KE9	Activation, 5HT2c	ABCC5	CNDP2
KE10	Acetylcholine accumulation in synapses	CHKA	CHAT	PDHA1	PEMT	PCYT1A	ACHE	PDHA2
KE12	Acetylcholinesterase (AchE) Inhibition	CHRNA3	CHRNA4	CHRNA5	CHRNB2	DRD2	DRD3	DRD4	KCNK3	KCNK9	PPP1R1B	CHRNA6	DDC	GNB1	GNG2	SLC18A2	TH	CDK5	ADCY2	GNAI1	PPP1CA	PRKACA
KE17	KE 17 - Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway	ABCC2	UGT1A9	ALAS1	ACAA1	APOA5	SCNN1A	VDR	KTN1	ALOX5AP	MFGE8	ETNK2	IGFBP1	STOM	DBI	TSC22D3	FABP1	SPRY1	CYP4F12	SLCO2B1	MYOF	BIRC3	NR1H3	SREBF1	SMC1A	HSP90AA1	NCOA1	BAX	ESR1	TGFB2	FKBP5	HSP90AB1	SCD	EP300	TGFB1	AHR	CCL2	IL2	PPARGC1A	CCND1	BIRC2	PTGES3	CDKN1B	IFNG	HBEGF	IL12B	NR3C1	KAT2B	CCL20	SLC5A7	SLC2A1	GPAM	POLK	NCOA3	PCK1	IL1B	IL17B	CDKN1C	JUND	BHLHE40	CDK4	MYC	ABCG5	NCOA2	CYP1A1	SLC6A3	PGD	ABCG8	EGFR	FOXO1	SLC26A2	G6PD	CYP3A4	SQSTM1	TGFA	CYP7A1	STAT3	IL12A	FASN	CDK1	JUN	NRIP1	SLC2A4	SP1	IRS2	RXRA	SRC	CYP2B6	HSPA1A	TNF	MGST1	PLTP	SMARCA1	UGT2B4	SLC6A13	SLC6A7	GCLM	SLC39A9	EPHA3	SLC6A16	ME1	TGFBR3	SLC6A15	GSTP1	MGST2	FTL	BLVRB	IL11	GSTT2	GGT1	SLC5A1	SLC5A4	SLC6A2	SLC39A14	GSR	PTGR1	SLC6A4	ALDH3A1	SOD3	SLC2A9	PPARD	SLC39A7	EHHADH	ABCC5	PRDX1	PRDX6	SLC5A9	EGR1	SLC6A8	SLC6A6	DNAJB1	SLC6A11	SLC39A11	SLC2A11	GSTM5	GSTM3	LRRC8A	SLC2A8	SLC5A6	CYP2C9	SLC39A8	SLC39A5	SLC5A2	SLC39A6	SLC39A3	SLC2A5	MGST3	SLC39A1	SLC2A12	SLC39A4	SLC39A12	SLC5A12	SLC7A11	SLC2A13	SLC5A10	SLC6A1	SLC5A11	APOA2	CBR1	CBR3	CES5A	SLC2A6	SLC6A20	SLC6A18	SLC39A2	SLC39A13	SLC6A5	FTH1	GSTM4	GSTA4	JUNB	CES4A	CES3	CES2	SLC2A14	GSTA3	SLC6A19	GPX2	GSTA5	MAFF	CYP4A11	ADH7	SLC6A9	SLC39A10	MAFG	SLC6A17	SLC2A7	SLC2A10	SERPINB2	TXNRD3	TXNRD1	SLC5A3	CES1	AGER	GPX3	UGT1A7	UGT1A4	CYP2A6	SLC5A8	SLC6A14	SRXN1	KLK15	GCLC	NR1H4	HGF	CUL1	SLC2A3	AHRR	ABCB11	PTGS2	NFKB2	KEAP1	SLC27A5	ABCB1	PSMC5	HMOX1	PDGFB	SLC10A1	CDC37	SLC5A5	ABCC3	AIP	HES1	NFE2L2	ACADM	APOA1	TNFAIP3	SRGN	ABCC4	FGF13	GSTM1	SLCO1B1	TXN	BAAT	CYP1B1	CYP1A2	EPHA2	NRG1	FGF19	TGFBR2	SLC2A2	UGT1A6	UGT2B7	THBD	CYP8B1	NQO1	PPARA	SULT1A1	SERPINA1	GSTM2	UGT1A1	GSTA1	GSTA2	ARNT	CPT1A	APOC3	SNAI2	ZIC2	NAV3	EPB41L4B	GADD45B	SLC7A5	SULT2A1	CPEB4	RGS2	SLC19A2	DNAJC15	EDN2	SEC14L1	TNS4	PRRG4	FGFBP1	FGD4	AMIGO2	ABHD2	NR1I3	ACKR3	NR1I2	PLK2	PMP2	ANKRD1	ADGRF4	CPT2	GPR153	CDC42EP3	S100P	CYP2C19	ARL5B	ANGPTL4	CAVIN2	SERPINB9	AKAP13	ENC1	B3GNT5	SERTAD2	PDE4B	DNER	NCOA6	PPP1R14C	POU5F1	SPINK13	PDK4	ABCB4	SRPX2	CYP3A5	CAP2	SCP2	PTPA	SLC27A1	NR0B2	CYP3A7	ACOX1	DNAJC7	IP6K3	GCC1	SLC51B	SLC51A
KE18	Activation, AhR	UGT1A9	IGFBP1	MYOF	HSP90AA1	NCOA1	BAX	EP300	TGFB1	AHR	IL2	PTGES3	CDKN1B	IFNG	IL12B	POLK	IL1B	IL17B	JUND	CYP1A1	EGFR	IL12A	JUN	SRC	TNF	MGST1	ALDH3A1	JUNB	CES3	SERPINB2	UGT1A7	UGT1A4	AHRR	CDC37	AIP	HES1	NFE2L2	CYP1B1	CYP1A2	UGT1A6	NQO1	UGT1A1	GSTA2	ARNT	SLC7A5	CAP2
KE25	KE 25 - Agonism, Androgen receptor	F2	F11	KLK1	SERPINB2	F7	F9	PLAT	SERPINE1	VWF	F3	PLG	PLAU	F10	F12	F13B	KLKB1	SERPINF2	FGG	FGA	FGB	F8	F5	PARK7	SMARCE1	CDKN1A	KLK3	PLPP1	BMF	CARM1	NCOA2	KAT5	CREB1	CREBBP	CTNNB1	DAXX	EGFR	EP300	AKT1	FKBP4	KDM1A	FOXO1	GSK3B	HDAC1	JUN	RHOA	SMAD4	MDM2	PIAS4	PIK3R1	PIK3R2	PAK6	RAC1	RAD9A	CCND1	RNF4	SP1	SRC	BRCA1	STAT3	UBE2I	SUMO1	NCOA3	RUNX2	NCOA1	KAT2B	CCNE1	ETV5	SIN3A	RHOB	PRDX1	ROCK1	CAV1	ROCK2	STUB1	PIAS3	FLNA	SIRT1	AR	SMAD3	PTEN	PTK2	RAN	RB1	RELA	CALR	PIAS1	NCOR2	CDC42	NCOR1	RACK1	DSTN	KAT7	TLE5	FHL2	PATZ1	ZNF318	PSMC3IP	LIMK2	ZMIZ1	BAG1	RLN1	RNF6	EFCAB6	TGFB1I1	TGIF1	NR2C2	UBE3A	NCOA4	NR0B2	PIAS2	RNF14	EIF4EBP1	MTOR	SPRY1	NDRG1	PTK2B	HSD3B1	HSD3B2	HSD17B3	HSD17B2	HSD17B7	ARID1B	SMARCA4	SMARCC1	SMARCC2	SMARCD1	SMARCD2	SMARCD3	ARID1A	MSH2	MSH6	PRKDC	HSD17B1	CDKN1B	MAPK14	PIK3CA	CDKN2A	MAP4K1	CRK	DOCK1	ELK1	FKBP5	FOS	RICTOR	RAPGEF1	FOXA1	HRAS	MYC	PAK1	MAPK1	MAPK3	MAPK8	MAP2K1	MAP2K2	PTPN11	PXN	RAF1	RASA1	SOS1	CHEK1	CHEK2	TP53	CDK1	BCL2	CDK4	JAK1	CDK2	STAT1	CASP3	TSC2	MRE11	BLM	CASP9	BAX	ATM	ATR	CASP8	RHEB	RPTOR	TSC1	RAD50	BAD	BARD1	ETV4	NOXA1	CDC25B	CPN1	CDKN2B	MIR21	CRKL	CYP17A1	KLK2	ATF1	SPINK1	CDC25A	PLK1	ABCC4	GAB1	GRB2	HGF	HSD17B4	ACTL6B	RAP1A	RAP1B	ACTL6A	EIF4E1B	MMP1	E2F1	SMAD2	SPRY2	ERG
KE28	Reduction, Angiogenesis	TIMP2	MAPK1	MMP9	AKT1	SMAD1	SRC	CREBBP	MAPK14	HIF1A	PIK3CA	VEGFA	TIMP3	PDGFB	FLT1	PLCG1	FGF2	NOS3	FGFR2	KDR	ARNT	TEK	PDGFRA	PTK2	ANGPT1
KE40	Mitochondrial ATP production, decreased	ABCC5	CNDP2	ECHS1	ACSL3	ACADL	ECI1	ACAA2	ACADSB	EHHADH	DECR1	HSD17B10	PKM	PGK1	GAPDH	LDHA	TP53	G6PD	ENO1	PRKAA1	RB1	ALDOC	HK1	PPARGC1A	CREB1	MTERF3	PPP3CA	SP1	CAMK4	PPARGC1B	ESRRA	HCFC1	PPRC1	GABPA	GABPB1	NRF1	MYEF2	TFB1M	POLRMT	TFB2M	TFAM	MTERF1
KE50	Increase, Ca++ (intracellular)	NFKBIB	NFKBIE	MIR29B1	MIR29B2	BCL2L11	CDKN2A	CHUK	DFFA	DFFB	AKT1	BBC3	APAF1	BIRC2	BIRC3	XIAP	BIRC5	IGF1	FAS	IKBKB	FASLG	IRF3	IRF7	JUN	MCL1	MDM2	MAP3K1	MYC	NFKB1	NFKBIA	PIK3R1	PMAIP1	CYCS	MAPK10	DIABLO	BAD	BAK1	BAX	BCL2	BCL2L1	BCL2L2	BID	MAP2K4	BOK	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF3	CASP1	CASP2	CASP3	CASP4	CASP6	CASP7	CASP8	CASP9	CASP10	IKBKG	TRADD	TNFRSF25	RIPK1	CRADD	HRK	TNFSF10	FADD	TNFRSF10B	CFLAR	LTA	IGF1R	RELA	TRAF1	TRAF2	TNFRSF21	GZMB	HELLS	IGF2	IRF2	IRF4	PRF1	BNIP3L	SCAF11	IRF6	TP73	TP63	MIR29A	IRF1	IRF5
