https://molaop-builder.vhp4safety.nl/mappings/01370c12-ff8e-4f05-adfe-c20d3980f9e4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:19:45.570964
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002532
go term name: production of molecular mediator involved in inflammatory response
key event id: KE 1493
key event name: Increased Pro-inflammatory mediators
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/01977aaf-a4ee-4849-aff9-c7701271c8b3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:36:37.556661
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0098930
go term name: axonal transport
key event id: KE 1582
key event name: Impaired axonial transport
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/02edbbe1-e511-4ec0-8c57-f86b1edf1800
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:42:34.844479
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0038166
go term name: angiotensin-activated signaling pathway
key event id: KE 1851
key event name: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/04252c8e-bbd0-423b-a3b3-d1e8c02667d1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:18.573566
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007179
go term name: transforming growth factor beta receptor signaling pathway
key event id: KE 1469
key event name: Activation, Transforming Growth Factor beta pathway
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/04c0b9e1-b531-48d5-9399-ff72b288457c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:36:51.439989
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007420
go term name: brain development
key event id: KE 1978
key event name: Increase risk, microcephaly
suggestion score: 1.0

https://molaop-builder.vhp4safety.nl/mappings/0651dda1-0edc-4cfe-bba6-35ee6aa02292
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:51:56.915906
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0019915
go term name: lipid storage
key event id: KE 2225
key event name: Disrupted Lipid Storage
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/075064f7-100d-4873-867b-cbf7453dcdca
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:47:45.660540
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0014051
go term name: gamma-aminobutyric acid secretion
key event id: KE 1414
key event name: Decreased, GABA
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/07ba4151-875d-4e45-850d-a646f0f3242c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:46:48.583792
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0000413
go term name: protein peptidyl-prolyl isomerization
key event id: KE 1794
key event name: Pin-1 activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/08b0a6c8-8417-456e-942e-3e775e32a74c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:11:53.458814
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 288
key event name: Activation of specific nuclear receptors, Transcriptional change
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/08d8c0ae-da6a-44e9-86bd-66e42a0c14f2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:24:49.418542
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048384
go term name: retinoic acid receptor signaling pathway
key event id: KE 2232
key event name: Antagonism, Retinoic acid receptors
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/091e0080-04f3-4674-9c02-b84a0bdf9a8c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:06:38.523534
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0019432
go term name: triglyceride biosynthetic process
key event id: KE 454
key event name: Increased, Triglyceride formation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/0a030b28-160e-4e8f-8192-9b314fdf5088
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:04:59.326470
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006633
go term name: fatty acid biosynthetic process
key event id: KE 458
key event name: Increased, De Novo FA synthesis
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/0a3dc428-e9ba-4717-97dd-32f4114ab593
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:41.177566
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034976
go term name: response to endoplasmic reticulum stress
key event id: KE 2017
key event name: Endoplasmic reticulum stress
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/0c314d0c-5b29-4db1-9da0-46ef0fcc603c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:37:12.886204
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042116
go term name: macrophage activation
key event id: KE 1576
key event name: Activation, Tissue resident cells (Kuppfer cells)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/0c4659d9-3502-4e1e-b75e-6649730d9065
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:34:41.030982
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042776
go term name: proton motive force-driven mitochondrial ATP synthesis
key event id: KE 1655
key event name: Binding of inhibitor to mitochondrial complex V
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/0ca1c6e8-ca6c-4531-89d9-e1df71e99da8
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:22.435984
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030574
go term name: collagen catabolic process
key event id: KE 68
key event name: Accumulation, Collagen
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/0dc706e7-e64a-45f9-8aab-b0409d8ceed6
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:25:07.141082
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 2222
key event name: Altered peroxisome proliferator–activated receptor alpha activity
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/0de0eb49-e9d6-428b-8cfb-dbb0ad743229
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:48:49.520712
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006693
go term name: prostaglandin metabolic process
key event id: KE 1104
key event name: Decreased, Prostaglandin F2alpha concentration, plasma
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/0e53b3f1-6955-43e0-aeb6-d2d250833975
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:09:54.645119
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006635
go term name: fatty acid beta-oxidation
key event id: KE 140
key event name: Decreased, HSD17B10 expression
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/0f1db208-120d-49c1-a7d0-16590eb45670
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:07:48.632742
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006094
go term name: gluconeogenesis
key event id: KE 216
key event name: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/11589b3e-3f7b-444e-b64d-26c070a36882
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:47:27.401948
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0051882
go term name: mitochondrial depolarization
key event id: KE 1770
key event name: Decrease, Mitochondrial membrane potential
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/11b46884-6591-4009-a4d1-bc06e940ead4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:09:59.530207
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006633
go term name: fatty acid biosynthetic process
key event id: KE 89
key event name: Synthesis, De Novo Fatty Acid (FA)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/11f640e7-a1f5-4813-8a83-739c5e312e34
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:10:37.560693
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007296
go term name: vitellogenesis
key event id: KE 307
key event name: Increase, Vitellogenin synthesis in liver
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/122a946d-8ccf-4635-b4f5-b6525369fab0
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:05.899502
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042404
go term name: thyroid hormone catabolic process
key event id: KE 961
key event name: Increased, Clearance of thyroxine from serum
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/12acd071-20ce-4dde-9d5d-a894ff2dc83f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:19:39.079326
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030595
go term name: leukocyte chemotaxis
key event id: KE 1494
key event name: Leukocyte recruitment/activation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/13519f97-96d0-48ec-ab24-8da3ceedab27
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:06:34.769982
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 456
key event name: Suppression, Constitutive androstane receptor, NR1l3
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/155c6de5-fb5a-45ad-8577-312db8ef6f36
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:40:43.442663
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0140645
go term name: neutrophil extracellular trap formation
key event id: KE 1899
key event name: formation of neutrophil extracellular traps (NETs)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/1611c3d4-42d1-4345-9e86-55d9f4712785
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:52:05.041607
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032964
go term name: collagen biosynthetic process
key event id: KE 1275
key event name: Collagen Deposition
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/164d9199-414c-4059-bfbf-2062ad968af6
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:17:36.594510
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0015722
go term name: canalicular bile acid transport
key event id: KE 41
key event name: Inhibition, Bile Salt Export Pump (ABCB11)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/169c6c8c-5bb7-41f2-8cd1-9d4c85055826
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:30:48.317521
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0060480
go term name: lung goblet cell differentiation
key event id: KE 2117
key event name: Increase, goblet cell number
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/1761da84-5d11-4efb-aac5-98bf56784ea7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:44:21.135156
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0060333
go term name: type II interferon-mediated signaling pathway
key event id: KE 1819
key event name: IFNγ signaling
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/17ad9ee8-22c7-4a86-adfd-31e33899a2c7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:32.854617
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030198
go term name: extracellular matrix organization
key event id: KE 1458
key event name: Pulmonary fibrosis
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/17c2dde8-b2c0-42d1-88d5-c55a3aa18a73
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:16:30.991618
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 233
key event name: Decreased, PPAR-gamma activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/1859d7d2-b3b1-4492-b6a4-1c85a430d67a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:56:01.760549
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006635
go term name: fatty acid beta-oxidation
key event id: KE 8
key event name: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/188e07c7-cd8d-492f-b5cf-bc0177849e62
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:43:32.950090
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0061028
go term name: establishment of endothelial barrier
key event id: KE 1498
key event name: Loss of alveolar capillary membrane integrity
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/18e1baa5-0e81-4645-aec4-3d26cab9c145
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:53:31.845197
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0061337
go term name: cardiac conduction
key event id: KE 1106
key event name: Occurrence, cardiac arrhythmia
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/19c6b67a-536d-472d-ab8d-2f286480ad6a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-29T16:53:36.100373
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002263
go term name: cell activation involved in immune response
key event id: KE 1492
key event name: Tissue resident cell activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/19d76a01-1a30-43a4-965b-53483e372347
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:30:57.384308
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008203
go term name: cholesterol metabolic process
key event id: KE 2115
key event name: Altered, cholesterol metabolism
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/1a4241b8-87f6-4692-ae18-89c3cbbb39cf
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:45:22.171031
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034976
go term name: response to endoplasmic reticulum stress
key event id: KE 1815
key event name: Activation of ER stress
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/1ab1d9fa-aaf2-4bf7-bb04-fa4a9c73d8d2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:45:35.432399
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0071604
go term name: transforming growth factor beta production
key event id: KE 1795
key event name: Latent Transforming growth Factor beta expression
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/1b1d2ab2-ffbf-4193-979a-92f983c5f758
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:52:55.715458
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0072574
go term name: hepatocyte proliferation
key event id: KE 1171
key event name: Increase, Clonal Expansion of Altered Hepatic Foci
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/1b8b8509-a631-475d-93be-2a331964fc8e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:06:52.802866
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0015908
go term name: fatty acid transport
key event id: KE 465
key event name: Increased, FA Influx
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/1cc2d4a9-a8eb-4d60-b50e-280ac88b2d9d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:46:21.811035
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006883
go term name: intracellular sodium ion homeostasis
key event id: KE 1321
key event name: Increased, intracellular sodium (Na+)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/1d53d4ed-4e29-4420-a768-d7c79430b686
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:11:29.477273
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006120
go term name: mitochondrial electron transport, NADH to ubiquinone
key event id: KE 888
key event name: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/1e1c0f88-9342-4422-9241-66454176671b
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:38:54.507428
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007249
go term name: canonical NF-kappaB signal transduction
key event id: KE 1921
key event name: Altered gene expression, NF-kB dependent Interleukin-6 pathway
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/1e70bcc4-8328-49c6-ae8d-2e7798091089
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:33:19.748813
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0003016
go term name: respiratory system process
key event id: KE 2088
key event name: Dysfunction of respiratory system
suggestion score: 1.0

