# molAOP Builder GMT export # resource: KE-WP-CENTRIC # export-revision: 85e4c689d5c53572 # source-fingerprint: 448:b635fdec7cc3f7b1296e0cc0e0cb10e7| # confidence: minimum high # generated: 2026-10-20T07:17:46+00:00 # Lines beginning with # are provenance, not gene sets. KE9 Activation, 5HT2c RAF1 RASGRF1 HTR2B MAPK1 ELK1 GNAQ HRAS ITPR1 KRAS NRAS MAPK3 MAP2K1 MAP2K2 SRF MAPKAPK2 ELK4 GATA4 RASGRP1 HTR2A HTR2C KE12 Acetylcholinesterase (AchE) Inhibition PAH COMT AANAT DDC GAD1 GAD2 MAOA ASMT PNMT TH TPH1 DBH ACHE CHAT HDC KE17 KE 17 - Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway AHRR TGFB1 CDC37 IL12A HSP90AA1 BAX EP300 AHR IL2 CDKN1B IFNG NFE2L2 IL1B CYP1A1 CYP1A2 EGFR JUNB JUN NQO1 SRC TNF NCOA1 HES1 POLK JUND IGFBP1 UGT1A1 GSTA2 ARNT UGT1A9 UGT1A4 MGST1 SLC7A5 ALDH3A1 AIP PTGES3 CAP2 CYP1B1 MYOF UGT1A6 CES3 UGT1A7 IL12B IL17B SERPINB2 SNAI2 NR1H3 CUL1 SREBF1 ABCB1 PSMC5 ESR1 TGFB2 IL11 SCD HMOX1 PDGFB SOD3 CPT1A CCL20 ACADM SLC2A1 PTPA EGR1 NCOA3 NR0B2 ABCG5 ABCG8 CPT2 TGFBR2 CYP7A1 STAT3 FASN CDK1 KLK15 IRS2 MAFG CYP2B6 AGER GCLC GCLM PTGS2 NFKB2 GSTP1 GSTT2 GGT1 GSR CCL2 PPARGC1A CCND1 APOC3 VDR PPARD HBEGF KAT2B APOA1 GPAM CDKN1C GSTM1 TXN MYC CYP2C9 NR1I2 FOXO1 APOA2 CES5A G6PD CYP3A4 SQSTM1 CYP2C19 GSTM4 CES2 GPX2 B3GNT5 SLC2A4 GSTA5 PDE4B SP1 RXRA PPARA CES1 GPX3 GSTM2 GSTA1 HGF ABCC2 ZIC2 SLC2A3 TGFBR3 SLC27A5 GADD45B SULT2A1 ABCC3 TNFAIP3 ABCC4 SLC27A1 BHLHE40 SLCO1B1 CDK4 BAAT MFGE8 ETNK2 SLC2A12 ANKRD1 SLC7A11 DBI NRG1 CYP3A7 TGFA FABP1 SLC6A20 SLC6A19 DNER SULT1A1 NR1H4 EPHA3 ABCB11 FTL SLC10A1 PLTP SLC5A5 CYP3A5 APOA5 BIRC2 SCP2 PCK1 NR1I3 ANGPTL4 AKAP13 TXNRD3 TXNRD1 POU5F1 CYP2A6 ALAS1 SMC1A NR3C1 PRDX1 DNAJB1 ALOX5AP LRRC8A AMIGO2 FGF19 DNAJC7 PTGR1 ABCC5 CBR1 FTH1 CYP4F12 HSP90AB1 SLC19A2 FGF13 SLC6A3 EPHA2 UGT2B7 THBD SERPINA1 FKBP5 TNS4 FGFBP1 SRXN1 BIRC3 ACAA1 ME1 KEAP1 SLC5A1 SLC6A4 EHHADH NCOA2 STOM ACOX1 SLC2A2 SPRY1 CYP8B1 NRIP1 MAFF CYP4A11 ADH7 NCOA6 PDK4 ABCB4 SLC6A13 SLC6A7 SLC39A9 SLC6A16 NAV3 SLC6A15 MGST2 BLVRB EPB41L4B SLC5A4 SMARCA1 SRPX2 SLC6A2 SLC39A14 SLC2A9 SCNN1A SLC39A7 CPEB4 SLC5A7 RGS2 PRDX6 SLC5A9 DNAJC15 SRGN KTN1 EDN2 SEC14L1 SLC6A8 SLC6A6 SLC6A11 SLC39A11 SLC2A11 GSTM5 GSTM3 PRRG4 SLC2A8 SLCO2B1 SLC5A6 SLC39A8 FGD4 SLC39A5 ABHD2 SLC5A2 SLC39A6 SLC39A3 SLC2A5 PGD MGST3 SLC39A1 ACKR3 PLK2 PMP2 SLC39A4 SLC39A12 SLC5A12 SLC2A13 ADGRF4 SLC5A10 SLC26A2 UGT2B4 SLC6A1 TSC22D3 GPR153 SLC5A11 CBR3 SLC2A6 IP6K3 CDC42EP3 S100P SLC6A18 SLC39A2 SLC39A13 SLC6A5 ARL5B CAVIN2 SERPINB9 GSTA4 ENC1 CES4A SLC2A14 GSTA3 GCC1 SERTAD2 SLC6A9 SLC39A10 SLC6A17 SLC2A7 SLC2A10 PPP1R14C SLC5A3 HSPA1A SPINK13 SLC5A8 SLC6A14 KE18 Activation, AhR AHRR TGFB1 CDC37 IL12A HSP90AA1 BAX EP300 AHR IL2 CDKN1B IFNG NFE2L2 IL1B CYP1A1 CYP1A2 EGFR JUNB JUN NQO1 SRC TNF NCOA1 HES1 POLK JUND IGFBP1 UGT1A1 GSTA2 ARNT UGT1A9 UGT1A4 MGST1 SLC7A5 ALDH3A1 AIP PTGES3 CAP2 CYP1B1 MYOF UGT1A6 CES3 UGT1A7 IL12B IL17B SERPINB2 KE25 KE 25 - Agonism, Androgen receptor CPN1 NDRG1 CRKL CYP17A1 EIF4EBP1 AR KLK2 PTEN PTPN11 PXN RAF1 STAT3 CDK1 CASP3 CASP9 SMAD3 MDM2 CASP8 RHEB SMAD2 BAD CDKN1B MAPK14 PIK3CA CDKN1A CDKN2A ELK1 ERG FOS RICTOR GAB1 GRB2 HRAS HSD3B1 HSD3B2 JUN MYC ATF1 MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 SOS1 SP1 TP53 RB1 BCL2 JAK1 CCND1 AKT1 STAT1 MTOR TSC2 E2F1 BAX ATM RPTOR TSC1 CDC25A MIR21 ABCC4 MAP4K1 CRK PTK2B RAPGEF1 HGF FOXA1 HSD17B1 HSD17B3 HSD17B2 HSD17B4 PAK1 CDK4 CDK2 MSH2 MRE11 PLK1 HSD17B7 RAP1A RAP1B RASA1 MMP1 BLM PRKDC RAD50 CDKN2B CHEK2 F13B EIF4E1B BRCA1 CDC25B SPRY2 ETV4 FKBP5 SPINK1 NOXA1 BARD1 SPRY1 DOCK1 KLK3 ACTL6B ARID1B SMARCA4 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 ARID1A ACTL6A CHEK1 MSH6 ATR KE28 Reduction, Angiogenesis PDGFB MMP9 FLT1 NOS3 KDR ANGPT1 MAPK1 PLCG1 FGF2 AKT1 SMAD1 SRC CREBBP MAPK14 HIF1A PIK3CA VEGFA PDGFRA PTK2 TIMP2 FGFR2 ARNT TEK TIMP3 KE40 Mitochondrial ATP production, decreased ACSL3 ACADL ECI1 DECR1 HSD17B10 ECHS1 ACAA2 ACADSB EHHADH PPARGC1B ESRRA NRF1 PPP3CA PPARGC1A CREB1 SP1 CAMK4 PPRC1 HCFC1 MTERF3 TFB1M POLRMT TFB2M MTERF1 GABPA GABPB1 TFAM MYEF2 KE41 Inhibition, Bile Salt Export Pump (ABCB11) ABCB1 ABCC3 ABCC4 ABCC2 SLCO1B1 ABCB11 SLC10A1 SLC51A SLC51B FABP6 SLC10A2 SLCO1B3 CYP7A1 CYP27A1 SLC27A5 AKR1D1 HSD17B4 SLC27A2 AKR1C4 BAAT ACOX2 SCP2 AMACR ATP8B1 HSD3B7 CYP7B1 CYP8B1 ABCB4 ABCD3 KE55 Increase, Cell injury/death BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A LTA IRF2 IRF3 MDM2 CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 MIR29A IRF1 IRF5 GZMB PRF1 TRAF1 IRF4 TNFRSF21 HELLS IGF2 NFKBIE TP73 SCAF11 KE64 Reduction, Ionotropic GABA receptor chloride channel conductance GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2B1 ABAT GAD2 GAD1 GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE87 Release, Cytokine BMP5 CCL28 LTA CCL26 CXCL2 TGFB2 IL11 CCL22 IL7 TGFB1 TGFBR1 CXCL12 CSF3 IL17A CCR6 CCL20 IL1R2 IL18RAP TPO CXCR4 CXCL6 IL22 IL6ST IL10 IL33 IL11RA CCL21 IL21 CXCL9 ACVRL1 IFNAR1 IL9 IL18 CCR5 CXCL16 CXCR1 TGFBR2 CXCL3 CXCL5 PF4 CXCL1 CXCL10 IFNB1 CXCR2 CCL27 TNFRSF10A BMP3 IL31RA CNTF GDF10 CCL23 ACKR4 BMP15 AMHR2 XCR1 CCR9 CCR10 FAS IFNGR1 TNFRSF1B TNFRSF1A IL4R IL5RA IL2RB CD40 CD40LG BMPR1A CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG IL4 IL5 IL1A IL1R1 IL1RL2 FASLG TGFB3 TNFSF10 IL37 IL2RA IL6 IL36G IL1RN IL36A IL36RN IL36B IL1F10 MSTN BMPR1B IL2RG CXCL13 IFNAR2 IFNGR2 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 IL1RAP BMPR2 TNF CCL5 CCL4 CCL18 CCL15 CCL4L2 CCL14 CCL3 CX3CL1 TNFRSF9 NGFR BMP7 AMH ACVR2B ACVR1 TNFSF4 TNFSF11 TNFRSF10B ACVR2A INHBA BMP4 TNFSF9 LIF EPO NGF NODAL IL6R CXCL11 GDF3 TNFRSF4 IL20RA IL26 LIFR GDF11 EDAR EDA INHBB IL3 EPOR LTB TNFRSF13B IL10RB IL3RA TNFSF13B CCR2 ACVR1B ANP32B IL17RC IL7R PRL IL17RA CCR8 TNFRSF12A IL12RB2 IL21R IL27RA IL1RL1 LEPR MPL CNTFR IL15RA IL22RA1 TNFRSF21 TNFSF12 CSF2RA IL9R TNFRSF17 RELT CCL24 PF4V1 BMP8B TNFRSF8 IL13RA2 ACVR1C CD70 TNFSF14 TNFRSF19 GDF1 CCL25 INHBE NFIC XCL1 XCL2 IFNK GDF6 IL34 TNFRSF13C IL20 IL24 BMP10 PPBP CXCR6 TNFRSF10C INHBC CLCF1 IFNW1 TNFSF15 TNFRSF18 CXCL17 IL27 IL31 TNFRSF25 GDF2 IL18R1 TNFRSF14 CCR1 CX3CR1 CCR4 CSF2RB IL10RA GHR PRLR CSF3R IL13RA1 GH2 CD27 BMP6 IFNL1 CCR3 IFNL2 IFNLR1 IFNL3 INHA CCR7 CXCL14 CXCR5 GDF9 CCL19 LTBR GDF15 IL17RB EDA2R GDF7 IL12RB1 IL17F IL17C GDF5 IL17B TNFRSF11A IL19 TSLP IL15 TNFRSF11B IL25 IL17D IL20RB LEP CSF1R GH1 ACKR3 IL23R HLA-DRA HLA-DRB1 CD4 IL1B PDGFA IL12B KE89 Synthesis, De Novo Fatty Acid (FA) ECH1 ECHDC2 ECHDC1 ECHDC3 ACSS2 DECR1 ACSL1 ACSL3 ACSL4 FASN ACSL6 ACLY ACSL5 SCD ECHS1 HADH ACACA PC ACAA2 MECR ACACB PECR KE105 Inhibition, Mitochondrial Electron Transport Chain Complexes SLC25A4 SLC25A5 SLC25A6 UCP1 MT-CO2 NDUFB10 NDUFA13 MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA12 SDHA COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 KE111 Agonism, Estrogen receptor ESR1 NR0B2 STAT3 GPAM CYP1A1 CYP1A2 JUN SP1 PPARA PCK1 CYP1B1 ACOX1 PDK4 KE115 Increase, FA Influx ACSL4 ACSL3 ACSL1 ACSL6 ACSL5 CD36 FABP3 FABP2 DBI FABP1 SLC27A4 FABP4 ACSBG2 FABP7 FABP5 FABP6 FABP9 HGNC:10995 HGNC:10996 HGNC:10997 HGNC:10999 HGNC:11000 HGNC:3555 ACSBG1 KE149 Increase, Inflammation IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG CSF3 CXCL1 CXCL2 HLA-DRA HLA-DRB1 IFNB1 IL7 IL10 IL11 TGFB1 CD4 CSF1 CSF2 IL1A IL1B IL6 IL13 TNF PDGFA IL3 IL12B IL15 KE155 Inadequate DNA repair POLE2 LIG1 POLE3 NEIL2 POLE ERCC1 RFC1 POLD1 POLB MLH1 XRCC5 RBX1 ERCC2 PMS2 PCNA BRCA2 FANCD2 XRCC4 XPC WRN LIG4 FAN1 LIG3 PARP2 PARP1 ATM H2AX MRE11 MSH2 POLK DDB2 ERCC5 FANCC ERCC3 MGMT POLH RAP1A CUL4B PRKDC RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 EXO1 KE165 Activation, Long term AHR receptor driven direct and indirect gene expression changes AHRR TGFB1 CDC37 IL12A HSP90AA1 BAX EP300 AHR IL2 CDKN1B IFNG NFE2L2 IL1B CYP1A1 CYP1A2 EGFR JUNB JUN NQO1 SRC TNF NCOA1 HES1 POLK JUND IGFBP1 UGT1A1 GSTA2 ARNT UGT1A9 UGT1A4 MGST1 SLC7A5 ALDH3A1 AIP PTGES3 CAP2 CYP1B1 MYOF UGT1A6 CES3 UGT1A7 IL12B IL17B SERPINB2 RAF1 ESR1 KLF6 NCOR2 NCOA7 PSRC1 KRAS MAP2K1 HRAS NRAS CDKN1A E2F1 GCLC LPL MYC NFKB1 MAPK1 PTGS2 RB1 RELA CCL1 VEGFA CD36 CDK2 FGF21 NF1 RET HPGDS PLAGL1 NRIP1 KE167 Activation, LXR NR1H3 CYP2B6 CYP7A1 FASN SCD ABCG5 ABCG8 SREBF1 CYP3A4 RXRA KE177 Increase, Mitochondrial dysfunction SLC25A4 SLC25A5 SLC25A6 UCP1 MT-CO2 NDUFB10 NDUFA13 MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA12 SDHA COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 ECSIT NDUFAF6 NDUFAF7 TMEM126B NDUFAF2 NUBPL TMEM186 FOXRED1 DMAC1 NDUFAF3 TMEM70 COA1 ACAD9 TIMMDC1 DMAC2 NDUFB11 NDUFAF4 NDUFAF1 ATP6AP1 MTCO3P12 NDUFA4L2 GZMB ATP6AP2 KE178 Mitochondrial electron transport chain, disrupted ECSIT NDUFB10 NDUFAB1 NDUFA1 NDUFS4 NDUFB5 NDUFB3 NDUFC1 NDUFA2 NDUFS5 NDUFS2 NDUFS6 NDUFB1 NDUFS3 NDUFB6 NDUFA3 NDUFB4 NDUFB8 NDUFB2 NDUFA7 NDUFC2 NDUFA10 MT-ND1 MT-ND2 MT-ND4L MT-ND4 MT-ND5 MT-ND6 NDUFB7 NDUFV2 NDUFS1 NDUFV1 NDUFA8 NDUFV3 NDUFA6 NDUFA5 NDUFAF6 NDUFAF7 TMEM126B NDUFAF2 NUBPL TMEM186 FOXRED1 DMAC1 NDUFAF3 TMEM70 COA1 ACAD9 TIMMDC1 DMAC2 NDUFB11 NDUFAF4 NDUFA13 NDUFA12 NDUFAF1 NDUFB9 SLC25A4 SLC25A5 SLC25A6 UCP1 MT-CO2 SDHA COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 KE179 Decrease, Fatty acid beta-oxidation CHKB CPT1A CPT1B CPT2 CRAT ECI1 DECR1 ACSL1 ACSL3 ACSL4 ACSL6 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL ACSL5 ACSS2 TPI1 SLC25A20 DLD ECHS1 GCDH GK GK2 HADH ACAT1 LIPC LIPE LPL PNPLA2 LIPF KE188 Neuroinflammation NOS2 NFKBIA MAPK8 MAPK14 TLR4 FOS RELA JUN MTOR CHUK MT-CO2 MT-CO1 ASCC1 TLR3 IL10 IL12A IL18 ACE2 TNF IFNA2 IFNG IL1A IL1B IL4 IL6 CXCL8 MAPK1 CCL11 IL2 TLR8 TLR7 GFAP TMPRSS2 HMGB1 FURIN KE193 Decreased, Nitric Oxide HBB NOS2 NOS3 AOX1 XDH NOS1 HBA2 HBA1 MB MT-CO1 KE202 Inhibition, Nuclear factor kappa B (NF-kB) CDC37 NOX1 APAF1 BAD RAF1 REL SKP1 CASP3 CASP7 CASP8 CASP9 CUL1 TRADD RIPK1 FADD BTRC TANK TAB1 CHUK RFFL MAP3K8 CREBBP CSNK2A1 AKT1 TAB2 TAB3 GRB2 TBK1 HRAS HSP90AA1 IKBKB IL6 JUN KRAS MAP3K1 MAP3K3 MAP3K5 NFKB1 NFKB2 NFKBIA NFKBIB NRAS PPP2CA PRKCZ MAPK1 MAPK3 MAPK8 MAPK9 MAP2K3 MAP2K6 MAP2K7 PSMD2 BAX RAC1 BCL2L1 CCL2 BID MAP2K4 SOS1 MAP3K7 TNF TNFRSF1A TNFRSF1B TRAF2 TXN IKBKG CFLAR MAP3K14 CYBA RFK MAP4K2 TNFAIP3 BIRC2 PLK1 TRAF1 TRAP1 RIPK3 NOXO1 GLUL KSR2 NFKBIE DIABLO OTUD7B PTPRCAP PYGL SMPD2 MADD FBXW11 BIRC3 SELE NSMAF KSR1 KE209 Peptide Oxidation NOS2 NOX1 ICAM1 HMOX1 NRF1 RHEB MDM2 PTEN SOD2 MAP2K3 MAP2K4 PTGS2 SIRT1 RPS6KA5 IKBKB CCNE1 MAPK8 NFKB1 MAPK14 IL1A ATF2 NFE2L2 CREB1 CAT PIK3CA CDKN1A IL6 TP53 AKT1 FOXO1 PINK1 TSC1 CXCL8 FOS BCL2L1 BCL2 NQO1 MAP3K5 MTOR TNF IKBKG CDK2 CUL3 IPCEF1 KEAP1 CHEK1 PIP GSX1 ATR NOX5 MT1X NFIX CYBB SOD3 CYP1A1 GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NOX4 MAPK10 SOD1 SP1 XDH NOX3 TXNRD2 TXNRD1 TXN2 MGST1 UGT1A6 KE214 Bile accumulation, Pathological condition ABCB1 ABCC3 ABCC4 ABCC2 SLCO1B1 ABCB11 SLC10A1 SLC51A SLC51B FABP6 SLC10A2 SLCO1B3 CYP7A1 CYP27A1 SLC27A5 AKR1D1 HSD17B4 SLC27A2 AKR1C4 BAAT ACOX2 SCP2 AMACR ATP8B1 HSD3B7 CYP7B1 CYP8B1 ABCB4 ABCD3 ABCG5 ABCG8 MAPK1 MAPK3 LDLR FGFR4 FGF19 FXR1 CYP3A4 VDR NR1I2 SULT2A1 NR1I3 NR1H4 KE216 Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) GAPDH ENO1 ALDOC HK2 LDHA MDH1 MDH2 PGK1 PKM SLC2A1 TPI1 DLD GOT1 GOT2 