# molAOP Builder GMT export # resource: KE-WP-CENTRIC # export-revision: f8b54eed4cfd02ea # source-fingerprint: 451:61aef555576354b63575554882ee9a03| # confidence: all tiers # generated: 2026-09-05T04:01:54+00:00 # Lines beginning with # are provenance, not gene sets. KE9 Activation, 5HT2c HTR2A HTR2C ELK4 RAF1 GATA4 RASGRP1 HTR2B MAPK1 ELK1 GNAQ HRAS ITPR1 KRAS NRAS MAPK3 MAP2K1 MAP2K2 SRF MAPKAPK2 RASGRF1 KE10 Acetylcholine accumulation in synapses CHAT PEMT CHKA PCYT1A PDHA1 ACHE PDHA2 KE12 Acetylcholinesterase (AchE) Inhibition CHAT HDC DBH ACHE PAH COMT AANAT DDC GAD1 GAD2 MAOA ASMT PNMT TH TPH1 KE17 KE 17 - Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway IL12B IL17B SERPINB2 NCOA1 TGFB1 HES1 POLK JUND IGFBP1 UGT1A1 ARNT MGST1 SLC7A5 ALDH3A1 AIP PTGES3 CAP2 CYP1B1 MYOF UGT1A6 CES3 UGT1A7 HSP90AA1 BAX EP300 AHR IL2 CDKN1B IFNG NFE2L2 IL1B CYP1A1 CYP1A2 EGFR JUNB JUN NQO1 SRC TNF AHRR CDC37 IL12A GSTA2 UGT1A9 UGT1A4 BIRC3 ACAA1 ME1 KEAP1 SLC5A1 SLC6A4 EHHADH NCOA2 STOM ACOX1 SLC2A2 SPRY1 CYP8B1 NRIP1 MAFF CYP4A11 ADH7 NCOA6 PTGR1 ABCC5 CBR1 FTH1 CYP4F12 HGF ZIC2 SLC2A3 TGFBR3 SREBF1 ESR1 TGFB2 SCD GADD45B PDGFB SULT2A1 SOD3 SLC2A1 TNFAIP3 EGR1 ABCC4 SLC27A1 BHLHE40 CDK4 BAAT MFGE8 ETNK2 SLC2A12 ANKRD1 SLC7A11 DBI NRG1 CYP3A7 TGFA TGFBR2 FABP1 SLC6A20 STAT3 FASN SLC6A19 IRS2 DNER SULT1A1 POU5F1 ALAS1 SMC1A NR3C1 PRDX1 DNAJB1 ALOX5AP LRRC8A AMIGO2 FGF19 DNAJC7 HSP90AB1 SLC19A2 FGF13 SLC6A3 EPHA2 UGT2B7 THBD SERPINA1 FKBP5 TNS4 FGFBP1 SRXN1 GCLC GCLM PTGS2 NFKB2 GSTP1 GSTT2 GGT1 GSR CCL2 PPARGC1A CCND1 APOC3 VDR PPARD HBEGF KAT2B APOA1 GPAM CDKN1C GSTM1 TXN MYC CYP2C9 NR1I2 FOXO1 APOA2 CES5A G6PD CYP3A4 SQSTM1 CYP2C19 GSTM4 CES2 GPX2 B3GNT5 SLC2A4 GSTA5 PDE4B SP1 RXRA PPARA CES1 GPX3 GSTM2 GSTA1 SNAI2 ABCC2 NR1H3 CUL1 SLC27A5 ABCB1 PSMC5 IL11 HMOX1 ABCC3 CPT1A CCL20 ACADM PTPA NCOA3 NR0B2 SLCO1B1 ABCG5 ABCG8 CPT2 CYP7A1 CDK1 KLK15 MAFG CYP2B6 AGER NR1H4 EPHA3 ABCB11 FTL SLC10A1 PLTP SLC5A5 CYP3A5 APOA5 BIRC2 SCP2 PCK1 NR1I3 ANGPTL4 AKAP13 TXNRD3 TXNRD1 CYP2A6 PDK4 ABCB4 SLC6A13 SLC6A7 SLC39A9 SLC6A16 NAV3 SLC6A15 MGST2 BLVRB EPB41L4B SLC5A4 SMARCA1 SRPX2 SLC6A2 SLC39A14 SLC2A9 SCNN1A SLC39A7 CPEB4 SLC5A7 RGS2 PRDX6 SLC5A9 DNAJC15 SRGN KTN1 EDN2 SEC14L1 SLC6A8 SLC6A6 SLC6A11 SLC39A11 SLC2A11 GSTM5 GSTM3 PRRG4 SLC2A8 