KE55	Increase, Cell injury/death	NFKBIB	NFKBIE	MIR29B1	MIR29B2	BCL2L11	CDKN2A	CHUK	DFFA	DFFB	AKT1	BBC3	APAF1	BIRC2	BIRC3	XIAP	BIRC5	IGF1	FAS	IKBKB	FASLG	IRF3	IRF7	JUN	MCL1	MDM2	MAP3K1	MYC	NFKB1	NFKBIA	PIK3R1	PMAIP1	CYCS	MAPK10	DIABLO	BAD	BAK1	BAX	BCL2	BCL2L1	BCL2L2	BID	MAP2K4	BOK	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF3	CASP1	CASP2	CASP3	CASP4	CASP6	CASP7	CASP8	CASP9	CASP10	IKBKG	TRADD	TNFRSF25	RIPK1	CRADD	HRK	TNFSF10	FADD	TNFRSF10B	CFLAR	LTA	IGF1R	RELA	TRAF1	TRAF2	TNFRSF21	GZMB	HELLS	IGF2	IRF2	IRF4	PRF1	BNIP3L	SCAF11	IRF6	TP73	TP63	MIR29A	IRF1	IRF5	HTRA2	AIFM1	ENDOG
KE68	Accumulation, Collagen	LTBP1	ZEB2	TFE3	CREBBP	CTNNB1	EP300	FOS	HRAS	IFNG	ITGB6	JAK1	JUN	SMAD1	SMAD4	SMAD5	SMAD9	NFKB1	MAPK3	MAPK9	BMP4	STAT1	STAT3	TGFB1	THBS1	TNF	WNT1	RUNX2	MIR302A	LEF1	TGFBR3	RUNX3	ENG	ZFYVE9	FST	EGF	FKBP1A	BAMBI	INHBA	LIF	SMAD2	SMAD3	SMAD6	SMAD7	SERPINE1	SKIL	SPP1	LEFTY2	TGFBR1	TGFBR2	FOXH1	NOG	ZNF423	LEFTY1	SKI	TGIF1
KE79	Inhibition, Cyclooxygenase activity	ACAA1	ACOX3	PTGS1	CYP4A22	CYP4F2	CYP4F12	PTGDR2	AKR1B1	PTGES	PRXL2B	PTGR1	PPARD	EHHADH	CYP4A11	PTGR2	PTGS2	PLA2G4A	PTGIS	PLA2G5	PTGIR	PTGDR	ACOX2	PLA2G6	PLA2G4B	PPARG	TBXA2R	PTGFR	HPGD	PTGDS	TBXAS1	ACOX1
KE87	Release, Cytokine	CSF1	CSF2	CXCL1	IFNG	IL1B	IL2	IL3	IL4	IL5	IL6	IL10	IL12B	IL13	TGFB1	TNF	IL1A	IL11	CSF3	CXCL2	HLA-DRA	HLA-DRB1	IFNB1	IL7	PDGFA	CD4	IL15
KE105	Inhibition, Mitochondrial Electron Transport Chain Complexes	ATP5PD	ATP5MG	COX15	DMAC2L	MT-ATP6	MT-ATP8	NDUFAB1	ATP5F1A	ATP5F1B	ATP5F1C	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP5PO	ATP5MF	NDUFB9	SDHB	ATP5IF1	COX8A	COX11	SDHA	SDHC	SDHD	COX5A	MT-ND2	MT-ND3	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	UCP3	SLC25A14	SLC25A27	SLC25A6	UCP1	NDUFA13	SLC25A4	COX4I1	COX5B	COX6A1	COX6B1	COX6C	COX7B	COX7C	MT-CO1	MT-CO2	MT-CO3	NDUFA4	SCO1	SURF1	UCP2	UQCRFS1	COX7A2L	SLC25A5	COX17	MT-ND1	UQCR11	NDUFA11	COX6A2	COX7A1	COX7A2	UQCRQ	UQCR10	NDUFS7	MT-CYB	NDUFA1	NDUFA2	NDUFA3	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA9	NDUFA10	NDUFB1	NDUFB2	NDUFB3	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB10	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFS8	NDUFV2	NDUFV3	NDUFA12	UQCRB	UQCRC1	UQCRC2	UQCRH
KE111	Agonism, Estrogen receptor	ESR1	GPAM	PCK1	CYP1A1	STAT3	JUN	SP1	CYP1B1	CYP1A2	PPARA	PDK4	NR0B2	ACOX1
KE122	Increase, Glucocorticoid receptor activation	SPRY1	TSC22D3	STOM	ALOX5AP	KTN1	MFGE8	ETNK2	SCNN1A	CDKN1C	PTGES3	SLC26A2	NR3C1	BIRC2	BIRC3	HSP90AA1	JUN	RXRA	CCL2	CCL20	BHLHE40	IL11	LRRC8A	TGFBR3	NFKB2	SRGN	PTGS2	THBD	TNFAIP3	CUL1	SLC19A2	CDC42EP3	PLK2	ABHD2	AKAP13	FGD4	SPINK13	EDN2	ARL5B	ADGRF4	ANKRD1	DNAJC15	AMIGO2	GPR153	GADD45B	ANGPTL4	PDE4B	SERPINB9	PMP2	EPB41L4B	POU5F1	ACKR3	RGS2	S100P	SEC14L1	SNAI2	ZIC2	PRRG4	CPEB4	PPP1R14C	B3GNT5	CAVIN2	TNS4	ENC1	NR1I2	MGAM	NAV3	DNER	SERTAD2	NR1I3	FGFBP1
KE134	Increase, Kupffer cell activation	CSF1	CSF2	CXCL1	IFNG	IL1B	IL2	IL3	IL4	IL5	IL6	IL10	IL12B	IL13	TGFB1	TNF	IL1A	IL11	CSF3	CXCL2	HLA-DRA	HLA-DRB1	IFNB1	IL7	PDGFA	CD4	IL15
KE149	Increase, Inflammation	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG	CSF1	CSF2	CXCL1	IL1B	IL3	IL6	IL10	IL12B	IL13	TGFB1	TNF	IL1A	IL11	CSF3	CXCL2	HLA-DRA	HLA-DRB1	IFNB1	IL7	PDGFA	CD4	IL15
KE177	Increase, Mitochondrial dysfunction	MT-ATP6	ATP5PD	ATP5MG	DMAC2L	NDUFAB1	ATP5F1A	ATP5F1B	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP6AP1	ATP5PO	ATP5MF	NDUFB9	MT-ND2	MT-ND3	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	GZMB	NDUFA4	ATP6AP2	MT-ND1	NDUFA11	NDUFS7	NDUFA2	NDUFA3	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA9	NDUFA10	NDUFB1	NDUFB2	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB10	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFS8	NDUFV2	NDUFV3	NDUFA4L2	MTCO3P12	GOT2	GLUD1	SLC25A13	SLC25A12	SLC25A22
KE178	Mitochondrial electron transport chain, disrupted	ATP5PD	ATP5MG	COX15	DMAC2L	MT-ATP6	MT-ATP8	NDUFAB1	ATP5F1A	ATP5F1B	ATP5F1C	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP5PO	ATP5MF	NDUFB9	SDHB	ATP5IF1	COX8A	COX11	SDHA	SDHC	SDHD	COX5A	MT-ND2	MT-ND3	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	UCP3	SLC25A14	SLC25A27	SLC25A6	UCP1	NDUFA13	SLC25A4	COX4I1	COX5B	COX6A1	COX6B1	COX6C	COX7B	COX7C	MT-CO1	MT-CO2	MT-CO3	NDUFA4	SCO1	SURF1	UCP2	UQCRFS1	COX7A2L	SLC25A5	COX17	MT-ND1	UQCR11	NDUFA11	COX6A2	COX7A1	COX7A2	UQCRQ	UQCR10	NDUFS7	MT-CYB	NDUFA1	NDUFA2	NDUFA3	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA9	NDUFA10	NDUFB1	NDUFB2	NDUFB3	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB10	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFS8	NDUFV2	NDUFV3	NDUFA12	UQCRB	UQCRC1	UQCRC2	UQCRH
KE188	Neuroinflammation	MTOR	NFKBIA	MAPK8	MAPK14	TLR4	FOS	JUN	CHUK	NOS2	RELA	MT-CO2	MT-CO1	ASCC1	TNF	IFNG	IL1B	IL4	IL6	HMGB1	CXCL8	IL10	MAPK1	IL12A	IL2	TLR7	IL1A	GFAP	IL18	TMPRSS2	TLR3	FURIN	CCL11	ACE2	TLR8	IFNA2