PC SLC2A4 HK1 PDHA1 PFKL PFKM SLC2A3 DLAT G6PC1 PCK1 PFKP GCK PGAM1 PGAM2 MPC1 ENO2 ENO3 FBP1 ALDOA ALDOB GPI HK3 LDHB LDHC PGK2 PKLR SLC2A2 MPC2 SLC2A5 FBP2 LDHAL6B KE227 Activation, PPARα NR1H3 CPT1A ACADM CPT2 CYP7A1 CDK1 KLK15 CCND1 APOC3 APOA1 MYC APOA2 RXRA PPARA SLC27A1 CDK4 DBI FABP1 PLTP APOA5 SCP2 UGT1A9 ACAA1 EHHADH CYP8B1 CYP4A11 KE231 Decreased, PPAR-alpha activation NR1H3 SCD HMGCS2 PDPK1 ACSL1 CPT2 CYP7A1 OLR1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB SLC27A5 SORBS1 FABP3 SLC27A1 DBI FABP1 SLC27A4 CPT1C FABP4 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 CPT1A ACADM CDK1 KLK15 CCND1 MYC CDK4 UGT1A9 KE232 Decreased, PPAR-beta activation NR1H3 SCD HMGCS2 PDPK1 ACSL1 CPT2 CYP7A1 OLR1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB SLC27A5 SORBS1 FABP3 SLC27A1 DBI FABP1 SLC27A4 CPT1C FABP4 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 KE233 Decreased, PPAR-gamma activation NR1H3 SCD HMGCS2 PDPK1 ACSL1 CPT2 CYP7A1 OLR1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB SLC27A5 SORBS1 FABP3 SLC27A1 DBI FABP1 SLC27A4 CPT1C FABP4 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 KE239 Activation, Pregnane-X receptor, NR1I2 ABCB1 PSMC5 NCOA3 CYP2B6 HSP90AA1 PPARGC1A CYP2C9 NR1I2 FOXO1 CYP3A4 CYP2C19 RXRA SRC ABCC2 NCOA1 SULT2A1 ABCC3 ABCC4 SLCO1B1 CYP3A7 UGT1A1 GSTA2 CYP3A5 UGT1A9 UGT1A4 CYP2A6 UGT1A6 DNAJC7 CYP4F12 NCOA2 NRIP1 SRPX2 KE245 Activation, PXR/SXR ABCB1 PSMC5 NCOA3 CYP2B6 HSP90AA1 PPARGC1A CYP2C9 NR1I2 FOXO1 CYP3A4 CYP2C19 RXRA SRC ABCC2 NCOA1 SULT2A1 ABCC3 ABCC4 SLCO1B1 CYP3A7 UGT1A1 GSTA2 CYP3A5 UGT1A9 UGT1A4 CYP2A6 UGT1A6 DNAJC7 CYP4F12 NCOA2 NRIP1 SRPX2 KE265 Activation, Stellate cells CTNNB1 EGF SMAD2 SMAD3 SMAD5 SMAD9 SERPINE1 STAT3 TGFB1 TGFBR1 TGFBR2 WNT1 ZEB2 BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD4 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG MIR302A LEFTY1 LIF LEF1 SPP1 LEFTY2 TGFBR3 ENG INHBA ITGB6 LTBP1 BMP4 FOXH1 ZNF423 SMAD7 RUNX3 FST FKBP1A SKIL KE269 Induction, Sustained Cell Proliferation FLT4 LRP6 FGFR1 ULK2 FLT1 RHEB PDGFRB WNT1 KDR RAF1 APC MDM2 NTRK2 DEPTOR KIT BRAF SHC1 LRP5 REL INSR PTEN NTRK1 AKT1S1 JAK2 STAT3 CTNNB1 FZD6 RETN PIK3CB FGFR3 GSK3B MAPK1 NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 PIK3CA CDKN1A ELK1 MAP2K2 KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 NGFR FGFR2 TCF3 RUNX1T1 SOS2 SALL4 MET ZBTB16 BCL9 TEK FLT3 RARA LEF1 PML FGFR4 PYGO1 IL6R JUP GAREM2 EPHA2 NFKBIE KSR1 CSF1R TELO2 TTI1 KE272 Activation/Proliferation, T-cells CD83 CCR5 CRKL FYN IL9 IL17A PDPK1 PTPN11 RAF1 REL SHC1 TGFB1 VIM CARD11 SKAP1 CD3E CD3G CD247 CD4 CD8A CDC42 PSTPIP1 FYB1 MAP3K14 CHUK MAP3K8 CREB1 ATF2 MAPK14 AKT1 FOS GATA3 GRB2 HRAS FAS IKBKB IL1A IL1B IL6 ITPR1 JUN LCK NFKB1 NFKBIA PIK3R1 PIK3R2 PLCG1 PRKCD PRKCQ MAPK1 MAPK3 MAPK8 MAPK9 MAP2K1 MAP2K2 RELA SOS1 MAP3K7 TRAF6 ZAP70 IKBKG CBL CD28 SH2B3 VAV3 MALT1 MAP4K1 CRK PTK2B LAT ICOS TNFRSF9 ITK LCP2 NCK1 NFATC1 NFATC2 PAK1 VAV1 WAS CBLB BCL10 CD3D GRAP2 DBNL IRF4 IL15RA RIPK2 OPRM1 GAB2 KE277 Thyroid hormone synthesis, Decreased PRKAA1 PRKAA2 TPO RAF1 MAP2K2 PRKCA MAP2K1 ELK1 MAPK1 MAPK3 CREB1 NFKB1 PLCD1 ANO1 DUOX1 DUOX2 CLCN5 SLC26A6 ACY1 CGA SLC5A5 TG TRH TSHR RAP1B RAP1A KE281 Thyroxine (T4) in serum, Decreased PRKAA1 PRKAA2 TPO RAF1 MAP2K2 PRKCA MAP2K1 ELK1 MAPK1 MAPK3 CREB1 NFKB1 PLCD1 ANO1 DUOX1 DUOX2 CLCN5 SLC26A6 ACY1 CGA SLC5A5 TG TRH TSHR RAP1B RAP1A KE288 Activation of specific nuclear receptors, Transcriptional change NR1H3 CYP2B6 CYP7A1 ABCA1 ABCB1 ABCG5 ABCG1 CYP26A1 CYP1A2 CYP2C9 CYP2E1 CYP3A4 CYP24A1 CYP27B1 PPARA PPARD PPARG VDR NR1I2 MIR33B MIR33A ABCC2 RARA RARB ABCC3 RARG ABCB11 NR1I3 NR1H4 CYP4B1 ABCD2 CYP4A11 CYP8B1 ABCB4 ABCD3 SNAI2 CUL1 AHRR SREBF1 PSMC5 ESR1 TGFB2 IL11 SCD HMOX1 PDGFB TGFB1 CDC37 SOD3 CPT1A CCL20 ACADM SLC2A1 PTPA EGR1 NCOA3 NR0B2 ABCG8 CPT2 TGFBR2 STAT3 IL12A FASN CDK1 KLK15 IRS2 MAFG AGER GCLC GCLM PTGS2 NFKB2 HSP90AA1 GSTP1 BAX GSTT2 GGT1 EP300 GSR AHR CCL2 IL2 PPARGC1A CCND1 APOC3 CDKN1B IFNG HBEGF KAT2B NFE2L2 APOA1 GPAM IL1B CDKN1C GSTM1 TXN MYC CYP1A1 EGFR FOXO1 APOA2 CES5A G6PD SQSTM1 CYP2C19 GSTM4 JUNB CES2 GPX2 B3GNT5 JUN NQO1 SLC2A4 GSTA5 PDE4B SP1 RXRA SRC CES1 GPX3 GSTM2 TNF GSTA1 HGF ZIC2 SLC2A3 TGFBR3 SLC27A5 NCOA1 GADD45B SULT2A1 HES1 TNFAIP3 POLK ABCC4 SLC27A1 JUND BHLHE40 SLCO1B1 CDK4 BAAT MFGE8 ETNK2 SLC2A12 IGFBP1 ANKRD1 SLC7A11 DBI NRG1 CYP3A7 TGFA FABP1 SLC6A20 SLC6A19 DNER SULT1A1 UGT1A1 GSTA2 ARNT EPHA3 FTL SLC10A1 PLTP SLC5A5 CYP3A5 APOA5 BIRC2 SCP2 PCK1 ANGPTL4 AKAP13 TXNRD3 TXNRD1 POU5F1 UGT1A9 UGT1A4 CYP2A6 MGST1 ALAS1 SMC1A SLC7A5 ALDH3A1 AIP PTGES3 CAP2 NR3C1 PRDX1 DNAJB1 ALOX5AP LRRC8A CYP1B1 MYOF AMIGO2 FGF19 UGT1A6 DNAJC7 CES3 UGT1A7 PTGR1 ABCC5 CBR1 FTH1 CYP4F12 HSP90AB1 SLC19A2 FGF13 SLC6A3 EPHA2 UGT2B7 THBD SERPINA1 FKBP5 TNS4 FGFBP1 SRXN1 BIRC3 ACAA1 ME1 KEAP1 SLC5A1 SLC6A4 IL12B EHHADH IL17B NCOA2 STOM ACOX1 SLC2A2 SPRY1 NRIP1 MAFF ADH7 SERPINB2 NCOA6 PDK4 SLC6A13 SLC6A7 SLC39A9 SLC6A16 NAV3 SLC6A15 MGST2 BLVRB EPB41L4B SLC5A4 SMARCA1 SRPX2 SLC6A2 SLC39A14 SLC2A9 SCNN1A SLC39A7 CPEB4 SLC5A7 RGS2 PRDX6 SLC5A9 DNAJC15 SRGN KTN1 EDN2 SEC14L1 SLC6A8 SLC6A6 SLC6A11 SLC39A11 SLC2A11 GSTM5 GSTM3 PRRG4 SLC2A8 SLCO2B1 SLC5A6 SLC39A8 FGD4 SLC39A5 ABHD2 SLC5A2 SLC39A6 SLC39A3 SLC2A5 PGD MGST3 SLC39A1 ACKR3 PLK2 PMP2 SLC39A4 SLC39A12 SLC5A12 SLC2A13 ADGRF4 SLC5A10 SLC26A2 UGT2B4 SLC6A1 TSC22D3 GPR153 SLC5A11 CBR3 SLC2A6 IP6K3 CDC42EP3 S100P SLC6A18 SLC39A2 SLC39A13 SLC6A5 ARL5B CAVIN2 SERPINB9 GSTA4 ENC1 CES4A SLC2A14 GSTA3 GCC1 SERTAD2 SLC6A9 SLC39A10 SLC6A17 SLC2A7 SLC2A10 PPP1R14C SLC5A3 HSPA1A SPINK13 SLC5A8 SLC6A14 KE291 Accumulation, Triglyceride ACSL6 ACSL5 ACSL1 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 OSBPL5 NPC2 FABP3 LDLRAP1 SLC27A4 LPA APOA4 DBI SOAT1 SLC27A2 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 AGPAT1 AGPAT2 MOGAT1 GK GK2 GPD1 MOGAT3 LIPC LIPE LPL AGPAT5 AGPAT3 AGPAT4 PNPLA2 GPAM MOGAT2 GNPAT DGAT2 LIPF AGPS PLPP1 PLPP2 PLPP3 DGAT1 KE295 Induction, Upregulation of glucuronyltransferase activity PGM5 UGT2B11 UGT2A1 UGT2B28 UGT1A5 UGT1A3 UGT2B15 UGT2B17 UGT2A3 HK1 UGT1A1 UGT1A10 UGT1A9 UGT1A4 UGDH UGP2 UGT1A7 UGT1A6 UGT1A8 UGT2A2 UGT2B7 PGM3 PGM1 PGM2 UGT2B4 UGT2B10 KE327 Accumulation, Fatty acid CHKB CPT1A CPT1B CPT2 CRAT ECI1 DECR1 ACSL1 ACSL3 ACSL4 ACSL6 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL ACSL5 ACSS2 TPI1 SLC25A20 DLD ECHS1 GCDH GK GK2 HADH ACAT1 LIPC LIPE LPL PNPLA2 LIPF KE357 Cholestasis, Pathology HMGCR ABCG8 ABCG5 LDLR RXRA SCARB1 ABCC3 ABCC4 ABCC2 NR1I3 ABCB11 SLC10A1 NR1H4 SLC22A1 ATP8B1 SLCO1A2 TJP2 EPHX1 ABCB4 KE376 Increased, Induced Mutations in Critical Genes POLE2 LIG1 POLE3 NEIL2 POLE ERCC1 RFC1 POLD1 POLB MLH1 XRCC5 RBX1 ERCC2 PMS2 PCNA BRCA2 FANCD2 XRCC4 XPC WRN LIG4 FAN1 LIG3 PARP2 PARP1 ATM H2AX MRE11 MSH2 POLK DDB2 ERCC5 FANCC ERCC3 MGMT POLH RAP1A CUL4B PRKDC RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 EXO1 KE381 Reduced levels of BDNF CDH2 CDK5 SIRPA CTNNB1 EEF2 EGR1 EIF4EBP1 FYN GABRB3 APC IRS1 JAK2 NTRK1 NTRK2 PDPK1 PRKAA1 PRKAA2 MAP2K5 BAD PTPN11 RAB3A RAF1 RASGRF1 RPS6 RPS6KA1 RPS6KA3 RPS6KB1 BDNF SHC1 STAT3 ADAM17 CASP3 IRS2 CDK5R1 EIF2S2 CDC42 BCL2L11 FRS2 CHUK CNR1 CREB1 MAPK14 CSNK2A1 EIF2S1 EIF4E ELK1 AKT1 FOXO3 FOS MTOR ALPL GRB2 GRIA1 GRIN1 GRIN2B GSK3B HRAS IKBKB JUN MAPT MAP3K1 NFKB1 NFKBIA PIK3R1 PIK3R2 PLCG1 PPP2CA PRKCD MAPK1 MAPK3 MAPK7 MAPK8 MAPK9 MAPK10 MAP2K1 MAP2K2 RAC1 RELA BMP2 SRC STAT1 TRAF6 TSC2 CAMK4 CAMK2A IKBKG CAMK1 SQSTM1 RPS6KA5 VAV3 SH2B2 MAP3K2 PTK2B SHC2 MEF2A MEF2C NCF2 NCK1 NFATC4 NGF NGFR NTRK3 SHC3 KIDINS220 PTPRF SORT1 NCF1 SPP1 TIAM1 RANBP9 CRTC1 GRIP1 GRIA2 RAP1A STAT5A STAT5B IGF2BP1 CFL1 RHOG NCAM1 RACK1 SH2B1 DLG1 SYN1 NCK2 NTF3 DPYSL2 FRS3 DOCK3 GRIA3 KCNA3 KCNN2 MARCKS YBX1 NSF DOK5 CDKL5 EGR2 ACACB SHC4 VAV2 KSR1 CYFIP1 LINGO1 KE383 Reduced, Presynaptic release of glutamate STX1B SYT1 RIMS1 NAPA CPLX1 UNC13B RAB3A ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2B1 CLTCL1 SLC25A4 VAMP2 DNM1 SNAP25 STXBP1 CLTA CLTC SLC18A2 STX1A SLC38A1 PARK7 SYN1 DNM1L CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 SLC6A4 CACNA1A SLC18A3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE385 Decrease of synaptogenesis RPS6KA1 BDNF CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 CCND2 NGF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMKK2 KE388 Overactivation, NMDARs GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C STAT3 CDH2 GABRG3 GABRA5 GABRD GABRQ CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B SLC1A1 GLS2 SLC7A11 NRG1 GRM5 ERBB4 GRM3 GNA11 CRTC1 GRIA2 DLG4 HOMER1 GRIP1 NRXN3 HDAC10 EFNB2 SDCBP GRIN3B GRIN3A GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE425 Decrease of Thyroidal iodide PRKAA1 PRKAA2 TPO RAF1 MAP2K2 PRKCA MAP2K1 ELK1 MAPK1 MAPK3 CREB1 NFKB1 PLCD1 ANO1 DUOX1 DUOX2 CLCN5 SLC26A6 ACY1 CGA SLC5A5 TG TRH TSHR RAP1B RAP1A KE450 Suppression, VLDL secretion ACSL6 ACSL5 ACSL1 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 OSBPL5 NPC2 FABP3 LDLRAP1 SLC27A4 LPA APOA4 DBI SOAT1 SLC27A2 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 KE451 Inhibition, Mitochondrial fatty acid beta-oxidation CPT1A CPT2 ECI1 ACSL1 ACSL3 ACSL4 HADHA ACADL ACADM ACADS ACADVL SLC25A20 HADH SCP2 EHHADH PECR ACSF2 CHKB CPT1B CRAT DECR1 ACSL6 GPD2 HADHB ACSL5 ACSS2 TPI1 DLD ECHS1 GCDH GK GK2 ACAT1 LIPC LIPE LPL PNPLA2 LIPF KE454 Increased, Triglyceride formation AGPAT1 AGPAT2 MOGAT1 GK GK2 GPD1 MOGAT3 LIPC LIPE LPL AGPAT5 AGPAT3 AGPAT4 PNPLA2 GPAM MOGAT2 GNPAT DGAT2 LIPF AGPS PLPP1 PLPP2 PLPP3 DGAT1 KE456 Suppression, Constitutive androstane receptor, NR1l3 PTPA CYP2B6 ABCB1 FOXO1 PPARGC1A CYP2C19 CYP2C9 CYP3A4 HSP90AA1 RXRA SP1 SULT2A1 SULT1A1 UGT1A1 ABCC2 GSTA2 NCOA1 ABCC3 UGT1A9 UGT1A4 CYP2A6 CYP3A5 NR1I3 ALAS1 UGT1A6 DNAJC7 SMC1A EHHADH CYP4A11 NCOA2 NCOA6 KE457 Activation, SREBF1 CYP51A1 MDH1 SREBF1 SCD PRKAG2 PRKAB1 HMGCS1 HMGCR PRKAG3 ATF6 NR1H2 ACLY PRKAB2 PRKAA1 PPARGC1B PRKAA2 FASN PRKAG1 SREBF2 PRKACA SCARB1 SIRT1 CREB1 GPAM PIK3CA LDLR PPARG AKT1 AMFR CAMP LPL SP1 MTOR ACACA INS NFYA MBTPS2 IDI1 SEC31B SAR1A FDFT1 MED15 YY1 SEC23A SEC23B SQLE FGF21 GSK3A KPNB1 SEC24A SCAP INSIG2 CDK8 LPIN1 RBP4 SEC31A SEC24B MBTPS1 SEC24D SAR1B ACSS1 DBI SEC13 LSS FDPS MVD RNF139 SEC24C INSIG1 MIR33A MIR33B KE458 Increased, De Novo FA synthesis ECH1 ECHDC2 ECHDC1 ECHDC3 ACSS2 DECR1 ACSL1 ACSL3 ACSL4 FASN ACSL6 ACLY ACSL5 SCD ECHS1 HADH ACACA PC ACAA2 MECR ACACB PECR KE459 Increased, Liver Steatosis PRKAG2 PRKAB1 PRKAG3 ACSS2 ACLY PRKAB2 PRKAA1 PRKAA2 FASN PRKAG1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA PDHA1 ABHD5 PRKAR2A HILPDA PLIN1 ACSBG1 BCKDHA KE465 Increased, Fatty acid influx ACSL4 ACSL3 ACSL1 ACSL6 ACSL5 CD36 FABP3 FABP2 DBI FABP1 SLC27A4 FABP4 ACSBG2 FABP7 FABP5 FABP6 FABP9 HGNC:10995 HGNC:10996 HGNC:10997 HGNC:10999 HGNC:11000 HGNC:3555 ACSBG1 KE468 Inhibition, PPAR alpha NR1H3 SCD HMGCS2 PDPK1 ACSL1 CPT2 CYP7A1 OLR1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB SLC27A5 SORBS1 FABP3 SLC27A1 DBI FABP1 SLC27A4 CPT1C FABP4 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 CPT1A ACADM CDK1 KLK15 CCND1 MYC CDK4 UGT1A9 KE471 Inhibition, FoxA2 MTTP PPARGC1B IRS1 FASN IRS2 SREBF1 FOXO1 GSTM2 