SLCO2B1 SLC5A6 SLC39A8 FGD4 SLC39A5 ABHD2 SLC5A2 SLC39A6 SLC39A3 SLC2A5 PGD MGST3 SLC39A1 ACKR3 PLK2 PMP2 SLC39A4 SLC39A12 SLC5A12 SLC2A13 ADGRF4 SLC5A10 SLC26A2 UGT2B4 SLC6A1 TSC22D3 GPR153 SLC5A11 CBR3 SLC2A6 IP6K3 CDC42EP3 S100P SLC6A18 SLC39A2 SLC39A13 SLC6A5 ARL5B CAVIN2 SERPINB9 GSTA4 ENC1 CES4A SLC2A14 GSTA3 GCC1 SERTAD2 SLC6A9 SLC39A10 SLC6A17 SLC2A7 SLC2A10 PPP1R14C SLC5A3 HSPA1A SPINK13 SLC5A8 SLC6A14 KE18 Activation, AhR IL12B IL17B SERPINB2 NCOA1 TGFB1 HES1 POLK JUND IGFBP1 UGT1A1 ARNT MGST1 SLC7A5 ALDH3A1 AIP PTGES3 CAP2 CYP1B1 MYOF UGT1A6 CES3 UGT1A7 HSP90AA1 BAX EP300 AHR IL2 CDKN1B IFNG NFE2L2 IL1B CYP1A1 CYP1A2 EGFR JUNB JUN NQO1 SRC TNF AHRR CDC37 IL12A GSTA2 UGT1A9 UGT1A4 KE25 KE 25 - Agonism, Androgen receptor NCOA2 KAT5 KLK3 UBE3A NCOR1 NCOA4 NCOR2 LIMK2 ZMIZ1 RACK1 CALR UBE2I PIAS3 CTNNB1 FHL2 KDM1A RHOB SMAD3 MDM2 PAK6 PTEN STAT3 PIAS1 NCOA1 CDC42 STUB1 PARK7 PRDX1 TGFB1I1 RAD9A BRCA1 SMARCE1 SUMO1 PSMC3IP TGIF1 DSTN KAT7 FKBP4 PATZ1 ZNF318 PIAS4 BAG1 RNF4 RNF6 EFCAB6 PIAS2 RNF14 CDKN1A CREB1 CREBBP EGFR EP300 AKT1 FOXO1 SIRT1 GSK3B HDAC1 JUN RHOA SMAD4 PIK3R1 PIK3R2 PTK2 RAC1 RB1 CCND1 RELA ROCK1 SP1 SRC CAV1 RUNX2 PLPP1 KAT2B CCNE1 BMF ROCK2 DAXX ETV5 SIN3A AR NCOA3 NR0B2 CARM1 FLNA NR2C2 RLN1 TLE5 RAN SPRY1 DOCK1 ACTL6B ARID1B SMARCA4 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 ARID1A ACTL6A CHEK1 MSH6 ATR CDKN2B CHEK2 CDC25A MIR21 ABCC4 MAP4K1 CRK CYP17A1 EIF4EBP1 PTK2B RAPGEF1 HGF FOXA1 HSD17B1 HSD17B3 HSD17B2 HSD17B4 PAK1 PTPN11 PXN RAF1 CDK4 CDK2 CASP3 MSH2 MRE11 CASP9 CASP8 RHEB SMAD2 BAD RAD50 F13B EIF4E1B CDC25B SPRY2 ETV4 FKBP5 SPINK1 NOXA1 BARD1 CDKN1B MAPK14 PIK3CA CDKN2A ELK1 ERG FOS RICTOR GAB1 GRB2 HRAS HSD3B1 HSD3B2 MYC ATF1 MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 SOS1 TP53 BCL2 JAK1 STAT1 MTOR TSC2 E2F1 BAX ATM RPTOR TSC1 CPN1 NDRG1 CRKL KLK2 CDK1 PLK1 HSD17B7 RAP1A RAP1B RASA1 MMP1 BLM PRKDC KE28 Reduction, Angiogenesis TIMP2 PDGFB MMP9 NOS3 FGFR2 KDR ARNT TEK ANGPT1 MAPK1 PLCG1 FGF2 AKT1 SMAD1 SRC CREBBP MAPK14 HIF1A PIK3CA VEGFA PDGFRA PTK2 FLT1 TIMP3 KE40 Mitochondrial ATP production, decreased CAMKK2 INS-IGF2 LEP ACACB STRADA CAB39 PFKFB3 LEPR CRTC2 SREBF1 STRADB HNF4A EEF2K GYS1 RPS6KB1 GYS2 HMGCR ADRA1A PPARGC1B FASN INSR RPS6KB2 CPT1C EIF4EBP1 PRKAG2 