https://molaop-builder.vhp4safety.nl/mappings/2312ebd0-4f33-47b0-b2e1-f8db17df3fae
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:38:59.403652
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032635
go term name: interleukin-6 production
key event id: KE 1921
key event name: Altered gene expression, NF-kB dependent Interleukin-6 pathway
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/235d1b46-c67d-43a2-9434-0774ced2bbc8
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:51:34.557703
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006749
go term name: glutathione metabolic process
key event id: KE 1290
key event name: Glutathione homeostasis
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/2370fb6e-3b60-4390-b594-04cf67b11024
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:51:06.099033
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0098928
go term name: presynaptic signal transduction
key event id: KE 1349
key event name: Activated, presynaptic neuron 1
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/251b775e-c035-436b-9002-db51a7430e48
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:23:26.378956
aop wiki snapshot date: 2026-08-06
confidence level: high
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:0006915
go term name: apoptotic process
key event id: KE 55
key event name: Increase, Cell injury/death

https://molaop-builder.vhp4safety.nl/mappings/25a234c3-bd22-41cd-bc50-a44c52749b00
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:51:16.045737
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0015908
go term name: fatty acid transport
key event id: KE 1305
key event name: Increase, cytosolic fatty acid
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/26540bf0-43b7-40ef-bc33-ed36f3dbf563
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:42:35.833661
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034440
go term name: lipid oxidation
key event id: KE 1511
key event name: Lipid Peroxidation
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/271e3beb-6031-4c4e-b67e-f444763f34c3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:38:18.463135
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006119
go term name: oxidative phosphorylation
key event id: KE 1545
key event name: Decreased, mitochondrial oxidative phosphorylation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/271e6831-fc0f-4272-898b-24ff68345097
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:47:40.397923
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002003
go term name: angiotensin maturation
key event id: KE 1743
key event name: Increase plasma Ang II
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/2740eab5-9910-434d-9faa-7b8d627d6dda
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:50:01.936480
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070460
go term name: thyroid-stimulating hormone secretion
key event id: KE 1023
key event name: Increased, Thyroid-stimulating hormone (TSH)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/27b5fd21-ea9a-4882-bd15-a18b8c158b53
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:27:53.542007
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007416
go term name: synapse assembly
key event id: KE 2208
key event name: Aberrant, synaptic formation and plasticity
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/2883eb71-b0bf-42fa-824c-4e6b0bb949c8
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:45:31.209588
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0001836
go term name: release of cytochrome c from mitochondria
key event id: KE 1812
key event name: Increase, Cytochrome c release
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/2890e5de-6e89-4d9e-935e-4c5c09d99382
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:48:48.040049
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0043129
go term name: surfactant homeostasis
key event id: KE 1672
key event name: Inhibition of lung surfactant function
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/28f0ba58-4a86-4101-ba65-25339b67d583
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:52:40.635133
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0046209
go term name: nitric oxide metabolic process
key event id: KE 193
key event name: Decreased, Nitric Oxide
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/2928371c-a8b9-4736-8688-c6823e17f9ce
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:52:09.045698
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 2224
key event name: Dysregulation of transcriptional expression within PPAR signaling network
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/292f5d9a-30ed-480f-b062-8f21e33ba4fe
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:51:57.181007
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0019915
go term name: lipid storage
key event id: KE 345
key event name: N/A, Liver Steatosis
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/29861b83-547c-40fa-be20-87bc6c65e0ac
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:48:26.030247
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007214
go term name: gamma-aminobutyric acid signaling pathway
key event id: KE 1415
key event name: Reduced, GABA-A receptor activation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/2ab45a50-7ea2-42a2-823c-5c570b3cc456
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-18T12:18:05.332002
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006979
go term name: response to oxidative stress
key event id: KE 1392
key event name: Oxidative Stress
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/2ac2422e-d861-4759-ba63-714be4a9b392
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:31:44.890923
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007160
go term name: cell-matrix adhesion
key event id: KE 2111
key event name: Decreased, neural progenitor cell adhesion to laminin
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/2af0faad-837c-424b-9f92-f6d6be5f3eb3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:43:22.111909
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035712
go term name: T-helper 2 cell activation
key event id: KE 1499
key event name: Increased, activation of T (T) helper (h) type 2 cells
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/2c0d8af8-2265-41dc-9095-a969f137e576
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:24:19.107665
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030520
go term name: estrogen receptor signaling pathway
key event id: KE 2233
key event name: Decreased, ERαβ heterodimers
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/2dbcda2a-570b-4342-bcdf-de7dcbc61745
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:36:42.737634
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007019
go term name: microtubule depolymerization
key event id: KE 1581
key event name: Disturbance in microtubule dynamic instability
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/2e55581a-8392-4ac2-88ac-3a950781d123
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:32:02.514667
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042552
go term name: myelination
key event id: KE 2108
key event name: Altered, white brain matter
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/2ed2788b-943d-4c00-93ac-cd78f4c59c73
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:02:07.496036
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0043491
go term name: phosphatidylinositol 3-kinase/protein kinase B signal transduction
key event id: KE 484
key event name: Activation, AKT2
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/2f6a86e9-961f-49dd-8643-bb4be796e09d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:27:46.758054
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048167
go term name: regulation of synaptic plasticity
key event id: KE 2208
key event name: Aberrant, synaptic formation and plasticity
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/3230afc9-22bd-40d2-bce1-63453fd783f4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:23:36.459357
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006644
go term name: phospholipid metabolic process
key event id: KE 2263
key event name: Lysolecithin, increased
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/32a2ece3-5f27-4066-887b-da68df565916
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:21:10.235108
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0050890
go term name: cognition
key event id: KE 402
key event name: Cognitive function, decreased
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/32a442c9-6e96-4305-a4f6-f07e7d035191
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:46:20.846126
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 1421
key event name: Activated, LXR
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/32ee4d38-33b3-4838-b778-a0bf1bd4cfdd
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:38:42.160388
aop wiki snapshot date: 2026-05-06
confidence level: low
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006805
go term name: xenobiotic metabolic process
key event id: KE 1922
key event name: Increased, Reactive metabolites production
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/3335cf7c-033f-49a4-a068-ccfef52a9221
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:16:49.370664
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006636
go term name: unsaturated fatty acid biosynthetic process
key event id: KE 258
key event name: Activation, SCD-1
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/348b5348-7c6b-4ff3-98eb-94d0b33ca3a2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:28:10.593183
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0061351
go term name: neural precursor cell proliferation
key event id: KE 2203
key event name: Decreased proliferation of cortical neural progenitor cells
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/35382c86-bb60-45f9-9163-784e4aaf163e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:28:56.206710
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0000278
go term name: mitotic cell cycle
key event id: KE 2202
key event name: Altered expression of cell cycle genes
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/354184fd-ed59-495c-9c8b-0cc6dacb4459
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:35:46.211854
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006515
go term name: protein quality control for misfolded or incompletely synthesized proteins
key event id: KE 1605
key event name: Accumulation of misfolded proteins
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/35b5a44d-9f09-4029-bb96-bb4878c5a992
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:03:16.746980
aop wiki snapshot date: 2026-08-06
confidence level: high
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:0048813
go term name: dendrite morphogenesis
key event id: KE 382
key event name: Aberrant, Dendritic morphology
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/361f56c2-8f74-421c-b4da-3fde9f0fd2f9
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:25:53.649741
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 2219
key event name: Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/365aa0df-6f78-40e1-91e1-7af92b84166e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:43:43.038944
aop wiki snapshot date: 2026-05-06
confidence level: low
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 1491
key event name: Increased, Oncotic Necrosis
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/36bb62c6-9682-4871-9df7-3677e4bb65be
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:25:48.911993
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 2221
key event name: Altered Liver X receptor activity
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/37c6d807-2e67-45d8-bcd0-7f9a1370e5e7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:55:30.519916
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006805
go term name: xenobiotic metabolic process
key event id: KE 80
key event name: Up Regulation, CYP1A1
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/3a01dc8e-0ad2-4050-a4a4-0112c99414e3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:42:27.040578
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0038166
go term name: angiotensin-activated signaling pathway
key event id: KE 1852
key event name: Increased Ang II type 1 receptor (AT1R)
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/3a86013f-8596-4eb5-819a-867ec9bab383
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:59:41.477144
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0072574
go term name: hepatocyte proliferation
key event id: KE 716
key event name: Increase, cell proliferation (hepatocytes)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/3a9d5ab1-319a-4ac4-923b-21dbb9e0e5d7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:51:56.074829
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030198
go term name: extracellular matrix organization
key event id: KE 1276
key event name: Lung fibrosis
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/3ab15a55-a24a-493a-851e-48cc2cfd078a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:59:53.037590
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008283
go term name: cell population proliferation
key event id: KE 57
key event name: Proliferation, Cell proliferation in the absence of cytotoxicity
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/3ab1ba44-d13b-4a87-966d-f81b9e3e81df
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:08:33.443678
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0072574
go term name: hepatocyte proliferation
key event id: KE 491
key event name: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/3ac79d2e-b75d-4852-a9b8-02bfd6da1a1e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:52:10.679763
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030730
go term name: triglyceride storage
key event id: KE 291
key event name: Accumulation, Triglyceride
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/3af916e9-f561-4c39-8206-aa9d496dc377
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:19:21.147843
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035733
go term name: hepatic stellate cell activation
key event id: KE 265
key event name: Activation, Stellate cells
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/3b76b973-5836-4a1d-94b1-8a1ec778c265
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:04:56.235528
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006633
go term name: fatty acid biosynthetic process
key event id: KE 463
key event name: Up Regulation, FAS
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/3b9060fb-290c-450a-b56d-0c99f897f24e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:37:30.617532
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007249
go term name: canonical NF-kappaB signal transduction
key event id: KE 1574
key event name: Inhibition, IKK complex
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/3ed4b5c9-292d-4a79-ac5d-dd1ffd946c55
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-23T13:43:18.470459
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006635
go term name: fatty acid beta-oxidation
key event id: KE 1490
key event name: Inhibition, Fatty Acid Beta Oxidation
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/3f6a9c6f-503b-4fdd-81d4-9adba1adb017
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:40:00.214669
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034599
go term name: cellular response to oxidative stress
key event id: KE 1538
key event name: Decreased protection against oxidative stress
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/3f7db15b-b8c6-4f17-962e-781929d9b13f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:19:08.988456
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007552
go term name: metamorphosis
key event id: KE 1101
key event name: Altered, Amphibian metamorphosis
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/3fe5db97-3a14-44ec-8621-e3d4b032c769
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:43:54.258030
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034162
go term name: toll-like receptor 9 signaling pathway
key event id: KE 1842
key event name: Prolonged TLR9 activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/40a30d20-b20d-4b14-b53f-894317ae7e74
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:14.760940
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006264
go term name: mitochondrial DNA replication
key event id: KE 1481
key event name: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/4124e998-4a9e-4cfe-a426-b668355e75ee
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:50:43.729192
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070327
go term name: thyroid hormone transport
key event id: KE 958
key event name: Displacement, Serum thyroxine (T4) from transthyretin
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/414a57f9-c1c4-4781-9c2a-b0992f48ea8a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:43:03.374709
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002224
go term name: toll-like receptor signaling pathway
key event id: KE 1848
key event name: Toll Like Receptor (TLR) Dysregulation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/41579e1b-c494-41d8-9be4-c70ca136cad6
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:43:04.394182
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048144
go term name: fibroblast proliferation
key event id: KE 1500
key event name: Increased, fibroblast proliferation and myofibroblast differentiation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/41a36201-6f75-48e6-8d1f-ee3ac647c0a6
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:36:07.074147
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070918
go term name: regulatory ncRNA processing
key event id: KE 2007
key event name: Non-coding RNA expression profile alteration
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/4426a371-416d-4506-ac66-635d8fb970a4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:07:10.559666
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034379
go term name: very-low-density lipoprotein particle assembly
key event id: KE 450
key event name: Suppression, VLDL secretion
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/449708c4-8d0f-4fc7-af7b-c25a587b4dde
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:00:04.964461
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0019915
go term name: lipid storage
key event id: KE 486
key event name: systemic inflammation leading to hepatic steatosis
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/44b34798-a9b1-4280-aaf4-f0e7a04e547d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:25:27.629936
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042921
go term name: nuclear receptor-mediated glucocorticoid signaling pathway
key event id: KE 2220
key event name: Antagonism, Glucocorticoid hormone receptor
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/452467f7-a9ba-434f-a8c7-bf87b8d6e227
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:13:09.258775
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 227
key event name: Activation, PPARα
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/4565fc20-8f19-401b-92b9-4d654c0378d3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:36:46.599892
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0046785
go term name: microtubule polymerization
key event id: KE 1581
key event name: Disturbance in microtubule dynamic instability
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/458d9168-2cdc-4ecc-879b-ce179f6e3705
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:12.580079
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0097190
go term name: apoptotic signaling pathway
key event id: KE 2031
key event name: Releasing, Apoptosis-Inducing Factor (AIF)
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/46a4479f-c9dd-41de-a4f7-7377dad1850f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:45:32.755715
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0038185
go term name: nuclear receptor-mediated bile acid signaling pathway
key event id: KE 1419
key event name: Reduced, FXR activity
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/49196a0b-a5bc-4771-a1cb-1ce62c942366
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:56:49.984049
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 786
key event name: Increase, Cytotoxicity (hepatocytes)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/4a94d13a-15a6-40a0-89f0-14e815cfce5d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:03:12.365882
aop wiki snapshot date: 2026-08-06
confidence level: high
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:0061535
go term name: glutamate secretion, neurotransmission
key event id: KE 383
key event name: Reduced, Presynaptic release of glutamate
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/4b17dea4-e13e-4ffa-a199-290b00904b0b
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:24.809948
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032964
go term name: collagen biosynthetic process
key event id: KE 68
key event name: Accumulation, Collagen
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/4b951b32-dfe9-4457-bd5f-e8404c69e0a2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:40:28.568956
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030321
go term name: transepithelial chloride transport
key event id: KE 1907
key event name: Airway Surface Liquid Height, Decreased
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/4bc64bc1-9b57-4f21-84f6-5c63a6993a02
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:38:29.032666
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006120
go term name: mitochondrial electron transport, NADH to ubiquinone
key event id: KE 1541
key event name: Mitochondrial Complex I inhibition
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/4dce72f1-36e5-4ef0-aa2b-5d1a22c3f1fc
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:56:44.823760
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0072574
go term name: hepatocyte proliferation
key event id: KE 787
key event name: Increase, Regenerative cell proliferation (hepatocytes)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/4de5e989-6b27-473b-b7e6-7d43dfe606f4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:44:01.706494
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0150076
go term name: neuroinflammatory response
key event id: KE 1841
key event name: Encephalitis
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/4e6eb728-93fc-427e-846e-09ba6ada6168
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:15:26.699530
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 239
key event name: Activation, Pregnane-X receptor, NR1l2
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/4f4ede3c-931b-4656-a252-e5af3eff5718
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:50:47.694482
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0051899
go term name: membrane depolarization
key event id: KE 1362
key event name: Increased, hippocampal hyperdepolarization
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/50c29b76-e968-4595-9387-f9f2d8a0fa91
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:51:32.330871
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007626
go term name: locomotory behavior
key event id: KE 896
key event name: Parkinsonian motor deficits
suggestion score: 1.0