GSTA1 INS APOB ACACA ABCC2 SLC27A5 ABCC3 ABCC4 FOXA2 FOXA1 SLCO1B1 GSTA2 MLXIPL KE478 Activation, NRF2 TGFB2 HMOX1 PDGFB TGFB1 SOD3 SLC2A1 EGR1 TGFBR2 MAFG AGER GCLC GCLM HSP90AA1 GSTP1 GSTT2 GGT1 GSR PPARD HBEGF NFE2L2 GSTM1 TXN CES5A G6PD SQSTM1 GSTM4 CES2 GPX2 NQO1 SLC2A4 GSTA5 RXRA CES1 GPX3 GSTM2 GSTA1 HGF ABCC2 SLC2A3 ABCC3 ABCC4 SLC2A12 SLC7A11 NRG1 TGFA SLC6A20 SLC6A19 UGT1A1 GSTA2 EPHA3 FTL SLC5A5 TXNRD3 TXNRD1 UGT1A9 UGT1A4 CYP2A6 ALDH3A1 PRDX1 DNAJB1 UGT1A6 CES3 UGT1A7 PTGR1 ABCC5 CBR1 FTH1 HSP90AB1 FGF13 SLC6A3 EPHA2 UGT2B7 SERPINA1 SRXN1 ME1 KEAP1 SLC5A1 SLC6A4 SLC2A2 MAFF CYP4A11 ADH7 SLC6A13 SLC6A7 SLC39A9 SLC6A16 SLC6A15 MGST2 BLVRB SLC5A4 SLC6A2 SLC39A14 SLC2A9 SLC39A7 SLC5A7 PRDX6 SLC5A9 SLC6A8 SLC6A6 SLC6A11 SLC39A11 SLC2A11 GSTM5 GSTM3 SLC2A8 SLC5A6 SLC39A8 SLC39A5 SLC5A2 SLC39A6 SLC39A3 SLC2A5 PGD MGST3 SLC39A1 SLC39A4 SLC39A12 SLC5A12 SLC2A13 SLC5A10 SLC6A1 SLC5A11 CBR3 SLC2A6 SLC6A18 SLC39A2 SLC39A13 SLC6A5 GSTA4 CES4A SLC2A14 GSTA3 SLC6A9 SLC39A10 SLC6A17 SLC2A7 SLC2A10 SLC5A3 HSPA1A SLC5A8 SLC6A14 FYN RBX1 INSR YES1 CEBPB GSK3B SRC PGAM5 EPHB2 PIK3CA PRKCA MAPK8 MAF CUL3 AIMP2 KE483 Activation, LXR alpha NR1H3 CYP2B6 CYP7A1 FASN SCD ABCG5 ABCG8 SREBF1 CYP3A4 RXRA KE484 Activation, AKT2 BAD ITGA3 IBSP FLT4 KITLG LAMA3 EIF4B FGFR1 JAK2 PDGFB FLT1 IL7 CDC37 RHEB CSF3 RPS6KB1 CCND3 PDGFRB IFNA6 IFNA8 KDR RAF1 PRKAA1 CASP9 MDM2 IFNA21 RPS6 EGF COL2A1 PDPK1 IFNAR1 IFNA5 IFNA16 NTRK2 ITGB1 ANGPT1 KIT PRKAA2 ITGA2 NOS3 DDIT4 IRS1 INSR IFNB1 PTEN RPS6KB2 BDNF IFNA10 COL4A1 EIF4EBP1 IFNA1 NTRK1 ITGA1 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 IGF1 PIK3CB LAMC2 CREB3L3 FGFR3 IL4R HSP90AA1 PHLPP1 GSK3B LAMB1 MAPK1 IL2RB MAPK3 TSC2 IKBKB PPP2CB CCNE1 AKT2 PIK3R2 PIK3CG CREB3 COL1A1 VTN NFKB1 IL2 CCND1 CDKN1B VEGFA IL4 PPP2CA FN1 SOS1 ATF2 AKT3 PIK3R3 FASLG STK11 CREB1 FOXO3 PIK3CA CDKN1A MAP2K2 ATF4 LAMA5 KRAS IL2RA PDGFRA LAMC1 RAC1 IL6 TLR4 MYC TLR2 THBS1 FGF2 FGF7 IGF1R PIK3R5 TP53 RPTOR AKT1 MCL1 CREB3L4 PIK3R1 CREB5 EGFR IL2RG EIF4E BCL2L11 PRKCA CREB3L1 IFNAR2 JAK1 COL1A2 TSC1 MLST8 MAP2K1 THBS3 PTK2 BCL2L1 PIK3CD BCL2 LAMB2 HRAS GRB2 CREB3L2 CSF1 IFNA2 MTOR NRAS CHUK ATF6B INS IKBKG PIK3R6 RELA HGF NGFR FGFR2 GNB5 ANGPT2 SOS2 SGK2 SGK3 GYS1 FGF21 CDK6 MET FGF8 GYS2 FGF1 SGK1 SPP1 CCND2 FGF23 PGF TEK FLT3 CDK2 GNG13 EPO NGF CDK4 ITGAV PDGFC VEGFC IL6R FGFR4 TGFA VEGFD CHRM1 PDGFD VEGFB RELN PDGFA ITGB3 TNC FGF10 FGF4 GNB1 FGF20 COL4A4 ITGB5 OSM FGF9 JAK3 FGF6 GNB3 LAMA4 ITGB6 PCK1 GNG11 GNGT1 G6PC1 ITGB4 COL4A2 ITGA11 FGF5 COL6A1 COL6A2 OSMR FGF18 GNG3 COL6A3 IL3 SYK GNGT2 GNG8 GNG4 TNXB COL4A3 GNB2 GNG12 GNG5 GNG7 THBS2 GNG2 FGF3 EPOR COL4A5 GNG10 PKN2 FGF19 IL7R PRL CD19 LPAR1 BRCA1 PHLPP2 COL9A2 LAMC3 LPAR2 PPP2R5A PPP2R5B FGF22 FLT3LG LAMB4 PPP2R3C COL9A3 HSP90AB1 EFNA2 TCL1A PCK2 ANGPT4 LAMA1 FGF14 RBL2 COMP VWF COL9A1 PPP2R5D GHR THBS4 PRLR FGF12 GNB4 TNR CSF3R TNN PKN1 FGF13 CHAD GH2 CSH1 LPAR6 G6PC3 EPHA2 EFNA3 LPAR4 G6PC2 PIK3AP1 FGF17 THEM4 PKN3 FGF11 HSP90B1 IGF2 EFNA1 LPAR3 COL6A5 CCNE2 PPP2R2D EIF4E1B CHRM2 F2R EFNA5 LPAR5 IL3RA NTF3 LAMB3 COL4A6 COL6A6 CSH2 TCL1B NTF4 EFNA4 ITGA2B PPP2R3A PPP2R2C ITGA8 PPP2R5C ITGA6 PPP2R1A ITGB8 ITGA4 MYB ITGA7 EIF4E2 PPP2R1B ITGB7 ITGA10 ITGA9 PPP2R5E PPP2R2B ITGA5 PPP2R3B CSF1R LAMA2 PPP2R2A GH1 KE493 Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts POLE2 LIG1 POLE3 NEIL2 POLE POLD1 POLB PCNA POLG RFC1 LIG3 PARP2 PARP1 PARP3 APTX POLD3 APEX1 POLD2 POLE4 TDG POLL POLD4 SMUG1 RFC3 RFC4 TDP1 RFC2 RFC5 ADPRS PARPG POLG2 NEIL1 PARP4 HMGB1 PNKP NTHL1 XRCC1 UNG MPG NEIL3 OGG1 MBD4 MUTYH FEN1 ERCC1 RBX1 ERCC2 XPC DDB2 ERCC5 ERCC3 CUL4B RAD23B RPA1 CETN2 MNAT1 GTF2H1 GTF2H3 CDK7 CCNH GTF2H2 GTF2H4 RPA3 RPA2 DDB1 CUL4A XPA ERCC4 RAD23A GTF2H5 ERCC8 ERCC6 KE570 Accumulation, Damaged mitochondrial DNA POLE2 LIG1 POLE3 NEIL2 POLE ERCC1 RFC1 POLD1 POLB MLH1 XRCC5 RBX1 ERCC2 PMS2 PCNA BRCA2 FANCD2 XRCC4 XPC WRN LIG4 FAN1 LIG3 PARP2 PARP1 ATM H2AX MRE11 MSH2 POLK DDB2 ERCC5 FANCC ERCC3 MGMT POLH RAP1A CUL4B PRKDC RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 EXO1 KE616 Occurrence, A paroxysmal depolarizing shift GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C STAT3 CDH2 GABRG3 GABRA5 GABRD GABRQ CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B SLC1A1 GLS2 SLC7A11 NRG1 GRM5 ERBB4 GRM3 GNA11 CRTC1 GRIA2 DLG4 HOMER1 GRIP1 NRXN3 HDAC10 EFNB2 SDCBP GRIN3B GRIN3A GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE654 Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists CYP17A1 SRD5A2 CYP3A4 HSD3B1 HSD3B2 HSD17B1 CYP11B1 POR AKR1C4 SRD5A1 CYP3A7 HSD11B1 HSD17B3 HSD17B2 AKR1C3 HSD17B4 AKR1D1 AKR1C2 HSD11B2 AKR1C1 SULT2A1 KE664 Overwhelmed, Mitochondrial DNA repair mechanisms POLE2 LIG1 POLE3 NEIL2 POLE ERCC1 RFC1 POLD1 POLB MLH1 XRCC5 RBX1 ERCC2 PMS2 PCNA BRCA2 FANCD2 XRCC4 XPC WRN LIG4 FAN1 LIG3 PARP2 PARP1 ATM H2AX MRE11 MSH2 POLK DDB2 ERCC5 FANCC ERCC3 MGMT POLH RAP1A CUL4B PRKDC RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 EXO1 KE667 Binding at picrotoxin site, iGABAR chloride channel GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2B1 ABAT GAD2 GAD1 GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE669 Reduction, Neuronal synaptic inhibition GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C STAT3 CDH2 GABRG3 GABRA5 GABRD GABRQ CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B SLC1A1 GLS2 SLC7A11 NRG1 GRM5 ERBB4 GRM3 GNA11 CRTC1 GRIA2 DLG4 HOMER1 GRIP1 NRXN3 HDAC10 EFNB2 SDCBP GRIN3B GRIN3A GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE709 Increase, Cytotoxicity (renal tubular cell) BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A KE756 Hippocampal gene expression, Altered RPS6KA1 BDNF CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 CCND2 NGF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMKK2 KE757 Hippocampal anatomy, Altered RPS6KA1 BDNF CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 CCND2 NGF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMKK2 KE758 Hippocampal Physiology, Altered RPS6KA1 BDNF CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 CCND2 NGF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMKK2 KE761 Increased, Chloride conductance GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2B1 ABAT GAD2 GAD1 GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE762 Activation, ionotropic GABA Receptor chloride channel GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2B1 ABAT GAD2 GAD1 GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE768 Increase, Cytotoxicity LTA APAF1 BIRC5 IRF2 IRF3 MDM2 BAD TRAF3 CASP3 CASP7 CASP8 CASP9 TRADD RIPK1 FADD BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR MIR29A BBC3 IRF1 IRF5 PMAIP1 TNFRSF10B GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 MIR29B1 MIR29B2 IRF4 TNFRSF21 HELLS XIAP CASP4 TNFRSF25 CRADD HRK DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BIRC3 TP73 SCAF11 KE769 Increase, Oxidative metabolism ATP6AP1 MTCO3P12 NDUFA4L2 NDUFB10 GZMB MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA4 MT-ATP6 ATP5PD ATP5MG NDUFA11 DMAC2L NDUFS7 MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO ATP5MF NDUFA9 ATP6AP2 KE771 Decrease, Serum thyroid hormone (T4/T3) PRKAA1 PRKAA2 TPO RAF1 MAP2K2 PRKCA MAP2K1 ELK1 MAPK1 MAPK3 CREB1 NFKB1 PLCD1 ANO1 DUOX1 DUOX2 CLCN5 SLC26A6 ACY1 CGA SLC5A5 TG TRH TSHR RAP1B RAP1A KE787 Increase, Regenerative cell proliferation (hepatocytes) CRKL ITGA1 ITGB1 PTEN PTPN11 PXN RAF1 STAT3 ELK1 FOS GAB1 GRB2 HRAS JUN PIK3CA MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTGS2 PTK2 SOS1 SRC MAP4K1 CRK PTK2B RAPGEF1 HGF MET PAK1 RAP1A RAP1B RASA1 DOCK1 KE835 Occurrence, Ballooning degeneration (hepatocyte) XBP1 ATF6 DDIT3 ERN1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 MBTPS2 BBC3 TNFRSF10B MBTPS1 PMAIP1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE838 Induction, Microvesicular fat CPT1A CPT2 ECI1 ACSL1 ACSL3 ACSL4 HADHA ACADL ACADM ACADS SLC25A20 ACADVL HADHB HADH SCP2 EHHADH PECR ACSF2 SLC22A5 KE840 Formation, Liver fibrosis LRP6 WNT1 SERPINH1 FZD1 LRP5 SP7 COL1A1 SERPINF1 ITPR1 CREB3L1 COL1A2 MBTPS2 TNFSF11 MBTPS1 BMP1 P4HA2 PLOD1 ADAMTS2 P3H2 TMEM38B LOX P3H1 P4HA1 COLGALT1 TNFRSF11A FKBP10 PLOD2 MIA3 TNFRSF11B PPIB CRTAP P4HB IFITM5 KE850 Induction, CYP1A2/CYP1A5 RAF1 CDC37 ESR1 AHRR KLF6 NCOR2 NCOA7 PSRC1 KRAS MAP2K1 HRAS NRAS CDKN1A CDKN1B CYP1A1 CYP1A2 NQO1 E2F1 EGFR AHR EP300 GCLC HSP90AA1 LPL MYC NFE2L2 NFKB1 MAPK1 PTGS2 RB1 RELA CCL1 SRC TNF VEGFA CD36 CDK2 FGF21 ARNT NF1 RET AIP CYP1B1 HPGDS PLAGL1 NRIP1 KE853 Changes/Inhibition, Cellular Homeostasis and Apoptosis BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A LTA IRF2 IRF3 MDM2 CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 MIR29A IRF1 IRF5 GZMB PRF1 TRAF1 IRF4 TNFRSF21 HELLS IGF2 NFKBIE TP73 SCAF11 KE860 Decreased, Mitochondrial Fatty Acid Beta Oxidation CHKB CPT1A CPT1B CPT2 CRAT ECI1 DECR1 ACSL1 ACSL3 ACSL4 ACSL6 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL ACSL5 ACSS2 TPI1 SLC25A20 DLD ECHS1 GCDH GK GK2 HADH ACAT1 LIPC LIPE LPL PNPLA2 LIPF SCP2 EHHADH PECR ACSF2 KE870 Increase, Cell Proliferation CUL1 TGFB2 ABL1 RBX1 TGFB1 CCND3 SKP1 PCNA CCNA1 CCNB1 MDM2 CCNB2 SMAD3 CDK1 SMAD2 GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 E2F2 GADD45B CDK6 E2F3 GADD45A CCND2 CDK2 GADD45G CDK4 CDC25C CDC25A SFN PLK1 PRKDC SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 KE878 Inhibition, SREBP1c CYP51A1 MDH1 SREBF1 SCD PRKAG2 PRKAB1 HMGCS1 HMGCR PRKAG3 ATF6 NR1H2 ACLY PRKAB2 PRKAA1 PPARGC1B PRKAA2 FASN PRKAG1 SREBF2 PRKACA SCARB1 SIRT1 CREB1 GPAM PIK3CA LDLR PPARG AKT1 AMFR CAMP LPL SP1 MTOR ACACA INS NFYA MBTPS2 IDI1 SEC31B SAR1A FDFT1 MED15 YY1 SEC23A SEC23B SQLE FGF21 GSK3A KPNB1 SEC24A SCAP INSIG2 CDK8 LPIN1 RBP4 SEC31A SEC24B MBTPS1 SEC24D SAR1B ACSS1 DBI SEC13 LSS FDPS MVD RNF139 SEC24C INSIG1 MIR33A MIR33B KE881 Increased, Triglyceride AGPAT1 AGPAT2 MOGAT1 GK GK2 GPD1 MOGAT3 LIPC LIPE LPL AGPAT5 AGPAT3 AGPAT4 PNPLA2 GPAM MOGAT2 GNPAT DGAT2 LIPF AGPS PLPP1 PLPP2 PLPP3 DGAT1 KE887 Inhibition, NADH-ubiquinone oxidoreductase (complex I) SLC25A4 SLC25A5 SLC25A6 UCP1 MT-CO2 NDUFB10 NDUFA13 MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA12 SDHA COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 KE888 Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ECSIT NDUFB10 NDUFAB1 NDUFA1 NDUFS4 NDUFB5 NDUFB3 NDUFC1 NDUFA2 NDUFS5 NDUFS2 NDUFS6 NDUFB1 NDUFS3 NDUFB6 NDUFA3 NDUFB4 NDUFB8 NDUFB2 NDUFA7 NDUFC2 NDUFA10 MT-ND1 MT-ND2 MT-ND4L MT-ND4 MT-ND5 MT-ND6 NDUFB7 NDUFV2 NDUFS1 NDUFV1 NDUFA8 NDUFV3 NDUFA6 NDUFA5 NDUFAF6 NDUFAF7 TMEM126B NDUFAF2 NUBPL TMEM186 FOXRED1 DMAC1 NDUFAF3 TMEM70 COA1 ACAD9 TIMMDC1 DMAC2 NDUFB11 NDUFAF4 NDUFA13 NDUFA12 NDUFAF1 NDUFB9 KE889 Proteostasis, impaired PSMD11 UBE2B H2AX H2AZ1 IFNG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD7 PSMD8 PSMD9 PSMD12 PSMD13 PSMD6 HLA-A HLA-C NEDD4 UBA1 UCHL1 UBE2D3 HLA-B HLA-E HLA-F HLA-G UCHL3 PSME3 HLA-H PSMB8 PSMB9 PSMB10 PSMD5 PSMD10 PSME1 PSME2 RPN1 RPN2 UBA7 UBB UBE2D1 H2AC4 UBC UBE2D2 PFDN4 PFDN1 PFDN5 PFDN2 VBP1 PFDN6 DNAJB1P1 HSP90AA2P HSPA7 KE926 Oxidation, Glutathione (To be considered with MIE) GSTA5 G6PD GGT5 OPLAH GCLC GCLM GPX1 GPX2 GPX3 