PRKAG3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 CAMKK1 ADIPOR2 PIK3CB PIK3C3 LIPE TSC2 AKT2 PIK3R2 PIK3CG PIK3R3 STK11 PIK3CA TP53 AKT1 CCNA2 PIK3R1 TSC1 PIK3CD ADIPOQ PLCB1 CDKN1A MTOR ACACA PRKACB PRKACG RPTOR SLC2A4 ELAVL1 CCNA1 CCNB1 ADRA1B CPT1A CPT1B EEF2 BORCS8-MEF2B SLC2A4RG ADIPOR1 ACADSB EHHADH ACSL3 ACAA2 ECHS1 ACADL ECI1 DECR1 HSD17B10 GABPA GABPB1 TFAM PPRC1 HCFC1 MTERF3 TFB1M POLRMT TFB2M MTERF1 PPP3CA PPARGC1A CREB1 SP1 CAMK4 ESRRA NRF1 MYEF2 KE41 Inhibition, Bile Salt Export Pump (ABCB11) FABP6 SLC10A2 SLCO1B3 ABCC4 ABCC3 ABCB1 ABCC2 SLCO1B1 ABCB11 SLC10A1 SLC51A SLC51B HSD3B7 CYP7B1 CYP8B1 ATP8B1 AKR1D1 HSD17B4 SLC27A2 AKR1C4 BAAT CYP27A1 SLC27A5 CYP7A1 ACOX2 SCP2 AMACR ABCB4 ABCD3 KE50 Increase, Ca++ (intracellular) ORAI1 FKBP1A GJA3 CACNA1A CASQ1 GJA5 CALR ATP1B1 FXYD2 GJB6 GJC2 GJB2 GNB5 CHRM1 ADRA1A ADRB1 GNAI1 SFN ATP2B1 ATP2B2 ATP2B3 GNG13 RGS10 RYR2 RYR3 SLC8A1 CACNA1C YWHAQ GJB1 GRK5 GRK6 CHRM2 GNB4 RGS1 YWHAB PLN GJA4 RGS4 YWHAE YWHAG YWHAH YWHAZ CACNA1B CHRM3 CHRM4 CHRM5 ADRB3 GJA8 ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB2 ADCY4 GJA1 GNAQ GNAS ITPR1 ITPR2 ITPR3 ARRB1 ARRB2 ATP2A2 PLCB3 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ RYR1 CACNB1 CALM1 CALM2 CALM3 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G CAMK1 ADRA1D ADRA1B GNAO1 ATP2A3 CACNA1D CACNA1S RGS9 GNA11 GNAI2 GNAI3 GNAZ GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG11 GNGT1 KCNJ3 GNG2 PRKAR2A PRKD1 GNG12 GNG8 STIM2 GJC1 GJB4 GJB3 GJB5 ANXA6 KCNB1 KCNJ5 ATP1A4 ATP1B2 ATP1B3 GJD2 SLC8A3 CACNA1E GJA9 CASQ2 RGS19 RGS14 PKIG RGS17 GRK4 PKIA PKIB RGS2 RGS3 RGS7 RGS16 RGS18 CACNB3 RGS5 RGS20 RGS11 RGS6 KE52 Decreased, Calcium influx ORAI1 FKBP1A GJA3 CACNA1A CASQ1 GJA5 CALR ATP1B1 FXYD2 GJB6 GJC2 GJB2 GNB5 CHRM1 ADRA1A ADRB1 GNAI1 SFN ATP2B1 ATP2B2 ATP2B3 GNG13 RGS10 RYR2 RYR3 SLC8A1 CACNA1C YWHAQ GJB1 GRK5 GRK6 CHRM2 GNB4 RGS1 YWHAB PLN GJA4 RGS4 YWHAE YWHAG YWHAH YWHAZ CACNA1B CHRM3 CHRM4 CHRM5 ADRB3 GJA8 ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB2 ADCY4 GJA1 GNAQ GNAS ITPR1 ITPR2 ITPR3 ARRB1 ARRB2 ATP2A2 PLCB3 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ RYR1 CACNB1 CALM1 CALM2 CALM3 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G CAMK1 ADRA1D ADRA1B GNAO1 ATP2A3 