https://molaop-builder.vhp4safety.nl/mappings/50f88cae-9e97-47ea-b2c5-ee76c32aae1c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:51:42.306412
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 2227
key event name: Disrupted PPAR isoform nuclear signaling
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/51165749-a0b5-479d-8d70-d8a44e252932
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:35:35.679905
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006457
go term name: protein folding
key event id: KE 1605
key event name: Accumulation of misfolded proteins
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/5118f538-ca49-4f8f-b783-a2e68810f05e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:31:15.552625
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0021987
go term name: cerebral cortex development
key event id: KE 2114
key event name: Disturbed, cortical architecture
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/527bc541-a03a-4f05-9070-1c073801d801
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:29:43.006287
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 2195
key event name: Increase, CNS Neural cell death
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/5321592e-2949-4b8c-b411-614bec45010e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:08:24.546067
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034383
go term name: low-density lipoprotein particle clearance
key event id: KE 467
key event name: Increased, LDL uptake
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/5364da86-7a29-4aac-b0aa-07cbe4dde5a7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:51:49.930052
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0097017
go term name: renal protein absorption
key event id: KE 708
key event name: Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/54058805-6c29-412a-93c3-008497aa6e38
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:03:46.871551
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034599
go term name: cellular response to oxidative stress
key event id: KE 478
key event name: Activation, NRF2
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/56134107-f4f2-4319-a2c2-1046a7ec4ca1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:09:45.931729
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 231
key event name: Decreased, PPAR-alpha activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/56219e0f-d6a3-4ae9-a0d9-abd2c0c59d63
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:53:13.652730
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0098989
go term name: NMDA selective glutamate receptor signaling pathway
key event id: KE 201
key event name: Binding of antagonist, NMDA receptors
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/565857c2-a456-4b29-8199-0a36f0465d78
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:38:19.651474
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0072332
go term name: intrinsic apoptotic signaling pathway by p53 class mediator
key event id: KE 1923
key event name: Altered gene expression, P53 dependent apoptosis pathway
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/5660b1ed-1324-4dbb-b2f8-872af30590a8
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:34:45.866870
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006123
go term name: mitochondrial electron transport, cytochrome c to oxygen
key event id: KE 1654
key event name: Binding of inhibitor to mitochondrial complex IV
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/56c5f1b4-8df1-4035-95a5-824424872f3c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:31:28.071966
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0014009
go term name: glial cell proliferation
key event id: KE 2113
key event name: Decreased, radial glia cell density
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/573b9002-24de-44e1-acc6-9a66351e8af3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-05-10T12:03:57.261920
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0051301
go term name: cell division
key event id: KE 57
key event name: Proliferation, Cell proliferation in the absence of cytotoxicity
suggestion score: 5.0