GPX4 ANPEP GSR GSS GSTA1 GSTM1 GSTM2 GSTT2 IDH1 GGT1 KE941 Activation, EGFR ERRFI1 STAM2 STAMBP EPS8 EPN1 SH3KBP1 LIMK2 MYBL2 PEBP1 ASAP1 PTPN12 PTPRR EPS15L1 ATXN2 SYNJ1 SH2D2A HGS REPS2 USP6NL IQSEC1 PIAS3 CRKL EGF EIF4EBP1 ABL1 INPP5D JAK2 MEF2D NOS3 PCNA PDPK1 MAP2K5 PTEN PTPN11 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 SHC1 BRAF STAT3 NCOA3 ITCH CDC42 CREB1 MAPK14 AP2B1 E2F1 EGFR ELK1 ERBB2 AKT1 FOXO1 FOS MTOR RICTOR GAB1 GJA1 GRB2 HRAS JAK1 JUN ARF6 KRAS MAP3K1 MAP3K3 ATF1 PLCE1 PIK3C2B PIK3R1 PIK3R2 PLCG1 PLD1 PRKCA PRKCB PRKCD PRKCZ MAPK1 MAPK7 MAPK8 MAPK9 MAP2K1 MAP2K2 PTK2 RAB5A RAC1 ROCK1 SOS1 SP1 SRC STAT1 CAMK2A CAV1 CBL USP8 RPS6KA5 VAV3 MAP3K2 MAP4K1 CRK DNM1 PTK2B FOSB CBLC GRB10 INPPL1 JUND MEF2A MEF2C MAP3K4 MT-CO2 NCK1 PAK1 PRKCI MAPK4 SOS2 AURKA STXBP1 TWIST1 VAV1 CBLB IQGAP1 DOK2 ABI1 TNK2 ELK4 FOXO4 NDUFA13 RAP1A RASA1 STAT5A STAT5B ARHGEF1 CFL1 NEDD4 PXDN STMN1 STAM PLSCR1 NCK2 RALBP1 PLD2 RIN1 SPRY2 EPS15 SH3GL2 PTK6 CSK RALA RALB RALGDS VAV2 CAV2 BCAR1 GAB2 AP2M1 AP2S1 AP2A1 NEDD8 SH3GL3 PTPN5 KE960 Increased, Uptake of thyroxine into tissue TTF2 TTF1 TSHB NPPB BAD FGFR1 RHEB RPS6KB1 RAF1 CASP9 MDM2 RPS6 PRDM16 NOTCH1 WNT4 CTNNB1 AKT1S1 TPO PFKFB2 PAX8 ADRB3 IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 KDM1A RPS6KA6 FGF21 NPY THRA TBC1D4 ITGAV SHH DIO2 ITGB3 PRKG2 MAP4K5 NPR1 SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG AQP7 SLC16A10 MGLL MC4R PLIN1 ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 ZNF516 KLB KDM3B KE1096 Increased, blood uric acid concentration PAICS TPMT MOCOS PNP HPRT1 ADA APRT IMPDH1 AMPD1 ADSS2 ADSL ATIC XDH PRPS1 AOX1 DGUOK ITPA MAT2A GRM5 RRM2B GART PPAT PFAS KE1097 Occurrence, renal proximal tubular necrosis NOX1 ATG5 ACSL4 TF HMOX1 HSPB1 HMGCR STEAP3 CTH ACSL3 MAP1LC3B ACSL1 CBS ACSL6 CYBB ACSL5 ATG7 CISD1 NCOA4 GCLC GCLM VDAC3 NOX4 GSS MAP1LC3A TP53 VDAC2 GPX4 ALOX15 FDFT1 SLC1A5 POR SAT1 SLC7A11 AKR1C2 SLC3A2 COQ2 AKR1C1 AKR1C3 PCBP2 CP TFRC FTL TXNRD1 SLC38A1 BACH1 SLC11A2 SLC40A1 FTH1 PRNP AIFM2 CHMP5 LPCAT3 GCH1 IREB2 SAT2 PCBP1 CHMP6 FTMT DPP4 SLC39A14 SLC39A8 PHKG2 MAP1LC3C KE1104 Decreased, Prostaglandin F2alpha concentration, plasma S100A10 PPARGC1B ANXA5 ANXA8 ANXA3 ANXA4 PTGFRN SCGB1A1 ANXA6 PPARGC1A CYP11A1 HPGD MITF PLA2G4A PPARG PTGDS PTGIS PTGS1 PTGS2 TBXAS1 PTGES ABCC4 AKR1C1 AKR1C2 EDN1 EDNRA EDNRB HSD11B1 HSD11B2 PTGIR SOX9 AKR1C3 ANXA1 PRL HPGDS PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR S100A6 CBR1 AKR1B1 ANXA2 TBXA2R KE1115 Increase, Reactive oxygen species NOX5 MT1X NFIX NOX1 CYBB HMOX1 SOD2 SOD3 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT NOX3 TXNRD2 TXNRD1 TXN2 MGST1 UGT1A6 NOS2 ICAM1 NRF1 RHEB MDM2 PTEN MAP2K3 MAP2K4 PTGS2 SIRT1 RPS6KA5 IKBKB CCNE1 MAPK8 IL1A ATF2 CREB1 PIK3CA CDKN1A IL6 TP53 AKT1 FOXO1 PINK1 TSC1 CXCL8 BCL2L1 BCL2 MAP3K5 MTOR TNF IKBKG CDK2 CUL3 IPCEF1 KEAP1 CHEK1 PIP GSX1 ATR KE1177 Decreased, Ionotropic GABA receptor chloride channel conductance GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C STAT3 CDH2 GABRG3 GABRA5 GABRD GABRQ CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B SLC1A1 GLS2 SLC7A11 NRG1 GRM5 ERBB4 GRM3 GNA11 CRTC1 GRIA2 DLG4 HOMER1 GRIP1 NRXN3 HDAC10 EFNB2 SDCBP GRIN3B GRIN3A GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 GAD2 GABBR2 GABBR1 ALDH9A1 AP2S1 AP2M1 GPHN KE1194 Increase, DNA damage HUS1B CASP8 ABL1 CCND3 APAF1 CASP9 CCNB1 MDM2 FANCD2 CCNB2 CASP3 CDK5 CDK1 RFC1 BID FAS BAX E2F1 CCNE1 CCND1 CDKN1B CDKN1A RB1 TP53 AKT1 TLK2 ATM CYCS H2AX CREB1 MYC RRM2B SESN1 GADD45B BBC3 CDK6 GADD45A CCND2 TP53AIP1 TNFRSF10B CDK2 GADD45G DDB2 CDK4 PML PMAIP1 CDC25C CDC25A SFN MRE11 PIDD1 PRKDC RAD52 RAD51 SMC1A RAD50 NBN RAD17 CHEK2 BRCA1 RAD1 RPA2 RAD9A CCNE2 ATRIP CCNB3 TLK1 CHEK1 ATR KE1214 Altered gene expression specific to CAR activation, Hepatocytes PTPA CYP2B6 ABCB1 FOXO1 PPARGC1A CYP2C19 CYP2C9 CYP3A4 HSP90AA1 RXRA SP1 SULT2A1 SULT1A1 UGT1A1 ABCC2 GSTA2 NCOA1 ABCC3 UGT1A9 UGT1A4 CYP2A6 CYP3A5 NR1I3 ALAS1 UGT1A6 DNAJC7 SMC1A EHHADH CYP4A11 NCOA2 NCOA6 KE1262 Apoptosis BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A LTA IRF2 IRF3 MDM2 CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 MIR29A IRF1 IRF5 GZMB PRF1 TRAF1 IRF4 TNFRSF21 HELLS IGF2 NFKBIE TP73 SCAF11 KE1263 Necrosis CASP8 TRADD TICAM1 RIPK1 FADD TNFRSF1A MAPK8 PLA2G4A PARP1 TNF FTL RIPK3 KE1270 Inactivation of PPARγ NR1H3 SCD HMGCS2 PDPK1 ACSL1 CPT2 CYP7A1 OLR1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB SLC27A5 SORBS1 FABP3 SLC27A1 DBI FABP1 SLC27A4 CPT1C FABP4 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 KE1271 Increase, Transforming growth factor-beta signaling TGFB1 SERPINE1 TGFBR1 TGFBR2 SMAD3 SMAD2 SMAD4 CCN2 TGFBR3 POSTN WWTR1 YWHAG SPARC CTNNB1 EGF SMAD5 SMAD9 STAT3 WNT1 ZEB2 BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG MIR302A LEFTY1 LIF LEF1 SPP1 LEFTY2 ENG INHBA ITGB6 LTBP1 BMP4 FOXH1 ZNF423 SMAD7 RUNX3 FST FKBP1A SKIL KE1283 Activation, TGF-beta pathway TGFB1 TGFBR1 LOXL4 TGFBR2 SMAD3 SMAD2 MAPK9 MAPK8 BMPR1A MAPK14 SMAD4 BMPR2 BMP1 LOXL2 LOXL1 LOX GREM1 CTNNB1 EGF SMAD5 SMAD9 SERPINE1 STAT3 WNT1 ZEB2 BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD6 NFKB1 MAPK3 STAT1 TFE3 THBS1 TNF RUNX2 NOG MIR302A LEFTY1 LIF LEF1 SPP1 LEFTY2 TGFBR3 ENG INHBA ITGB6 LTBP1 BMP4 FOXH1 ZNF423 SMAD7 RUNX3 FST FKBP1A SKIL KE1284 Up Regulation, SREBF2 CYP51A1 MDH1 SREBF1 SCD PRKAG2 PRKAB1 HMGCS1 HMGCR PRKAG3 ATF6 NR1H2 ACLY PRKAB2 PRKAA1 PPARGC1B PRKAA2 FASN PRKAG1 SREBF2 PRKACA SCARB1 SIRT1 CREB1 GPAM PIK3CA LDLR PPARG AKT1 AMFR CAMP LPL SP1 MTOR ACACA INS NFYA MBTPS2 IDI1 SEC31B SAR1A FDFT1 MED15 YY1 SEC23A SEC23B SQLE FGF21 GSK3A KPNB1 SEC24A SCAP INSIG2 CDK8 LPIN1 RBP4 SEC31A SEC24B MBTPS1 SEC24D SAR1B ACSS1 DBI SEC13 LSS FDPS MVD RNF139 SEC24C INSIG1 MIR33A MIR33B NR1H3 ABCA1 PPARGC1A PPARA SIRT6 KE1285 Up Regulation, Unsaturated fatty acid ECH1 ECHDC2 ECHDC1 ECHDC3 ACSS2 DECR1 ACSL1 ACSL3 ACSL4 FASN ACSL6 ACLY ACSL5 SCD ECHS1 HADH ACACA PC ACAA2 MECR ACACB PECR ELOVL5 PLA2G4A FADS2 FADS1 ELOVL2 ACOT2 PLA2G6 ACOT1 PLA2G5 ACOX3 PLA2G4B ACOX1 ELOVL1 ELOVL3 ELOVL6 SCD5 KE1287 Glutathione synthesis GSTA5 G6PD GGT5 OPLAH GCLC GCLM GPX1 GPX2 GPX3 GPX4 ANPEP GSR GSS GSTA1 GSTM1 GSTM2 GSTT2 IDH1 GGT1 KE1289 Perturbation of cholesterol CYP51A1 HMGCR HMGCS1 DHCR7 FDFT1 FDPS IDI1 LSS MVD SQLE PMVK MVK NSDHL MSMO1 SC5D APOH LRP1 APOC1 ABCG5 MTTP ABCA1 CYP7A1 ABCG8 NPC1L1 SCARB1 APOB CETP LIPA APOC3 APOA1 LDLR APOE STARD3 CD36 CYP27A1 STAR APOA2 LIPC LPL DGAT1 LCAT VDAC1 APOC2 MYLIP OSBPL5 SOAT1 APOA4 NPC2 SORT1 FABP2 SAR1B LDLRAP1 SLC27A4 PCSK9 LPA ABCB11 TSPO VAPA LIPG DHCR24 ACAT2 ANGPTL8 MGAT1 HSD17B7 ANGPTL3 CIDEB LBR EBP TM7SF2 LRPAP1 NPC1 PLTP KE1290 Glutathione homeostasis GSTA5 G6PD GGT5 OPLAH GCLC GCLM GPX1 GPX2 GPX3 GPX4 ANPEP GSR GSS GSTA1 GSTM1 GSTM2 GSTT2 IDH1 GGT1 KE1292 Activation, JNK HSPA2 HSPA6 HSPA1B HSPA1L PTPRR TAOK2 RASGRF1 NFATC3 ARAF CACNA1S CACNA1F PDGFRB RRAS NTRK2 CACNA1C CACNA1D RPS6KA4 CRKL DAXX DDIT3 DUSP1 DUSP4 DUSP6 EGF FGFR1 NR4A1 HSPA8 HSPB1 MAX NTRK1 ECSIT PDGFB PPP3CA PPP3CB PPP3R1 PPP3R2 MAP2K5 RAF1 RPS6KA3 BDNF BRAF TGFB1 TGFB2 TGFBR1 TGFBR2 IL1R2 CASP3 MAPKAPK5 CD14 CDC42 PPM1B CACNA1E MAP3K14 TNFRSF1A CACNB1 FGFR3 NFKB2 MKNK2 RELB SOS1 PLA2G4A FGF2 FGF7 PRKACB PRKCA PRKACG RELA HRAS MAPK11 CHUK AKT3 TAB1 MAP3K8 ATF2 MAPK14 EGFR ELK1 AKT1 AKT2 TAB2 FOS GRB2 FAS IKBKB IL1A IL1B IL1R1 FASLG JUN KRAS ARRB1 ARRB2 MAPT MAP3K1 MAP3K5 MYC ATF4 NFKB1 NRAS PPP3CC PRKACA PRKCD PRKCG MAPK1 MAPK3 MAPK7 MAPK8 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP2K7 RAC1 MAPK12 MAP2K4 SRF MAP3K7 TGFB3 TNF TP53 TRAF2 TRAF6 IKBKG MKNK1 RPS6KA5 MAPKAPK2 FGFR2 FGF21 FGF8 FGF1 FGF23 NGF FGFR4 MAP4K2 NF1 PDGFA MAP3K2 MAP4K1 CRK GADD45A JUND MEF2C MAP3K4 MAP3K11 NFATC1 PAK1 PAK2 NLK RAC2 RASA2 SOS2 MAP3K12 MAP4K3 MAP3K6 MAP3K13 MAP4K4 FGF10 FGF4 FGF20 FGF9 FGF6 FGF5 FGF18 ELK4 GNG12 FGF3 FLNA GNA12 RAP1A RAP1B RASA1 STK4 MAPK8IP1 DUSP2 FGF19 MAPK8IP2 FLNC FLNB DUSP10 STMN1 PPP5C CACNA2D2 CACNG5 CACNG4 CACNG7 CACNG6 CACNA2D4 CACNA2D3 CACNB4 CACNG3 PTPN7 RASGRP2 FGF22 FGF14 PLA2G4C FGF12 FGF13 RASGRP3 FGF17 PLA2G4D FGF11 PLA2G4F RASGRP4 NTF3 PLA2G4E NTF4 PLA2G4B RASGRP1 RASGRF2 STK3 CACNA1B FGF16 TAOK1 CDC25B CACNG8 CACNG2 CACNA1H CACNA1G CACNG1 RRAS2 CACNA1A CACNA2D1 CACNB2 RAC3 LRRK2 MRAS LAMTOR3 CACNA1I DUSP3 MAPKAPK3 CACNB3 HSPA1A PTPN5 RAPGEF2 DUSP16 DUSP9 TAOK3 MAPK8IP3 DUSP8 PPP5D1P DUSP7 MAP3K20 PPM1A KE1299 Activation, AKT BAD ITGA3 IBSP FLT4 KITLG LAMA3 EIF4B FGFR1 JAK2 PDGFB FLT1 IL7 CDC37 RHEB CSF3 RPS6KB1 CCND3 PDGFRB IFNA6 IFNA8 KDR RAF1 PRKAA1 CASP9 MDM2 IFNA21 RPS6 EGF COL2A1 PDPK1 IFNAR1 IFNA5 IFNA16 NTRK2 ITGB1 ANGPT1 KIT PRKAA2 ITGA2 NOS3 DDIT4 IRS1 INSR IFNB1 PTEN RPS6KB2 BDNF IFNA10 COL4A1 EIF4EBP1 IFNA1 NTRK1 ITGA1 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 IGF1 PIK3CB LAMC2 CREB3L3 FGFR3 IL4R HSP90AA1 PHLPP1 GSK3B LAMB1 MAPK1 IL2RB MAPK3 TSC2 IKBKB PPP2CB CCNE1 AKT2 PIK3R2 PIK3CG CREB3 COL1A1 VTN NFKB1 IL2 CCND1 CDKN1B VEGFA IL4 PPP2CA FN1 SOS1 ATF2 AKT3 PIK3R3 FASLG STK11 CREB1 FOXO3 PIK3CA CDKN1A MAP2K2 ATF4 LAMA5 KRAS IL2RA PDGFRA LAMC1 RAC1 IL6 TLR4 MYC TLR2 THBS1 FGF2 FGF7 IGF1R PIK3R5 TP53 RPTOR AKT1 MCL1 CREB3L4 PIK3R1 CREB5 EGFR IL2RG EIF4E BCL2L11 PRKCA CREB3L1 IFNAR2 JAK1 COL1A2 TSC1 MLST8 MAP2K1 THBS3 PTK2 BCL2L1 PIK3CD BCL2 LAMB2 HRAS GRB2 CREB3L2 CSF1 IFNA2 MTOR NRAS CHUK ATF6B INS IKBKG PIK3R6 RELA HGF NGFR FGFR2 GNB5 ANGPT2 SOS2 SGK2 SGK3 GYS1 FGF21 CDK6 MET FGF8 GYS2 FGF1 SGK1 SPP1 CCND2 FGF23 PGF TEK FLT3 CDK2 GNG13 EPO NGF CDK4 ITGAV PDGFC VEGFC IL6R FGFR4 TGFA VEGFD CHRM1 PDGFD VEGFB RELN PDGFA ITGB3 TNC FGF10 FGF4 GNB1 FGF20 COL4A4 ITGB5 OSM FGF9 JAK3 FGF6 GNB3 LAMA4 ITGB6 PCK1 GNG11 GNGT1 G6PC1 ITGB4 COL4A2 ITGA11 FGF5 COL6A1 COL6A2 OSMR FGF18 GNG3 COL6A3 IL3 SYK GNGT2 GNG8 GNG4 TNXB COL4A3 GNB2 GNG12 GNG5 GNG7 THBS2 GNG2 FGF3 EPOR COL4A5 GNG10 PKN2 FGF19 IL7R PRL CD19 LPAR1 BRCA1 PHLPP2 COL9A2 LAMC3 LPAR2 PPP2R5A PPP2R5B FGF22 FLT3LG LAMB4 PPP2R3C COL9A3 HSP90AB1 EFNA2 TCL1A PCK2 ANGPT4 LAMA1 FGF14 RBL2 COMP VWF COL9A1 PPP2R5D GHR THBS4 PRLR FGF12 GNB4 TNR CSF3R TNN PKN1 FGF13 CHAD GH2 CSH1 LPAR6 G6PC3 EPHA2 EFNA3 LPAR4 G6PC2 PIK3AP1 FGF17 THEM4 PKN3 FGF11 HSP90B1 IGF2 EFNA1 LPAR3 COL6A5 CCNE2 PPP2R2D EIF4E1B CHRM2 F2R EFNA5 LPAR5 IL3RA NTF3 LAMB3 COL4A6 COL6A6 CSH2 TCL1B NTF4 EFNA4 ITGA2B PPP2R3A PPP2R2C ITGA8 PPP2R5C ITGA6 PPP2R1A ITGB8 ITGA4 MYB ITGA7 EIF4E2 PPP2R1B ITGB7 ITGA10 ITGA9 PPP2R5E PPP2R2B ITGA5 PPP2R3B CSF1R LAMA2 PPP2R2A GH1 KE1300 Activation, mTORC1 CDC42 ULK2 RHEB PRKAG2 RPS6KB1 PRKAB1 PRKAG3 PRKAB2 PRKAA1 PRR5L PRKAA2 DDIT4 PRKAG1 EIF4EBP1 AKT1S1 HMGCR TSC2 MAPKAP1 RAC1 RPTOR AKT1 PRKCA RICTOR TSC1 MLST8 ULK1 MTOR IDI1 RRAGA ULK3 DDIT4L PRR5 FKBP1A RRAGC RRAGD RRAGB KE1306 Increase, De novo lipogenesis PRKAG2 PRKAB1 PRKAG3 ACSS2 ACLY PRKAB2 PRKAA1 PRKAA2 FASN PRKAG1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA PDHA1 ABHD5 PRKAR2A HILPDA PLIN1 ACSBG1 BCKDHA KE1310 Activation, PI3K BAD ITGA3 IBSP FLT4 KITLG LAMA3 EIF4B FGFR1 JAK2 PDGFB FLT1 IL7 CDC37 RHEB CSF3 RPS6KB1 CCND3 PDGFRB IFNA6 IFNA8 KDR RAF1 PRKAA1 CASP9 MDM2 IFNA21 RPS6 EGF COL2A1 PDPK1 IFNAR1 IFNA5 IFNA16 NTRK2 ITGB1 ANGPT1 KIT PRKAA2 ITGA2 NOS3 DDIT4 IRS1 INSR IFNB1 PTEN RPS6KB2 