CACNA1D CACNA1S RGS9 GNA11 GNAI2 GNAI3 GNAZ GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG11 GNGT1 KCNJ3 GNG2 PRKAR2A PRKD1 GNG12 GNG8 STIM2 GJC1 GJB4 GJB3 GJB5 ANXA6 KCNB1 KCNJ5 ATP1A4 ATP1B2 ATP1B3 GJD2 SLC8A3 CACNA1E GJA9 CASQ2 RGS19 RGS14 PKIG RGS17 GRK4 PKIA PKIB RGS2 RGS3 RGS7 RGS16 RGS18 CACNB3 RGS5 RGS20 RGS11 RGS6 KE55 Increase, Cell injury/death HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 TNFRSF21 HELLS LTA MIR29A IRF1 IRF3 IRF5 MDM2 IRF4 IGF2 NFKBIE CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 IRF2 GZMB PRF1 TRAF1 TP73 SCAF11 KE57 Proliferation, Cell proliferation in the absence of cytotoxicity MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 E2F2 TGFB2 GADD45B TGFB1 CDK6 E2F3 CCND3 GADD45A CCND2 CDK2 GADD45G PCNA CDK4 MDM2 CDC25C CDC25A SMAD3 SMAD2 SFN SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 CUL1 ABL1 RBX1 SKP1 CCNA1 CCNB1 CCNB2 CDK1 PLK1 PRKDC KE64 Reduction, Ionotropic GABA receptor chloride channel conductance GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2B1 ABAT GAD2 GAD1 GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE68 Accumulation, Collagen IL12B SKIL GREM1 SFTPC TERC CYSLTR2 TERT ATP11A SFTPA1 PTX3 HGF EDN1 PDGFB MMP9 BMP7 TIMP1 TGFB1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 CEBPB PDGFA SMAD7 CCR2 ELMOD2 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 CXCL2 HMOX1 CSF3 EGF P4HA2 ADAMTS2 GPI P4HA1 PGM1 PLOD1 PHGDH GLS LDHA SLC2A1 FGFR1 FGFR4 SLC16A1 PSPH SLC1A5 PSAT1 LPAR1 UGDH PYCR1 GCK ALDH18A1 UGP2 P4HA3 P3H3 P3H4 LOXL2 CD36 PLCG1 RHOA SERPINH1 GLUD1 BMP1 P3H2 TMEM38B LOX P3H1 COLGALT1 TNFRSF11A FKBP10 PLOD2 MIA3 TNFRSF11B PPIB CRTAP P4HB IFITM5 MBTPS2 LRP6 TNFSF11 WNT1 MBTPS1 FZD1 LRP5 COL1A1 SERPINF1 ITPR1 CREB3L1 COL1A2 SP7 KE79 Inhibition, Cyclooxygenase activity TBXA2R ACAA1 EHHADH ACOX1 CYP4A11 AKR1B1 ACOX3 PTGR1 PTGFR PTGR2 PRXL2B CYP4A22 PTGDR PTGDR2 CYP4F2 CYP4F12 PTGIR PLA2G5 PLA2G4B TBXAS1 PTGS2 PTGS1 PTGDS PPARD PLA2G4A PTGIS PTGES HPGD PPARG ACOX2 PLA2G6 KE87 Release, Cytokine IL12RB1 IL17F IL17C GDF5 IL17B TNFRSF11A IL19 TSLP IL15 TNFRSF11B IL25 IL17D IL20RB LEP CSF1R GH1 TNFRSF10A BMP3 IL31RA CNTF GDF10 CCL23 TNFRSF12A IL12RB2 IL21R IL27RA IL1RL1 LEPR MPL CNTFR IL15RA IL22RA1 TNFRSF21 TNFSF12 CSF2RA IL9R