https://molaop-builder.vhp4safety.nl/mappings/57482978-b566-4655-8ebf-6854994021ec
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:38:14.457515
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007005
go term name: mitochondrion organization
key event id: KE 1547
key event name: Mitochondrial Injury
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/576dc3d1-1537-4864-8143-7df6ab24cfef
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-18T12:17:20.458094
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007005
go term name: mitochondrion organization
key event id: KE 177
key event name: Mitochondrial dysfunction
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/58fd00fb-de20-4041-ad63-2186acdba365
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:09:37.833706
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006636
go term name: unsaturated fatty acid biosynthetic process
key event id: KE 462
key event name: Up Regulation, SCD-1
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/5965847e-6c9b-4442-b208-78f281e0bae6
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:08:45.780528
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006915
go term name: apoptotic process
key event id: KE 853
key event name: Changes/Inhibition, Cellular Homeostasis and Apoptosis
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/5a52f28a-4137-4b80-9780-e3d7b2559214
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:31:51.760565
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007160
go term name: cell-matrix adhesion
key event id: KE 2110
key event name: Disrupted binding, laminin-beta1-integrin receptors with laminin
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/5c1304bb-9a71-4515-9485-e17202707f87
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:36:34.091176
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0018195
go term name: peptidyl-arginine modification
key event id: KE 1584
key event name: Interaction of α-diketones with arginine residues
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/5c43027e-0932-4787-af3f-53931dc8c275
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:23:12.148034
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 1214
key event name: Altered gene expression specific to CAR activation, Hepatocytes
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/5d321142-0d0f-42d5-bd95-09e19eb96f28
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:44:12.746054
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0097066
go term name: response to thyroid hormone
key event id: KE 1829
key event name: Altered, Thyroid hormone-dependent gene expression
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/5dabfb69-82a4-4e03-b422-c9f5c1800a39
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:47:53.840986
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0072538
go term name: T-helper 17 type immune response
key event id: KE 1708
key event name: Th17 cell migration and inflammation induction
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/5e498d0e-a79f-47f7-a7ee-1ee4c408f7ea
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:49.736916
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048762
go term name: mesenchymal cell differentiation
key event id: KE 2012
key event name: Fibroblast proliferation and differentiation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/5e5cf388-78db-44b7-9459-2497145ef069
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:44:50.078671
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002263
go term name: cell activation involved in immune response
key event id: KE 1818
key event name: Immune cell activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/5eda1b16-ef94-4b4d-8a57-cdce1f771411
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:21:18.872651
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042403
go term name: thyroid hormone metabolic process
key event id: KE 280
key event name: Thyroxine (T4) in neuronal tissue, Decreased
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/5f4b06b3-7cb1-4127-b01b-e46c9f9d4ef4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:16:22.195005
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030522
go term name: intracellular receptor signaling pathway
key event id: KE 165
key event name: Activation, Long term AHR receptor driven direct and indirect gene expression changes
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/5f888c18-1edc-41d1-838d-20251168a9b3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:03:04.055037
aop wiki snapshot date: 2026-08-06
confidence level: medium
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:0007268
go term name: chemical synaptic transmission
key event id: KE 386
key event name: Decrease of neuronal network function
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/61e8aca9-f9c8-4ae4-b446-cc4c01feb8ab
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:29:52.757480
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070588
go term name: calcium ion transmembrane transport
key event id: KE 2187
key event name: Opening, voltage-gated calcium channels
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/62e8e745-b73d-4754-938c-f690a5988afb
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:32:06.472063
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042552
go term name: myelination
key event id: KE 2107
key event name: Hypomyelination
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/63153e93-2923-4064-ac0c-821ab9b24b03
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:54:10.822237
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034379
go term name: very-low-density lipoprotein particle assembly
key event id: KE 879
key event name: Activation, MTTP
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/6421c871-27ab-4ccd-a500-aff564b8f842
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:02:36.604969
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141209
go term name: oxysterol receptor signaling pathway
key event id: KE 483
key event name: Activation, LXR alpha
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/64ab7e71-fac4-465c-b8d0-78768ecbfc44
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:36:22.317848
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0010498
go term name: proteasomal protein catabolic process
key event id: KE 1585
key event name: Proteasomal dysfunction
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/68999f03-8e1f-45b9-b8ea-1e788bf6a597
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:52:48.569901
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0019432
go term name: triglyceride biosynthetic process
key event id: KE 881
key event name: Increased, Triglyceride
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/689b93ea-31a1-44ce-8d8c-e58378b651fc
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:03:28.384509
aop wiki snapshot date: 2026-08-06
confidence level: high
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:0070509
go term name: calcium ion import
key event id: KE 52
key event name: Decreased, Calcium influx
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/68af460b-5495-488e-9dbd-1ceffb4bc6c3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:50.166484
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 1422
key event name: Reduced, PPARalpha
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/69bd2f39-76af-4994-8404-a8c679c5542e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:16.568777
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007040
go term name: lysosome organization
key event id: KE 898
key event name: Disruption, Lysosome
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/6adeb122-8b41-428b-9731-a9b408f478d6
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:41:57.563502
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008217
go term name: regulation of blood pressure
key event id: KE 1855
key event name: Increased Sodium-sensitive hypertension
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/6b685412-e6b5-4c89-9c00-0aea6b522536
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:37:26.389975
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006468
go term name: protein phosphorylation
key event id: KE 1943
key event name: Hyperphosphorylation of Tau
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/6d6e8e4e-0a1e-46a5-92d0-9ba971834426
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:07:56.933529
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 2199
key event name: Increased, Expression of LXR activated genes
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/6daa7fb4-b2a9-4487-af9c-8854f353d6bf
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:36:55.771586
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006914
go term name: autophagy
key event id: KE 1945
key event name: Dysfunctional Autophagy
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/6dd4a340-c395-4955-9688-db1035379593
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:40:38.246926
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034394
go term name: protein localization to cell surface
key event id: KE 1900
key event name: increased platelet surface TLR9 expression
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/6e435b7b-792d-468f-949e-e8fefe45039a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-29T16:53:32.718374
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002526
go term name: acute inflammatory response
key event id: KE 1493
key event name: Increased Pro-inflammatory mediators
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/6eb6c0c6-3932-4f05-9076-086e24f91e28
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:36:00.422683
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030198
go term name: extracellular matrix organization
key event id: KE 1587
key event name: Fibroproliferative airway lesions
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/6ec5170e-cbdf-4929-8686-085d9d3c8b19
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:02:56.990914
aop wiki snapshot date: 2026-08-06
confidence level: high
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:0007611
go term name: learning or memory
key event id: KE 341
key event name: Impairment, Learning and memory
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/6ee86417-aa02-4625-8923-5a0e8ed40a17
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:03:17.232839
aop wiki snapshot date: 2026-05-06
confidence level: low
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 480
key event name: Activation, SHP
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/6f577176-1420-4c47-8ebb-20032dda2caf
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:43:02.362657
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0036446
go term name: myofibroblast differentiation
key event id: KE 1500
key event name: Increased, fibroblast proliferation and myofibroblast differentiation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/6f6c60ae-4374-441a-bab2-05c7074596ad
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:44:30.257653
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006915
go term name: apoptotic process
key event id: KE 1817
key event name: Apoptotic cell death
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/6f9abc81-0364-410b-8ebb-75a8cf1c1869
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:44.957450
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0021766
go term name: hippocampus development
key event id: KE 757
key event name: Hippocampal anatomy, Altered
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/70eb7a2f-5165-4430-9445-f26e9fb14071
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-18T12:18:09.277806
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0072593
go term name: reactive oxygen species metabolic process
key event id: KE 1115
key event name: Increase, Reactive oxygen species
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/712ef97f-1a40-499b-a835-2a7f93565abe
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:12:53.669131
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032933
go term name: SREBP signaling pathway
key event id: KE 1284
key event name: Up Regulation, SREBF2
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/71cec9d2-c49e-40c4-8729-4254219abddd
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:53:07.053784
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0022904
go term name: respiratory electron transport chain
key event id: KE 105
key event name: Inhibition, Mitochondrial Electron Transport Chain Complexes
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/71e97c6f-eb82-4368-b950-1145544dc2d1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:53:12.634016
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0022904
go term name: respiratory electron transport chain
key event id: KE 178
key event name: Mitochondrial electron transport chain, disrupted
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/7234272f-66df-495b-ae7f-accd425c72cd
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:52:16.502094
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007296
go term name: vitellogenesis
key event id: KE 220
key event name: Increase, Plasma vitellogenin concentrations
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/72fc5c58-724e-430f-977c-a521d3f6da72
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:52:37.610037
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0019433
go term name: triglyceride catabolic process
key event id: KE 881
key event name: Increased, Triglyceride
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/7342d485-d5e8-4bee-9273-97eb39ea1d70
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:38:07.917839
aop wiki snapshot date: 2026-05-06
confidence level: low
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 1548
key event name: Necrotic Tissue
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/7372d89a-2402-4d0b-b2f3-3926c7a2df10
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:45:27.502383
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042178
go term name: xenobiotic catabolic process
key event id: KE 1814
key event name: benzoquinone imine and acylglucuronide metabolites
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/746ee08a-d6e6-4002-9d15-fbea7e142f24
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:06:20.766993
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032933
go term name: SREBP signaling pathway
key event id: KE 457
key event name: Activation, SREBF1
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/74e36328-eb10-4df1-a4a7-3d09b6f56cab
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:04:08.859524
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0046951
go term name: ketone body biosynthetic process
key event id: KE 474
key event name: Down Regulation, HMGCS2
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/750fdbad-cb12-42a8-915d-2be74556fde9
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:47:12.204017
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0051899
go term name: membrane depolarization
key event id: KE 1355
key event name: Activated, membrane depolarization
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/75a4d88f-6f6e-48c5-9604-4517692884c2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:41:49.207260
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002283
go term name: neutrophil activation involved in immune response
key event id: KE 1857
key event name: Platelet-neutrophil interactions, Increased
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/77608144-22d7-455a-93d4-187003256969
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:42:07.372760
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 1514
key event name: Neurodegeneration
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/778db1e5-df98-4ab5-bc2e-5c82815ff43f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:39:13.075187
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0044458
go term name: motile cilium assembly
key event id: KE 1912
key event name: Motile Cilia Number/Length, Decreased
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/78079956-eb7c-49f0-820b-5f3411059d70
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:51:33.347012
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0061024
go term name: membrane organization
key event id: KE 829
key event name: Damage, Lipid bilayer
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/79019b1e-03b8-4508-9a55-d0bd2adf7003
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:03:34.590250
aop wiki snapshot date: 2026-08-06
confidence level: high
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:2000310
go term name: regulation of NMDA receptor activity
key event id: KE 195
key event name: Inhibition, NMDARs
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/7957f03c-b881-4e32-bab5-49e80b87b640
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:08:56.412885
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006853
go term name: carnitine shuttle
key event id: KE 472
key event name: Down Regulation, CPT1A
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/79f75f2b-8d09-42ba-9203-f71d24dc3af3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:39.620624
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048762
go term name: mesenchymal cell differentiation
key event id: KE 1456
key event name: Increase, Differentiation of fibroblasts
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/7c2618ef-00f8-4984-b865-898c6a6fa99c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:45.225336
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048771
go term name: tissue remodeling
key event id: KE 2013
key event name: Airway remodeling
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/7c418550-5777-41d6-b8f5-693eb2792e64
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:27:34.621652
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0021987
go term name: cerebral cortex development
key event id: KE 2210
key event name: Reduced cortical thickness
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/7c5b2b65-291f-4a5c-bd34-213c267ce234
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:37:42.907440
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032635
go term name: interleukin-6 production
key event id: KE 1933
key event name: Increased, Interleukin-6 production
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/7c611578-3c5f-42bb-a283-493e8c34e00a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:39:54.256723
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0051899
go term name: membrane depolarization
key event id: KE 1527
key event name: Increase, Cell membrane depolarization
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/7c675c41-9f26-4676-884f-488a6c166931
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-05-10T12:03:54.056165
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0014738
go term name: regulation of muscle hyperplasia
key event id: KE 142
key event name: Hyperplasia, Hyperplasia
suggestion score: 6.5