KE227	Activation, PPARα	UGT1A9	ACAA1	APOA5	DBI	FABP1	NR1H3	CCND1	CDK4	MYC	CYP7A1	CDK1	RXRA	PLTP	EHHADH	APOA2	CYP4A11	KLK15	ACADM	APOA1	CYP8B1	PPARA	CPT1A	APOC3	CPT2	SCP2	SLC27A1
KE245	Activation, PXR/SXR	TRAM1	TAB2	TAB1	NFKB1	IRF3	TRAF3	IL6	TLR4	TIRAP	MYD88	TRAF6	TBK1	IRAK1	IRF7	IRAK4	IKBKB	CHUK	MAP3K7	TNF	CXCL8	NFKBIA	RIPK1	IKBKE	TICAM1	IRAK3	IKBKG	IFNB1	INPP5D
KE265	Activation, Stellate cells	LTBP1	ZEB2	TFE3	CREBBP	CTNNB1	EP300	FOS	HRAS	IFNG	ITGB6	JAK1	JUN	SMAD1	SMAD4	SMAD5	SMAD9	NFKB1	MAPK3	MAPK9	BMP4	STAT1	STAT3	TGFB1	THBS1	TNF	WNT1	RUNX2	MIR302A	LEF1	TGFBR3	RUNX3	ENG	ZFYVE9	FST	EGF	FKBP1A	BAMBI	INHBA	LIF	SMAD2	SMAD3	SMAD6	SMAD7	SERPINE1	SKIL	SPP1	LEFTY2	TGFBR1	TGFBR2	FOXH1	NOG	ZNF423	LEFTY1	SKI	TGIF1
KE269	Induction, Sustained Cell Proliferation	MTOR	TCF3	RUNX1T1	SALL4	ZBTB16	RARA	PML	NFKBIE	CDKN1A	PIK3CB	GSK3B	MAPK1	SOS2	NFKBIA	MAPK3	TSC2	IKBKB	PIK3CG	RHEB	NFKB1	SOS1	BCL9	PIK3CA	WNT1	ELK1	MAP2K2	RAF1	MDM2	MYC	TP53	RPTOR	EGFR	FOXO1	SHC1	LRP5	TSC1	MLST8	MAP2K1	FOS	PYGO1	INSR	PIK3CD	HRAS	JUN	SRC	CHUK	IKBKG	AKT3	AKT1	AKT2	IL6	JAK2	STAT3	CTNNB1	CCND1	PPARD	CSNK1A1	LEF1	JUP	FLT4	NGFR	FGFR2	FGFR3	LRP6	FGFR1	FLT1	MET	PDGFRB	TEK	FLT3	KDR	KRAS	PDGFRA	APC	IGF1R	KSR1	EPHA2	NTRK2	DEPTOR	KIT	BRAF	FGFR4	REL	AXIN2	PTK2	PTEN	RELA	GRB2	CSF1R	NTRK1	AKT1S1	IL6R	FZD6	RETN	GAREM2	ULK2	TELO2	TTI1
KE281	Thyroxine (T4) in serum, Decreased	ANO1	CLCN5	ACY1	MAP2K2	PRKAA1	PRKCA	PRKAA2	MAP2K1	CGA	ELK1	MAPK1	MAPK3	RAF1	CREB1	NFKB1	DUOX2	SLC5A5	TG	TPO	TRH	TSHR	RAP1B	RAP1A	PLCD1	SLC26A6	DUOX1
KE459	Increase, Liver steatosis	CRAT	ACSL4	HADHA	ACADS	ACADVL	CPT1B	DLD	ECHS1	ACSL1	GCDH	HADH	ACAT1	LPL	CHKB	ECI1	DECR1	ACSL3	ACADL	ACSS2	GPD2	HADHB	ACADM	LIPE	PNPLA2	CPT1A	CPT2	ACSL6	ACSL5	TPI1	SLC25A20	GK	GK2	LIPF	LIPC	ACSBG1	DBI	FABP1	CD36	ACSBG2	FABP6	FABP5	FABP9	HGNC:10995	HGNC:10996	HGNC:10997	HGNC:10999	HGNC:11000	HGNC:3555	FABP3	FABP2	SLC27A4	FABP4	FABP7	PRKAR2B	ABHD5	PRKAR1A	PRKAR2A	HILPDA	PRKAR1B	AKT2	PRKAG2	PRKAB1	PRKAG3	AKT3	ACLY	PRKAB2	PDHA1	PRKAA1	AKT1	PRKAA2	FASN	PRKAG1	BCKDHA	PRKACA	PRKACB	PRKACG	PLIN1	ACACA
KE465	Increased, Fatty acid influx	ACSL4	ACSBG1	DBI	FABP1	CD36	ACSL1	ACSBG2	ACSL3	FABP6	FABP5	FABP9	ACSL6	ACSL5	HGNC:10995	HGNC:10996	HGNC:10997	HGNC:10999	HGNC:11000	HGNC:3555	FABP3	FABP2	SLC27A4	FABP4	FABP7
KE468	Inhibition, PPAR alpha	UGT1A9	ACAA1	APOA5	DBI	FABP1	NR1H3	CCND1	CDK4	MYC	CYP7A1	CDK1	RXRA	PLTP	EHHADH	APOA2	CYP4A11	KLK15	ACADM	APOA1	CYP8B1	PPARA	CPT1A	APOC3	CPT2	SCP2	SLC27A1
KE570	Accumulation, Damaged mitochondrial DNA	LIG3	REV3L	PNKP	ERCC8	NTHL1	XRCC1	UNG	MSH2	POLI	MPG	LIG1	NEIL3	MSH3	OGG1	MSH6	POLM	SMUG1	MBD4	TERF2	MUTYH	ERCC5	REV1	XPA	TDG	CUL4A	CETN2	DCLRE1C	NEIL2	CUL4B	POLL	DDB1	FEN1	APEX2	MGMT	NHEJ1	XRCC6	RAD54B	ERCC6	PRKDC	RAD52	BRCA1	ERCC1	MRE11	RFC1	RFC2	RAD51	POLD1	POLD3	PALB2	POLE2	NBN	RPA3	POLD2	RAD51C	RFC5	FANCE	RAD50	WDR48	POLE4	FANCL	RPA2	POLK	FAAP24	RPA1	PCNA	RFC3	BRIP1	BRCA2	FANCI	FANCD2	POLE3	ATM	CHEK1	FANCC	USP1	RFC4	WRN	CENPX	POLH	EXO1	ATR	CENPS	POLD4	ERCC4	POLE	FANCB	FANCF	FAAP100	FANCA	FANCM	H2AX	HMGB1	FAN1	FANCG	MLH1	XRCC5	RBX1	APEX1	PMS2	PARP2	XRCC4	XPC	LIG4	GTF2H5	MNAT1	POLB	ERCC2	GTF2H1	GTF2H3	RAP1A	RAD23B	CDK7	CCNH	DDB2	PARP1	GTF2H2	ERCC3	RAD23A	GTF2H4
KE654	KE 654 - Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists	PTK2B	MAPT	IL2RA	HRAS	AKT1	FOXO3	FOS	IL2	IL2RB	IL2RG	JAK1	JUN	LCK	MYC	PIK3R1	MAPK1	MAPK3	MAP2K1	MAP2K2	PTPN11	RAF1	BCL2	RPS6	RPS6KB1	RPS6KB2	SHC1	SOS1	STAT1	STAT3	SYK	CBL	CCND2	SOCS3	CRKL	CISH	FYN	GRB2	JAK3	STAT5A	STAT5B	GAB2	NMI
KE664	Overwhelmed, Mitochondrial DNA repair mechanisms	LIG3	REV3L	PNKP	ERCC8	NTHL1	XRCC1	UNG	MSH2	POLI	MPG	LIG1	NEIL3	MSH3	OGG1	MSH6	POLM	SMUG1	MBD4	TERF2	MUTYH	ERCC5	REV1	XPA	TDG	CUL4A	CETN2	DCLRE1C	NEIL2	CUL4B	POLL	DDB1	FEN1	APEX2	MGMT	NHEJ1	XRCC6	RAD54B	ERCC6	PRKDC	RAD52	BRCA1	ERCC1	MRE11	RFC1	RFC2	RAD51	POLD1	POLD3	PALB2	POLE2	NBN	RPA3	POLD2	RAD51C	RFC5	FANCE	RAD50	WDR48	POLE4	FANCL	RPA2	POLK	FAAP24	RPA1	PCNA	RFC3	BRIP1	BRCA2	FANCI	FANCD2	POLE3	ATM	CHEK1	FANCC	USP1	RFC4	WRN	CENPX	POLH	EXO1	ATR	CENPS	POLD4	ERCC4	POLE	FANCB	FANCF	FAAP100	FANCA	FANCM	H2AX	HMGB1	FAN1	FANCG	MLH1	XRCC5	RBX1	APEX1	PMS2	PARP2	XRCC4	XPC	LIG4	GTF2H5	MNAT1	POLB	ERCC2	GTF2H1	GTF2H3	RAP1A	RAD23B	CDK7	CCNH	DDB2	PARP1	GTF2H2	ERCC3	RAD23A	GTF2H4
KE709	Increase, Cytotoxicity (renal tubular cell)	BAD	BID	CASP8	BAX	BBC3	MAPK14	FASLG	APAF1	CASP9	MCL1	BCL2L11	MAPK13	CASP3	CASP7	FADD	BCL2L1	BCL2	MAPK11	MAPK12	TNF	AKT1
KE819	Decreased, Glomerular filtration	PAX2	TRPC6	CLDN1	CDKN1A	CAMK2B	TGFB1	DKK1	VTN	CDKN1B	CD80	WNT1	CDKN1C	LAMA5	ITGB4	PCNA	YWHAQ	TLR4	LMX1B	AKT1	NOTCH1	ITGB1	LRP5	CTNNB1	LAMB2	ITGB3	VIM	ACTN4	CDH2	PARVA	ITGA3	FYN	PLAUR	VCL	LRP6	COL4A4	JAG1	DNM1	PLCG1	CTSL	TLN1	PLCE1	ITGAV	NCK1	ILK	PTK2	AGRN	CR1	FAT1	MYH9	NPHS2	IRF6	KIRREL2	PODXL	SMARCAL1	SCARB2	MKI67	KIRREL3	PTPRO	UTRN	MYO1E	NPHS1	COL4A3	LIMS1	KRT8	SYNPO	DAG1	CD151	WT1	COL4A5	MME	CD2AP	INF2	MT-TL1