IL18R1 TNFRSF14 CCR1 CX3CR1 CCR4 GDF15 CCL28 LTA TNFRSF17 RELT CCL24 PF4V1 BMP8B TNFRSF8 IL13RA2 ACVR1C CD70 TNFSF14 TNFRSF19 GDF1 CCL25 INHBE NFIC XCL1 XCL2 IFNK GDF6 IL34 TNFRSF13C IL20 IL24 BMP10 PPBP CXCR6 TNFRSF10C INHBC CLCF1 IFNW1 TNFSF15 TNFRSF18 CXCL17 IL27 IL31 TNFRSF25 GDF2 CX3CL1 TNFRSF9 NGFR TGFB2 BMP7 CCL22 AMH TGFB1 TGFBR1 CXCL12 IL17A CCR6 ACVR2B ACVR1 TNFSF4 TNFSF11 TNFRSF10B CXCR4 ACVR2A INHBA BMP4 TNFSF9 LIF EPO NGF IL6ST IL10 CXCL9 IFNAR1 IL18 NODAL IL6R CCR5 TGFBR2 CXCL10 CXCL11 GDF3 TNFRSF4 TNFSF13B CCR2 ACVR1B ANP32B IL17RC IL7R PRL IL17RA CCR8 CSF2RB IL10RA GHR PRLR CSF3R IL13RA1 GH2 CD27 BMP6 IFNL1 CCR3 IFNL2 IFNLR1 IFNL3 INHA CCR7 CXCL14 CXCR5 GDF9 CCL19 LTBR ACKR4 BMP15 AMHR2 XCR1 CCR9 CCR10 FAS IFNGR1 TNFRSF1B TNFRSF1A IL4R IL5RA IL2RB CD40 CD40LG BMPR1A CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG IL4 IL5 IL1A IL1R1 IL1RL2 FASLG TGFB3 TNFSF10 IL37 IL2RA IL6 IL36G IL1RN IL36A IL36RN IL36B IL1F10 MSTN BMPR1B IL2RG CXCL13 IFNAR2 IFNGR2 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 IL1RAP BMPR2 TNF CCL5 CCL4 CCL18 CCL15 CCL4L2 CCL14 CCL3 CCL26 CXCL2 IL11 IL7 CSF3 CCL20 IL1R2 IL18RAP TPO CXCL6 IL22 IL33 IL11RA CCL21 IL21 ACVRL1 IL9 CXCL16 CXCR1 CXCL3 CXCL5 PF4 CXCL1 IFNB1 CXCR2 CCL27 IL20RA IL26 LIFR GDF11 EDAR EDA INHBB IL3 EPOR LTB TNFRSF13B IL10RB IL3RA ACKR3 IL23R IL17RB BMP5 EDA2R GDF7 IL12B PDGFA IL1B HLA-DRA HLA-DRB1 CD4 KE89 Synthesis, De Novo Fatty Acid (FA) ACACB ECH1 ECHDC2 ECHDC1 ECHDC3 ACSL1 ACSL3 ACSL4 FASN ACSL6 ACLY ACSL5 SCD ACAA2 MECR ECHS1 HADH ACACA PC ACSS2 DECR1 PECR KE105 Inhibition, Mitochondrial Electron Transport Chain Complexes COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 MT-CO2 NDUFB10 COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF UCP1 SLC25A4 SLC25A5 SLC25A6 NDUFA13 MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA12 SDHA KE111 Agonism, Estrogen receptor ACOX1 ESR1 STAT3 CYP1B1 GPAM CYP1A1 CYP1A2 JUN SP1 PPARA NR0B2 PCK1 PDK4 KE115 Increase, FA Influx ACSBG2 FABP7 FABP5 FABP6 FABP9 HGNC:10995 HGNC:10996 HGNC:10997 HGNC:10999 HGNC:11000 HGNC:3555 ACSL4 FABP3 ACSL3 FABP2 ACSL1 DBI FABP1 ACSL6 SLC27A4 FABP4 ACSL5 CD36 ACSBG1 KE122 Increase, Glucocorticoid receptor activation SPRY1 STOM BIRC3 MGAM ANKRD1 MFGE8 GADD45B POU5F1 ETNK2 