ff-f944-43ba-be34-3f35006c219f
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:15:52.003925
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1496
key event name: Increased, secretion of proinflammatory mediators
pathway id: WP5095
pathway title: Overview of proinflammatory and profibrotic mediators
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/b53d61ea-d3d8-45ea-b44c-309247dc7d28
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-08-13T05:47:13
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 17
key event name: KE 17 - Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway
pathway id: WP2882
pathway title: Nuclear receptors meta-pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b684145d-c10c-45cd-bcd2-d92eb80479e3
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:38:58.096891
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 835
key event name: Occurrence, Ballooning degeneration (hepatocyte)
pathway id: WP4925
pathway title: Unfolded protein response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b6bf69b1-7de6-4a51-919b-29fced13d641
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:27:33.625261
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 887
key event name: Inhibition, NADH-ubiquinone oxidoreductase (complex I)
pathway id: WP111
pathway title: Electron transport chain: OXPHOS system in mitochondria
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/b6c2ac14-406f-4115-a3a5-cb3143173753
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931715
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 231
key event name: Decreased, PPAR-alpha activation
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b6edd972-4d6e-4157-8333-53e6d8e9afa0
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:33:34.038349
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1497
key event name: Increased, recruitment of inflammatory cells
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/b766fed5-d9c9-44ca-91d8-304a2b62f101
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:13:29.017146
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2097
key event name: Increase, Pro-Inflammatory Mediators
pathway id: WP5095
pathway title: Overview of proinflammatory and profibrotic mediators
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/b812ffae-2a8a-4aa4-8eb4-757f709ddc3b
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:17:59.989171
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1656
key event name: Antagonism, Thyroid Receptor
pathway id: WP4746
pathway title: Thyroid hormones production and peripheral downstream signaling effects
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/b825a39b-4cd7-4c4c-8359-408d0596bf0d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:39.012014
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1548
key event name: Necrotic Tissue
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b8decd6a-e53e-4101-b8d1-e15dd9f0dc61
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:21:28.787404
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1581
key event name: Disturbance in microtubule dynamic instability
pathway id: WP2038
pathway title: Microtubule cytoskeleton regulation
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/b8eeaa97-12cc-466d-b735-2fdfb03d3e22
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-08-13T05:42:58
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 25
key event name: KE 25 - Agonism, Androgen receptor
pathway id: WP2263
pathway title: Androgen receptor network in prostate cancer
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/b930e45f-98de-452c-a295-e81353f13fe2
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:36:04.540248
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 762
key event name: Activation, ionotropic GABA Receptor chloride channel
pathway id: WP4159
pathway title: GABA receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/baf27503-2a2d-4d54-a8b6-a564ad005658
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:04.419930
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1817
key event name: Apoptotic cell death
pathway id: WP254
pathway title: Apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/bb7b4563-1c93-4822-a3dc-3f77b1f509e1
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-25T12:29:38.622413
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1104
key event name: Decreased, Prostaglandin F2alpha concentration, plasma
pathway id: WP98
pathway title: Prostaglandin synthesis and regulation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/bc2b4468-103b-4012-a06a-9dcd29bc1cff
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:46:09.931706
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 398
key event name: Activation, Dendritic Cells
pathway id: WP5187
pathway title: mRNA vaccine activation of dendritic cell and induction of IFN-1
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/bc61c5f7-1634-4110-80dc-9afa7bb338b8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:22.903700
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1289
key event name: Perturbation of cholesterol
pathway id: WP2011
pathway title: SREBF and miR33 in cholesterol and lipid homeostasis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/bcb9009c-0096-44e9-8ee5-edc6c44914ea
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:57:39.221787
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2195
key event name: Increase, CNS Neural cell death
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/be0733b8-1452-4f0c-b79f-7bbc4e90e11c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:57.515116
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 787