KE828	Inhibition, Phospholipase A	PRKAR2B	ABHD5	ACSBG1	PRKAR1A	PRKAR2A	HILPDA	PRKAR1B	AKT2	PRKAG2	PRKAB1	PRKAG3	AKT3	ACLY	PRKAB2	PDHA1	PRKAA1	AKT1	PRKAA2	FASN	PRKAG1	ACSS2	BCKDHA	PRKACA	LIPE	PRKACB	PRKACG	PLIN1	PNPLA2	ACACA
KE829	Damage, Lipid bilayer	GPX4	CYP4F2	FADS2	ALOX5	CYP2B6	CYP7A1	PTGES	PRXL2B	CYP2C8	CYP2C9	CBR1	EPHX2	CYP7B1	PLA2G1B	PTGS2	CYP27A1	PLA1A	PLCB1	CYP8B1	HPGD	MT-CO1	LTA4H	ALOX15	ALOX12	PTGDS	LTC4S	TBXAS1
KE831	Disturbance, Lysosomal function	RPN1	RPN2	UBB	H2AX	H2AZ1	IFNG	UBC	UBE2D1	UBE2D2	UBE2D3	H2AC4	UBE2B	UCHL3	UCHL1	PSME3	HLA-A	HLA-B	HLA-C	HLA-E	HLA-F	HLA-G	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMB8	PSMB9	PSMB10	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD2	PSMD3	PSMD4	PSMD5	PSMD7	PSMD8	PSMD9	PSMD10	PSMD11	PSMD12	PSMD13	PSME1	PSME2	PSMD6	NEDD4	UBA1	UBA7	MTOR	RB1CC1	ATG5	PIK3C3	ATG16L1	PRKAG2	AMBRA1	PRKAB1	PRKAG3	ATG101	BECN1	PRKAB2	PRKAA1	MAP1LC3B	RPTOR	ATG3	ATG12	PRKAA2	MLST8	ATG13	ULK1	PRKAG1	PIK3R4	ATG7	WIPI2	ATG14	DEPTOR	AKT1S1	UVRAG	ATG9A
KE833	Occurrence, Cytoplasmic vacuolization (hepatocyte)	PRKAR2B	ABHD5	ACSBG1	PRKAR1A	PRKAR2A	HILPDA	PRKAR1B	AKT2	PRKAG2	PRKAB1	PRKAG3	AKT3	ACLY	PRKAB2	PDHA1	PRKAA1	AKT1	PRKAA2	FASN	PRKAG1	ACSS2	BCKDHA	PRKACA	LIPE	PRKACB	PRKACG	PLIN1	PNPLA2	ACACA
KE835	Occurrence, Ballooning degeneration (hepatocyte)	EIF2AK3	TXNIP	BID	BBC3	TNFRSF10B	IL1B	TP53	PMAIP1	BCL2L11	BCL2	CASP2	RTCB	XBP1	ATF6	EIF2S1	DDIT3	ERN1	MBTPS2	HSPA5	PPP1R15A	NFE2L2	ATF4	MBTPS1
KE836	Occurrence, Cytoplasmic vacuolization (Bile duct cell)	PRKAR2B	ABHD5	ACSBG1	PRKAR1A	PRKAR2A	HILPDA	PRKAR1B	AKT2	PRKAG2	PRKAB1	PRKAG3	AKT3	ACLY	PRKAB2	PDHA1	PRKAA1	AKT1	PRKAA2	FASN	PRKAG1	ACSS2	BCKDHA	PRKACA	LIPE	PRKACB	PRKACG	PLIN1	PNPLA2	ACACA
KE837	Occurrence, Cytoplasmic vacuolization (kupffer cell)	PRKAR2B	ABHD5	ACSBG1	PRKAR1A	PRKAR2A	HILPDA	PRKAR1B	AKT2	PRKAG2	PRKAB1	PRKAG3	AKT3	ACLY	PRKAB2	PDHA1	PRKAA1	AKT1	PRKAA2	FASN	PRKAG1	ACSS2	BCKDHA	PRKACA	LIPE	PRKACB	PRKACG	PLIN1	PNPLA2	ACACA
KE838	Induction, Microvesicular fat	RARA	GATA2	CEBPD	CEBPA	NR1H3	CTNNA1	SREBF1	GATA3	NR3C1	CREB1	IRF3	KLF4	TLE3	FOXO1	WNT10B	INS	KLF5	KLF15	EBF1	TCF7L1	DDIT3	STAT5A	PPARG	CEBPB	STAT5B	IRF4	ZNF423	NR2F2	RORA	EGR2	MECOM	KLF2
KE839	Formation, Mallory body	NFKBIB	NFKBIE	MIR29B1	MIR29B2	BCL2L11	CDKN2A	CHUK	DFFA	DFFB	AKT1	BBC3	APAF1	BIRC2	BIRC3	XIAP	BIRC5	IGF1	FAS	IKBKB	FASLG	IRF3	IRF7	JUN	MCL1	MDM2	MAP3K1	MYC	NFKB1	NFKBIA	PIK3R1	PMAIP1	CYCS	MAPK10	DIABLO	BAD	BAK1	BAX	BCL2	BCL2L1	BCL2L2	BID	MAP2K4	BOK	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF3	CASP1	CASP2	CASP3	CASP4	CASP6	CASP7	CASP8	CASP9	CASP10	IKBKG	TRADD	TNFRSF25	RIPK1	CRADD	HRK	TNFSF10	FADD	TNFRSF10B	CFLAR	LTA	IGF1R	RELA	TRAF1	TRAF2	TNFRSF21	GZMB	HELLS	IGF2	IRF2	IRF4	PRF1	BNIP3L	SCAF11	IRF6	TP73	TP63	MIR29A	IRF1	IRF5	RPN1	RPN2	UBB	H2AX	H2AZ1	IFNG	UBC	UBE2D1	UBE2D2	UBE2D3	H2AC4	UBE2B	UCHL3	UCHL1	PSME3	HLA-A	HLA-B	HLA-C	HLA-E	HLA-F	HLA-G	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMB8	PSMB9	PSMB10	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD2	PSMD3	PSMD4	PSMD5	PSMD7	PSMD8	PSMD9	PSMD10	PSMD11	PSMD12	PSMD13	PSME1	PSME2	PSMD6	NEDD4	UBA1	UBA7
KE870	Increase, Cell Proliferation	PRKDC	MAD2L2	ZBTB17	CDKN1A	SMC1A	GSK3B	TGFB2	ABL1	EP300	STAG2	CCNE1	TGFB1	SMC3	CCND1	CDKN1B	HDAC1	STAG1	CCND2	TGFB3	CDK2	CDKN1C	PCNA	CCNA1	CDK4	MDM2	MYC	TP53	SMAD4	CCNA2	CDKN2A	ATM	RAD21	CDK1	ATR	YWHAQ	CHEK1	CHEK2	CCNB3	E2F2	MCM2	MCM6	ORC1	ORC6	CDC45	MCM5	RBX1	CDC25B	MCM4	CDK6	MCM3	E2F3	CCND3	TFDP2	ORC2	ORC4	GADD45A	CDKN2C	CDKN2D	E2F5	ORC3	CDKN2B	CCNB2	CDC25C	ORC5	WEE1	MCM7	CCNE2	TFDP1	YWHAB	YWHAE	YWHAG	YWHAZ	CDC14B	TTK	PKMYT1	WEE2	PTTG2	CDC27	ANAPC4	CUL1	CDC14A	ANAPC5	CDC23	E2F1	FZR1	SKP1	CDC16	CCNB1	CDK7	CCNH	RB1	ANAPC11	SKP2	ANAPC1	BUB3	CDC25A	ANAPC10	PTTG1	PLK1	SMAD3	SMAD2	ANAPC2	ANAPC7	HDAC2	CDC20	RBL1	RBL2	GADD45G	E2F4	GADD45B	ESPL1	SFN	YWHAH	MAD1L1	DBF4	SMC1B	CDC6	CDC7	BUB1	ANAPC13
KE889	Proteostasis, impaired	PFDN4	PFDN1	PFDN5	PFDN2	VBP1	PFDN6	DNAJB1P1	HSP90AA2P	HSPA7
KE898	Disruption, Lysosome	MTOR	RB1CC1	ATG5	PIK3C3	ATG16L1	PRKAG2	AMBRA1	PRKAB1	PRKAG3	ATG101	BECN1	PRKAB2	PRKAA1	MAP1LC3B	RPTOR	ATG3	ATG12	PRKAA2	MLST8	ATG13	ULK1	PRKAG1	PIK3R4	ATG7	WIPI2	ATG14	DEPTOR	AKT1S1	UVRAG	ATG9A	RPN1	RPN2	UBB	H2AX	H2AZ1	IFNG	UBC	UBE2D1	UBE2D2	UBE2D3	H2AC4	UBE2B	UCHL3	UCHL1	PSME3	HLA-A	HLA-B	HLA-C	HLA-E	HLA-F	HLA-G	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMB8	PSMB9	PSMB10	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD2	PSMD3	PSMD4	PSMD5	PSMD7	PSMD8	PSMD9	PSMD10	PSMD11	PSMD12	PSMD13	PSME1	PSME2	PSMD6	NEDD4	UBA1	UBA7
KE926	Oxidation, Glutathione (To be considered with MIE)	GPX4	IDH1	GGT1	G6PD	GSTA5	GCLM	GPX1	GPX2	GPX3	GSR	GSTT2	GCLC	GSTA1	GSTM1	GSTM2	GGT5	OPLAH	ANPEP	GSS
KE1096	Increased, blood uric acid concentration	MDH1	OTC	ASS1	ASL	CPS1	NAGS	SLC25A15	GLUD1	GOT2	FH	PYCR1	MDH2	GLS2	ARG1	GOT1	SLC25A12	SLC25A13	NOS3	NOS1	NOS2	OAT	LDHB	GPT	ALDH4A1	ODC1	SRM	SMS	ALDH18A1	ARG2	ACY1	SARDH	CKM	CKB	GATM	GAMT	PYCR3