https://molaop-builder.vhp4safety.nl/mappings/7ca95131-02e7-4c6a-809c-27858a96e738
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:29:33.964837
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048384
go term name: retinoic acid receptor signaling pathway
key event id: KE 2201
key event name: Agonism, Retinoic acid receptor
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/7cf1a058-88ca-4f26-9356-4b3441b25b6c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:43:55.714738
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006954
go term name: inflammatory response
key event id: KE 1844
key event name: systemic inflammatory response syndrome
suggestion score: 1.0

https://molaop-builder.vhp4safety.nl/mappings/7d4c0b9a-96fa-47e6-8032-49a135665b03
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:21.058656
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070212
go term name: protein poly-ADP-ribosylation
key event id: KE 2030
key event name: Activation, PARP1
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/7da62bb0-6495-441f-85e2-de13fa236d13
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:36:54.381341
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0000226
go term name: microtubule cytoskeleton organization
key event id: KE 1580
key event name: Binding of microtubule stabilizing agents (MSA) to microtubules
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/806fbb88-cba9-4d88-8cd7-de6d56eba70e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:51:40.861760
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042403
go term name: thyroid hormone metabolic process
key event id: KE 771
key event name: Decrease, Serum thyroid hormone (T4/T3)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/819a4c10-4ced-460a-a489-132851959603
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:10:27.050071
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0010255
go term name: glucose mediated signaling pathway
key event id: KE 66
key event name: Activation, ChREBP
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/81d18758-5495-4861-81f2-8c31319a7d2c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:49:28.404189
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0098989
go term name: NMDA selective glutamate receptor signaling pathway
key event id: KE 1351
key event name: Activated, NMDA receptor
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/8214f53d-ff47-4257-90c2-3018b83e525c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:16:35.699489
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0015908
go term name: fatty acid transport
key event id: KE 54
key event name: Up Regulation, CD36
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/825033a3-9a3e-4ff8-8a40-7b21753a9615
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:53:10.817206
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034379
go term name: very-low-density lipoprotein particle assembly
key event id: KE 880
key event name: Increased, ApoB100
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/82616406-a26a-4493-9ceb-eded1666fed1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:00:48.651976
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006954
go term name: inflammatory response
key event id: KE 486
key event name: systemic inflammation leading to hepatic steatosis
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/835ff4d4-564e-4d06-8249-d0220394f369
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:12:18.334199
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006695
go term name: cholesterol biosynthetic process
key event id: KE 1288
key event name: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/853db91b-fbea-4436-9824-f3a82ee9e347
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:53:47.336149
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006874
go term name: intracellular calcium ion homeostasis
key event id: KE 50
key event name: Increase, Ca++ (intracellular)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/86c6e1c7-812b-4703-801e-fd666e55558d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:44.643575
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006635
go term name: fatty acid beta-oxidation
key event id: KE 1424
key event name: Reduced, fatty acid beta oxidation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/87b9b8f5-1584-41c1-a8e9-3ac9ea8c5fb9
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:15:01.189035
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 245
key event name: Activation, PXR/SXR
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/89d4eee9-b648-42d2-ae29-e54333305e16
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:37:01.061995
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032640
go term name: tumor necrosis factor production
key event id: KE 1579
key event name: Increase, proinflammatory mediators (TNFalpha)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/8c8989b3-a886-4f75-9c2c-e89ae26ff406
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:53:18.955016
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006805
go term name: xenobiotic metabolic process
key event id: KE 1391
key event name: Activation of Cyp2E1
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/8d0caa26-f894-4daf-9c49-1669b9edf135
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-05-10T12:03:46.397764
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0015721
go term name: bile acid and bile salt transport
key event id: KE 214
key event name: Bile accumulation, Pathological condition
suggestion score: 5.0

https://molaop-builder.vhp4safety.nl/mappings/8dc13086-6fc9-438c-9151-4d1bf0fae3c2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:47:50.870991
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0009449
go term name: GABA biosynthetic process
key event id: KE 1414
key event name: Decreased, GABA
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/8dcbab1b-42fa-4d63-a816-dda68641d993
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:16:43.807783
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032933
go term name: SREBP signaling pathway
key event id: KE 264
key event name: Activation, SREBP-1c
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/8e4f61f3-a947-4e14-8592-b23dabc0fa38
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:49:50.161580
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0055075
go term name: potassium ion homeostasis
key event id: KE 1098
key event name: Increased, blood potassium concentration
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/8f7d62bc-1db2-4907-a547-4d86508647bb
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:59:36.943808
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0010510
go term name: regulation of pyruvate decarboxylation to acetyl-CoA
key event id: KE 724
key event name: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/8fa9d0d6-8c1f-43bb-9a7d-4ea65ebf898a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:49:59.460156
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0046415
go term name: urate metabolic process
key event id: KE 1096
key event name: Increased, blood uric acid concentration
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/9039e256-099a-4d49-a3d5-9664064a3b57
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:52:01.672981
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0015908
go term name: fatty acid transport
key event id: KE 327
key event name: Accumulation, Fatty acid
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/90695dd4-6dcf-4835-9b17-1eaa965332b9
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:56.781500
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006954
go term name: inflammatory response
key event id: KE 2010
key event name: Pulmonary inflammation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/9094ef32-02c3-4b31-971e-d432c70dfc6a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:51:27.445022
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006631
go term name: fatty acid metabolic process
key event id: KE 1305
key event name: Increase, cytosolic fatty acid
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/918436f3-3c21-4334-b501-f5bdd6fe60d3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:03:07.634311
aop wiki snapshot date: 2026-08-06
confidence level: high
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:0007416
go term name: synapse assembly
key event id: KE 385
key event name: Decrease of synaptogenesis
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/921cb90c-a04d-402f-99bb-44038b682e6f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:19:04.962535
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006915
go term name: apoptotic process
key event id: KE 1262
key event name: Apoptosis
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/929f0f18-b9b4-43d2-a237-8dc7af7546bd
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:33:45.376817
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0009611
go term name: response to wounding
key event id: KE 2085
key event name: Pulmonary epithelial injury
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/936ec17f-0db2-4fcb-9f5c-bb63dd647f43
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:34:14.279836
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007214
go term name: gamma-aminobutyric acid signaling pathway
key event id: KE 2039
key event name: Inhibition GABAA receptor
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/93c95f70-c246-4c1c-830d-b2945f109d43
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:31:23.726620
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0010001
go term name: glial cell differentiation
key event id: KE 2113
key event name: Decreased, radial glia cell density
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/94958921-8bbc-4e0c-9d0f-39d6598dba9e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:34:50.791486
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006954
go term name: inflammatory response
key event id: KE 1633
key event name: Increase in inflammation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/94da2a3a-683f-48f8-b980-66d5afa7a79f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:03:41.529159
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0038185
go term name: nuclear receptor-mediated bile acid signaling pathway
key event id: KE 479
key event name: Activation, NR1H4
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/95f6cbb3-7841-4d30-8316-1e78c1a5e544
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:29:47.690909
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0097190
go term name: apoptotic signaling pathway
key event id: KE 2188
key event name: Activation, caspases
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/96520cc7-b6d1-46b2-8963-af03c6f7167a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:32:10.644843
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0097402
go term name: neuroblast migration
key event id: KE 2094
key event name: Abnormal, neuroblast migration
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/9678c4d0-d3a1-4a78-b164-aa20f51a609a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:42:10.781795
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030968
go term name: endoplasmic reticulum unfolded protein response
key event id: KE 1512
key event name: Unfolded Protein Response
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/9682dfe0-17f9-4e19-93b2-5d84f6048a19
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:21:07.536700
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042921
go term name: nuclear receptor-mediated glucocorticoid signaling pathway
key event id: KE 122
key event name: Activation, Glucocorticoid Receptor
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/97226b6e-bb08-4f9b-97ee-02aa2a558fd1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:08:48.634593
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0019725
go term name: cellular homeostasis
key event id: KE 853
key event name: Changes/Inhibition, Cellular Homeostasis and Apoptosis
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/97c82084-1137-476c-b0b1-6673bc5faa27
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-08-15T12:03:22.541049
aop wiki snapshot date: 2026-08-06
confidence level: high
go namespace: biological_process
go release date: 2026-06-15
go term id: GO:0032898
go term name: neurotrophin production
key event id: KE 381
key event name: Reduced levels of BDNF
suggestion score: 2.67