key event name: Increase, Regenerative cell proliferation (hepatocytes)
pathway id: WP313
pathway title: Hepatocyte growth factor receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/be8e0812-0e81-4af2-a584-d280b04f8a19
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:14:21.402913
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1977
key event name: Disruption of sodium channel gating kinetics
pathway id: WP5598
pathway title: Sodium channel in epilepsy
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c07b904a-6f45-49ca-b49c-8dafd9979e4c
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:38:41.106045
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1415
key event name: Reduced, GABA-A receptor activation
pathway id: WP4159
pathway title: GABA receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c11425fd-d781-4f36-815d-d8931a5d5c8c
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-10-02T11:08:38
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 10
key event name: Acetylcholine accumulation in synapses
pathway id: WP528
pathway title: Acetylcholine synthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c22f212d-7fcb-42fe-be87-920ad5c25d3a
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:31:54.223415
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 388
key event name: Overactivation, NMDARs
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c2c192fb-179d-4e1a-b36e-938c134a6cd2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:45:00.692033
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1501
key event name: Increased, extracellular matrix deposition
pathway id: WP560
pathway title: TGF-beta receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c2c3a715-900f-496d-aa4c-722ac0a8ce99
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:16.200327
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1421
key event name: Activated, LXR
pathway id: WP2874
pathway title: Liver X receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c46697c2-0a08-4f9b-bd38-d63653c81217
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934173
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 214
key event name: Bile accumulation, Pathological condition
pathway id: WP5176
pathway title: Disorders of bile acid synthesis and biliary transport
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c4afe1c4-6ba7-4bbb-bebc-e76706f11d35
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:19:01.029791
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1223
key event name: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
pathway id: WP4962
pathway title: Airway smooth muscle cell contraction
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c4b296c4-0762-4456-91e6-b19d1e6c879a
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:37:37.298801
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1468
key event name: Activation, Latent Transforming Growth Factor Beta 1
pathway id: WP560
pathway title: TGF-beta receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c4c66b60-8087-4852-ad28-6cd02bb80c26
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:18:33.803448
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1579
key event name: Increase, proinflammatory mediators (TNFalpha)
pathway id: WP231
pathway title: TNF-alpha signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c4d5693f-11de-4bdc-94e5-53339c6ce250
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:44:20.320141
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 193
key event name: Decreased, Nitric Oxide
pathway id: WP1995
pathway title: Effects of nitric oxide
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c62826a9-3e1c-49c8-aa9c-1d25e71263c2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934600
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 41
key event name: Inhibition, Bile Salt Export Pump (ABCB11)
pathway id: WP5396
pathway title: Enterohepatic circulation of bile acids
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c63f005f-980e-472c-8b77-5a753872dbfb
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:17:41.043424
aop wiki snapshot date: 2026-08-06
confidence level: low
key event id: KE 1445
key event name: Increase, Lipid peroxidation
pathway id: WP4313
pathway title: Ferroptosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c701ae5c-50f4-483f-88a8-f0fadebc0487
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:49:57.676354
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 17
key event name: Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway
pathway id: WP2873
pathway title: Aryl hydrocarbon receptor pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c75463d3-2a7c-4000-b542-58cf82da1fc8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:32:12.662914
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 12
key event name: Acetylcholinesterase (AchE) Inhibition
pathway id: WP550
pathway title: Biogenic amine synthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c843f1b7-61d2-4ee6-9e1a-eea2631c6012
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-13T08:09:11.297665
aop wiki snapshot date: 2026-05-06
confidence level: low
key event id: KE 2410
key event name: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity
pathway id: WP2880
pathway title: Glucocorticoid receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c85eefc9-977b-4bee-a654-f2ac96a7b1cc
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:32:00.095228
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 40
key event name: Mitochondrial ATP production, decreased
pathway id: WP1403
pathway title: AMP-activated protein kinase signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c97a47c0-da19-439c-806f-4ca2b4ad5303