BDNF IFNA10 COL4A1 EIF4EBP1 IFNA1 NTRK1 ITGA1 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 IGF1 PIK3CB LAMC2 CREB3L3 FGFR3 IL4R HSP90AA1 PHLPP1 GSK3B LAMB1 MAPK1 IL2RB MAPK3 TSC2 IKBKB PPP2CB CCNE1 AKT2 PIK3R2 PIK3CG CREB3 COL1A1 VTN NFKB1 IL2 CCND1 CDKN1B VEGFA IL4 PPP2CA FN1 SOS1 ATF2 AKT3 PIK3R3 FASLG STK11 CREB1 FOXO3 PIK3CA CDKN1A MAP2K2 ATF4 LAMA5 KRAS IL2RA PDGFRA LAMC1 RAC1 IL6 TLR4 MYC TLR2 THBS1 FGF2 FGF7 IGF1R PIK3R5 TP53 RPTOR AKT1 MCL1 CREB3L4 PIK3R1 CREB5 EGFR IL2RG EIF4E BCL2L11 PRKCA CREB3L1 IFNAR2 JAK1 COL1A2 TSC1 MLST8 MAP2K1 THBS3 PTK2 BCL2L1 PIK3CD BCL2 LAMB2 HRAS GRB2 CREB3L2 CSF1 IFNA2 MTOR NRAS CHUK ATF6B INS IKBKG PIK3R6 RELA HGF NGFR FGFR2 GNB5 ANGPT2 SOS2 SGK2 SGK3 GYS1 FGF21 CDK6 MET FGF8 GYS2 FGF1 SGK1 SPP1 CCND2 FGF23 PGF TEK FLT3 CDK2 GNG13 EPO NGF CDK4 ITGAV PDGFC VEGFC IL6R FGFR4 TGFA VEGFD CHRM1 PDGFD VEGFB RELN PDGFA ITGB3 TNC FGF10 FGF4 GNB1 FGF20 COL4A4 ITGB5 OSM FGF9 JAK3 FGF6 GNB3 LAMA4 ITGB6 PCK1 GNG11 GNGT1 G6PC1 ITGB4 COL4A2 ITGA11 FGF5 COL6A1 COL6A2 OSMR FGF18 GNG3 COL6A3 IL3 SYK GNGT2 GNG8 GNG4 TNXB COL4A3 GNB2 GNG12 GNG5 GNG7 THBS2 GNG2 FGF3 EPOR COL4A5 GNG10 PKN2 FGF19 IL7R PRL CD19 LPAR1 BRCA1 PHLPP2 COL9A2 LAMC3 LPAR2 PPP2R5A PPP2R5B FGF22 FLT3LG LAMB4 PPP2R3C COL9A3 HSP90AB1 EFNA2 TCL1A PCK2 ANGPT4 LAMA1 FGF14 RBL2 COMP VWF COL9A1 PPP2R5D GHR THBS4 PRLR FGF12 GNB4 TNR CSF3R TNN PKN1 FGF13 CHAD GH2 CSH1 LPAR6 G6PC3 EPHA2 EFNA3 LPAR4 G6PC2 PIK3AP1 FGF17 THEM4 PKN3 FGF11 HSP90B1 IGF2 EFNA1 LPAR3 COL6A5 CCNE2 PPP2R2D EIF4E1B CHRM2 F2R EFNA5 LPAR5 IL3RA NTF3 LAMB3 COL4A6 COL6A6 CSH2 TCL1B NTF4 EFNA4 ITGA2B PPP2R3A PPP2R2C ITGA8 PPP2R5C ITGA6 PPP2R1A ITGB8 ITGA4 MYB ITGA7 EIF4E2 PPP2R1B ITGB7 ITGA10 ITGA9 PPP2R5E PPP2R2B ITGA5 PPP2R3B CSF1R LAMA2 PPP2R2A GH1 PIK3C2A PIK3C2B PIK3C2G PIK3R4 KE1339 Increase, intracellular calcium GJB6 GJC2 ADRA1D ADRA1B ADRA1A GNAO1 ATP2A3 RYR3 CACNA1C CACNA1D CACNA1S RGS9 CHRM3 CHRM4 ADRB3 STIM2 GJC1 GJB4 GJB3 GJB5 ANXA6 KCNB1 KCNJ5 ATP1A4 ATP1B2 ATP1B3 GJD2 SLC8A3 CACNA1E GJA9 CASQ2 ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB2 ADCY4 GJA1 GNAQ GNAS ITPR1 ITPR2 ITPR3 ARRB1 ARRB2 ATP2A2 PLCB3 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ RYR1 CACNB1 CALM1 CALM2 CALM3 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G CAMK1 GNB5 CHRM1 ADRB1 GNAI1 SFN ATP2B1 ATP2B2 ATP2B3 GNG13 RGS10 RYR2 SLC8A1 GNA11 GNAI2 GNAI3 GNAZ GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG11 GNGT1 KCNJ3 GNG2 PRKAR2A PRKD1 GNG12 GNG8 YWHAQ GJB1 GRK5 GRK6 GJA5 CALR GJB2 ATP1B1 FXYD2 GJA8 CHRM2 GNB4 RGS1 YWHAB PLN GJA4 RGS4 YWHAE YWHAG YWHAH YWHAZ CACNA1B CHRM5 ORAI1 FKBP1A GJA3 CACNA1A CASQ1 RGS19 RGS14 PKIG RGS17 GRK4 PKIA PKIB RGS2 RGS3 RGS7 RGS16 RGS18 CACNB3 RGS5 RGS20 RGS11 RGS6 KE1349 Activated, presynaptic neuron 1 STX1B SYT1 RIMS1 NAPA CPLX1 UNC13B RAB3A ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2B1 CLTCL1 SLC25A4 VAMP2 DNM1 SNAP25 STXBP1 CLTA CLTC SLC18A2 STX1A SLC38A1 PARK7 SYN1 DNM1L CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 SLC6A4 CACNA1A SLC18A3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE1350 Increased, glutamate LTA GRM1 PSAT1 IL6ST IL10 IL12A INSR IRS1 SMAD2 SMAD3 BDNF SHMT1 SLC2A1 STAT3 TGFB1 TGFB2 TGFBR1 TGFBR2 IL1R2 CNTF ADCY1 ADCY3 ADCY8 CREB1 DLD AKT1 FGF2 PLCB1 FOS GOT1 GRIA1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D IFNG IFNGR1 IFNGR2 IGF1 IL1A IL1B IL1R1 IL4 IL4R IL6 IL13 JAK1 SMAD4 NFKB1 NFKB2 NOS1 PLCB2 PLCB3 PLCB4 PPP1CB PRKACA PRKCA PRKCB PRKCG MAPK1 MAPK3 BCL2 STAT1 TGFB3 TNF TNFRSF1A TNFRSF1B TRAF5 CALM1 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G SOCS3 PHGDH GLS2 DISC1 GLS GRM5 IL6R LIF NGF PDHA1 PSPH SHMT2 SLC1A1 SLC2A3 STAT6 TGFBR3 DLAT GRIA2 IL10RB PPP1CA CFL1 GFAP SMAD7 SLC38A2 LRRC8A SLC1A4 SLC38A1 CAMKK1 SLC38A5 GRIN3A GRIN3B DAO GRM2 GRM4 GRM7 GRM8 IL10RA IL13RA1 GLUL SLC7A10 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 SLC17A7 SLC17A6 SLC1A3 SLC1A6 SLC38A3 LRRC8B NSMF TRPM4 LRRC8D SRR LRRC8E CAMKK2 ARC IL12B PPP1CC SLC1A2 LRRC8C SLC6A9 KE1362 Increased, hippocampal hyperdepolarization GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C STAT3 CDH2 GABRG3 GABRA5 GABRD GABRQ CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B SLC1A1 GLS2 SLC7A11 NRG1 GRM5 ERBB4 GRM3 GNA11 CRTC1 GRIA2 DLG4 HOMER1 GRIP1 NRXN3 HDAC10 EFNB2 SDCBP GRIN3B GRIN3A GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1363 Increased, epilepsy GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C STAT3 CDH2 GABRG3 GABRA5 GABRD GABRQ CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B SLC1A1 GLS2 SLC7A11 NRG1 GRM5 ERBB4 GRM3 GNA11 CRTC1 GRIA2 DLG4 HOMER1 GRIP1 NRXN3 HDAC10 EFNB2 SDCBP GRIN3B GRIN3A GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1365 Increase, Apoptosis BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A LTA IRF2 IRF3 MDM2 CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 MIR29A IRF1 IRF5 GZMB PRF1 TRAF1 IRF4 TNFRSF21 HELLS IGF2 NFKBIE TP73 SCAF11 KE1391 Activation of Cyp2E1 CYP51A1 CYP26B1 CYP46A1 CYP17A1 CYP7A1 CYP2B6 CYP26A1 CYP26C1 CYP24A1 CYP2D6 CYP27B1 CYP2E1 CYP27A1 CYP2C9 CYP2C8 CYP11A1 CYP1A1 CYP1A2 CYP3A4 CYP2C19 CYP11B2 CYP2R1 POR CYP19A1 CYP3A7 CYP11B1 CYB5A CYP3A5 CYP2A6 CYP1B1 CYP3A43 CYP2C18 CYP4A22 CYP2S1 CYP4F2 CYP4F12 CYP4F8 CYP4B1 CYB5R4 CYB5R3 CYB5B CYP20A1 CYP2G1P CYP2J2 CYP4V2 CYP2U1 CYB5R1 CYB5R2 CYP4F11 CYP4F22 CYP4Z1 CYP4X1 CYP27C1 CYP2F1 CYP2A13 CYP2A7 CYP2W1 CYP39A1 CYP7B1 CYP8B1 CYP4A11 CYP4F3 KE1392 Increase, Oxidative Stress BAD MAP3K9 CDC42 APAF1 TRAF3 PCNA CASP9 C1R CASP3 C1QA C1S TNFRSF1B BAK1 MAP2K4 MAP3K1 NFKB1 MAPK10 CDKN1B CDKN1A TRAF2 CDKN1C MAPK13 BCL2 CYCS TRAF6 TNF GADD45A TRAF1 TNK2 C5 C1QB CR2 NFKBIE C1QC C2 C3AR1 C5AR1 C4B TDP2 BAG4 NOX5 MT1X NFIX NOX1 CYBB HMOX1 SOD2 SOD3 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NOX4 SOD1 SP1 XDH CAT NOX3 TXNRD2 TXNRD1 TXN2 MGST1 UGT1A6 NOS2 ICAM1 NRF1 RHEB MDM2 PTEN MAP2K3 PTGS2 SIRT1 RPS6KA5 IKBKB CCNE1 MAPK8 IL1A ATF2 CREB1 PIK3CA IL6 TP53 AKT1 FOXO1 PINK1 TSC1 CXCL8 BCL2L1 MAP3K5 MTOR IKBKG CDK2 CUL3 IPCEF1 KEAP1 CHEK1 PIP GSX1 ATR KE1393 Hepatocytotoxicity BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A KE1394 Induction, persistent proliferation/sustained proliferation CRKL ITGA1 ITGB1 PTEN PTPN11 PXN RAF1 STAT3 ELK1 FOS GAB1 GRB2 HRAS JUN PIK3CA MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTGS2 PTK2 SOS1 SRC MAP4K1 CRK PTK2B RAPGEF1 HGF MET PAK1 RAP1A RAP1B RASA1 DOCK1 FLT4 LRP6 FGFR1 ULK2 FLT1 RHEB PDGFRB WNT1 KDR APC MDM2 NTRK2 DEPTOR KIT BRAF SHC1 LRP5 REL INSR NTRK1 AKT1S1 JAK2 CTNNB1 FZD6 RETN PIK3CB FGFR3 GSK3B NFKBIA TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 CDKN1A KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 PIK3CD RELA MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 NGFR FGFR2 TCF3 RUNX1T1 SOS2 SALL4 ZBTB16 BCL9 TEK FLT3 RARA LEF1 PML FGFR4 PYGO1 IL6R JUP GAREM2 EPHA2 NFKBIE KSR1 CSF1R TELO2 TTI1 KE1413 Reduced, presynaptic neuron 2 activity STX1B SYT1 RIMS1 NAPA CPLX1 UNC13B RAB3A ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2B1 CLTCL1 SLC25A4 VAMP2 DNM1 SNAP25 STXBP1 CLTA CLTC SLC18A2 STX1A SLC38A1 PARK7 SYN1 DNM1L CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 SLC6A4 CACNA1A SLC18A3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE1414 Decreased, GABA AKR7A2 DPEP1 MAOB ABAT GAD2 PON3 GAD1 GLS GLS2 ADHFE1 ALDH5A1 KE1415 Reduced, GABA-A receptor activation GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2B1 ABAT GAD2 GAD1 GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE1417 NFE2/Nrf2 repression TGFB2 HMOX1 PDGFB TGFB1 SOD3 SLC2A1 EGR1 TGFBR2 MAFG AGER GCLC GCLM HSP90AA1 GSTP1 GSTT2 GGT1 GSR PPARD HBEGF NFE2L2 GSTM1 TXN CES5A G6PD SQSTM1 GSTM4 CES2 GPX2 NQO1 SLC2A4 GSTA5 RXRA CES1 GPX3 GSTM2 GSTA1 HGF ABCC2 SLC2A3 ABCC3 ABCC4 SLC2A12 SLC7A11 NRG1 TGFA SLC6A20 SLC6A19 UGT1A1 GSTA2 EPHA3 FTL SLC5A5 TXNRD3 TXNRD1 UGT1A9 UGT1A4 CYP2A6 ALDH3A1 PRDX1 DNAJB1 UGT1A6 CES3 UGT1A7 PTGR1 ABCC5 CBR1 FTH1 HSP90AB1 FGF13 SLC6A3 EPHA2 UGT2B7 SERPINA1 SRXN1 ME1 KEAP1 SLC5A1 SLC6A4 SLC2A2 MAFF CYP4A11 ADH7 SLC6A13 SLC6A7 SLC39A9 SLC6A16 SLC6A15 MGST2 BLVRB SLC5A4 SLC6A2 SLC39A14 SLC2A9 SLC39A7 SLC5A7 PRDX6 SLC5A9 SLC6A8 SLC6A6 SLC6A11 SLC39A11 SLC2A11 GSTM5 GSTM3 SLC2A8 SLC5A6 SLC39A8 SLC39A5 SLC5A2 SLC39A6 SLC39A3 SLC2A5 PGD MGST3 SLC39A1 SLC39A4 SLC39A12 SLC5A12 SLC2A13 SLC5A10 SLC6A1 SLC5A11 CBR3 SLC2A6 SLC6A18 SLC39A2 SLC39A13 SLC6A5 GSTA4 CES4A SLC2A14 GSTA3 SLC6A9 SLC39A10 SLC6A17 SLC2A7 SLC2A10 SLC5A3 HSPA1A SLC5A8 SLC6A14 FYN RBX1 INSR YES1 CEBPB GSK3B SRC PGAM5 EPHB2 PIK3CA PRKCA MAPK8 MAF CUL3 AIMP2 KE1421 Activated, LXR NR1H3 CYP2B6 CYP7A1 FASN SCD ABCG5 ABCG8 SREBF1 CYP3A4 RXRA KE1422 Reduced, PPARalpha NR1H3 CPT1A ACADM CPT2 CYP7A1 CDK1 KLK15 CCND1 APOC3 APOA1 MYC APOA2 RXRA PPARA SLC27A1 CDK4 DBI FABP1 PLTP APOA5 SCP2 UGT1A9 ACAA1 EHHADH CYP8B1 CYP4A11 SCD HMGCS2 PDPK1 ACSL1 OLR1 UCP1 PPARD PPARG FADS2 CD36 CYP27A1 RXRG LPL ADIPOQ GK RXRB SLC27A5 SORBS1 FABP3 SLC27A4 CPT1C FABP4 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ME1 UBC ACOX1 ILK KE1458 Pulmonary fibrosis CXCL2 HMOX1 PDGFB MMP9 TGFB1 CSF3 EGF CEBPB TERC IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 HGF EDN1 BMP7 TIMP1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 PDGFA SMAD7 CCR2 ELMOD2 CYSLTR2 TERT ATP11A SFTPA1 PTX3 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IL12B SKIL GREM1 SFTPC KE1469 Activation, Transforming Growth Factor beta pathway CTNNB1 EGF SMAD2 SMAD3 SMAD5 SMAD9 SERPINE1 STAT3 TGFB1 TGFBR1 TGFBR2 WNT1 ZEB2 BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD4 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG MIR302A LEFTY1 LIF LEF1 SPP1 LEFTY2 TGFBR3 ENG INHBA ITGB6 LTBP1 BMP4 FOXH1 ZNF423 SMAD7 RUNX3 FST FKBP1A SKIL KE1488 Glutamate dyshomeostasis LTA GRM1 PSAT1 IL6ST IL10 IL12A INSR IRS1 SMAD2 SMAD3 BDNF SHMT1 SLC2A1 STAT3 TGFB1 TGFB2 TGFBR1 TGFBR2 IL1R2 CNTF ADCY1 ADCY3 ADCY8 CREB1 DLD AKT1 FGF2 PLCB1 FOS GOT1 GRIA1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D IFNG IFNGR1 IFNGR2 IGF1 IL1A IL1B IL1R1 IL4 IL4R IL6 IL13 JAK1 SMAD4 NFKB1 NFKB2 NOS1 PLCB2 PLCB3 PLCB4 PPP1CB PRKACA PRKCA PRKCB PRKCG MAPK1 MAPK3 BCL2 STAT1 TGFB3 TNF TNFRSF1A TNFRSF1B TRAF5 CALM1 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G SOCS3 PHGDH GLS2 DISC1 GLS GRM5 IL6R LIF NGF PDHA1 PSPH SHMT2 SLC1A1 SLC2A3 STAT6 TGFBR3 DLAT GRIA2 IL10RB PPP1CA CFL1 GFAP SMAD7 SLC38A2 LRRC8A SLC1A4 SLC38A1 CAMKK1 SLC38A5 GRIN3A GRIN3B DAO GRM2 GRM4 GRM7 GRM8 IL10RA IL13RA1 GLUL SLC7A10 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 SLC17A7 SLC17A6 SLC1A3 SLC1A6 SLC38A3 LRRC8B NSMF TRPM4 LRRC8D SRR LRRC8E CAMKK2 ARC IL12B PPP1CC SLC1A2 LRRC8C SLC6A9 KE1489 N/A, Steatohepatisis NR1H3 DDIT3 ERN1 INSR IRS1 PRKAG2 PRKAG3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 SREBF1 TGFB1 XBP1 CASP3 ITCH CASP7 CASP8 IRS2 CDC42 NDUFC2-KCTD14 COX6B2 COX7B2 MLXIP COX8C UQCRHL NDUFA4L2 MLX AKT3 BCL2L11 CYP2E1 EIF2S1 AKT1 AKT2 GSK3B FAS IKBKB IL1A IL1B FASLG IL6 CXCL8 INS JUN MAP3K5 ATF4 NFKB1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 CYCS PPARA MAPK8 MAPK9 BAK1 BAX RAC1 RELA RXRA CCL2 BID TNF TNFRSF1A TRAF2 PIK3R3 SOCS3 ADIPOQ EIF2AK3 BBC3 GSK3A IL6R