https://molaop-builder.vhp4safety.nl/mappings/98286814-3a23-464d-a9a4-bf3f69adb482
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:19:29.283654
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0045321
go term name: leukocyte activation
key event id: KE 1494
key event name: Leukocyte recruitment/activation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/993d1fb4-be93-4bfc-b0e2-53e9a41ddb47
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:47:36.335128
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006954
go term name: inflammatory response
key event id: KE 1750
key event name: Increased inflammatory immune responses
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/996a7a4b-d093-47b5-9807-e8a7e7492aad
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:00.567863
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006805
go term name: xenobiotic metabolic process
key event id: KE 295
key event name: Induction, Upregulation of glucuronyltransferase activity
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/999fe9f3-4cd2-4282-bb16-1015b2678f75
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:12:04.195871
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0001816
go term name: cytokine production
key event id: KE 87
key event name: Release, Cytokine
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/99a11f35-518f-463e-bd20-94fe3aba9abf
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:22:25.905641
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030522
go term name: intracellular receptor signaling pathway
key event id: KE 18
key event name: Activation, AhR
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/9ac91369-f2b5-4c31-a47a-42a9bb1485e8
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:02:43.674998
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0033540
go term name: fatty acid beta-oxidation using acyl-CoA oxidase
key event id: KE 482
key event name: Decreased, DHB4/HSD17B4
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/9baabbd9-2491-4fcc-acff-0f09504fc552
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:17:27.906600
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006633
go term name: fatty acid biosynthetic process
key event id: KE 116
key event name: Activation, FAS
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/9c502461-a952-4ace-97ba-f4a7d062409d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:08:37.552583
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008283
go term name: cell population proliferation
key event id: KE 854
key event name: Alterations, Cellular proliferation / hyperplasia
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/9d832bd2-7463-4c0d-a1ce-3b133bfdfbb7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:39:08.682019
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034599
go term name: cellular response to oxidative stress
key event id: KE 1917
key event name: Altered gene expression, NRF2 dependent antioxidant pathway
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/9f41cb06-4137-4fc0-96ec-db55eb2a6b77
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:43:49.148779
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0090461
go term name: intracellular glutamate homeostasis
key event id: KE 1488
key event name: Glutamate dyshomeostasis
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/a0356f52-605c-4cd7-a3c0-5aa78c3ab911
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:06:48.235603
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034383
go term name: low-density lipoprotein particle clearance
key event id: KE 466
key event name: Up Regulation, LDLR (low density lipoprotein receptor)
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/a23005f0-5dcb-4f0f-880d-8383789bc404
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:36:00.004592
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006954
go term name: inflammatory response
key event id: KE 2009
key event name: Activation of inflammation pathway
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/a3e95982-225a-47bf-8880-eb173e592caf
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:09:42.872969
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 232
key event name: Decreased, PPAR-beta activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/a531ab44-35a2-4670-a6c8-0833a8fe741c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:33:39.017269
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006954
go term name: inflammatory response
key event id: KE 2086
key event name: Airway inflammation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/a53e2217-40ef-4480-a0c8-83782868f524
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:12:08.013671
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008213
go term name: protein alkylation
key event id: KE 244
key event name: Alkylation, Protein
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/a66e204f-38da-4b7e-8a21-2cd61b1c2894
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-24T14:26:50.823502
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006750
go term name: glutathione biosynthetic process
key event id: KE 1287
key event name: Glutathione synthesis
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/a8033cf0-63bd-438c-8a1f-fa69848fb307
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:38:27.073600
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006122
go term name: mitochondrial electron transport, ubiquinol to cytochrome c
key event id: KE 1542
key event name: Inhibition, Mitochondrial complex III
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/a8fbadbd-5f19-4bcc-964d-427a8d5b7c95
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:26:40.842050
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042921
go term name: nuclear receptor-mediated glucocorticoid signaling pathway
key event id: KE 2217
key event name: Binding of antagonist to glucocorticoid hormone receptor
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/a91448ea-1d81-45a2-b1a9-1e7db439fe67
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:53:51.164255
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0061526
go term name: acetylcholine secretion
key event id: KE 10
key event name: Acetylcholine accumulation in synapses
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/a98f8bbf-ed62-4394-9282-3a2a44830970
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:34:22.332082
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006508
go term name: proteolysis
key event id: KE 2038
key event name: Activation of calpain signalling
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/aa9624f1-5655-46c6-9534-ac002bf23584
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:50:57.041527
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007040
go term name: lysosome organization
key event id: KE 831
key event name: Disturbance, Lysosomal function
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/aa9ad0f3-e88f-49ad-90bb-35a69facc44f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:32:22.305966
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042403
go term name: thyroid hormone metabolic process
key event id: KE 2093
key event name: Brain thyroid hormone (T4/T3) decreased
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/ab3c09cf-611e-407e-b477-44ae4d31e3db
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:52:25.252506
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 1270
key event name: Inactivation of PPARγ
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/acffb98a-a528-4a79-88f6-fcad70b9779a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:39.379997
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007268
go term name: chemical synaptic transmission
key event id: KE 758
key event name: Hippocampal Physiology, Altered
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/ad221407-898f-4d5e-83fd-414fd1f203da
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:12:40.951034
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006636
go term name: unsaturated fatty acid biosynthetic process
key event id: KE 1285
key event name: Up Regulation, Unsaturated fatty acid
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/ad91b424-a4a0-4ec0-9df2-1dc4beb501a5
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:35:54.668443
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006487
go term name: protein N-linked glycosylation
key event id: KE 1604
key event name: Inhibition of N-linked glycosylation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/ade300c2-44b0-4f27-95c7-975e4ad0bdea
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:34:58.336620
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035733
go term name: hepatic stellate cell activation
key event id: KE 1606
key event name: Activation of hepatic stellate cells
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/ae20a34b-f839-4eee-aa3c-7bd8cf734956
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:17:16.002559
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141166
go term name: chromosomal 5-methylcytosine DNA demethylation pathway
key event id: KE 228
key event name: peroxisome proliferator activated receptor promoter demethylation
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/af5c0e07-0019-4131-a2fc-451b9b80715c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:58:09.686559
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0045333
go term name: cellular respiration
key event id: KE 769
key event name: Increase, Oxidative metabolism
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/af605187-39fc-433c-8444-6eeaac6c0896
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:19:17.540984
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0001775
go term name: cell activation
key event id: KE 1492
key event name: Tissue resident cell activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/af8e5278-809b-4527-9c30-1e4e9bec2bf5
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:15:08.959645
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 715
key event name: Activation, Constitutive androstane receptor
suggestion score: 1.67