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:47:39.937104
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1945
key event name: Dysfunctional Autophagy
pathway id: WP4923
pathway title: Autophagy
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/c9869477-7ba5-4ddf-8888-c6b6ed5d9251
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:17.810806
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1289
key event name: Perturbation of cholesterol
pathway id: WP5304
pathway title: Cholesterol metabolism
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/c9e640ae-8843-41d9-a641-8b874d084502
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931857
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 228
key event name: peroxisome proliferator activated receptor promoter demethylation
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ca311e87-a33b-41a5-b210-15dfd81d87a6
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:48:40.749628
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 821
key event name: Decreased, Sodium reabsorption
pathway id: WP4917
pathway title: Proximal tubule transport
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/cafe9d03-1b66-4241-8d09-5ec0fc0bbccc
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933071
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 491
key event name: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
pathway id: WP313
pathway title: Hepatocyte growth factor receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/cb21d4fd-e591-472f-8640-a06d155ae02a
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:16:07.101413
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1669
key event name: Increased, DNA damage and mutation
pathway id: WP707
pathway title: DNA damage response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/cb58db28-269c-4fa6-abcc-b03561fca305
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:58:01.538397
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2111
key event name: Decreased, neural progenitor cell adhesion to laminin
pathway id: WP185
pathway title: Integrin-mediated cell adhesion
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/cc85af9e-ede8-4b7f-9118-c862686480c0
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:44:50.242977
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 2017
key event name: Endoplasmic reticulum stress
pathway id: WP4925
pathway title: Unfolded protein response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/cd182a2c-877b-4566-99e4-cf2927379632
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:45.551751
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 478
key event name: Activation, NRF2
pathway id: WP2884
pathway title: NRF2 pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ceb41bb5-d6bb-46a9-957a-b2f1629da547
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:18:13.240214
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1635
key event name: Increase, DNA strand breaks
pathway id: WP4946
pathway title: Genes and complexes involved in the DNA repair pathways
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/ced7c569-aea1-4a72-b06b-223957a874d9
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-13T08:09:06.437923
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 149
key event name: Increase, Inflammation
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/cf0e5998-d9f0-46c2-a6c1-ef6bd580de60
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-19T12:08:35.604991
aop wiki snapshot date: 2026-08-13
confidence level: high
key event id: KE 1512
key event name: Unfolded Protein Response
pathway id: WP4925
pathway title: Unfolded protein response
wp release date: 2026-08-10

https://molaop-builder.vhp4safety.nl/mappings/cf9384c8-2c3e-4380-a51c-86b5b49c55b2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:49:20.921762
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 795
key event name: Increase, Regenerative cell proliferation (urothelial cells)
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/d03eb198-e060-4046-9349-038d809dcaea
type: KeyEventPathwayMapping
creator: marvinm2
date: 2025-10-01T16:38:58
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 79
key event name: Inhibition, Cyclooxygenase activity
pathway id: WP4719
pathway title: Eicosanoid metabolism via cyclooxygenases (COX)
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d04d0c5b-6581-4514-bf08-f320bf09827b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:45:48.772175
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 613
key event name: Occurrence, Epileptic seizure
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/d1f67cbc-e3f0-40e8-88cf-a2f4865f0717
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:17:53.082073
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1820
key event name: Immune mediated hepatitis
pathway id: WP530
pathway title: Cytokines and inflammatory response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d40838f6-05d2-47ce-959e-b2d366de5bd2
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:57:41.693388
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1853
key event name: Hyperactivation of ACE/Ang-II/AT1R axis
pathway id: WP4756
pathway title: Renin-angiotensin-aldosterone system (RAAS)
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/d43548d9-7453-4d95-ab88-22c8c3fe9328
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:16.832404
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 719
key event name: Increase, hepatocellular adenomas and carcinomas
pathway id: WP4336