MIR21 MAP3K11 MT-CO2 NDUFB10 MLXIPL COX4I2 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA13 NDUFB11 NDUFA12 SDHA NR1H4 SMAD7 MT-CO1 UQCRFS1 ADIPOR2 LEPR CYC1 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A MT-CO3 NDUFA4 COX5A UQCR11 NDUFA11 COX6A2 UQCRQ UQCR10 NDUFS7 MT-CYB NDUFS8 UQCRB UQCRC1 UQCRC2 UQCRH COX7A2L ADIPOR1 CEBPA COX6C COX7A1 LEP NDUFA9 PKLR SDHB SDHC SDHD VCAM1 KE1493 Increased Pro-inflammatory mediators ICAM1 ITGB1 SELP IL1A IL6 CXCL8 TNF KNG1 C3 C5 SELPLG C6 C7 ITGA4 ITGAL ITGB2 VCAM1 CCL28 LTA CCL26 CXCL2 IL11 MMP9 CCL22 IL7 TGFB1 CXCL12 CSF3 AREG IL17A CCL20 IFNA6 IFNA8 CXCL6 IL22 IL10 IL33 CCL21 IFNA21 IL21 CXCL9 IL9 IFNA5 IFNA16 IL18 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A CXCL10 IFNB1 IFNA10 IFNA1 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 CNTF CCL23 CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1B IL37 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CCL11 CCL13 CSF1 IFNA2 CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 NFKB1 CX3CL1 CCL17 SPP1 LIF EPO CXCL11 OSM IL26 MMP3 TNFSF13 IL3 MMP1 TNFSF13B CTF1 CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IL2RA IL2RB IL2RG IL4R IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG HLA-DRA HLA-DRB1 CD4 PDGFA KE1494 Leukocyte recruitment/activation ICAM1 ITGB1 SELP IL1A IL6 CXCL8 TNF KNG1 C3 C5 SELPLG C6 C7 ITGA4 ITGAL ITGB2 VCAM1 KE1496 Increased, secretion of proinflammatory mediators CCL28 LTA CCL26 CXCL2 IL11 MMP9 CCL22 IL7 TGFB1 CXCL12 CSF3 AREG IL17A CCL20 IFNA6 IFNA8 CXCL6 IL22 IL10 IL33 CCL21 IFNA21 IL21 CXCL9 IL9 IFNA5 IFNA16 IL18 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A CXCL10 IFNB1 IFNA10 IFNA1 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 CNTF CCL23 CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1A IL1B IL37 IL6 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 TNF CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 NFKB1 CX3CL1 CCL17 SPP1 LIF EPO CXCL11 OSM IL26 MMP3 TNFSF13 IL3 MMP1 TNFSF13B CTF1 CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D KE1501 Increased, extracellular matrix deposition CTNNB1 EGF SMAD2 SMAD3 SMAD5 SMAD9 SERPINE1 STAT3 TGFB1 TGFBR1 TGFBR2 WNT1 ZEB2 BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD4 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG MIR302A LEFTY1 LIF LEF1 SPP1 LEFTY2 TGFBR3 ENG INHBA ITGB6 LTBP1 BMP4 FOXH1 ZNF423 SMAD7 RUNX3 FST FKBP1A SKIL KE1508 CYP2E1 Activation CYP51A1 CYP26B1 CYP46A1 CYP17A1 CYP7A1 CYP2B6 CYP26A1 CYP26C1 CYP24A1 CYP2D6 CYP27B1 CYP2E1 CYP27A1 CYP2C9 CYP2C8 CYP11A1 CYP1A1 CYP1A2 CYP3A4 CYP2C19 CYP11B2 CYP2R1 POR CYP19A1 CYP3A7 CYP11B1 CYB5A CYP3A5 CYP2A6 CYP1B1 CYP3A43 CYP2C18 CYP4A22 CYP2S1 CYP4F2 CYP4F12 CYP4F8 CYP4B1 CYB5R4 CYB5R3 CYB5B CYP20A1 CYP2G1P CYP2J2 CYP4V2 CYP2U1 CYB5R1 CYB5R2 CYP4F11 CYP4F22 CYP4Z1 CYP4X1 CYP27C1 CYP2F1 CYP2A13 CYP2A7 CYP2W1 CYP39A1 CYP7B1 CYP8B1 CYP4A11 CYP4F3 KE1512 Unfolded Protein Response XBP1 ATF6 DDIT3 ERN1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 MBTPS2 BBC3 TNFRSF10B MBTPS1 PMAIP1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE1513 General Apoptosis LTA APAF1 BIRC5 IRF2 IRF3 MDM2 BAD TRAF3 CASP3 CASP7 CASP8 CASP9 TRADD RIPK1 FADD BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR MIR29A BBC3 IRF1 IRF5 PMAIP1 TNFRSF10B GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 MIR29B1 MIR29B2 IRF4 TNFRSF21 HELLS XIAP CASP4 TNFRSF25 CRADD HRK DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BIRC3 TP73 SCAF11 KE1528 Fatty Acid Beta Oxidation, Decreased CHKB CPT1A CPT1B CPT2 CRAT ECI1 DECR1 ACSL1 ACSL3 ACSL4 ACSL6 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL ACSL5 ACSS2 TPI1 SLC25A20 DLD ECHS1 GCDH GK GK2 HADH ACAT1 LIPC LIPE LPL PNPLA2 LIPF KE1538 Decreased protection against oxidative stress NOX5 MT1X NFIX NOX1 CYBB HMOX1 SOD2 SOD3 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT NOX3 TXNRD2 TXNRD1 TXN2 MGST1 UGT1A6 KE1541 Mitochondrial Complex I inhibition ECSIT NDUFB10 NDUFAB1 NDUFA1 NDUFS4 NDUFB5 NDUFB3 NDUFC1 NDUFA2 NDUFS5 NDUFS2 NDUFS6 NDUFB1 NDUFS3 NDUFB6 NDUFA3 NDUFB4 NDUFB8 NDUFB2 NDUFA7 NDUFC2 NDUFA10 MT-ND1 MT-ND2 MT-ND4L MT-ND4 MT-ND5 MT-ND6 NDUFB7 NDUFV2 NDUFS1 NDUFV1 NDUFA8 NDUFV3 NDUFA6 NDUFA5 NDUFAF6 NDUFAF7 TMEM126B NDUFAF2 NUBPL TMEM186 FOXRED1 DMAC1 NDUFAF3 TMEM70 COA1 ACAD9 TIMMDC1 DMAC2 NDUFB11 NDUFAF4 NDUFA13 NDUFA12 NDUFAF1 NDUFB9 KE1575 Activation, Caspase 8 pathway LTA APAF1 BIRC5 IRF2 IRF3 MDM2 BAD TRAF3 CASP3 CASP7 CASP8 CASP9 TRADD RIPK1 FADD BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR MIR29A BBC3 IRF1 IRF5 PMAIP1 TNFRSF10B GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 MIR29B1 MIR29B2 IRF4 TNFRSF21 HELLS XIAP CASP4 TNFRSF25 CRADD HRK DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BIRC3 TP73 SCAF11 KE1579 Increase, proinflammatory mediators (TNFalpha) CDC37 NOX1 APAF1 BAD RAF1 REL SKP1 CASP3 CASP7 CASP8 CASP9 CUL1 TRADD RIPK1 FADD BTRC TANK TAB1 CHUK RFFL MAP3K8 CREBBP CSNK2A1 AKT1 TAB2 TAB3 GRB2 TBK1 HRAS HSP90AA1 IKBKB IL6 JUN KRAS MAP3K1 MAP3K3 MAP3K5 NFKB1 NFKB2 NFKBIA NFKBIB NRAS PPP2CA PRKCZ MAPK1 MAPK3 MAPK8 MAPK9 MAP2K3 MAP2K6 MAP2K7 PSMD2 BAX RAC1 BCL2L1 CCL2 BID MAP2K4 SOS1 MAP3K7 TNF TNFRSF1A TNFRSF1B TRAF2 TXN IKBKG CFLAR MAP3K14 CYBA RFK MAP4K2 TNFAIP3 BIRC2 PLK1 TRAF1 TRAP1 RIPK3 NOXO1 GLUL KSR2 NFKBIE DIABLO OTUD7B PTPRCAP PYGL SMPD2 MADD FBXW11 BIRC3 SELE NSMAF KSR1 CCL28 LTA CCL26 CXCL2 IL11 MMP9 CCL22 IL7 TGFB1 CXCL12 CSF3 AREG IL17A CCL20 IFNA6 IFNA8 CXCL6 IL22 IL10 IL33 CCL21 IFNA21 IL21 CXCL9 IL9 IFNA5 IFNA16 IL18 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A CXCL10 IFNB1 IFNA10 IFNA1 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 CNTF CCL23 CCL7 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1A IL1B IL37 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 CX3CL1 CCL17 SPP1 LIF EPO CXCL11 OSM IL26 MMP3 TNFSF13 IL3 MMP1 TNFSF13B CTF1 CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D KE1581 Disturbance in microtubule dynamic instability CDC42 MARK2 ABL1 DVL1 APC WNT3A STAT3 CDK1 PTEN NTRK1 NTRK2 ROCK1 PRKACA GSK3B EPHB2 RAC1 AKT1 CAMK4 PRKCA GNAQ MAPKAPK2 MAPT SRC TRIO MAP1B PAK1 TIAM1 NTRK3 F2RL2 LIMK1 DIAPH1 RHO CFL2 MAPRE1 PTPRA PHLDB2 TPPP STMN1 AURKB TESK2 CLASP1 DPYSL2 PARD6A MARK1 CLIP1 KIF2C TAOK1 SPRED1 KE1585 Proteasomal dysfunction PSMD11 UBE2B H2AX H2AZ1 IFNG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD7 PSMD8 PSMD9 PSMD12 PSMD13 PSMD6 HLA-A HLA-C NEDD4 UBA1 UCHL1 UBE2D3 HLA-B HLA-E HLA-F HLA-G UCHL3 PSME3 HLA-H PSMB8 PSMB9 PSMB10 PSMD5 PSMD10 PSME1 PSME2 RPN1 RPN2 UBA7 UBB UBE2D1 H2AC4 UBC UBE2D2 KE1587 Fibroproliferative airway lesions CXCL2 HMOX1 PDGFB MMP9 TGFB1 CSF3 EGF CEBPB TERC IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 HGF EDN1 BMP7 TIMP1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 PDGFA SMAD7 CCR2 ELMOD2 CYSLTR2 TERT ATP11A SFTPA1 PTX3 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IL12B SKIL GREM1 SFTPC KE1605 Accumulation of misfolded proteins XBP1 ATF6 DDIT3 ERN1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 MBTPS2 BBC3 TNFRSF10B MBTPS1 PMAIP1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE1607 Increase, Necrosis NOX1 ATG5 ACSL4 TF HMOX1 HSPB1 HMGCR STEAP3 CTH ACSL3 MAP1LC3B ACSL1 CBS ACSL6 CYBB ACSL5 ATG7 CISD1 NCOA4 GCLC GCLM VDAC3 NOX4 GSS MAP1LC3A TP53 VDAC2 GPX4 ALOX15 FDFT1 SLC1A5 POR SAT1 SLC7A11 AKR1C2 SLC3A2 COQ2 AKR1C1 AKR1C3 PCBP2 CP TFRC FTL TXNRD1 SLC38A1 BACH1 SLC11A2 SLC40A1 FTH1 PRNP AIFM2 CHMP5 LPCAT3 GCH1 IREB2 SAT2 PCBP1 CHMP6 FTMT DPP4 SLC39A14 SLC39A8 PHKG2 MAP1LC3C KE1633 Increase in inflammation IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG KE1635 Increase, DNA strand breaks APAF1 ABL1 PCNA CASP3 BRCA2 CASP9 CDK5 MDM2 UPF1 FANCD2 ATF2 ATM TP53 PARP1 H2AX YAP1 BID E2F1 BAX BAK1 CDKN2A TRAF6 LATS1 CDC25C MRE11 BLM PRKDC TRIM28 NABP2 NBN RAD52 RAD51 SMC1A RAD50 DCLRE1C RASSF1 RAD17 RNF8 CHEK2 TP53BP1 MDC1 RAD9A BRCA1 STK3 SMC3 CHEK1 ACTL6A HSF1 ATR TERF2 RIF1 KAT5 TP73 MCPH1 EXO1 POLE2 LIG1 POLE3 NEIL2 POLE ERCC1 RFC1 POLD1 POLB MLH1 XRCC5 RBX1 ERCC2 PMS2 XRCC4 XPC WRN LIG4 FAN1 LIG3 PARP2 MSH2 POLK DDB2 ERCC5 FANCC ERCC3 MGMT POLH RAP1A CUL4B POLD3 APEX1 POLD2 POLE4 RAD23B POLM RPA1 TDG CETN2 USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 RPA3 RPA2 DDB1 HMGB1 CUL4A REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 ERCC8 MSH3 MSH6 ERCC6 KE1669 Increased, DNA damage and mutation POLE2 LIG1 POLE3 NEIL2 POLE ERCC1 RFC1 POLD1 POLB MLH1 XRCC5 RBX1 ERCC2 PMS2 PCNA BRCA2 FANCD2 XRCC4 XPC WRN LIG4 FAN1 LIG3 PARP2 PARP1 ATM H2AX MRE11 MSH2 POLK DDB2 ERCC5 FANCC ERCC3 MGMT POLH RAP1A CUL4B PRKDC RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 EXO1 HUS1B CASP8 ABL1 CCND3 APAF1 CASP9 CCNB1 MDM2 CCNB2 CASP3 CDK5 CDK1 BID FAS BAX E2F1 CCNE1 CCND1 CDKN1B CDKN1A RB1 TP53 AKT1 TLK2 CYCS CREB1 MYC RRM2B SESN1 GADD45B BBC3 CDK6 GADD45A CCND2 TP53AIP1 TNFRSF10B CDK2 GADD45G CDK4 PML PMAIP1 CDC25C CDC25A SFN PIDD1 SMC1A RAD17 CHEK2 RAD1 RAD9A CCNE2 ATRIP CCNB3 TLK1 KE1708 Th17 cell migration and inflammation induction CEBPB IL17A JAK2 STAT3 TRAF3 AKT1 GSK3B IKBKB JAK1 NFKB1 NFKBIB PIK3CA MAPK1 MAPK3 RELA SP1 MAP3K7 TRAF6 IKBKG MAP3K14 CEBPD IL17RA IL17RC IL17RD TRAF3IP2 IL17RE IL17RB IL17F IL17C IL17B IL17D IL25 CD4 TGFB1 TGFBR1 IL22 BMAL1 CLOCK IL21 PPP3CA CD3G SMAD2 CD247 CD3E IFNGR1 PRKCQ IL4R HSP90AA1 HIF1A NFKBIA TYK2 AHR GATA3 MAPK8 IL2 IL23A IFNG MAPK14 IL4 ZAP70 STAT1 PLCG1 IL1B IL2RA IL6 FOS JUN LCK SOCS3 RXRA MTOR FOXP3 NFATC1 RARA IL6R STAT6 CD3D HLA-DMA LAT CRY1 STAT5A RORC PER1 IRF4 IL21R IL27RA IL27 RORA TBX21 NR1D1 RUNX1 NFIL3 IL23R KE1738 SARS-CoV-2 cell entry CTSL ACE2 TMPRSS4 SCARB1 ACAT1 SLC6A19 NRP1 TLR7 TMPRSS2 FURIN KE1743 Increase plasma Ang II ATF1 ATF2 ATF4 ATF6B CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CYP11A1 CYP11B2 CYP21A2 GNAQ HSD3B1 HSD3B2 ITPR1 ITPR2 ITPR3 PLCB2 STAR CMA1 CTSG ACE AGT AGTR1 AGTR2 REN KE1750 Increased inflammatory immune responses ICAM1 ITGB1 SELP IL1A IL6 CXCL8 TNF KNG1 C3 C5 SELPLG C6 C7 ITGA4 ITGAL ITGB2 VCAM1 IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG KE1770 Decrease, Mitochondrial membrane potential SLC25A4 SLC25A5 SLC25A6 UCP1 MT-CO2 NDUFB10 NDUFA13 MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA12 SDHA COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 KE1788 Status epilepticus GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C STAT3 CDH2 GABRG3 GABRA5 GABRD GABRQ CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B SLC1A1 GLS2 SLC7A11 NRG1 GRM5 ERBB4 GRM3 GNA11 CRTC1 GRIA2 DLG4 HOMER1 GRIP1 NRXN3 HDAC10 EFNB2 SDCBP GRIN3B GRIN3A GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1790 Increased, Differentiation to Testis WNT4 CTNNB1 RBFOX2 AMHR2 DMRT1 CBX2 FOXL2 SRY PTGDS MAPK11 FGFR2 AMH SOX9 SRD5A1 PBX1 FGF9 RSPO1 EMX2 WT1 INSL3 GATA4 SOX8 NR5A1 FST DHH KE1812 Increase, Cytochrome c release LTA APAF1 BIRC5 IRF2 IRF3 MDM2 BAD TRAF3 CASP3 CASP7 CASP8 CASP9 TRADD RIPK1 FADD BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR MIR29A BBC3 IRF1 IRF5 PMAIP1 TNFRSF10B GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 MIR29B1 MIR29B2 IRF4 TNFRSF21 HELLS XIAP CASP4 TNFRSF25 CRADD