https://molaop-builder.vhp4safety.nl/mappings/b2eba6d8-1565-41a4-bf8c-b99986093a5d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:10:33.149584
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0061458
go term name: reproductive system development
key event id: KE 364
key event name: Impaired development of, Reproductive organs
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/b307a0be-6ecb-43fc-b3d9-c55f422884d0
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:24:59.522325
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048709
go term name: oligodendrocyte differentiation
key event id: KE 2223
key event name: Reduced number of oligodendrocytes
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/b32d276d-625a-4736-b962-6b38150c45f2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:06:56.766178
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006635
go term name: fatty acid beta-oxidation
key event id: KE 451
key event name: Inhibition, Mitochondrial fatty acid beta-oxidation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/b3ab39e2-a2b2-4cbb-8f01-a745dbb4923e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:52:13.161767
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007179
go term name: transforming growth factor beta receptor signaling pathway
key event id: KE 1271
key event name: Activation of TGF-β signaling
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/b46ec6d6-4bd8-4a11-bda6-b0fdd16bc3f0
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-29T16:54:09.257778
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 228
key event name: peroxisome proliferator activated receptor promoter demethylation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/b496f138-22ea-44ad-934a-771f197fb897
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:36:12.318678
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007268
go term name: chemical synaptic transmission
key event id: KE 2005
key event name: Altered neurotransmission in development
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/b4a7340b-6201-4849-9338-2edf79f29ca5
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:11:24.056489
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030520
go term name: estrogen receptor signaling pathway
key event id: KE 111
key event name: Agonism, Estrogen receptor
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/b5282460-80f3-44e2-9d87-334e0c047e81
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:34:48.027494
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006122
go term name: mitochondrial electron transport, ubiquinol to cytochrome c
key event id: KE 1653
key event name: Binding of inhibitor to mitochondrial complex III
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/b532cd98-efa0-4d2f-98b3-e34307e3e78f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:25.794115
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0071604
go term name: transforming growth factor beta production
key event id: KE 1468
key event name: Activation, Latent Transforming Growth Factor Beta 1
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/b77871b5-7dbe-484c-b133-3e4d2c5c908a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:12:59.356973
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070327
go term name: thyroid hormone transport
key event id: KE 1158
key event name: Increased, Hepatic thyroid hormone uptake/transport
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/b7a7d5f5-e576-4498-b6fa-2fa12f58ba15
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:42:41.812004
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008213
go term name: protein alkylation
key event id: KE 1509
key event name: Protein Adduct Formation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/b81aaf86-71ac-4e49-b575-05ecadc0268d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:09:48.980250
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006635
go term name: fatty acid beta-oxidation
key event id: KE 179
key event name: Decrease, Fatty acid beta-oxidation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/b89f5b2f-239f-40ee-8e6c-35ffbd7e4f6d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:44:07.266252
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0033539
go term name: fatty acid beta-oxidation using acyl-CoA dehydrogenase
key event id: KE 1834
key event name: Decrease, Acyl-CoA dehydrogenases
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/bc3d0f4a-165d-40a1-8d50-9683778be877
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:42:07.912228
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002003
go term name: angiotensin maturation
key event id: KE 1853
key event name: Hyperactivation of ACE/Ang-II/AT1R axis
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/bc458a90-e8eb-48e4-a5dc-29870cae405d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:50:39.756128
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070327
go term name: thyroid hormone transport
key event id: KE 959
key event name: Increased, Free serum thyroxine (T4)
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/bd83f4e3-fa12-4a35-a530-a2ea36970462
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:48:00.949343
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0098928
go term name: presynaptic signal transduction
key event id: KE 1413
key event name: Reduced, presynaptic neuron 2 activity
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/bd9e6968-be73-4662-bdac-6f826e3fdf21
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:12:37.114462
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006749
go term name: glutathione metabolic process
key event id: KE 1286
key event name: Down Regulation, GSS and GSTs gene
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/bdb720d7-4297-436a-ac5c-3fcd62efd626
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:49:28.531888
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002154
go term name: thyroid hormone receptor signaling pathway
key event id: KE 1656
key event name: Antagonism, Thyroid Receptor
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/bdfd2ff4-704f-4754-894e-a26a32b738d7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:36.425891
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030520
go term name: estrogen receptor signaling pathway
key event id: KE 2029
key event name: protein-coupled estrogen receptor 1 (GPER) activation
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/be30f297-7e88-401d-974b-9ca03340069f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:48:10.919779
aop wiki snapshot date: 2026-05-06
confidence level: low
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0003016
go term name: respiratory system process
key event id: KE 1677
key event name: Reduced tidal volume
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/beed3170-31c4-4f1e-a891-fde26dd3fb5f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:19:02.604152
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008283
go term name: cell population proliferation
key event id: KE 1394
key event name: Induction, persistent proliferation/sustained proliferation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/bf4d2247-d29a-4602-bfc2-547b9581b573
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:20:25.898504
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007249
go term name: canonical NF-kappaB signal transduction
key event id: KE 202
key event name: Inhibition, Nuclear factor kappa B (NF-kB)
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/bf905680-4db6-4237-9fa3-5aaa3ed71e31
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:56:59.515626
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0016049
go term name: cell growth
key event id: KE 739
key event name: Increase, Hypertrophy and proliferation (follicular cell)
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/c1365104-da0a-4f8e-ae3b-1c812d61d76b
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:23:05.526699
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030521
go term name: androgen receptor signaling pathway
key event id: KE 25
key event name: Agonism, Androgen receptor
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/c1b0d567-6e3c-4869-8933-0267c20dd8a2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:04:49.209765
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 468
key event name: Inhibition, PPAR alpha
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/c3184688-5cd7-46fb-a39e-e652618b2386
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:52:44.882964
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007214
go term name: gamma-aminobutyric acid signaling pathway
key event id: KE 1177
key event name: Decreased, Ionotropic GABA receptor chloride channel conductance
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/c3bc5443-db53-4e49-88cb-82672f823208
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:38:22.426109
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042776
go term name: proton motive force-driven mitochondrial ATP synthesis
key event id: KE 1544
key event name: Mitochondrial Complex V inhibition
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/c4a57331-174b-40c5-ad4c-dcb05d549d6f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:24:54.966134
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070444
go term name: oligodendrocyte progenitor proliferation
key event id: KE 2223
key event name: Reduced number of oligodendrocytes
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/c508d9e7-98ad-4403-9b1e-68687777bbc8
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:51:52.952531
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007611
go term name: learning or memory
key event id: KE 637
key event name: impaired, Learning and memory
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/c53c64cc-eb7f-49c5-94a3-a5b8e9aa884a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:34:34.161438
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:1903514
go term name: release of sequestered calcium ion into cytosol by endoplasmic reticulum
key event id: KE 2037
key event name: Inositol triphosphate receptor activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/c5dc2e48-20b5-4910-b2e7-9cd028ab9c36
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:49:56.621922
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0015747
go term name: urate transport
key event id: KE 1096
key event name: Increased, blood uric acid concentration
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/c5ed4c20-bd3f-4fee-8b1b-290a823cf9c1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-29T16:53:51.071104
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:1903008
go term name: organelle disassembly
key event id: KE 898
key event name: Disruption, Lysosome
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/c6c9c489-cf13-4dc0-8b2e-06b862c0ac09
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:21:15.225646
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070327
go term name: thyroid hormone transport
key event id: KE 280
key event name: Thyroxine (T4) in neuronal tissue, Decreased
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/c7c39fc4-8836-4fc8-9065-4b92628a2234
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:11.161405
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006897
go term name: endocytosis
key event id: KE 1539
key event name: Endocytotic lysosomal uptake
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/c89e9c13-eb1e-4ccb-bac7-6e140cefdaa0
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:15:55.323924
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0046222
go term name: aflatoxin metabolic process
key event id: KE 409
key event name: Metabolism of AFB1, Production of Reactive Electrophiles
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/c9dc651c-8311-4463-9118-5eecf8b28d38
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:26:58.317837
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002154
go term name: thyroid hormone receptor signaling pathway
key event id: KE 2216
key event name: Binding of antagonist to thyroid hormone receptor
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/ca2bc552-d868-4a57-9f82-38e7d3eacdfa
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:05.452753
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007216
go term name: G protein-coupled glutamate receptor signaling pathway
key event id: KE 2036
key event name: Activation of metabotropic glutamate receptor
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/cb265caa-7433-4cc2-9094-513d7973ae5d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:34:55.158215
aop wiki snapshot date: 2026-05-06
confidence level: low
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 1607
key event name: Increase, Necrosis
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/cb2b2430-9118-4477-9462-f22526e3c292
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:50:37.852478
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006915
go term name: apoptotic process
key event id: KE 1365
key event name: Increase, Apoptosis
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/cb8ff575-7ae9-4a9a-81ad-a5c7e1b283d3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:26:22.771610
aop wiki snapshot date: 2026-05-06
confidence level: low
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 2218
key event name: Binding of (ant)agonist to liver X receptor
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/cea18ecc-be62-4a22-a55e-2deb40797a26
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:42:44.556657
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006805
go term name: xenobiotic metabolic process
key event id: KE 1508
key event name: CYP2E1 Activation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/cfe11aee-fb2f-4746-8438-896aeb4f4860
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:53:53.860638
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0001507
go term name: acetylcholine catabolic process in synaptic cleft
key event id: KE 10
key event name: Acetylcholine accumulation in synapses
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/d15a2a79-7863-41f8-8f5c-cf3959162cd4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:40:32.015610
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035377
go term name: transepithelial water transport
key event id: KE 1907
key event name: Airway Surface Liquid Height, Decreased
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/d1ea8cc6-b71a-4bda-b6bf-5d6d6b11a9ca
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:13:05.319570
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141193
go term name: nuclear receptor-mediated signaling pathway
key event id: KE 1157
key event name: Activation, Hepatic nuclear receptor(s)
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/d2535453-a1be-4e2f-a949-708ba2d9296d
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:37:32.312522
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:1990000
go term name: amyloid fibril formation
key event id: KE 1942
key event name: Accumulation, Cytosolic toxic Tau oligomers
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/d298018c-045a-4b72-b9b2-7f6b63cb39b4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:14:56.508395
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 55
key event name: Increase, Cell injury/death
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/d2ae0c86-1628-4b81-a2b2-eeff5929bdb1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-18T12:18:01.775179
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0097300
go term name: programmed necrotic cell death
key event id: KE 1097
key event name: Occurrence, renal proximal tubular necrosis
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/d2ba80eb-9807-45e7-ab79-a26823b574c4
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:58:02.941303
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:1990789
go term name: thyroid gland epithelial cell proliferation
key event id: KE 739
key event name: Increase, Hypertrophy and proliferation (follicular cell)
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/d45c0413-0c90-4fa6-aa0b-e4338385420e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:32:18.224281
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0070327
go term name: thyroid hormone transport
key event id: KE 2093
key event name: Brain thyroid hormone (T4/T3) decreased
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/d5220e0a-7d3b-43f2-8a61-26462ac97414
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:47.879950
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006635
go term name: fatty acid beta-oxidation
key event id: KE 1423
key event name: Reduced, HSD17B4 activity
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/d7919683-9d25-4bd8-895a-5634ba7b19a7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:56:33.784053
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0009395
go term name: phospholipid catabolic process
key event id: KE 828
key event name: Inhibition, Phospholipase A
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/d86c21e0-d05e-4ba8-ab75-30b458ea68f7
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-29T16:53:40.991621
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:1903409
go term name: reactive oxygen species biosynthetic process
key event id: KE 1115
key event name: Increase, Reactive oxygen species
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/d8c0f21f-4b15-48da-af02-3eda9bea22f3
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:56:07.642389
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006635
go term name: fatty acid beta-oxidation
key event id: KE 860
key event name: Decreased, Mitochondrial Fatty Acid Beta Oxidation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/d99ecccb-ee50-4da0-a988-bd2b76ab6af8
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:11:32.048236
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006120
go term name: mitochondrial electron transport, NADH to ubiquinone
key event id: KE 887
key event name: Inhibition, NADH-ubiquinone oxidoreductase (complex I)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/df18c7ba-0242-4712-a50d-4ac2e1c2f48a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:47:32.613637
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002003
go term name: angiotensin maturation
key event id: KE 1752
key event name: Increased Angiotensin II
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/df63e4be-bc56-41b0-a070-97ac4aeaf956
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:46:59.580659
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0030644
go term name: intracellular chloride ion homeostasis
key event id: KE 1416
key event name: Decreased, intracellular chloride
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/e0201d4b-3242-4abc-b354-4d3f35a9932b
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:17:30.705807
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0015908
go term name: fatty acid transport
key event id: KE 115
key event name: Increase, FA Influx
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/e08271fa-1376-46da-9bb8-78489786a170
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:31:35.795520
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008347
go term name: glial cell migration
key event id: KE 2112
key event name: Disturbed, radial glia cell alignment and migration
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/e11a851b-8910-4ab8-a2bf-41ec137c8f94
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:15:34.366078
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006281
go term name: DNA repair
key event id: KE 493
key event name: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/e1247d84-d876-4b81-8e92-f1f42fa82c66
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-22T14:20:46.358956
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006974
go term name: DNA damage response
key event id: KE 1194
key event name: Increase, DNA damage
suggestion score: 2.67