KE1097	Occurrence, renal proximal tubular necrosis	ABCC2	ATP6V1H	ATP6V1D	ATP6V0A4	ATP6V0E1	ATP6V1A	ATP6V1B1	ATP6V0B	ATP6V1F	ATP6V1E1	ATP6V1G1	FXYD2	ATP1B1	ATP6V0D2	ATP6V1C1	ATP1A1	ATP6V0C	SLC1A1	SLC22A2	SLC2A1	SLC34A1	SLC5A1	ABCG2	SLC5A2	SLC7A7	SLC6A20	SLC6A18	SLC6A19	AQP1	SLC5A8	ABCB1	SLC5A5	SLC16A10	ABCC4	SLC2A2	SLC34A3	SLC9A3	CA2	CA4	SLC3A2	SLC7A9	SLC4A4	SLC7A8	SLC12A4	SLC3A1	SLC4A2	SLC20A2	SLC36A2	SLC26A6	SLC22A7	SLC47A1	CLTRN	SLC22A8	SLC13A3	SLC22A11	SLC47A2	SLC22A6
KE1103	Inhibition, Cyclooxygenase 1 activity	ACAA1	ACOX3	PTGS1	CYP4A22	CYP4F2	CYP4F12	PTGDR2	AKR1B1	PTGES	PRXL2B	PTGR1	PPARD	EHHADH	CYP4A11	PTGR2	PTGS2	PLA2G4A	PTGIS	PLA2G5	PTGIR	PTGDR	ACOX2	PLA2G6	PLA2G4B	PPARG	TBXA2R	PTGFR	HPGD	PTGDS	TBXAS1	ACOX1
KE1104	Decreased, Prostaglandin F2alpha concentration, plasma	ANXA8	CYP11A1	EDNRA	EDNRB	MITF	PTGS1	S100A10	S100A6	PPARGC1A	PRL	PTGER2	PTGER3	PTGES	AKR1B1	ANXA1	SOX9	CBR1	ABCC4	PPARGC1B	AKR1C1	AKR1C2	EDN1	HPGDS	ANXA5	PLA2G4A	PPARG	PTGDR	PTGER4	PTGIR	PTGIS	PTGS2	AKR1C3	HPGD	PTGER1	PTGFR	TBXA2R	PTGDS	ANXA3	ANXA4	PTGFRN	SCGB1A1	ANXA2	ANXA6	HSD11B1	HSD11B2	TBXAS1
KE1105	Occurrence, renal ischemia	PABPC1	EIF4G1	CASP8	ACTB	GSK3B	BAX	ABL1	MAPK1	MMP9	CD40LG	MAPK3	TGFB1	CASP2	CCND1	IFNG	IL12B	STAT1	SOS1	CREB1	CD80	RAC2	CASP9	IL6	IL10	TLR4	CASP6	AKT1	PIK3R1	RASA1	DFFA	ITGB2	JAK1	CASP3	CASP7	ENDOG	STAT3	IL12A	DFFB	RAC3	BCL2L1	BCL2	CYCS	SOCS1	SRC	TNF	TICAM1	BID	CASP1	IL2	CXADR	PYCARD	CAV1	CCR5	AIF1	ITGAL	CD4	FYN	NFKB2	CXCR4	ABL2	PARP1	TLR3	ILK	PTCRA	CCR3	TLR5	CD55	LAMA2	NOS1	NOD2	EDN1	KRT8	DAG1	MYH6	DMD	HLA-DMA	SGCG	CHRAC1	SGCA	EIF4G2	CAAP1	BNIP2	SGCB	SGCD	MICA
KE1115	Increase, Reactive oxygen species	MTOR	CDKN1A	MAP2K3	MAP2K4	RPS6KA5	IKBKB	CCNE1	RHEB	MAPK8	NFKB1	MAPK14	ATF2	CREB1	CAT	PIK3CA	CDK2	MDM2	IL6	TP53	AKT1	CHEK1	FOXO1	PINK1	TSC1	CXCL8	FOS	BCL2L1	BCL2	ATR	MAP3K5	TNF	IKBKG	CUL3	ICAM1	IL1A	SOD2	NOS2	PTGS2	KEAP1	SIRT1	HMOX1	NFE2L2	PTEN	NQO1	PIP	NOX1	NRF1	IPCEF1	GSX1
KE1194	Increase, DNA damage	PML	PRKDC	CDKN1A	RAD52	BRCA1	BID	FAS	RAD51	CASP8	SMC1A	BAX	ABL1	CCNE1	BBC3	CCND1	CDKN1B	RAD1	RAD50	RPA2	CCND2	APAF1	TNFRSF10B	CDK2	CASP9	CDK4	MDM2	TP53	PMAIP1	AKT1	FANCD2	ATM	CHEK1	RAD17	CASP3	CDK1	CYCS	RAD9A	ATR	CHEK2	H2AX	CREB1	MRE11	MYC	NBN	PIDD1	RFC1	ATRIP	TP53AIP1	TLK2	CCNB3	HUS1B	CDK6	CCND3	GADD45A	CCNB2	CDC25C	CDK5	CCNE2	E2F1	CCNB1	DDB2	RB1	CDC25A	GADD45G	RRM2B	SESN1	GADD45B	SFN	TLK1
KE1195	modulation, Extracellular Matrix Composition	SMAD4	WWTR1	YWHAG	TGFBR3	POSTN	SERPINE1	SPARC	CCN2	TGFBR1	TGFBR2	SMAD3	SMAD2
KE1262	Apoptosis	NFKBIB	NFKBIE	MIR29B1	MIR29B2	BCL2L11	CDKN2A	CHUK	DFFA	DFFB	AKT1	BBC3	APAF1	BIRC2	BIRC3	XIAP	BIRC5	IGF1	FAS	IKBKB	FASLG	IRF3	IRF7	JUN	MCL1	MDM2	MAP3K1	MYC	NFKB1	NFKBIA	PIK3R1	PMAIP1	CYCS	MAPK10	DIABLO	BAD	BAK1	BAX	BCL2	BCL2L1	BCL2L2	BID	MAP2K4	BOK	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF3	CASP1	CASP2	CASP3	CASP4	CASP6	CASP7	CASP8	CASP9	CASP10	IKBKG	TRADD	TNFRSF25	RIPK1	CRADD	HRK	TNFSF10	FADD	TNFRSF10B	CFLAR	LTA	IGF1R	RELA	TRAF1	TRAF2	TNFRSF21	GZMB	HELLS	IGF2	IRF2	IRF4	PRF1	BNIP3L	SCAF11	IRF6	TP73	TP63	MIR29A	IRF1	IRF5
KE1271	Increase, Transforming growth factor-beta signaling	SMAD4	WWTR1	YWHAG	TGFBR3	POSTN	SERPINE1	SPARC	CCN2	TGFBR1	TGFBR2	SMAD3	SMAD2	LTBP1	ZEB2	TFE3	CREBBP	CTNNB1	EP300	FOS	HRAS	IFNG	ITGB6	JAK1	JUN	SMAD1	SMAD5	SMAD9	NFKB1	MAPK3	MAPK9	BMP4	STAT1	STAT3	TGFB1	THBS1	TNF	WNT1	RUNX2	MIR302A	LEF1	RUNX3	ENG	ZFYVE9	FST	EGF	FKBP1A	BAMBI	INHBA	LIF	SMAD6	SMAD7	SKIL	SPP1	LEFTY2	FOXH1	NOG	ZNF423	LEFTY1	SKI	TGIF1
KE1283	Activation, TGF-beta pathway	LTBP1	ZEB2	TFE3	CREBBP	CTNNB1	EP300	FOS	HRAS	IFNG	ITGB6	JAK1	JUN	SMAD1	SMAD4	SMAD5	SMAD9	NFKB1	MAPK3	MAPK9	BMP4	STAT1	STAT3	TGFB1	THBS1	TNF	WNT1	RUNX2	MIR302A	LEF1	TGFBR3	RUNX3	ENG	ZFYVE9	FST	EGF	FKBP1A	BAMBI	INHBA	LIF	SMAD2	SMAD3	SMAD6	SMAD7	SERPINE1	SKIL	SPP1	LEFTY2	TGFBR1	TGFBR2	FOXH1	NOG	ZNF423	LEFTY1	SKI	TGIF1
KE1306	Increase, De novo lipogenesis	ZMPSTE24	CEBPA	CEBPD	FOXC2	GATA2	LMNA	RARA	SFRP4	ADIPOQ	CDKN1A	NR1H3	NCOA2	PPARGC1A	CREB1	CTNNB1	AHR	EPAS1	FOXO1	WWTR1	GATA3	NR3C1	HIF1A	IGF1	FAS	IL6	INS	IRS1	LEP	LPL	MEF2A	MEF2B	MEF2C	MEF2D	PCK1	RXRA	SCD	BMP2	BMP3	SLC2A4	BMP4	SP1	SREBF1	STAT1	STAT2	STAT3	TGFB1	TNF	WNT1	WNT10B	NRIP1	IRS4	NCOA1	SOCS1	IRS2	SOCS3	AGPAT2	CELF1	PLIN2	EBF1	FRZB	BSCL2	GDF10	KLF15	GTF3A	MBNL1	ASIP	NDN	PCK2	CISD1	SPOCK1	KLF5	NR2F1	MIXL1	KLF7	GADD45A	DDIT3	GATA4	HMGA1	MIF	PPARD	CYP26B1	STAT6	PNPLA3	CEBPB	CNTFR	KLF6	CFD	AGT	DVL1	E2F1	GH1	IL6ST	LIF	LIFR	LIPE	SMAD3	OSM	SERPINE1	PLIN1	PPARA	PPARG	PRLR	PTGIS	TRIB3	RB1	BMP1	STAT5A	STAT5B	HNF1A	TWIST1	UCP1	WNT5B	FZD1	NCOR2	NAMPT	E2F4	ID3	RBL1	RBL2	RXRG	GADD45B	RETN	DLK1	NCOR1	CYP26A1	EGR2	LPIN1	RORA	LPIN3	LPIN2	PRKAR2B	ABHD5	ACSBG1	PRKAR1A	PRKAR2A	HILPDA	PRKAR1B	AKT2	PRKAG2	PRKAB1	PRKAG3	AKT3	ACLY	PRKAB2	PDHA1	PRKAA1	AKT1	PRKAA2	FASN	PRKAG1	ACSS2	BCKDHA	PRKACA	PRKACB	PRKACG	PNPLA2	ACACA