pathway title: ncRNAs in Wnt signaling in hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d458df4e-9359-43b6-ad37-a598c82ce577
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933883
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 357
key event name: Cholestasis, Pathology
pathway id: WP5238
pathway title: Cholestasis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d4b29dcb-1157-491c-8b25-aa5ba74b9c6b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:47:32.632106
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 709
key event name: Increase, Cytotoxicity (renal tubular cell)
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/d52b38c6-4c5d-4727-9dac-127fddfc7ae3
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.930671
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 345
key event name: N/A, Liver Steatosis
pathway id: WP4396
pathway title: Nonalcoholic fatty liver disease
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d538e92b-1285-4436-a2a3-d973b7b9388a
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:46.761093
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1394
key event name: Induction, persistent proliferation/sustained proliferation
pathway id: WP313
pathway title: Hepatocyte growth factor receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d5e142c1-3c7b-4a81-9d44-4836b6495da6
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:54:30.445856
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1869
key event name: Diminished protective oxidative stress response
pathway id: WP408
pathway title: Oxidative stress response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/d62063c3-549f-4ae7-9337-d3ca2d21a8ff
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:17:00.777408
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1995
key event name: Abnormal lipid metabolism
pathway id: WP3965
pathway title: Lipid metabolism pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d6469dc4-f63f-4bba-a630-c87cd770e7cf
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:53:48.933013
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1901
key event name: Interferon-I antiviral response, antagonized by SARS-CoV-2
pathway id: WP4868
pathway title: Type I interferon induction and signaling during SARS-CoV-2 infection
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/d67dbe34-4a26-4d0c-92f5-8458d3385807
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:19:00.783521
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1197
key event name: Activation, Fibroblasts
pathway id: WP3624
pathway title: Lung fibrosis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/d68607e9-5b52-4ee7-80c3-a21885bdb06b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:39.947637
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 483
key event name: Activation, LXR alpha
pathway id: WP2874
pathway title: Liver X receptor pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d6d3f689-00ab-4f9a-8c49-e3a1e35a1547
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-03T08:48:33.834124
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 281
key event name: Thyroxine (T4) in serum, Decreased
pathway id: WP1981
pathway title: Thyroxine (thyroid hormone) production
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/d7dc11b2-d7c0-4e2f-8a65-8d817d405ccd
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:19:26.048390
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1177
key event name: Decreased, Ionotropic GABA receptor chloride channel conductance
pathway id: WP5600
pathway title: GABA and glutamate signalling in epileptogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/d7e9b570-013c-460e-83ae-d47f6eed499f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:30.042117
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1285
key event name: Up Regulation, Unsaturated fatty acid
pathway id: WP4723
pathway title: Omega-3 / omega-6 fatty acid synthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/dab85f99-fb90-498f-b3ba-3833063fe3ff
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:21:16.601463
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1585
key event name: Proteasomal dysfunction
pathway id: WP183
pathway title: Proteasome degradation
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/db828dc6-9737-4e63-ba87-c6d45ad4ae8d
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-25T12:29:07.474042
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 709
key event name: Increase, Cytotoxicity (renal tubular cell)
pathway id: WP4864
pathway title: Host-pathogen interaction of human coronaviruses - apoptosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/dbfd4847-7998-47e3-83e3-f1e170f868cf
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:14:55.429969
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1353
key event name: Binding to voltage-gated sodium channel
pathway id: WP5598
pathway title: Sodium channel in epilepsy
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/dc0c9c08-ea06-4841-83e4-c807f64e5108
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:55.608155
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 457
key event name: Activation, SREBF1
pathway id: WP1982
pathway title: Sterol regulatory element-binding proteins (SREBP) signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/dc7b7289-517d-45dc-9f1f-88976fb11f35
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-18T08:08:41
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1528
key event name: Fatty Acid Beta Oxidation, Decreased
pathway id: WP143
pathway title: Fatty acid beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/dce50cc0-e125-4b3e-afa1-b977dfcc0bc0
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:47:01.110088