HRK DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BIRC3 TP73 SCAF11 KE1815 Increase, Endoplasmic reticulum stress XBP1 ATF6 DDIT3 ERN1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 MBTPS2 BBC3 TNFRSF10B MBTPS1 PMAIP1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE1816 Mitochondrial dysfunction EMPTY AGK MIPEP TIMM50 MICU1 CLPP TIMM8A YME1L1 PPA2 CLPB PMPCA MFF SFXN4 ATAD3A SPG7 DNAJC19 PAM16 GDAP1L1 GFER LONP1 UBXN1 OXA1L PYCR3 COQ5 NPLOC4 RTN4IP1 UFD1 PYCR2 MSTO1 UBXN6 TMEM126A OPA3 SACS COQ3 PMPCB PITRM1 C1QBP USP9X MFN2 PINK1 STAT2 PRKN OPA1 VCP MCL1 MFN1 MARCHF5 TIMMDC1 TXNRD2 TXN2 PYCR1 HSPD1 TRAK1 DNM1L SLC25A46 MICOS13 HSPA9 HTRA2 AFG3L2 AIFM1 XPNPEP3 PLEK KE1817 Apoptotic cell death BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A LTA IRF2 IRF3 MDM2 CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 MIR29A IRF1 IRF5 GZMB PRF1 TRAF1 IRF4 TNFRSF21 HELLS IGF2 NFKBIE TP73 SCAF11 KE1818 Immune cell activation CD83 CCR5 CRKL FYN IL9 IL17A PDPK1 PTPN11 RAF1 REL SHC1 TGFB1 VIM CARD11 SKAP1 CD3E CD3G CD247 CD4 CD8A CDC42 PSTPIP1 FYB1 MAP3K14 CHUK MAP3K8 CREB1 ATF2 MAPK14 AKT1 FOS GATA3 GRB2 HRAS FAS IKBKB IL1A IL1B IL6 ITPR1 JUN LCK NFKB1 NFKBIA PIK3R1 PIK3R2 PLCG1 PRKCD PRKCQ MAPK1 MAPK3 MAPK8 MAPK9 MAP2K1 MAP2K2 RELA SOS1 MAP3K7 TRAF6 ZAP70 IKBKG CBL CD28 SH2B3 VAV3 MALT1 MAP4K1 CRK PTK2B LAT ICOS TNFRSF9 ITK LCP2 NCK1 NFATC1 NFATC2 PAK1 VAV1 WAS CBLB BCL10 CD3D GRAP2 DBNL IRF4 IL15RA RIPK2 OPRM1 GAB2 KE1819 IFNγ signaling OAS1 IRF9 CYBB IFI6 ICAM1 IFNB1 CXCL10 IRF2 JAK2 CXCL9 NOS2 EIF2AK2 PTPN11 IFNA2 IFNG IFNGR1 IFNGR2 IL1B JAK1 PRKCD SPI1 STAT1 STAT2 H4C14 SOCS1 SOCS3 ISG15 IRF1 REG1A IRF8 IRF4 HLA-B PSMB9 TAP1 GBP1 IFIT2 CIITA KE1825 Increase, Cell death BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A TICAM1 PLA2G4A PARP1 TNF FTL RIPK3 LTA IRF2 IRF3 MDM2 CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TRAF2 IKBKG TP63 MIR29A IRF1 IRF5 GZMB PRF1 TRAF1 IRF4 TNFRSF21 HELLS IGF2 NFKBIE TP73 SCAF11 KE1829 Altered, Thyroid hormone-dependent gene expression TTF2 TTF1 TSHB NPPB BAD FGFR1 RHEB RPS6KB1 RAF1 CASP9 MDM2 RPS6 PRDM16 NOTCH1 WNT4 CTNNB1 AKT1S1 TPO PFKFB2 PAX8 ADRB3 IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 KDM1A RPS6KA6 FGF21 NPY THRA TBC1D4 ITGAV SHH DIO2 ITGB3 PRKG2 MAP4K5 NPR1 SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG AQP7 SLC16A10 MGLL MC4R PLIN1 ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 ZNF516 KLB KDM3B KE1842 Prolonged TLR9 activation IRAK3 PTPN6 TICAM1 IFNA1 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNAR1 IFNB1 IL12A CXCL10 IRF3 LBP CXCL9 TLR9 TLR3 TRAF3 CASP8 RIPK1 FADD CD14 IKBKE SARM1 RNF31 CUEDC2 CTNNAL1 SFTPD CD180 TRAFD1 PELI2 FBXW5 PELI3 SIGIRR PELI1 MIR105-1 TAB2 IRAK2 TLR4 TLR2 SMAD6 TAB3 SQSTM1 MYD88 SOCS1 MIR146A AKT3 TAB1 CHUK MAP3K8 MAPK14 AKT1 AKT2 FOS PIK3R5 TBK1 IFNA2 IFNAR2 IKBKB IL1B IL6 CXCL8 IRAK1 IRF7 JUN NFKB1 NFKB2 NFKBIA IRAK4 TLR8 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 TOLLIP MAPK1 MAPK3 MAPK8 MAPK11 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP2K7 RAC1 RELA MAPK12 CCL3 CCL4 CCL5 MAP2K4 MLST8 STAT1 MAP3K7 TNF TRAF6 PIK3R3 IKBKG CD80 CD86 CD40 BTK TNFAIP3 MIR155 IRF5 MIR98 TLR7 CXCL11 SPP1 SYK PLK1 RNF41 TIRAP TMED7 MIRLET7E OTUD5 ZMYND11 RBCK1 MBL2 RNF216 USP7 CISH TREM1 SFTPA2 MIRLET7I TLR1 TLR5 TLR6 LY96 TICAM2 CYLD TIFA IL12B KE1846 Thrombosis and Disseminated Intravascular Coagulation SERPINE1 FGG FGA FGB PLAU F2 F12 KLKB1 KLK1 PLAT PLG F11 F9 VWF F3 F10 F13B SERPINF2 F8 F5 F7 SERPINB2 KE1847 Increased SARS-CoV-2 production CTSL ACE2 TMPRSS4 SCARB1 ACAT1 SLC6A19 NRP1 TLR7 TMPRSS2 FURIN KE1848 Toll Like Receptor (TLR) Dysregulation IRF3 TICAM1 TRAF3 TLR3 TLR9 IKBKE REL NFKB2 TOLLIP MAPK1 TLR8 IKBKB NFKB1 TLR4 TLR2 MYD88 TRAF6 TBK1 IRAK1 IRF7 IRAK4 CHUK IKBKG RELA RELB TLR7 TIRAP TLR1 TLR5 TLR6 TICAM2 KE1851 Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) ATF1 ATF2 ATF4 ATF6B CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CYP11A1 CYP11B2 CYP21A2 GNAQ HSD3B1 HSD3B2 ITPR1 ITPR2 ITPR3 PLCB2 STAR CMA1 CTSG ACE AGT AGTR1 AGTR2 REN IL11 TGFB1 TGFBR1 ACTA2 RRAS RAF1 IL6ST IL11RA TGFBR2 SMAD3 PTPN11 ACE2 MAPK1 HIF1A COL1A1 MAP2K6 SMAD4 COL1A2 SP1 NOX4 CCN2 JUND PDGFD F12 RACK1 MAS1 KE1852 Increased Ang II type 1 receptor (AT1R) IL11 TGFB1 TGFBR1 ACTA2 RRAS RAF1 IL6ST IL11RA TGFBR2 SMAD3 PTPN11 ACE2 MAPK1 HIF1A COL1A1 MAP2K6 SMAD4 AGTR1 COL1A2 SP1 NOX4 AGT CCN2 JUND PDGFD F12 RACK1 MAS1 KE1853 Hyperactivation of ACE/Ang-II/AT1R axis ATF1 ATF2 ATF4 ATF6B CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CYP11A1 CYP11B2 CYP21A2 GNAQ HSD3B1 HSD3B2 ITPR1 ITPR2 ITPR3 PLCB2 STAR CMA1 CTSG ACE AGT AGTR1 AGTR2 REN IL11 TGFB1 TGFBR1 ACTA2 RRAS RAF1 IL6ST IL11RA TGFBR2 SMAD3 PTPN11 ACE2 MAPK1 HIF1A COL1A1 MAP2K6 SMAD4 COL1A2 SP1 NOX4 CCN2 JUND PDGFD F12 RACK1 MAS1 KE1857 Platelet-neutrophil interactions, Increased ICAM1 TGFB2 TGFB1 PF4 SELP CD40 CD40LG CCL2 TGFB3 IL1B CCL5 TLR4 TLR2 TLR7 SELPLG SELE VCAM1 KE1868 Hyperinflammation CCL28 LTA CCL26 CXCL2 IL11 MMP9 CCL22 IL7 TGFB1 CXCL12 CSF3 AREG IL17A CCL20 IFNA6 IFNA8 CXCL6 IL22 IL10 IL33 CCL21 IFNA21 IL21 CXCL9 IL9 IFNA5 IFNA16 IL18 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A CXCL10 IFNB1 IFNA10 IFNA1 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 CNTF CCL23 CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1A IL1B IL37 IL6 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 TNF CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 NFKB1 CX3CL1 CCL17 SPP1 LIF EPO CXCL11 OSM IL26 MMP3 TNFSF13 IL3 MMP1 TNFSF13B CTF1 CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D KE1869 Diminished protective oxidative stress response NOX5 MT1X NFIX NOX1 CYBB HMOX1 SOD2 SOD3 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT NOX3 TXNRD2 TXNRD1 TXN2 MGST1 UGT1A6 KE1897 increased MyD88 activation TLR9 TLR8 NFKB1 IL1A TLR4 TLR2 MYD88 TRAF6 IRAK1 JUN TLR7 TLR10 TLR1 TLR5 TLR6 TIFA UBE2N UBE2V1 KE1901 Interferon-I antiviral response, antagonized by SARS-CoV-2 OAS1 OAS3 EIF2AK2 MAVS RIGI IFIH1 IRF3 TRAF3 IFNAR1 IRF9 IKBKE TLR3 ACE2 TLR9 TYK2 OAS2 STAT1 IFNAR2 JAK1 STAT2 MYD88 TRAF6 TBK1 IRF7 IRAK4 TLR4 TLR2 TLR7 TREML4 TMPRSS2 TLR6 KE1908 Cilia Beat Frequency, Decreased PKD1 NEK9 OCRL AHI1 ZMYND10 KATNIP CNGB1 DNAAF6 POMGNT1 KIZ RPGRIP1 EFHC1 ARL2BP RP1 ODAD1 DNAH11 RSPH4A MAK DNAH6 NEK2 CENPF DDX59 TRIM32 DNAL1 TTLL5 DNAI1 USP9X DNAAF11 ATXN10 NEK1 POC1B AK7 PLK4 NME7 DCDC2 TBC1D32 CEP78 CCNO DNAAF1 CFAP418 HYDIN RAB28 PKD1L1 CFAP298 CCDC28B RSPH1 CFAP410 POC1A DNAAF5 DNAAF2 TUB CFAP52 DNAAF19 DNAAF3 ODAD2 TAPT1 FAM161A PKHD1 DNAI2 CFAP53 GALNT11 PCARE NME9 RP1L1 TOPORS ODAD3 HYLS1 CNGA1 ODAD4 MCIDAS DNAAF4 CCNQ CCDC39 TULP1 PDE6D ADCY6 PIK3R4 ZIC2 NPHP3 INVS IFT80 GLI2 IFT27 IFT52 CLUAP1 GLI3 IFT57 PKD2 IFT81 TTC21B SMO IFT172 CCDC65 GAS8 FLCN DRC1 TRAF3IP1 OFD1 CC2D2A EVC PIBF1 KIAA0586 RP2 ZNF423 RPGRIP1L CSPP1 CEP41 SUFU B9D1 UNC119 CEP164 CILK1 RAB23 ARL6 CEP104 WDR35 TCTN3 B9D2 MKKS TTBK2 NPHP4 DYNC2LI1 ARL3 WDPCP NPHP1 INPP5E TMEM138 SCLT1 TMEM237 WDR19 TMEM67 C2CD3 TCTN2 CEP120 ARL13B EVC2 CEP83 CEP19 TMEM107 BBS10 BBS12 TMEM17 TMEM216 DYNC2H1 CPLANE1 KIAA0753 TCTN1 TMEM231 SPAG1 RSPH3 RSPH9 DNAJB13 SDCCAG8 MKS1 SPATA7 CRX DYNC2I2 IFT43 BBS9 BBS2 GLIS2 DYNC2I1 LCA5 BBS7 BBS4 CCDC40 NEK8 BBS5 LZTFL1 IFT122 INTU ANKS6 TTC8 ANKS3 IQCB1 BBS1 IFT140 XPNPEP3 CEP290 DYNLT2B BBIP1 ALMS1 GPR161 KIF7 KE1912 Motile Cilia Number/Length, Decreased PKD1 NEK9 OCRL AHI1 ZMYND10 KATNIP CNGB1 DNAAF6 POMGNT1 KIZ RPGRIP1 EFHC1 ARL2BP RP1 ODAD1 DNAH11 RSPH4A MAK DNAH6 NEK2 CENPF DDX59 TRIM32 DNAL1 TTLL5 DNAI1 USP9X DNAAF11 ATXN10 NEK1 POC1B AK7 PLK4 NME7 DCDC2 TBC1D32 CEP78 CCNO DNAAF1 CFAP418 HYDIN RAB28 PKD1L1 CFAP298 CCDC28B RSPH1 CFAP410 POC1A DNAAF5 DNAAF2 TUB CFAP52 DNAAF19 DNAAF3 ODAD2 TAPT1 FAM161A PKHD1 DNAI2 CFAP53 GALNT11 PCARE NME9 RP1L1 TOPORS ODAD3 HYLS1 CNGA1 ODAD4 MCIDAS DNAAF4 CCNQ CCDC39 TULP1 PDE6D ADCY6 PIK3R4 ZIC2 NPHP3 INVS IFT80 GLI2 IFT27 IFT52 CLUAP1 GLI3 IFT57 PKD2 IFT81 TTC21B SMO IFT172 CCDC65 GAS8 FLCN DRC1 TRAF3IP1 OFD1 CC2D2A EVC PIBF1 KIAA0586 RP2 ZNF423 RPGRIP1L CSPP1 CEP41 SUFU B9D1 UNC119 CEP164 CILK1 RAB23 ARL6 CEP104 WDR35 TCTN3 B9D2 MKKS TTBK2 NPHP4 DYNC2LI1 ARL3 WDPCP NPHP1 INPP5E TMEM138 SCLT1 TMEM237 WDR19 TMEM67 C2CD3 TCTN2 CEP120 ARL13B EVC2 CEP83 CEP19 TMEM107 BBS10 BBS12 TMEM17 TMEM216 DYNC2H1 CPLANE1 KIAA0753 TCTN1 TMEM231 SPAG1 RSPH3 RSPH9 DNAJB13 SDCCAG8 MKS1 SPATA7 CRX DYNC2I2 IFT43 BBS9 BBS2 GLIS2 DYNC2I1 LCA5 BBS7 BBS4 CCDC40 NEK8 BBS5 LZTFL1 IFT122 INTU ANKS6 TTC8 ANKS3 IQCB1 BBS1 IFT140 XPNPEP3 CEP290 DYNLT2B BBIP1 ALMS1 GPR161 KIF7 KE1917 Altered gene expression, NRF2 dependent antioxidant pathway CEBPB HMOX1 NQO1 EPHB2 GCLC GCLM NFE2L2 PIK3CA PRKCA MAPK8 SLC7A11 GSTA2 MAF AIMP2 KEAP1 KE1923 Altered gene expression, P53 dependent apoptosis pathway MLH1 XRCC5 ULK2 ICAM1 SERPINE1 PRKAG2 PRKAB1 TP53I3 PRKAG3 SLC2A1 APAF1 PRKAB2 PRKAA1 PCNA NOTCH1 XPC DEPTOR PRKAA2 DDIT4 PTEN PRKAG1 AKT1S1 IRF9 FAS BAX TSC2 CCNE1 CCL2 FASLG CDKN1A THBS1 RPTOR MLST8 ULK1 ISG15 MTOR TNF GPX1 CX3CL1 RRM2B TRAF4 TIGAR SESN1 AURKA MSH2 BBC3 NANOG ULBP1 PERP CCNG1 NCF2 GADD45A TP53AIP1 TNFRSF10B POLK CDK2 LIF IRF5 SAT1 SESN2 ULBP2 DDB2 ERCC5 GLS2 DRAM1 PML PMAIP1 SLC7A11 FANCC CDC25C BTG2 ALDH4A1 TP53INP1 E2F7 CPT1C ADORA2B MGMT POLH SMR3B ZMAT3 TNFRSF10D SFN RPRM PIDD1 FUCA1 ADGRB1 SIVA1 SERPINB5 MIR34C MIR200C MIR34B ACAD11 MIR145 SCO2 MIR34A CDC25A KE1933 Increased, Interleukin-6 production ICAM1 ITGB1 SELP IL1A IL6 CXCL8 TNF KNG1 C3 C5 SELPLG C6 C7 ITGA4 ITGAL ITGB2 VCAM1 KE1944 Synaptic dysfunction STX1B SYT1 RIMS1 NAPA CPLX1 UNC13B RAB3A ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2B1 CLTCL1 SLC25A4 VAMP2 DNM1 SNAP25 STXBP1 CLTA CLTC SLC18A2 STX1A SLC38A1 PARK7 SYN1 DNM1L CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 SLC6A4 CACNA1A SLC18A3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE1945 Dysfunctional Autophagy ATG5 ATG16L1 PRKAG2 PRKAB1 PRKAG3 ATG101 PRKAB2 PRKAA1 MAP1LC3B ATG3 ATG12 DEPTOR WIPI2 PRKAA2 ATG13 PRKAG1 ATG7 AKT1S1 RB1CC1 PIK3C3 AMBRA1 BECN1 ATG14 RPTOR MLST8 ULK1 PIK3R4 MTOR ATG9A UVRAG KE1977 Disruption of sodium channel gating kinetics FYN JAK2 CAMK2A PSEN1 GSK3B AKT1 BACE1 CALM1 TNF NEDD4 SCN4A MAPK8IP2 NEDD4L PTPRN SCN1B PDCD10 SCN2A SCN7A RNF121 SCN1A SCN2B SCN3A SCNM1 NFASC SCN3B PRRT2 SCN11A SCN9A SCN4B SCN5A SCN10A SCN8A RACK1 FGF14 FGF12 FGF13 WEE1 KE1995 Abnormal lipid metabolism NR1H3 CYP2B6 CYP7A1 ABCA1 ABCB1 ABCG5 ABCG1 CYP26A1 CYP1A2 CYP2C9 CYP2E1 CYP3A4 CYP24A1 CYP27B1 PPARA PPARD PPARG VDR NR1I2 MIR33B MIR33A ABCC2 RARA RARB ABCC3 RARG ABCB11 NR1I3 NR1H4 CYP4B1 ABCD2 CYP4A11 CYP8B1 ABCB4 ABCD3 PRKAG2 PRKAB1 PRKAG3 ACSS2 ACLY PRKAB2 PRKAA1 PRKAA2 FASN PRKAG1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA PDHA1 ABHD5 PRKAR2A HILPDA PLIN1 ACSBG1 BCKDHA KE2005 Altered neurotransmission in development STX1B SYT1 RIMS1 NAPA CPLX1 UNC13B RAB3A ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2B1 CLTCL1 SLC25A4 VAMP2 DNM1 SNAP25 STXBP1 CLTA CLTC SLC18A2 STX1A SLC38A1 PARK7 SYN1 DNM1L CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 SLC6A4 CACNA1A SLC18A3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE2009 