KE1365	Increase, Apoptosis	NFKBIB	NFKBIE	MIR29B1	MIR29B2	BCL2L11	CDKN2A	CHUK	DFFA	DFFB	AKT1	BBC3	APAF1	BIRC2	BIRC3	XIAP	BIRC5	IGF1	FAS	IKBKB	FASLG	IRF3	IRF7	JUN	MCL1	MDM2	MAP3K1	MYC	NFKB1	NFKBIA	PIK3R1	PMAIP1	CYCS	MAPK10	DIABLO	BAD	BAK1	BAX	BCL2	BCL2L1	BCL2L2	BID	MAP2K4	BOK	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF3	CASP1	CASP2	CASP3	CASP4	CASP6	CASP7	CASP8	CASP9	CASP10	IKBKG	TRADD	TNFRSF25	RIPK1	CRADD	HRK	TNFSF10	FADD	TNFRSF10B	CFLAR	LTA	IGF1R	RELA	TRAF1	TRAF2	TNFRSF21	GZMB	HELLS	IGF2	IRF2	IRF4	PRF1	BNIP3L	SCAF11	IRF6	TP73	TP63	MIR29A	IRF1	IRF5
KE1392	Increase, Oxidative Stress	TXNRD2	NOX5	TXN2	CYBB	MAPK14	CYP1A1	FOS	MAOA	NFKB1	MAPK10	SP1	CAT	MGST1	GPX1	GPX3	GSR	GSTT2	JUNB	NOX4	SOD2	SOD3	TXNRD1	NFE2L2	NQO1	GCLC	HMOX1	UGT1A6	SOD1	XDH	NOX3	NFIX	NOX1	MT1X	MTOR	CDKN1A	MAP2K3	MAP2K4	RPS6KA5	IKBKB	CCNE1	RHEB	MAPK8	ATF2	CREB1	PIK3CA	CDK2	MDM2	IL6	TP53	AKT1	CHEK1	FOXO1	PINK1	TSC1	CXCL8	BCL2L1	BCL2	ATR	MAP3K5	TNF	IKBKG	CUL3	ICAM1	IL1A	NOS2	PTGS2	KEAP1	SIRT1	PTEN	PIP	NRF1	IPCEF1	GSX1
KE1395	Liver Cancer	MYOF	MIR744	MIR92A2	MIR92A1	CDKN1A	BRCA1	BIRC3	BIRC5	HIF1A	MAPK3	TGFB1	MAPK8	NFKB1	CCND1	MAPK14	VEGFA	SOS1	FASLG	CASP9	RAC1	IL6	MYC	TP53	SMAD4	AKT1	VAV2	JAK1	CASP3	CASP7	STAT3	CXCL8	BCL2L1	JUN	PTPN11	FRZB	E2F2	LEF1	CXCR1	RRM2	MIR34A	NOS2	PTGS2	TGFBR1	COL4A2	HNF1A	UCHL1	IL6R	SMAD3	GRB2	MMP1	PODXL	CD44	CTTN	MIR155	MIR24-2	MIR24-1	NOTCH2	MMP2	MTOR	BDKRB2	CEBPA	EDNRA	EDNRB	FRAT1	FRAT2	MAX	MITF	MSH2	MSH3	MSH6	PML	RARA	RUNX1T1	SPI1	TXNRD2	ZBTB16	ARHGEF1	ARHGEF11	ARHGEF12	DAPK2	PLEKHG5	RARB	WNT8A	ZBTB17	CKS1B	CALML1	CALML2	GSTT1	ABL1	ADCY2	ADCY7	AGT	APC	AR	ARAF	BRAF	CCNA1	CCNE1	CCNE2	CDK6	CREBBP	CSF2RB	DLL3	DLL4	DVL1	EGFR	EP300	EPAS1	ESR2	FOXO1	FZD1	FZD2	FZD9	GLI3	GNA13	GNAI1	GNB5	GSK3B	HDAC2	ITGAV	JAG2	JAK2	KLK3	NCOA1	NOTCH3	PLCG1	PLD1	PLD2	PRKCA	PRKCB	RALBP1	RB1	ROCK1	ROCK2	RPS6KA5	RPS6KB1	SKP2	STAT2	TCF7L1	TCF7L2	WNT1	WNT16	WNT2	WNT2B	WNT3A	WNT6	ADCY1	ADCY3	APAF1	APPL1	CTBP2	DVL3	FZD8	GNA12	GNG4	HEY1	KNG1	LRP6	PDGFRB	PIK3R3	PTCH2	RALB	RALGDS	WNT9B	GNG5	SP1	AKT2	AKT3	AXIN1	BAD	BAK1	BAX	BBC3	BCL2	BCL2L11	BID	BIRC2	BIRC7	BMP2	BMP4	BRCA2	CAMK2A	CAMK2B	CAMK2D	CASP8	CBL	CCNA2	CCND2	CDH1	CDK2	CDK4	CDKN1B	CDKN2A	CHUK	CRK	CSF2RA	CTNNA1	CTNNB1	CXCL12	CYCS	ELK1	ESR1	F2	F2R	F2RL3	FADD	FAS	FH	FN1	FOS	GLI1	GLI2	GNA11	GNAQ	GNB1	GNB2	GNB3	GNB4	GNG10	GNG11	GNG12	GNG13	GNG2	GNG3	GNG7	GNG8	GNGT1	GNGT2	HDAC1	HRAS	HSP90AA1	HSP90AB1	IFNG	IGF1	IKBKB	IKBKG	IL12A	IL12B	IL13	IL2	IL23A	IL2RA	IL2RB	IL2RG	IL3	IL4	IL4R	IL5	IL5RA	ITGA6	ITGB1	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LRP5	MAP2K1	MAP2K2	MAPK1	MAPK10	MAPK9	MDM2	MST1	NCOA3	NFKBIA	NOTCH1	NRAS	PIK3CA	PIK3CB	PIK3CD	PIK3R1	PIK3R2	PLCG2	PMAIP1	POLK	PTGER2	RAC3	RAD51	RAF1	RET	RHOA	RPS6KB2	RUNX1	RXRA	SHH	SLC2A1	SOS2	STAT1	TGFA	TGFB2	TGFB3	TRAF3	TRAF6	VEGFB	VEGFC	VEGFD	WNT10B	WNT5A	XIAP	RAC2	EGLN3	GSTO2	GSTT2B	MGST1	PTGER3	EML4	NKX3-1	CAMK2G	CCND3	CDKN2B	CRKL	E2F3	ERBB2	FZD10	GADD45A	GSTA3	GSTA4	GSTA5	GSTM3	GSTM4	GSTM5	GSTP1	GSTT2	HHIP	IL13RA1	JUP	KIF7	MGST2	MGST3	MLH1	PLCB2	PLCB3	PLCB4	PPARD	PTCH1	RBX1	SMO	STAT6	SUFU	TCF7	TFG	TRAF5	TXNRD1	TXNRD3	VHL	CCDC42	ADCY4	ADCY5	ADCY6	ADCY8	ADCY9	AGTR1	ARNT	AXIN2	BDKRB1	CALML3	CALML4	CALML5	CALML6	COL4A1	COL4A4	COL4A6	CSF1R	CSF3R	CTBP1	CUL1	CXCR4	DDB2	DLL1	DVL2	E2F1	EDN1	EGF	EPO	EPOR	ETS1	FGF1	FGFR1	FGFR2	FGFR3	FGFR4	FLT3	FLT3LG	FLT4	FZD3	FZD4	FZD5	FZD6	FZD7	GNAI2	GNAI3	GNAS	GSTA1	GSTA2	GSTM1	GSTM2	HES1	HES5	HGF	HMOX1	HSP90B1	IFNA7	IFNAR1	IFNAR2	IFNGR1	IFNGR2	IGF1R	IL12RB1	IL12RB2	IL15RA	IL3RA	IL6ST	IL7	IL7R	ITGA2	ITGA2B	ITGA3	JAG1	JAK3	KEAP1	KIT	KITLG	KRAS	LAMA1	LAMA2	LAMA3	LAMA4	LAMB3	LAMC3	LPAR1	LPAR2	LPAR3	LPAR4	LPAR5	LPAR6	MET	MMP3	NFE2L2	NFKB2	NOTCH4	NQO1	NTRK1	PAX8	PDGFA	PDGFB	PDGFRA	PGF	PLCB1	PPARG	PRKACA	PRKACB	PRKACG	PRKCG	PTEN	PTGER4	PTK2	RALA	RASGRP1	RASGRP2	RASGRP3	RASGRP4	RASSF1	RASSF5	RELA	SKP1	SMAD2	STAT4	STAT5A	STAT5B	TERC	TERT	TGFBR2	TPR	TRAF1	TRAF2	WNT10A	WNT11	WNT3	WNT4	WNT5B	WNT7A	WNT7B	APC2	CTNNA2	EGLN1	EGLN2	GADD45G	IGF2	PIM2	PTGER1	RXRB	RXRG	DAPK1	DAPK3	ALK	COL4A3	COL4A5	ELOB	ELOC	GADD45B	IL15	HEY2	TPM3	WNT8B	WNT9A	ARNT2	CTNNA3	CUL2	DCC	GSTO1	IFNA1	IFNA10	IFNA13	IFNA14	IFNA16	IFNA17	IFNA2	IFNA21	IFNA4	IFNA5	IFNA6	IFNA8	NCOA4	PIM1	HEYL	TRAF4	CCDC6	MECOM	BCR	LAMB4
KE1489	N/A, Steatohepatisis	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG
KE1492	Tissue resident cell activation	LTBP1	ZEB2	TFE3	CREBBP	CTNNB1	EP300	FOS	HRAS	IFNG	ITGB6	JAK1	JUN	SMAD1	SMAD4	SMAD5	SMAD9	NFKB1	MAPK3	MAPK9	BMP4	STAT1	STAT3	TGFB1	THBS1	TNF	WNT1	RUNX2	MIR302A	LEF1	TGFBR3	RUNX3	ENG	ZFYVE9	FST	EGF	FKBP1A	BAMBI	INHBA	LIF	SMAD2	SMAD3	SMAD6	SMAD7	SERPINE1	SKIL	SPP1	LEFTY2	TGFBR1	TGFBR2	FOXH1	NOG	ZNF423	LEFTY1	SKI	TGIF1
KE1493	Increased Pro-inflammatory mediators	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG	CSF1	CSF2	CXCL1	IL1B	IL3	IL6	IL10	IL12B	IL13	TGFB1	TNF	IL1A	IL11	CSF3	CXCL2	HLA-DRA	HLA-DRB1	IFNB1	IL7	PDGFA	CD4	IL15
KE1494	Leukocyte recruitment/activation	NDRG1	CCR7	CD19	YAP1	YWHAQ	MAPK14	FOXO1	FOXO3	WWTR1	RHOA	LPL	MST1	RAC1	SAV1	PRDM1	STK3	TEAD1	TEAD4	TEAD3	TEAD2	LATS1	MIR21	ITGAL	FOXO4	RAP1A	RASSF5	FERMT3	STK38L	FYB1	MOB1A	FOXO6	FOXP3	RAB13	LATS2	KNSTRN