https://molaop-builder.vhp4safety.nl/mappings/e13b3007-eade-4626-9680-7cc7e03e757c
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:05.630323
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032042
go term name: mitochondrial DNA metabolic process
key event id: KE 1482
key event name: Depletion, mtDNA
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/e34b3198-a1f6-4069-8ccc-37fd65a9a5d8
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:49:29.770001
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 1393
key event name: Hepatocytotoxicity
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/e38286e6-9f53-4171-9fde-3d46cce2eec6
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:23:27.363018
aop wiki snapshot date: 2026-05-06
confidence level: low
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0061024
go term name: membrane organization
key event id: KE 2264
key event name: Lysolecithin cell membrane integration, increased
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/e4040476-6988-4e49-8d8c-ee879657f3ae
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:47:14.093037
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034142
go term name: toll-like receptor 4 signaling pathway
key event id: KE 1792
key event name: Toll-like receptor 4 activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/e58d6e62-b31e-40e5-a3b1-eb05b5f119fa
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:46:53.689724
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0034599
go term name: cellular response to oxidative stress
key event id: KE 1417
key event name: NFE2/Nrf2 repression
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/e5d27b93-415b-4e2a-a52d-5855dfda286e
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:58:13.848977
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 768
key event name: Increase, Cytotoxicity
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/e644b7dd-3027-4d23-b663-1c857a65f668
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:42:02.635364
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0038166
go term name: angiotensin-activated signaling pathway
key event id: KE 1853
key event name: Hyperactivation of ACE/Ang-II/AT1R axis
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/e6688e1d-bd67-479c-8338-5ddb34d2d314
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:31:55.891764
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007160
go term name: cell-matrix adhesion
key event id: KE 2109
key event name: Binding, extracellular matrix protein laminin
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/e6c21b14-07c0-4ba0-9e9f-034ede643c80
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:55:15.649793
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032933
go term name: SREBP signaling pathway
key event id: KE 878
key event name: Inhibition, SREBP1c
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/e6d4b424-5040-428d-9e3a-93ee20ffac21
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:58:34.964159
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006086
go term name: pyruvate decarboxylation to acetyl-CoA
key event id: KE 726
key event name: Increased, Induction of pyruvate dehydrogenase (PDH)
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/e7112f59-f8a3-4df7-8c25-94819aada8c2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:53:59.765165
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0032782
go term name: bile acid secretion
key event id: KE 357
key event name: Cholestasis, Pathology
suggestion score: 1.33

https://molaop-builder.vhp4safety.nl/mappings/e77084dd-e7af-41c5-b60f-a5679a483d43
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:51:41.093595
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0042632
go term name: cholesterol homeostasis
key event id: KE 1289
key event name: Perturbation of cholesterol
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/ea173a11-c7b3-4792-9d77-d7cff1e3c929
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-22T19:45:08.755947
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008219
go term name: cell death
key event id: KE 1825
key event name: Increase, Cell death

https://molaop-builder.vhp4safety.nl/mappings/ea6d0d06-43ee-478b-8eec-82e420a495b2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:52:05.704948
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006631
go term name: fatty acid metabolic process
key event id: KE 327
key event name: Accumulation, Fatty acid
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/eac5be7a-25f2-46ee-85da-629c6ff57180
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:37:37.727974
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0007613
go term name: memory
key event id: KE 1941
key event name: Memory Loss
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/eb9ef0ef-fa36-4468-8f14-4cc053166e42
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:23:47.070329
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006644
go term name: phospholipid metabolic process
key event id: KE 2262
key event name: Neuropathy target esterase, inhibited
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/ed566050-7fd6-4ba2-b38b-bb602b221858
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:37:21.012640
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0099536
go term name: synaptic signaling
key event id: KE 1944
key event name: Synaptic dysfunction
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/ee88c1ba-1c9c-4585-8537-9cf485a3815b
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:30:40.306122
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006898
go term name: receptor-mediated endocytosis
key event id: KE 2148
key event name: Increased LCN2/iron complex binds to SLC22A17 receptor in neuron
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/efb48302-c1de-42bc-9bb6-4ab395bc8e39
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-05-10T12:03:50.501040
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:2000345
go term name: regulation of hepatocyte proliferation
key event id: KE 334
key event name: Promotion, Hepatocelluar carcinoma
suggestion score: 4.5

https://molaop-builder.vhp4safety.nl/mappings/efca8fd5-3715-47a4-abf8-c6a39ddbd092
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:42:55.818071
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0085029
go term name: extracellular matrix assembly
key event id: KE 1501
key event name: Increased, extracellular matrix deposition
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/efdcf6d6-7624-4f58-9416-bd497a87f07f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:36:03.984379
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0009611
go term name: response to wounding
key event id: KE 1586
key event name: Airway epithelial injury
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/f04dfffe-80f9-4ec6-bdce-86fcf919bb97
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:30:53.747150
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048709
go term name: oligodendrocyte differentiation
key event id: KE 2116
key event name: Decreased, oligodendrocyte differentiation
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/f169257e-394e-4cc7-8a5d-a4339d5782b1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:35:52.345182
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048144
go term name: fibroblast proliferation
key event id: KE 2012
key event name: Fibroblast proliferation and differentiation
suggestion score: 2.0

https://molaop-builder.vhp4safety.nl/mappings/f1a45237-a945-46e9-9303-b415ecb7efcc
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T11:51:52.616056
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035357
go term name: peroxisome proliferator activated receptor signaling pathway
key event id: KE 2226
key event name: Stressor binding PPAR isoforms
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/f38424cc-6218-4a1a-b06c-c17a671d3fe1
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:17:24.345034
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0141209
go term name: oxysterol receptor signaling pathway
key event id: KE 167
key event name: Activation, LXR
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/f40aabc2-26e0-43c8-a06e-190dda235a46
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:27:59.864127
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0048854
go term name: brain morphogenesis
key event id: KE 2204
key event name: Altered brain morphology
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/f6db3866-5f63-4ab2-aac9-f7b1b9d53034
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:30:22.504087
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006879
go term name: intracellular iron ion homeostasis
key event id: KE 2149
key event name: Increased intracelluar Iron accumulation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/f856d75b-2bd9-424a-a252-ea9be6802a0f
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:41:21.642177
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002755
go term name: MyD88-dependent toll-like receptor signaling pathway
key event id: KE 1897
key event name: increased MyD88 activation
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/f8a31305-7d1b-4578-9afe-b90fc1282faf
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T10:49:57.279474
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0035725
go term name: sodium ion transmembrane transport
key event id: KE 1352
key event name: Activated, voltage-gated sodium channel
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/f8c5b813-3d2d-4deb-8a97-79009c28e640
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:04:42.929556
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:2001295
go term name: malonyl-CoA biosynthetic process
key event id: KE 470
key event name: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/fa66c522-da3e-4cb4-8d30-7646a130d600
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:37:23.691462
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0008625
go term name: extrinsic apoptotic signaling pathway via death domain receptors
key event id: KE 1575
key event name: Activation, Caspase 8 pathway
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/fae0ac4a-2d89-4b58-bcbf-caf4e1cffb7a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:47:43.889486
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002003
go term name: angiotensin maturation
key event id: KE 1740
key event name: Induced dysregulation of ACE2
suggestion score: 1.6600000000000001

https://molaop-builder.vhp4safety.nl/mappings/fafff144-7250-49ee-a670-9abe754ff79a
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:44:00.309722
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006898
go term name: receptor-mediated endocytosis
key event id: KE 1486
key event name: Binding of substrate, endocytic receptor
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/fdc00fa8-fcf0-4c78-b6af-8544bd0ec223
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T16:38:24.810607
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006123
go term name: mitochondrial electron transport, cytochrome c to oxygen
key event id: KE 1543
key event name: Mitochondrial Complex IV inhibition
suggestion score: 2.66

https://molaop-builder.vhp4safety.nl/mappings/fdd3591c-bbe3-4b37-bdf9-0c2fb767bce2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-28T12:44:17.429720
aop wiki snapshot date: 2026-05-06
confidence level: medium
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0002384
go term name: hepatic immune response
key event id: KE 1820
key event name: Immune mediated hepatitis
suggestion score: 2.33

https://molaop-builder.vhp4safety.nl/mappings/ff8c081c-0a2f-4ea4-91a8-4032f450d18b
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-22T14:10:10.177551
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:0006954
go term name: inflammatory response
key event id: KE 149
key event name: Increase, Inflammation
suggestion score: 3.0

https://molaop-builder.vhp4safety.nl/mappings/ffe9ace7-6ab3-4e80-9345-d2198af48ab2
type: KeyEventGOMapping
creator: github:marvinm2
date: 2026-07-29T16:54:19.560035
aop wiki snapshot date: 2026-05-06
confidence level: high
go namespace: biological_process
go release date: 2026-01-23
go term id: GO:2000191
go term name: regulation of fatty acid transport
key event id: KE 115
key event name: Increase, FA Influx
suggestion score: 2.67