production of molecular mediator involved in inflammatory response
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
transforming growth factor beta receptor signaling pathway
Activation, Transforming Growth Factor beta pathway
nuclear receptor-mediated signaling pathway
Activation of specific nuclear receptors, Transcriptional change
retinoic acid receptor signaling pathway
response to endoplasmic reticulum stress
Activation, Tissue resident cells (Kuppfer cells)
proton motive force-driven mitochondrial ATP synthesis
Binding of inhibitor to mitochondrial complex V
peroxisome proliferator activated receptor signaling pathway
Altered peroxisome proliferator–activated receptor alpha activity
Decreased, Prostaglandin F2alpha concentration, plasma
Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
Decrease, Mitochondrial membrane potential
Increase, Vitellogenin synthesis in liver
Increased, Clearance of thyroxine from serum
Suppression, Constitutive androstane receptor, NR1l3
formation of neutrophil extracellular traps (NETs)
Inhibition, Bile Salt Export Pump (ABCB11)
type II interferon-mediated signaling pathway
Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity
Loss of alveolar capillary membrane integrity
cell activation involved in immune response
transforming growth factor beta production
Latent Transforming growth Factor beta expression
Increase, Clonal Expansion of Altered Hepatic Foci
mitochondrial electron transport, NADH to ubiquinone
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Altered gene expression, NF-kB dependent Interleukin-6 pathway
Decreased, mitochondrial oxidative phosphorylation
Increased, Thyroid-stimulating hormone (TSH)
Aberrant, synaptic formation and plasticity
release of cytochrome c from mitochondria
Dysregulation of transcriptional expression within PPAR signaling network
gamma-aminobutyric acid signaling pathway
Decreased, neural progenitor cell adhesion to laminin
Increased, activation of T (T) helper (h) type 2 cells
Disturbance in microtubule dynamic instability
phosphatidylinositol 3-kinase/protein kinase B signal transduction
Increased, Reactive metabolites production
unsaturated fatty acid biosynthetic process
Decreased proliferation of cortical neural progenitor cells
protein quality control for misfolded or incompletely synthesized proteins
Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha
Increase, cell proliferation (hepatocytes)
Proliferation, Cell proliferation in the absence of cytotoxicity
Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
Decreased protection against oxidative stress
Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
Displacement, Serum thyroxine (T4) from transthyretin
Increased, fibroblast proliferation and myofibroblast differentiation
Non-coding RNA expression profile alteration
very-low-density lipoprotein particle assembly
systemic inflammation leading to hepatic steatosis
nuclear receptor-mediated glucocorticoid signaling pathway
Antagonism, Glucocorticoid hormone receptor
Releasing, Apoptosis-Inducing Factor (AIF)
nuclear receptor-mediated bile acid signaling pathway
Reduced, Presynaptic release of glutamate
Increase, Regenerative cell proliferation (hepatocytes)
Increased, hippocampal hyperdepolarization
Disrupted PPAR isoform nuclear signaling
low-density lipoprotein particle clearance
Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
NMDA selective glutamate receptor signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator
Altered gene expression, P53 dependent apoptosis pathway
mitochondrial electron transport, cytochrome c to oxygen
Binding of inhibitor to mitochondrial complex IV
Changes/Inhibition, Cellular Homeostasis and Apoptosis
Disrupted binding, laminin-beta1-integrin receptors with laminin
Interaction of α-diketones with arginine residues
Altered gene expression specific to CAR activation, Hepatocytes
Altered, Thyroid hormone-dependent gene expression
Th17 cell migration and inflammation induction
Fibroblast proliferation and differentiation
Thyroxine (T4) in neuronal tissue, Decreased
intracellular receptor signaling pathway
Activation, Long term AHR receptor driven direct and indirect gene expression changes
Increased, Expression of LXR activated genes
increased platelet surface TLR9 expression
reactive oxygen species metabolic process
Inhibition, Mitochondrial Electron Transport Chain Complexes
Mitochondrial electron transport chain, disrupted
Increase, Plasma vitellogenin concentrations
benzoquinone imine and acylglucuronide metabolites
neutrophil activation involved in immune response
Platelet-neutrophil interactions, Increased
Increase, Differentiation of fibroblasts
Binding of microtubule stabilizing agents (MSA) to microtubules
Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
Increase, proinflammatory mediators (TNFalpha)
Bile accumulation, Pathological condition
Increased, blood potassium concentration
regulation of pyruvate decarboxylation to acetyl-CoA
Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
Increased, blood uric acid concentration
endoplasmic reticulum unfolded protein response
Induction, Upregulation of glucuronyltransferase activity
fatty acid beta-oxidation using acyl-CoA oxidase
Alterations, Cellular proliferation / hyperplasia
Altered gene expression, NRF2 dependent antioxidant pathway
Up Regulation, LDLR (low density lipoprotein receptor)
mitochondrial electron transport, ubiquinol to cytochrome c
Binding of antagonist to glucocorticoid hormone receptor
chromosomal 5-methylcytosine DNA demethylation pathway
peroxisome proliferator activated receptor promoter demethylation
Activation, Constitutive androstane receptor
Impaired development of, Reproductive organs
Inhibition, Mitochondrial fatty acid beta-oxidation
Altered neurotransmission in development
Binding of inhibitor to mitochondrial complex III
Activation, Latent Transforming Growth Factor Beta 1
Increased, Hepatic thyroid hormone uptake/transport
fatty acid beta-oxidation using acyl-CoA dehydrogenase
thyroid hormone receptor signaling pathway
protein-coupled estrogen receptor 1 (GPER) activation
Induction, persistent proliferation/sustained proliferation
Inhibition, Nuclear factor kappa B (NF-kB)
Increase, Hypertrophy and proliferation (follicular cell)
Decreased, Ionotropic GABA receptor chloride channel conductance
oligodendrocyte progenitor proliferation
release of sequestered calcium ion into cytosol by endoplasmic reticulum
Inositol triphosphate receptor activation
Metabolism of AFB1, Production of Reactive Electrophiles
Binding of antagonist to thyroid hormone receptor
G protein-coupled glutamate receptor signaling pathway
Activation of metabotropic glutamate receptor
Binding of (ant)agonist to liver X receptor
acetylcholine catabolic process in synaptic cleft
Accumulation, Cytosolic toxic Tau oligomers
Occurrence, renal proximal tubular necrosis
thyroid gland epithelial cell proliferation
reactive oxygen species biosynthetic process
Decreased, Mitochondrial Fatty Acid Beta Oxidation
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Disturbed, radial glia cell alignment and migration
Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
Lysolecithin cell membrane integration, increased
Binding, extracellular matrix protein laminin
Increased, Induction of pyruvate dehydrogenase (PDH)
Increased LCN2/iron complex binds to SLC22A17 receptor in neuron
Increased, extracellular matrix deposition
Decreased, oligodendrocyte differentiation
Increased intracelluar Iron accumulation
MyD88-dependent toll-like receptor signaling pathway
Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
extrinsic apoptotic signaling pathway via death domain receptors
Binding of substrate, endocytic receptor