KE1501	Increased, extracellular matrix deposition	LTBP1	ZEB2	TFE3	CREBBP	CTNNB1	EP300	FOS	HRAS	IFNG	ITGB6	JAK1	JUN	SMAD1	SMAD4	SMAD5	SMAD9	NFKB1	MAPK3	MAPK9	BMP4	STAT1	STAT3	TGFB1	THBS1	TNF	WNT1	RUNX2	MIR302A	LEF1	TGFBR3	RUNX3	ENG	ZFYVE9	FST	EGF	FKBP1A	BAMBI	INHBA	LIF	SMAD2	SMAD3	SMAD6	SMAD7	SERPINE1	SKIL	SPP1	LEFTY2	TGFBR1	TGFBR2	FOXH1	NOG	ZNF423	LEFTY1	SKI	TGIF1	GPC4	NLK	CHD8	NFATC4	PORCN	SFRP1	DKK4	SFRP4	PPP3CB	INVS	SFRP5	PPP3CC	PRICKLE1	NKD1	SFRP2	NKD2	DAAM2	CER1	DKK2	WIF1	VANGL2	PRICKLE2	SENP2	SOX17	CXXC4	VANGL1	CTNNBIP1	FRAT2	NOTUM	PPP3R2	PPP3R1	CSNK2A3	FRAT1	CSNK1E	ROR1	ROR2	RYK	FOSL1	KREMEN1	CAMK2B	CSNK2A2	CAMK2A	CSNK2A1	MAPK8	DKK1	NFATC1	SERPINF1	MAP3K7	PPP3CA	CAMK2D	PRKCB	SOST	CSNK2B	GSK3B	RHOA	LRP5	MYC	WNT16	PRKCA	RAC1	CCND1	WNT5A	WNT10B	AXIN1	CCND2	NFATC3	TCF7	PLCB4	CSNK1A1	ROCK2	PLCB2	CAMK2G	TCF7L2	PLCB3	TCF7L1	FZD10	CCND3	DAAM1	NFATC2	CTBP1	CTBP2	PLCB1	DVL1	DVL2	DVL3	FZD2	APC	LRP6	PLAU	WNT4	PRKCG	WNT2	WNT3	WNT6	WNT7A	WNT7B	WNT11	WNT2B	FZD5	FZD3	WNT10A	WNT5B	FZD1	FZD6	FZD7	FZD8	FZD9	WNT3A
KE1528	Fatty Acid Beta Oxidation, Decreased	CRAT	ACSL4	HADHA	ACADS	ACADVL	CPT1B	DLD	ECHS1	ACSL1	GCDH	HADH	ACAT1	LPL	CHKB	ECI1	DECR1	ACSL3	ACADL	ACSS2	GPD2	HADHB	ACADM	LIPE	PNPLA2	CPT1A	CPT2	ACSL6	ACSL5	TPI1	SLC25A20	GK	GK2	LIPF	LIPC
KE1539	Endocytotic lysosomal uptake	NFKBIB	NLRX1	AIM2	CASP10	ATG5	CASP8	POLR2E	POLR2F	NFKBIA	TRADD	IKBKB	IL1B	IRF3	RIPK3	IL6	RIPK1	CASP1	ATG12	POLR2K	POLR2H	FADD	POLR2L	TBK1	IRF7	CHUK	IKBKE	IKBKG	CCL5	NFKB1	ADAR	PYCARD	IL18	CGAS	POLR1C	STING1	POLR3B	POLR3E	CYLD	MAVS	POLR3H	RIGI	POLR3G	TRIM25	POLR3GL	POLR3F	IL33	POLR3K	POLR3D	CXCL10	RELA	POLR3C	POLR1D	ISG15	CCL4	IFNA7	IFNB1	CCL4L2	POLR3A	IFNA1	IFNA2	IFNA4	IFNA5	IFNA6	IFNA8	IFNA10	IFNA13	IFNA14	IFNA16	IFNA17	IFNA21	RNF125	ZBP1	TREX1
KE1632	Increase in reactive oxygen and nitrogen species (RONS)	ATP1A1	CAT	VDAC1	SDHA	SOD1	UQCRFS1	GSTO1	COA3	MT-ND1	AS3MT
KE1740	Induced dysregulation of ACE2	CYP11B2	ACE	NR3C2	REN	BDKRB2	TGFB1	CTSG	CMA1	AGT	AGTR1	AGTR2	KNG1	NOS3	ACE2	BDKRB1	MAS1	ATP6AP2
KE1743	Increase plasma Ang II	CYP11A1	CYP11B2	HSD3B1	HSD3B2	ACE	REN	CALM3	ATF2	CALM1	CAMK2A	CAMK2B	CAMK2D	CAMK4	CREB1	GNAQ	CTSG	ATF1	CAMK2G	PLCB2	CAMK1D	CAMK1G	ATF4	ATF6B	CALM2	CALML3	CALML4	CALML5	CALML6	CAMK1	CREB3	CREB3L1	CREB3L2	CREB3L3	CREB3L4	CREB5	ITPR1	ITPR2	CMA1	AGT	AGTR1	AGTR2	CYP21A2	ITPR3	STAR
KE1815	Increase, Endoplasmic reticulum stress	EIF2AK3	TXNIP	BID	BBC3	TNFRSF10B	IL1B	TP53	PMAIP1	BCL2L11	BCL2	CASP2	RTCB	XBP1	ATF6	EIF2S1	DDIT3	ERN1	MBTPS2	HSPA5	PPP1R15A	NFE2L2	ATF4	MBTPS1
KE1825	Increase, Cell death	CASP8	TNFRSF1A	TRADD	MAPK8	TICAM1	RIPK3	RIPK1	FADD	TNF	FTL	PLA2G4A	PARP1	MTOR	RB1CC1	ATG5	PIK3C3	ATG16L1	PRKAG2	AMBRA1	PRKAB1	PRKAG3	ATG101	BECN1	PRKAB2	PRKAA1	MAP1LC3B	RPTOR	ATG3	ATG12	PRKAA2	MLST8	ATG13	ULK1	PRKAG1	PIK3R4	ATG7	WIPI2	ATG14	DEPTOR	AKT1S1	UVRAG	ATG9A	CP	ACSL4	FDFT1	HSPB1	HMGCR	CTH	CBS	GPX4	CHMP6	AIFM2	MAP1LC3A	SLC1A5	TP53	ACSL1	CYBB	CISD1	SAT1	GCLM	NOX4	SLC39A14	SLC38A1	STEAP3	ACSL3	SLC39A8	SLC7A11	FTH1	PCBP1	PCBP2	TXNRD1	LPCAT3	BACH1	GCLC	VDAC3	TF	HMOX1	AKR1C2	VDAC2	PRNP	AKR1C1	AKR1C3	NOX1	TFRC	GSS	SLC11A2	POR	GCH1	SLC40A1	ACSL6	SLC3A2	ACSL5	ALOX15	COQ2	CHMP5	SAT2	DPP4	PHKG2	NCOA4	IREB2	FTMT	MAP1LC3C	NFKBIB	NFKBIE	MIR29B1	MIR29B2	BCL2L11	CDKN2A	CHUK	DFFA	DFFB	AKT1	BBC3	APAF1	BIRC2	BIRC3	XIAP	BIRC5	IGF1	FAS	IKBKB	FASLG	IRF3	IRF7	JUN	MCL1	MDM2	MAP3K1	MYC	NFKB1	NFKBIA	PIK3R1	PMAIP1	CYCS	MAPK10	DIABLO	BAD	BAK1	BAX	BCL2	BCL2L1	BCL2L2	BID	MAP2K4	BOK	TNFRSF1B	TRAF3	CASP1	CASP2	CASP3	CASP4	CASP6	CASP7	CASP9	CASP10	IKBKG	TNFRSF25	CRADD	HRK	TNFSF10	TNFRSF10B	CFLAR	LTA	IGF1R	RELA	TRAF1	TRAF2	TNFRSF21	GZMB	HELLS	IGF2	IRF2	IRF4	PRF1	BNIP3L	SCAF11	IRF6	TP73	TP63	MIR29A	IRF1	IRF5
KE1852	Increased Ang II type 1 receptor (AT1R)	MAPK1	HIF1A	TGFB1	ACTA2	COL1A1	MAP2K6	JUND	RAF1	SMAD4	COL1A2	PTPN11	SP1	IL11	NOX4	TGFBR1	CCN2	RRAS	F12	IL6ST	IL11RA	AGTR1	TGFBR2	SMAD3	PDGFD	AGT	ACE2	MAS1	RACK1
KE1967	Pyroptosis	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG
KE2009	Activation of inflammation pathway	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG
KE2072	Increase, Mitochondrial swelling	ECHS1	ACSL3	ACADL	ECI1	ACAA2	ACADSB	EHHADH	DECR1	HSD17B10
KE2119	Increase, Insulin resistance	EIF4EBP1	MTOR	SGK2	SGK3	ENPP1	PTPRF	PIK3CA	FLOT1	CAP1	MAP3K2	MAP4K5	MAP4K1	MAP3K8	CRK	MAPK14	EIF4E	ELK1	AKT1	AKT2	FOXO1	FOXO3	FLOT2	RHOQ	FOS	CBLC	SHC2	RPS6KA6	RAPGEF1	GSK3A	GSK3B	GYS1	PIK3R4	HRAS	IKBKB	INSR	IRS1	JUN	MAP3K1	MAP3K3	MAP3K4	MAP3K5	MAP3K9	MAP3K10	MAP3K11	MINK1	PDPK1	PFKL	PIK3C2A	PIK3C2G	PIK3C3	PIK3CB	PIK3CD	PIK3CG	PIK3R1	PIK3R2	SHC3	PRKAA1	PRKAA2	PRKCA	PRKCB	MAPK1	MAPK3	MAPK4	MAPK6	MAPK7	MAPK8	MAPK11	MAPK9	MAPK10	MAPK13	MAP2K1	MAP2K2	MAP2K3	MAP2K5	MAP2K6	MAP2K7	PTPN1	PTPN11	MAP4K2	RAC1	RAC2	RAF1	RHEB	RPS6KA1	RPS6KA2	RPS6KA3	RPS6KB1	RPS6KB2	MAPK12	MAP2K4	SGK1	SHC1	SLC2A1	SLC2A4	SNAP25	SOS1	SOS2	SRF	VAMP2	MAP3K7	TSC1	TSC2	MAP3K12	IRS4	MAP4K3	PIK3R3	SOCS1	IRS2	CBL	CBLB	RPS6KA4	MAP3K14	SOCS3	MAP3K6	MAP3K13	RPS6KA5	MAP4K4	RRAD	KIF3A	EGR1	GRB10	PRKCD	PRKCH	PRKCQ	XBP1	GAB1	GRB2	GYS2	IGF1R	ARF1	ARF6	LIPE	PRKCZ	PTEN	TRIB3	STX4	STXBP2	STXBP3	TBC1D4	KIF5B	STXBP1	SH2B2	MYO1C	PFKM	PRKCI	RAB4A	SNAP23	SORBS1	EHD1	ARHGAP33	STXBP4	GRB14	EHD2	INPP4A	INPPL1	PPP1R3A	RHOJ	REG1A	CYTH3	GYG1