TGFBR3 TNFAIP3 ZIC2 BHLHE40 DNER PTGES3 ALOX5AP NR3C1 AMIGO2 LRRC8A SLC19A2 THBD TNS4 FGFBP1 CDKN1C HSP90AA1 JUN NFKB2 PDE4B PTGS2 RXRA CCL2 B3GNT5 NR1I2 IL11 CCL20 SNAI2 CUL1 AKAP13 BIRC2 ANGPTL4 NR1I3 CDC42EP3 PLK2 ABHD2 FGD4 SPINK13 TSC22D3 SLC26A2 EDN2 ARL5B ADGRF4 DNAJC15 GPR153 KTN1 SERPINB9 PMP2 EPB41L4B SRGN ACKR3 RGS2 S100P SCNN1A SEC14L1 PRRG4 CPEB4 PPP1R14C CAVIN2 ENC1 NAV3 SERTAD2 KE134 Increase, Kupffer cell activation IL12B IL15 IL10 PDGFA TGFB1 CSF1 CSF2 IFNG IL1A IL1B IL2 IL4 IL5 IL6 IL13 TNF CSF3 CXCL1 CXCL2 HLA-DRA HLA-DRB1 IFNB1 IL7 IL11 CD4 IL3 KE149 Increase, Inflammation IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG IL12B IL15 IL10 PDGFA TGFB1 CSF1 CSF2 IL1A IL1B IL6 IL13 TNF CSF3 CXCL1 CXCL2 HLA-DRA HLA-DRB1 IFNB1 IL7 IL11 CD4 IL3 KE155 Inadequate DNA repair ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 POLE2 LIG1 POLE3 NEIL2 POLE MRE11 MLH1 XRCC5 MSH2 POLK PCNA DDB2 ERCC5 XPC FANCC CUL4B ERCC3 MGMT POLH RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A LIG3 PARP2 PARP1 ATM H2AX ERCC1 RFC1 POLD1 POLB RBX1 ERCC2 PMS2 BRCA2 FANCD2 XRCC4 WRN LIG4 FAN1 RAP1A PRKDC EXO1 REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 KE165 Activation, Long term AHR receptor driven direct and indirect gene expression changes IL12B IL17B SERPINB2 NCOA1 TGFB1 HES1 POLK JUND IGFBP1 UGT1A1 ARNT MGST1 SLC7A5 ALDH3A1 AIP PTGES3 CAP2 CYP1B1 MYOF UGT1A6 CES3 UGT1A7 HSP90AA1 BAX EP300 AHR IL2 CDKN1B IFNG NFE2L2 IL1B CYP1A1 CYP1A2 EGFR JUNB JUN NQO1 SRC TNF AHRR CDC37 IL12A GSTA2 UGT1A9 UGT1A4 NRIP1 KLF6 NCOR2 HPGDS PLAGL1 RAF1 CDK2 ESR1 FGF21 NF1 RET NCOA7 PSRC1 KRAS MAP2K1 HRAS NRAS CDKN1A E2F1 GCLC LPL MYC NFKB1 MAPK1 PTGS2 RB1 RELA CCL1 VEGFA CD36 KE167 Activation, LXR FASN SCD SREBF1 CYP3A4 RXRA NR1H3 CYP2B6 CYP7A1 ABCG5 ABCG8 KE177 Increase, Mitochondrial dysfunction COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 MT-CO2 NDUFB10 COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF UCP1 SLC25A4 SLC25A5 SLC25A6 NDUFA13 MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA12 SDHA ACADSB EHHADH ACSL3 ACAA2 ECHS1 ACADL ECI1 DECR1 HSD17B10 ECSIT NDUFAF6 NDUFAF7 TMEM126B NDUFAF2 NUBPL TMEM186 FOXRED1 DMAC1 NDUFAF3 TMEM70 COA1 ACAD9 TIMMDC1 DMAC2 NDUFB11 NDUFAF4 NDUFAF1 IDH2 ACO2 SUCLG1 