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 202
key event name: Inhibition, Nuclear factor kappa B (NF-kB)
pathway id: WP231
pathway title: TNF-alpha signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/dd0ff531-228c-4517-9157-3ed8c2611517
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933445
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1115
key event name: Increase, Reactive oxygen species
pathway id: WP408
pathway title: Oxidative stress response
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/dd25eb43-5329-41a4-aa48-7061f0c2cc45
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:12.479948
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1299
key event name: Activation, AKT
pathway id: WP4172
pathway title: PI3K-Akt signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ddf497e1-e1e9-42b3-a2f3-9f6c2a4345d3
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:39:01.003333
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1414
key event name: Decreased, GABA
pathway id: WP4157
pathway title: GABA metabolism (aka GHB)
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/df514a68-d0c8-4b08-8523-0d9fce3ac24f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931641
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 232
key event name: Decreased, PPAR-beta activation
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/df81b858-2c52-4950-a128-bd4fefc8885d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931787
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 231
key event name: Decreased, PPAR-alpha activation
pathway id: WP2878
pathway title: PPAR-alpha pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/df850130-029c-4f22-9d28-5e288de77448
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:57.812667
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1310
key event name: Activation, PI3K
pathway id: WP5472
pathway title: Phosphoinositide 3-kinase (PI3K) family
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/dfa95510-459e-4f2c-8ce9-d8183aee3e00
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-05-10T11:13:49.668075
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 89
key event name: Synthesis, De Novo Fatty Acid (FA)
pathway id: WP357
pathway title: Fatty acid biosynthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/dfb0b5c9-2a67-447c-b95e-c23b3d2d5816
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:25:30.139947
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1096
key event name: Increased, blood uric acid concentration
pathway id: WP4224
pathway title: Purine metabolism and related disorders
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/dfb291ad-7dc0-45d2-971d-fa479cb8d070
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:39:52.772623
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 385
key event name: Decrease of synaptogenesis
pathway id: WP4875
pathway title: Disruption of postsynaptic signaling by CNV
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/dfb6c1f3-4b23-4ab2-81a2-c3650824cd80
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:35:22.894943
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 767
key event name: Increase, Hyperplasia (renal tubular cells)
pathway id: WP4838
pathway title: Regucalcin in proximal tubule epithelial kidney cells
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/e0539278-f0f4-4ddf-8e88-f7b12c089e9b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934388
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 209
key event name: Peptide Oxidation
pathway id: WP5477
pathway title: Molecular pathway for oxidative stress
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e236ffe8-0043-4e83-9d24-9e756aacaf6d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.931128
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 327
key event name: Accumulation, Fatty acid
pathway id: WP357
pathway title: Fatty acid biosynthesis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e2f8ad31-eec4-41ac-833a-f61c200b53f1
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.930903
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 334
key event name: Promotion, Hepatocelluar carcinoma
pathway id: WP4336
pathway title: ncRNAs in Wnt signaling in hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e3c8c56d-5490-43a8-8be9-ad7d6cd3b301
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.933518
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 493
key event name: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
pathway id: WP4752
pathway title: Base excision repair
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e48630a6-1691-4cb3-8269-4613a6950df9
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:16:32.432695
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2226
key event name: Stressor binding PPAR isoforms
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e504e8f9-7f6c-455d-9274-9620de30cc50
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:13:59.804422
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1708
key event name: Th17 cell migration and inflammation induction
pathway id: WP5130
pathway title: Th17 cell differentiation pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/e5598c00-469a-4fbe-bd65-953a08897484
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:32.839555
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 854
key event name: Alterations, Cellular proliferation / hyperplasia
pathway id: WP179
pathway title: Cell cycle
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e56c4319-04a4-4515-b099-4e804ec94b8f
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:47.586125