KE2336	Increase, SREBF1	CDK9	IL2RG	JAK1	PIK3R1	PIK3R2	MAPK1	MAPK3	MAP2K1	MAP2K2	STAT1	STAT3	IL9	GRB2	IL9R	JAK3	STAT5A	STAT5B
KE2405	Increase, Hepatocellular lipotoxicity	APOE	DBI	SOAT1	PCSK9	LDLR	VDAC1	ACSL1	NPC2	SCARB1	SLC27A2	APOB	SORT1	ACSL6	ACSL5	STAR	OSBPL5	FABP3	LDLRAP1	SLC27A4	LPA	APOA4	LIPA	SLC27A1	FABP2	APOC1	FABP4	FABP1	LRP1	SOAT2	ACSL3	ABCA1	MYLIP	SLC27A3	APOC2	STARD3
KE2406	Increase, Regenerative nodule formation	EIF4EBP1	MTOR	CDKN1A	BAD	PIK3C2A	IGF1	PIK3CB	LAMC2	SREBF1	IL4R	PPP2R5C	GNB1	HSP90AA1	GSK3B	ITGB5	LAMB1	ITGA6	HSP90AB1	JAK2	MAPK1	IL2RB	HIF1A	MAPK3	TSC2	IKBKB	PPP2CB	GYS1	AKT2	PPP2R1A	PIK3R2	COMP	PIK3CG	ITGB8	RHEB	FGF8	RPS6KB1	COL1A1	VTN	IL2	PPARGC1A	CDKN1B	GNB3	VEGFA	PPP2CA	GNB4	ITGB6	FN1	SOS1	ATF2	EPAS1	AKT3	SLC2A1	CREB1	FOXO3	PIK3CA	MAP2K2	GNG13	GNG11	GNGT1	FOXA1	LAMA5	RAF1	PRKAA1	ITGB4	CASP9	IRS4	NGF	IL2RA	MDM2	LAMC1	RPS6	PPP2R1B	THBS1	ITGB7	PDPK1	RPTOR	AKT1	PIK3R1	EGFR	IL2RG	ITGB1	VEGFC	FOXO1	EIF4E	ITGB2	GNG3	PRKAA2	JAK1	COL1A2	VEGFD	TSC1	GNGT2	GNG8	MLST8	GNG4	COL3A1	MAP2K1	IRS1	THBS3	ITGAM	INSR	PIK3CD	LAMB2	PRL	GNB2	GNG12	VEGFB	GNG5	HRAS	RPS6KB2	GNG7	ULK1	F2R	SLC2A4	CSF1	IRS2	GNG2	PIK3R4	NRAS	GNG10	INS	ITGB3	IKBKG	ITGAL	ITGA3	ITGA2B	NOS2	HGF	IBSP	FLT4	PHLPP2	TNC	KITLG	LAMC3	LAMA3	SLC2A3	CREB3L3	COL11A1	EIF4B	NGFR	LPAR2	TBC1D1	PPP2R5A	ELAVL1	FGFR2	FGFR3	PPP2R5B	FGF10	FGF22	PPP2R3A	PPP2R2C	FGF4	FGFR1	ITGA8	FGF20	LIPE	COL5A3	COL4A4	PHLPP1	ITGAE	RAB10	NOS1	ANGPT2	PPP2R3C	EFNA2	OSM	PIK3IP1	PDGFB	TCL1A	ANGPT4	LAMA1	FGF14	CAB39L	FGF9	FLT1	RAB2A	CDC37	FGF21	JAK3	MET	CREB3	CSF3	VWF	FGF6	GYS2	PPP2R5D	LAMA4	GHR	THBS4	PRLR	FGF1	PDGFRB	PFKFB4	FGF12	ITGA4	TNR	STK11	SPP1	RAB14	CSF3R	PGF	TEK	TNN	PFKFB2	HIF3A	KDR	ATF4	FGF13	EPO	COL5A1	PIK3C2B	KRAS	PDGFRA	COL4A2	ITGA7	EIF4E2	CAB39	CHAD	CSH1	ITGA11	ITGAV	FGF2	EGF	COL2A1	LPAR6	FGF7	IGF1R	ITGAX	PIK3R5	IFNAR1	COL6A2	EPHA2	ITGA10	CREB3L4	EFNA3	ITGA9	PDGFC	OSMR	CREB5	LPAR4	PELO	PPP2R5E	ANGPT1	FGF18	PPP2R2B	ITGAD	KIT	CREB3L1	PFKFB1	FGF17	IFNAR2	IL6R	CRTC2	FGFR4	ITGA5	FGF11	FGF19	SLC2A2	ITGA2	NOS3	HSP90B1	RAB8A	DDIT4	TNXB	CHRM1	IL7R	EFNA1	PTK2	PFKFB3	PDGFD	LPAR3	IFNB1	PTEN	PPP2R2D	EIF4E1B	GRB2	CHRM2	CREB3L2	CSF1R	EFNA5	LPAR5	RAB11B	IL3RA	THBS2	FGF3	EPOR	COL4A1	RELN	FGF16	LAMA2	LAMB3	PDGFA	COL4A6	LPAR1	COL11A2	COL5A2	AKT1S1	TCL1B	ATF6B	IFNA7	EFNA4	STRADA	ACACA	GPC4	NLK	CHD8	NFATC4	PORCN	SFRP1	DKK4	SFRP4	PPP3CB	INVS	SFRP5	PPP3CC	PRICKLE1	NKD1	SFRP2	NKD2	DAAM2	CER1	DKK2	WIF1	VANGL2	PRICKLE2	SENP2	SOX17	CXXC4	VANGL1	CTNNBIP1	FRAT2	NOTUM	PPP3R2	PPP3R1	CSNK2A3	FRAT1	CSNK1E	ROR1	ROR2	RYK	FOSL1	KREMEN1	MAPK9	CAMK2B	CSNK2A2	CAMK2A	CSNK2A1	MAPK8	DKK1	NFATC1	SERPINF1	MAP3K7	PPP3CA	CAMK2D	PRKCB	SOST	CSNK2B	CTNNB1	JUN	RHOA	LRP5	MYC	WNT16	PRKCA	RAC1	CCND1	WNT1	WNT5A	WNT10B	AXIN1	CCND2	NFATC3	TCF7	PLCB4	CSNK1A1	ROCK2	PLCB2	LEF1	CAMK2G	TCF7L2	PLCB3	TCF7L1	FZD10	CCND3	DAAM1	NFATC2	CTBP1	CTBP2	PLCB1	DVL1	DVL2	DVL3	FZD2	APC	LRP6	PLAU	WNT4	PRKCG	WNT2	WNT3	WNT6	WNT7A	WNT7B	WNT11	WNT2B	FZD5	FZD3	WNT10A	WNT5B	FZD1	FZD6	FZD7	FZD8	FZD9	WNT3A
KE2407	Increase, Cirrhosis	SMAD4	WWTR1	YWHAG	TGFBR3	POSTN	SERPINE1	SPARC	CCN2	TGFBR1	TGFBR2	SMAD3	SMAD2
KE2408	Increase, Adipose lipolysis	ZMPSTE24	CEBPA	CEBPD	FOXC2	GATA2	LMNA	RARA	SFRP4	ADIPOQ	CDKN1A	NR1H3	NCOA2	PPARGC1A	CREB1	CTNNB1	AHR	EPAS1	FOXO1	WWTR1	GATA3	NR3C1	HIF1A	IGF1	FAS	IL6	INS	IRS1	LEP	LPL	MEF2A	MEF2B	MEF2C	MEF2D	PCK1	RXRA	SCD	BMP2	BMP3	SLC2A4	BMP4	SP1	SREBF1	STAT1	STAT2	STAT3	TGFB1	TNF	WNT1	WNT10B	NRIP1	IRS4	NCOA1	SOCS1	IRS2	SOCS3	AGPAT2	CELF1	PLIN2	EBF1	FRZB	BSCL2	GDF10	KLF15	GTF3A	MBNL1	ASIP	NDN	PCK2	CISD1	SPOCK1	KLF5	NR2F1	MIXL1	KLF7	GADD45A	DDIT3	GATA4	HMGA1	MIF	PPARD	CYP26B1	STAT6	PNPLA3	CEBPB	CNTFR	KLF6	CFD	AGT	DVL1	E2F1	GH1	IL6ST	LIF	LIFR	LIPE	SMAD3	OSM	SERPINE1	PLIN1	PPARA	PPARG	PRLR	PTGIS	TRIB3	RB1	BMP1	STAT5A	STAT5B	HNF1A	TWIST1	UCP1	WNT5B	FZD1	NCOR2	NAMPT	E2F4	ID3	RBL1	RBL2	RXRG	GADD45B	RETN	DLK1	NCOR1	CYP26A1	EGR2	LPIN1	RORA	LPIN3	LPIN2
KE2410	Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity	SPRY1	TSC22D3	STOM	ALOX5AP	KTN1	MFGE8	ETNK2	SCNN1A	CDKN1C	PTGES3	SLC26A2	NR3C1	BIRC2	BIRC3	HSP90AA1	JUN	RXRA	CCL2	CCL20	BHLHE40	IL11	LRRC8A	TGFBR3	NFKB2	SRGN	PTGS2	THBD	TNFAIP3	CUL1	SLC19A2	CDC42EP3	PLK2	ABHD2	AKAP13	FGD4	SPINK13	EDN2	ARL5B	ADGRF4	ANKRD1	DNAJC15	AMIGO2	GPR153	GADD45B	ANGPTL4	PDE4B	SERPINB9	PMP2	EPB41L4B	POU5F1	ACKR3	RGS2	S100P	SEC14L1	SNAI2	ZIC2	PRRG4	CPEB4	PPP1R14C	B3GNT5	CAVIN2	TNS4	ENC1	NR1I2	MGAM	NAV3	DNER	SERTAD2	NR1I3	FGFBP1
KE2412	Increase, Hepatic intracellular active glucocorticoids	SRD5A1	CYP11B2	CYP3A4	CBR1	SRD5A2	AKR1C4	AKR1C3	AKR1D1	AKR1C2	AKR1C1	CYP21A2	CYP11B1	HSD11B1	HSD11B2