SUCLA2 IDH3B IDH3G DLD MDH2 CS DLST FH IDH3A OGDH SUCLG2 ATP6AP2 MTCO3P12 ATP6AP1 GZMB NDUFA4L2 GOT2 SLC25A13 SLC25A12 GLUD1 SLC25A22 KE178 Mitochondrial electron transport chain, disrupted NDUFB10 ECSIT NDUFAB1 NDUFA1 NDUFS4 NDUFB5 NDUFB3 NDUFC1 NDUFA2 NDUFS5 NDUFS2 NDUFS6 NDUFB1 NDUFS3 NDUFB6 NDUFA3 NDUFB4 NDUFB8 NDUFB2 NDUFA7 NDUFC2 NDUFA10 MT-ND1 MT-ND2 MT-ND4L MT-ND4 MT-ND5 MT-ND6 NDUFB7 NDUFV2 NDUFS1 NDUFV1 NDUFA8 NDUFV3 NDUFA6 NDUFA5 NDUFAF6 NDUFAF7 TMEM126B NDUFAF2 NUBPL TMEM186 FOXRED1 DMAC1 NDUFAF3 TMEM70 COA1 ACAD9 TIMMDC1 DMAC2 NDUFB11 NDUFAF4 NDUFA13 NDUFA12 NDUFAF1 NDUFB9 COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 MT-CO2 COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF UCP1 SLC25A4 SLC25A5 SLC25A6 SDHA KE179 Decrease, Fatty acid beta-oxidation CHKB ACSL1 ACSL3 ACSL4 ACSL6 ACSL5 DLD ECHS1 GCDH GK GK2 HADH ACAT1 LIPC LIPE LPL PNPLA2 LIPF CPT1A CPT1B CPT2 CRAT ECI1 DECR1 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL ACSS2 TPI1 SLC25A20 KE186 Altered, Neuroanatomy CAMKK2 RPS6KA1 CCND2 NGF BDNF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 KE188 Neuroinflammation CAMKK2 ARC IL12B PPP1CC SLC1A2 LRRC8C CNTF GRIN3A GRIN3B DAO LTA PHGDH GLS2 DISC1 GLS GRM5 PSAT1 IL6R IL6ST IL10 INSR IRS1 LIF SMAD2 SMAD3 NGF PDHA1 PSPH BDNF SHMT1 SHMT2 SLC1A1 SLC2A1 SLC2A3 STAT3 STAT6 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 CFL1 GFAP SMAD7 SLC38A2 LRRC8A SLC1A4 SLC38A1 CAMKK1 SLC38A5 GRM2 GRM4 GRM7 GRM8 IL10RA IL13RA1 GLUL SLC7A10 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 SLC17A7 SLC17A6 SLC1A3 SLC1A6 ADCY1 ADCY3 ADCY8 CREB1 DLD AKT1 FGF2 PLCB1 FOS GOT1 GRIA1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D IFNG IFNGR1 IFNGR2 IGF1 IL1A IL1B IL1R1 IL4 IL4R IL6 IL13 JAK1 SMAD4 NFKB1 NFKB2 NOS1 PLCB2 PLCB3 PLCB4 PPP1CB PRKACA PRKCA PRKCB PRKCG MAPK1 MAPK3 BCL2 STAT1 TGFB3 TNF TNFRSF1A TNFRSF1B TRAF5 CALM1 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G SOCS3 GRM1 IL12A IL1R2 DLAT GRIA2 IL10RB PPP1CA SLC6A9 SLC38A3 LRRC8B NSMF TRPM4 LRRC8D SRR LRRC8E NOS2 MT-CO2 MT-CO1 ASCC1 NFKBIA MAPK8 MAPK14 TLR4 RELA JUN MTOR CHUK TLR3 IL18 ACE2 TLR7 TMPRSS2 HMGB1 FURIN IFNA2 CXCL8 CCL11 IL2 TLR8 KE192 Altered, Neurophysiology CAMKK2 RPS6KA1 CCND2 NGF BDNF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 