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 468
key event name: Inhibition, PPAR alpha
pathway id: WP3942
pathway title: PPAR signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e603bbce-6354-40ff-bcd4-672859312be8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934246
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 214
key event name: Bile accumulation, Pathological condition
pathway id: WP4389
pathway title: Bile acid synthesis and enterohepatic circulation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e762a290-66f0-4db1-8f1a-8380420e9bde
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-03-03T08:48:42.278147
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1103
key event name: Inhibition, Cyclooxygenase 1 activity
pathway id: WP4719
pathway title: Eicosanoid metabolism via cyclooxygenases (COX)
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/e7df0c38-390d-42c9-97ff-90a5b214f501
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T12:03:55.616057
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 277
key event name: Thyroid hormone synthesis, Decreased
pathway id: WP1981
pathway title: Thyroxine (thyroid hormone) production
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/ea4eac1c-302d-4950-abe1-35207db42480
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.930830
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 334
key event name: Promotion, Hepatocelluar carcinoma
pathway id: WP4337
pathway title: ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ea99d510-dd40-4206-884f-0b3654db8702
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:21:15.270508
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1198
key event name: Activation, Macrophages
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/eaf79af8-3e17-42b5-97a6-57696106913b
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:44:31.953027
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 192
key event name: Altered, Neurophysiology
pathway id: WP5231
pathway title: Hippocampal synaptogenesis and neurogenesis
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/eb957e5f-b3dc-4c1e-9be9-33cd17989f49
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:32:43.293298
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1508
key event name: CYP2E1 Activation
pathway id: WP43
pathway title: Oxidation by cytochrome P450
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/ebe94629-c5aa-44a8-86fb-6da0f48ce9b6
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-19T09:44:12
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1632
key event name: Increase in reactive oxygen and nitrogen species (RONS)
pathway id: WP5233
pathway title: Arsenic metabolism and reactive oxygen species generation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ec1bdb66-e23d-4493-9d64-83d4186af1aa
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:54:48.034822
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1868
key event name: Hyperinflammation
pathway id: WP5095
pathway title: Overview of proinflammatory and profibrotic mediators
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/ec62ae9d-98ef-46ac-b724-3d2060916e80
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:12.423642
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 902
key event name: Inflammation, Liver
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ed25d939-b504-4377-8a00-a45f061c26ec
type: KeyEventPathwayMapping
creator: marvinm2
date: 2026-02-11T11:29:39
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 188
key event name: Neuroinflammation
pathway id: WP5485
pathway title: Post-COVID neuroinflammation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ed70e647-51c4-48c7-9ea9-132c243bb562
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-18T12:18:49.000031
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1790
key event name: Increased, Differentiation to Testis
pathway id: WP4842
pathway title: Mammalian disorder of sexual development
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ee3080d6-845b-48a6-8348-2f786753a3a6
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-05-10T11:13:25.964476
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 860
key event name: Decreased, Mitochondrial Fatty Acid Beta Oxidation
pathway id: WP368
pathway title: Mitochondrial long chain fatty acid beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/eeaafd26-1839-4f8d-ad45-e25d812e16cc
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:50:38.016121
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 853
key event name: Changes/Inhibition, Cellular Homeostasis and Apoptosis
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f102739b-644c-409d-bb5a-3cac34aceb12
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.932924
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 378
key event name: Tumorigenesis, Hepatocellular carcinoma
pathway id: WP4337
pathway title: ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f149001c-5fb1-423a-9411-e5e9e57d1bad
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.930192
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 451
key event name: Inhibition, Mitochondrial fatty acid beta-oxidation
pathway id: WP143
pathway title: Fatty acid beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f1709f6c-b259-4f45-8d9b-1e22f35121f8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:42.779844
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1394
key event name: Induction, persistent proliferation/sustained proliferation
pathway id: WP5475
pathway title: Hallmark of cancer: sustaining proliferative signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f2878706-a7de-4265-98a1-ef6823e2521c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.934317