Activation of inflammation pathway IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG KE2017 Endoplasmic reticulum stress XBP1 ATF6 DDIT3 ERN1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 MBTPS2 BBC3 TNFRSF10B MBTPS1 PMAIP1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE2029 protein-coupled estrogen receptor 1 (GPER) activation ESR1 BRAF GPER1 MAPK1 MAP2K1 CHUK CREB1 MAPK14 ELK1 AKT1 FOS GNAS IKBKB JUN NFKB1 PIK3CA PRKACA MAPK9 BCL2 SP1 IKBKG GNB1 GNGT1 KE2031 Releasing, Apoptosis-Inducing Factor (AIF) BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A KE2036 Activation of metabotropic glutamate receptor GRM1 GRM6 GRM3 GRM5 GABBR1 GRM2 GRM4 GRM7 GRM8 GPRC5B GPRC5D GPRC5C CASR GPRC5A GABBR2 KE2039 Inhibition GABAA receptor GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2B1 ABAT GAD2 GAD1 GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE2097 Increase, Pro-Inflammatory Mediators CCL28 LTA CCL26 CXCL2 IL11 MMP9 CCL22 IL7 TGFB1 CXCL12 CSF3 AREG IL17A CCL20 IFNA6 IFNA8 CXCL6 IL22 IL10 IL33 CCL21 IFNA21 IL21 CXCL9 IL9 IFNA5 IFNA16 IL18 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A CXCL10 IFNB1 IFNA10 IFNA1 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 CNTF CCL23 CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1A IL1B IL37 IL6 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 TNF CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 NFKB1 CX3CL1 CCL17 SPP1 LIF EPO CXCL11 OSM IL26 MMP3 TNFSF13 IL3 MMP1 TNFSF13B CTF1 CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D KE2110 Disrupted binding, laminin-beta1-integrin receptors with laminin FYN ITGA1 ITGA2 ITGA3 ITGAD ITGB1 ARAF PDPK1 MAP2K5 PXN RAF1 SHC1 BRAF TLN1 CAPN1 CAPN2 CDC42 AKT3 AKT1 AKT2 GRB2 HRAS PIK3R2 MAPK1 MAPK7 MAPK10 MAP2K1 MAP2K2 MAP2K3 MAP2K6 PTK2 RAC1 ROCK1 MAPK12 SOS1 SRC CAV1 ROCK2 MYPN MIR34C PAK4 VAV3 SORBS1 CRK RAPGEF1 ITGAV ITGB3 PAK1 PAK2 PAK3 SHC3 MAPK4 MAPK6 PAK6 RAC2 VCL ITGA11 ITGB4 ITGB5 ITGB6 RAP1A RAP1B RHO SELENOP ARHGEF7 CAPN9 CAPN11 CAPN10 CSK DOCK1 CAPN7 ILK ITGA6 ITGA2B ITGA4 ITGA5 ITGA7 ITGA9 ITGAE ITGAL ITGAM ITGAX ITGB2 ITGB7 ITGB8 RAC3 TNS1 CAPN5 VASP VAV2 ZYX CAPN3 CAPNS1 CAPN6 ITGA10 ITGA8 MYLK2 CAV2 CAV3 BCAR1 GIT2 KE2111 Decreased, neural progenitor cell adhesion to laminin FYN ITGA1 ITGA2 ITGA3 ITGAD ITGB1 ARAF PDPK1 MAP2K5 PXN RAF1 SHC1 BRAF TLN1 CAPN1 CAPN2 CDC42 AKT3 AKT1 AKT2 GRB2 HRAS PIK3R2 MAPK1 MAPK7 MAPK10 MAP2K1 MAP2K2 MAP2K3 MAP2K6 PTK2 RAC1 ROCK1 MAPK12 SOS1 SRC CAV1 ROCK2 MYPN MIR34C PAK4 VAV3 SORBS1 CRK RAPGEF1 ITGAV ITGB3 PAK1 PAK2 PAK3 SHC3 MAPK4 MAPK6 PAK6 RAC2 VCL ITGA11 ITGB4 ITGB5 ITGB6 RAP1A RAP1B RHO SELENOP ARHGEF7 CAPN9 CAPN11 CAPN10 CSK DOCK1 CAPN7 ILK ITGA6 ITGA2B ITGA4 ITGA5 ITGA7 ITGA9 ITGAE ITGAL ITGAM ITGAX ITGB2 ITGB7 ITGB8 RAC3 TNS1 CAPN5 VASP VAV2 ZYX CAPN3 CAPNS1 CAPN6 ITGA10 ITGA8 MYLK2 CAV2 CAV3 BCAR1 GIT2 KE2115 Altered, cholesterol metabolism CYP51A1 HMGCR HMGCS1 DHCR7 FDFT1 FDPS IDI1 LSS MVD SQLE PMVK MVK NSDHL MSMO1 SC5D KE2116 Decreased, oligodendrocyte differentiation PDGFB CXCL1 CXCL2 SOX5 CNTF PLP1 MOG MBP TNF IL1B IGF1 FGF2 BMP2 LIF SOX9 ASCL1 SHH GLI2 BMP4 MAG OMG SOX10 OLIG2 OLIG1 SOX6 SOX8 NKX2-6 NKX2-2 CNP MYT1 ZEB2 PDGFRA WNT10A PRKCA SMAD1 CHD8 NFATC2 ID2 TCF7L2 SOX2 RELN BMP1 SOX11 PTPRZ1 NFIA CSPG4 HES5 NKX6-1 TMEM98 CNTN1 PTN LGI1 MYRF DUSP15 CHD7 ZNF24 OPALIN ZNF488 EGR2 ID4 ZBTB33 KE2119 Increase, Insulin resistance EGR1 EIF4EBP1 INSR IRS1 KIF5B MAP3K9 MAP3K10 PDPK1 PIK3C3 PRKAA1 PRKAA2 MAP2K5 PTEN PTPN11 RAF1 RHEB RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KB2 SHC1 SLC2A1 XBP1 IRS2 RPS6KA4 PIK3CA MAP3K8 MAPK14 EIF4E ELK1 AKT1 AKT2 FOXO1 FOXO3 FOS MTOR GAB1 GRB2 GSK3B PIK3R4 HRAS IGF1R IKBKB JUN ARF6 LIPE MAP3K1 MAP3K3 MAP3K5 PIK3C2A PIK3C2G PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PRKCA PRKCB PRKCD PRKCH PRKCQ PRKCZ MAPK1 MAPK3 MAPK7 MAPK8 MAPK11 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP2K7 RAC1 MAPK12 MAP2K4 SLC2A4 SOS1 SRF VAMP2 MAP3K7 TSC1 TSC2 IRS4 PIK3R3 SOCS1 CBL MAP3K14 SOCS3 RPS6KA5 SGK2 FLOT1 CAP1 SORBS1 SH2B2 MAP3K2 EHD1 KIF3A MAP4K5 MAP4K1 ARHGAP33 CRK FLOT2 RHOQ CBLC SGK3 STXBP4 SHC2 RPS6KA6 GRB10 GRB14 RAPGEF1 GSK3A GYG1 GYS1 GYS2 EHD2 INPP4A INPPL1 ARF1 MAP3K4 MAP3K11 MYO1C MINK1 ENPP1 PFKL PFKM SHC3 PPP1R3A PRKCI MAPK4 MAPK6 RHOJ PTPN1 TRIB3 PTPRF RAB4A MAP4K2 RAC2 REG1A RRAD SGK1 SNAP25 SOS2 STX4 STXBP1 STXBP2 STXBP3 MAP3K12 MAP4K3 CBLB SNAP23 MAP3K6 MAP3K13 CYTH3 MAP4K4 TBC1D4 KE2151 Disruption, neurotransmitter release STX1B SYT1 RIMS1 NAPA CPLX1 UNC13B RAB3A ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2B1 CLTCL1 SLC25A4 VAMP2 DNM1 SNAP25 STXBP1 CLTA CLTC SLC18A2 STX1A SLC38A1 PARK7 SYN1 DNM1L CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 SLC6A4 CACNA1A SLC18A3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE2188 Activation, caspases LTA APAF1 BIRC5 IRF2 IRF3 MDM2 BAD TRAF3 CASP3 CASP7 CASP8 CASP9 TRADD RIPK1 FADD BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR MIR29A BBC3 IRF1 IRF5 PMAIP1 TNFRSF10B GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 MIR29B1 MIR29B2 IRF4 TNFRSF21 HELLS XIAP CASP4 TNFRSF25 CRADD HRK DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BIRC3 TP73 SCAF11 KE2195 Increase, CNS Neural cell death BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A KE2202 Altered expression of cell cycle genes CUL1 TGFB2 ABL1 RBX1 TGFB1 CCND3 SKP1 PCNA CCNA1 CCNB1 MDM2 CCNB2 SMAD3 CDK1 SMAD2 GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 E2F2 GADD45B CDK6 E2F3 GADD45A CCND2 CDK2 GADD45G CDK4 CDC25C CDC25A SFN PLK1 PRKDC SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 KE2208 Aberrant, synaptic formation and plasticity TJP1 GRM1 CAMK2B CAMK2A GRIN2D CAMK2D CAMK2G GRIN2C GRIN1 GRIN2A GRIN2B MAPK1 MAPK3 RYR2 HOMER1 DLGAP1 SYNGAP1 STX1A DLG2 NRXN3 NRXN1 NRXN2 DLG1 RPH3A NLGN2 NLGN3 NLGN4X YWHAG FMR1 NLGN1 ARC SHANK1 CYFIP1 RPS6KA1 BDNF RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 CCND2 NGF DIO2 CAMKK1 HNRNPL SYT2 NCAM1 PRL SYT12 HGNC:1464 HGNC:9393 CAMKK2 KE2216 Binding of antagonist to thyroid hormone receptor TTF2 TTF1 TSHB NPPB BAD FGFR1 RHEB RPS6KB1 RAF1 CASP9 MDM2 RPS6 PRDM16 NOTCH1 WNT4 CTNNB1 AKT1S1 TPO PFKFB2 PAX8 ADRB3 IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 KDM1A RPS6KA6 FGF21 NPY THRA TBC1D4 ITGAV SHH DIO2 ITGB3 PRKG2 MAP4K5 NPR1 SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG AQP7 SLC16A10 MGLL MC4R PLIN1 ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 ZNF516 KLB KDM3B KE2217 Binding of antagonist to glucocorticoid hormone receptor IL11 CCL20 SNAI2 CUL1 CDKN1C HSP90AA1 JUN NFKB2 PDE4B PTGS2 RXRA CCL2 B3GNT5 NR1I2 ANKRD1 MFGE8 GADD45B ETNK2 TGFBR3 TNFAIP3 ZIC2 BHLHE40 DNER AKAP13 BIRC2 ANGPTL4 POU5F1 NR1I3 PTGES3 ALOX5AP NR3C1 AMIGO2 LRRC8A MGAM SLC19A2 THBD TNS4 FGFBP1 SPRY1 STOM BIRC3 CDC42EP3 PLK2 ABHD2 FGD4 SPINK13 TSC22D3 SLC26A2 EDN2 ARL5B ADGRF4 DNAJC15 GPR153 KTN1 SERPINB9 PMP2 EPB41L4B SRGN ACKR3 RGS2 S100P SCNN1A SEC14L1 PRRG4 CPEB4 PPP1R14C CAVIN2 ENC1 NAV3 SERTAD2 KE2218 Binding of (ant)agonist to liver X receptor NR1H3 CYP2B6 CYP7A1 FASN SCD ABCG5 ABCG8 SREBF1 CYP3A4 RXRA KE2220 Antagonism, Glucocorticoid hormone receptor IL11 CCL20 SNAI2 CUL1 CDKN1C HSP90AA1 JUN NFKB2 PDE4B PTGS2 RXRA CCL2 B3GNT5 NR1I2 ANKRD1 MFGE8 GADD45B ETNK2 TGFBR3 TNFAIP3 ZIC2 BHLHE40 DNER AKAP13 BIRC2 ANGPTL4 POU5F1 NR1I3 PTGES3 ALOX5AP NR3C1 AMIGO2 LRRC8A MGAM SLC19A2 THBD TNS4 FGFBP1 SPRY1 STOM BIRC3 CDC42EP3 PLK2 ABHD2 FGD4 SPINK13 TSC22D3 SLC26A2 EDN2 ARL5B ADGRF4 DNAJC15 GPR153 KTN1 SERPINB9 PMP2 EPB41L4B SRGN ACKR3 RGS2 S100P SCNN1A SEC14L1 PRRG4 CPEB4 PPP1R14C CAVIN2 ENC1 NAV3 SERTAD2 KE2221 Altered Liver X receptor activity NR1H3 CYP2B6 CYP7A1 FASN SCD ABCG5 ABCG8 SREBF1 CYP3A4 RXRA KE2223 Reduced number of oligodendrocytes SOX5 ZEB2 PDGFRA WNT10A FGF2 PRKCA SMAD1 MBP CHD8 NFATC2 ID2 BMP4 SOX9 ASCL1 TCF7L2 SHH SOX2 RELN GLI2 BMP1 SOX11 SOX10 MAG PTPRZ1 NFIA CSPG4 OLIG1 HES5 OLIG2 SOX6 SOX8 NKX6-1 TMEM98 CNTN1 PTN LGI1 MYRF NKX2-2 DUSP15 CHD7 ZNF24 NKX2-6 MYT1 OPALIN ZNF488 EGR2 ID4 ZBTB33 KE2224 Dysregulation of transcriptional expression within PPAR signaling network NR1H3 SCD HMGCS2 PDPK1 ACSL1 CPT2 CYP7A1 OLR1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB SLC27A5 SORBS1 FABP3 SLC27A1 DBI FABP1 SLC27A4 CPT1C FABP4 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 KE2225 Disrupted Lipid Storage PRKAG2 PRKAB1 PRKAG3 ACSS2 ACLY PRKAB2 PRKAA1 PRKAA2 FASN PRKAG1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA PDHA1 ABHD5 PRKAR2A HILPDA PLIN1 ACSBG1 BCKDHA ACSL6 ACSL5 ACSL1 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 OSBPL5 NPC2 FABP3 LDLRAP1 SLC27A4 LPA APOA4 DBI SOAT1 SLC27A2 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 KE2226 Stressor binding PPAR isoforms NR1H3 SCD HMGCS2 PDPK1 ACSL1 CPT2 CYP7A1 OLR1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB SLC27A5 SORBS1 FABP3 SLC27A1 DBI FABP1 SLC27A4 CPT1C FABP4 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 KE2227 Disrupted PPAR isoform nuclear signaling NR1H3 SCD HMGCS2 PDPK1 ACSL1 CPT2 CYP7A1 OLR1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB SLC27A5 SORBS1 FABP3 SLC27A1 DBI FABP1 SLC27A4 CPT1C FABP4 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 AQP7 PCK2 PLIN1 ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 KE2232 Antagonism, Retinoic acid receptors RXRA RXRB RXRG RARA RARB RARG KE2265 Oligodendrocyte death, increased BLK BIRC5 APAF1 BAD CAPNS1 CASP3 CASP7 CASP8 CASP9 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC7 TNFRSF10A TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BCL2A1 PIDD1 BIRC2 CASP2 PRKD1 CASP1 MIR29B1 MIR29B2 BAG3 CASP10 XIAP NAIP PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 PTPN13 HTRA2 BIRC3 AIFM1 SEPTIN4 HSPA1A KE2299 Altered, Redox Homeostasis NOX5 MT1X NFIX NOX1 CYBB HMOX1 SOD2 SOD3 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT NOX3 TXNRD2 TXNRD1 TXN2 MGST1 UGT1A6 KE2300 Disruption, Glucolipid metabolism PRKAG2 PRKAB1 PRKAG3 ACSS2 ACLY PRKAB2 PRKAA1 PRKAA2 FASN PRKAG1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA PDHA1 ABHD5 PRKAR2A HILPDA PLIN1 ACSBG1 BCKDHA GAPDH ENO1 ALDOC HK2 LDHA MDH1 MDH2 PGK1 PKM SLC2A1 TPI1 DLD GOT1 GOT2 PC SLC2A4 HK1 PFKL PFKM SLC2A3 DLAT G6PC1 PCK1 PFKP GCK PGAM1 PGAM2 MPC1 ENO2 ENO3 FBP1 ALDOA ALDOB GPI HK3 LDHB LDHC PGK2 PKLR SLC2A2 MPC2 SLC2A5 FBP2 LDHAL6B KE2336 Increase, SREBF1 CYP51A1 MDH1 SREBF1 SCD PRKAG2 PRKAB1 HMGCS1 HMGCR PRKAG3 ATF6 NR1H2 ACLY PRKAB2 PRKAA1 PPARGC1B PRKAA2 FASN PRKAG1 SREBF2 PRKACA SCARB1 SIRT1 CREB1 GPAM PIK3CA LDLR PPARG AKT1 AMFR CAMP LPL SP1 MTOR ACACA INS NFYA MBTPS2 IDI1 SEC31B SAR1A FDFT1 MED15 YY1 SEC23A SEC23B SQLE FGF21 GSK3A KPNB1 SEC24A SCAP INSIG2 CDK8 LPIN1 RBP4 SEC31A SEC24B MBTPS1 SEC24D SAR1B ACSS1 DBI SEC13 LSS FDPS MVD RNF139 SEC24C INSIG1 MIR33A MIR33B KE2408 Increase, Adipose lipolysis PRKAG2 PRKAB1 PRKAG3 ACSS2 ACLY PRKAB2 PRKAA1 PRKAA2 FASN PRKAG1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA PDHA1 ABHD5 PRKAR2A HILPDA PLIN1 ACSBG1 BCKDHA KE2412 Increase, Hepatic intracellular active glucocorticoids SRD5A2 CYP3A4 CYP21A2 CYP11B2 CYP11B1 AKR1C4 SRD5A1 HSD11B1 AKR1C3 AKR1D1 AKR1C2 HSD11B2 AKR1C1 CBR1