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 214
key event name: Bile accumulation, Pathological condition
pathway id: WP2289
pathway title: Drug induction of bile acid pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f2ecea3e-2881-4389-a0b5-ec5e2ccc5ad8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-13T08:09:29.271039
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1825
key event name: Increase, Cell death
pathway id: WP2513
pathway title: Nanoparticle triggered regulated necrosis
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f3030700-5c99-48c2-bb43-236389aaf7f4
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-13T12:11:39.101173
aop wiki snapshot date: 2026-08-06
confidence level: low
key event id: KE 1501
key event name: Increase, Extracellular matrix deposition
pathway id: WP5312
pathway title: Metabolic pathways of fibroblasts
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/f3ad91c0-5551-4d5a-8ce4-a6b4db9f7151
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:44:05.523675
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 64
key event name: Reduction, Ionotropic GABA receptor chloride channel conductance
pathway id: WP4159
pathway title: GABA receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/f3d36837-8f9b-48c0-be57-b89f90a077a2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:48:15.164295
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1290
key event name: Glutathione homeostasis
pathway id: WP100
pathway title: Glutathione metabolism
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f4632f88-67a2-47e5-97fb-601bd8456ace
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:51:24.930588
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 345
key event name: N/A, Liver Steatosis
pathway id: WP5323
pathway title: Fatty acid and lipoprotein transport in hepatocytes
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f48d8413-3d7c-4c9f-acf8-1cbcc021a56c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:40:01.519442
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2119
key event name: Increase, Insulin resistance
pathway id: WP481
pathway title: Insulin signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f5410fcd-5287-4519-b2f0-15d62a8a1544
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-05-11T18:35:50.387531
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 177
key event name: Increase, Mitochondrial dysfunction
pathway id: WP5241
pathway title: Mitochondrial beta-oxidation
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f6e918fc-193c-423a-8420-182f288a3af8
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:45:03.200664
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 177
key event name: Increase, Mitochondrial dysfunction
pathway id: WP4324
pathway title: Mitochondrial complex I assembly model OXPHOS system
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/f85fc763-04b3-420d-8049-83ef77f9cfbd
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:26:09.564728
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 959
key event name: Increased, Free serum thyroxine (T4)
pathway id: WP4746
pathway title: Thyroid hormones production and peripheral downstream signaling effects
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/f888d6bc-d54c-48af-abcc-0613c58a7a18
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:46:15.999985
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 888
key event name: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
pathway id: WP4324
pathway title: Mitochondrial complex I assembly model OXPHOS system
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/f8bcab2f-ff2a-47eb-a007-cbcb0c585aa3
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:16:53.062229
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1439
key event name: Systemic acute phase response
pathway id: WP4493
pathway title: Cells and molecules involved in local acute inflammatory response
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/f973d660-527b-4181-8ae1-b9c355801645
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T11:15:04.566101
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1292
key event name: Activation, JNK
pathway id: WP382
pathway title: MAPK signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/f986ecb0-fd86-4afb-bce4-3a8fa6947789
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:06:10.130286
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1816
key event name: Mitochondrial dysfunction EMPTY
pathway id: WP5504
pathway title: Disorders of mitochondrial homeostatis, dynamics, protein import, and quality control
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/f9a821c4-c0ac-4751-9a51-64219f310370
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T12:13:37.994033
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1854
key event name: Dysregulation, ACE2 expression and activity
pathway id: WP4969
pathway title: Renin Angiotensin System and Bradykinin pathways in COVID-19
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/f9bd1580-7dc1-43da-abf0-b9b26db2982e
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:16:51.251377
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1668
key event name: Frustrated phagocytosis
pathway id: WP3937
pathway title: Microglia pathogen phagocytosis pathway
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/fa12d400-ac9c-471c-b344-4ebdb9fe0fcb
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-03-16T14:14:43.096653
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 570
key event name: Accumulation, Damaged mitochondrial DNA
pathway id: WP4946
pathway title: DNA repair pathways, full network
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/fa9c36da-b698-44e0-8365-e30a7933c243
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-03-16T14:15:12.513985
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1271
key event name: Increase, Transforming growth factor-beta signaling
pathway id: WP560
pathway title: TGF-beta receptor signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/fb46738b-1edd-4f60-9bec-0108685860e5
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T07:51:40.024913
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1912
key event name: Motile Cilia Number/Length, Decreased
pathway id: WP4803
pathway title: Ciliopathies
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/fb6bd845-35c0-4800-a5de-01d32a2d7ffd
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:15:40.449802
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1708
key event name: Th17 cell migration and inflammation induction
pathway id: WP2112
pathway title: IL17 signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/fbbeec70-e0e0-40bb-9534-191f96e0c3dc
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:38:34.937295
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 2009
key event name: Activation of inflammation pathway
pathway id: WP453
pathway title: Inflammatory response pathway
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/fbc66184-224b-4fde-9fab-4132f3eb3f4d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T17:31:18.839853
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 837
key event name: Occurrence, Cytoplasmic vacuolization (kupffer cell)
pathway id: WP4923
pathway title: Autophagy
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/fbca0fba-3aa3-45be-b081-92e962543299
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:19:07.867217
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1908
key event name: Cilia Beat Frequency, Decreased
pathway id: WP4803
pathway title: Ciliopathies
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/fbd2ffe6-02ed-4d71-97e1-729807ba60a1
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-11T12:28:23.053930
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 783
key event name: Increase, Cytotoxicity (tubular epithelial cells)
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/fbf7ceb9-b466-44e6-a7d9-9e2ba2be03b2
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:00.565018
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 787
key event name: Increase, Regenerative cell proliferation (hepatocytes)
pathway id: WP179
pathway title: Cell cycle
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/fc3dd7f8-778e-40fb-ae9e-10b4637cef93
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T16:58:33.573911
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 459
key event name: Increased, Liver Steatosis
pathway id: WP5061
pathway title: Fatty acid transporters
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/fd099dec-4739-47af-889b-86f5ec62d1c6
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:08:34.345927
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 1795
key event name: Latent Transforming growth Factor beta expression
pathway id: WP560
pathway title: TGF-beta receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/fd513d6e-4ca9-467a-aade-3632e6c75548
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T08:04:20.252728
aop wiki snapshot date: 2026-08-06
confidence level: high
key event id: KE 1842
key event name: Prolonged TLR9 activation
pathway id: WP1449
pathway title: Regulation of toll-like receptor signaling
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/fd605d6a-deb5-4656-866a-0665634cc36d
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:49:46.805026
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1262
key event name: Apoptosis
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/fda5c1f7-15f5-4516-84ad-0411df22c532
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:47:53.075578
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1393
key event name: Hepatocytotoxicity
pathway id: WP1772
pathway title: Apoptosis modulation and signaling
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ff0901bc-7781-46ab-9cdd-6585f72f444c
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-07-29T16:46:54.162177
aop wiki snapshot date: 2026-05-06
confidence level: medium
key event id: KE 1501
key event name: Increased, extracellular matrix deposition
pathway id: WP129
pathway title: Matrix metalloproteinases
wp release date: 2026-05-10

https://molaop-builder.vhp4safety.nl/mappings/ff4e4513-24d7-49f9-8e32-1faaf9d959ec
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-08-11T11:43:58.490916
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 52
key event name: Decreased, Calcium influx
pathway id: WP536
pathway title: Calcium regulation in cardiac cells
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/ff5f81d7-cda3-4441-90b4-eb3f26c71d5d
type: KeyEventPathwayMapping
creator: github:SidraAdil
date: 2026-08-10T10:12:52.743382
aop wiki snapshot date: 2026-08-06
confidence level: medium
key event id: KE 2098
key event name: Increase, Abnormal Neural Remodeling
pathway id: WP5090
pathway title: Complement system in neuronal development and plasticity
wp release date: 2026-07-10

https://molaop-builder.vhp4safety.nl/mappings/ff784cdd-b8a1-4245-84af-6db3decdba23
type: KeyEventPathwayMapping
creator: github:marvinm2
date: 2026-04-12T21:39:28.789358
aop wiki snapshot date: 2026-05-06
confidence level: high
key event id: KE 1271
key event name: Activation of TGF-β signaling
pathway id: WP5382
pathway title: TGFB / Smad signaling
wp release date: 2026-05-10