KE193 Decreased, Nitric Oxide NOS2 NOS3 MB MT-CO1 AOX1 XDH NOS1 HBB HBA2 HBA1 KE202 Inhibition, Nuclear factor kappa B (NF-kB) FBXW11 BIRC3 SELE NSMAF KSR1 CYBA NOX1 APAF1 RFK BAD MAP4K2 RAF1 REL TNFAIP3 CASP3 CASP8 CASP9 TRAP1 RIPK3 NOXO1 GLUL KSR2 NFKBIE DIABLO OTUD7B PTPRCAP PYGL SMPD2 MADD TANK TAB1 CHUK RFFL MAP3K8 CREBBP CSNK2A1 AKT1 TAB2 TAB3 GRB2 TBK1 HRAS HSP90AA1 IKBKB IL6 JUN KRAS MAP3K1 MAP3K3 MAP3K5 NFKB1 NFKB2 NFKBIA NFKBIB NRAS PPP2CA PRKCZ MAPK1 MAPK3 MAPK8 MAPK9 MAP2K3 MAP2K6 MAP2K7 PSMD2 BAX RAC1 BCL2L1 CCL2 BID MAP2K4 SOS1 MAP3K7 TNF TNFRSF1A TNFRSF1B TRAF2 TXN IKBKG CFLAR MAP3K14 CDC37 SKP1 CASP7 CUL1 TRADD RIPK1 FADD BTRC BIRC2 PLK1 TRAF1 AJUBA TIFA UBE2N UBE2V1 IL1A SQSTM1 TRAF6 IRAK1 KE209 Peptide Oxidation CUL3 IPCEF1 KEAP1 CHEK1 PIP GSX1 ATR NOS2 NOX1 ICAM1 RHEB CDK2 MDM2 PTEN MAP2K3 MAP2K4 PTGS2 SIRT1 RPS6KA5 IKBKB CCNE1 MAPK8 NFKB1 MAPK14 IL1A ATF2 NFE2L2 CREB1 CAT PIK3CA CDKN1A IL6 TP53 AKT1 FOXO1 PINK1 TSC1 CXCL8 FOS BCL2L1 BCL2 NQO1 MAP3K5 MTOR TNF IKBKG HMOX1 NRF1 SOD2 NOX5 MT1X NFIX NOX3 CYBB SOD3 TXN2 MGST1 UGT1A6 CYP1A1 GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NOX4 MAPK10 SOD1 SP1 XDH TXNRD2 TXNRD1 KE214 Bile accumulation, Pathological condition FABP6 SLC10A2 SLCO1B3 ABCC4 ABCC3 ABCB1 ABCC2 SLCO1B1 ABCB11 SLC10A1 SLC51A SLC51B HSD3B7 CYP7B1 CYP8B1 ATP8B1 AKR1D1 HSD17B4 SLC27A2 AKR1C4 BAAT CYP27A1 SLC27A5 CYP7A1 ACOX2 SCP2 AMACR ABCB4 ABCD3 FGFR4 FGF19 MAPK1 MAPK3 LDLR ABCG5 ABCG8 FXR1 SULT2A1 CYP3A4 VDR NR1I2 NR1I3 NR1H4 KE216 Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) ENO2 ENO3 FBP1 ALDOA ALDOB GPI HK3 LDHB LDHC PGK2 PKLR SLC2A2 PGAM1 HK1 LDHA MDH1 PDHA1 PFKL PFKM PGK1 PKM SLC2A1 SLC2A3 GCK PGAM2 MPC1 DLD GOT1 GOT2 PC SLC2A4 GAPDH ENO1 ALDOC HK2 MDH2 TPI1 DLAT G6PC1 PCK1 PFKP MPC2 SLC2A5 FBP2 LDHAL6B KE227 Activation, PPARα ACAA1 EHHADH CYP8B1 CYP4A11 SLC27A1 CDK4 DBI FABP1 CCND1 APOC3 APOA1 MYC APOA2 RXRA PPARA NR1H3 CPT1A ACADM CPT2 CYP7A1 CDK1 KLK15 PLTP APOA5 SCP2 UGT1A9 KE228 peroxisome proliferator activated receptor promoter demethylation ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 KE231 Decreased, PPAR-alpha activation ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 CDK4 CCND1 MYC CPT1A ACADM CDK1 KLK15 UGT1A9 KE232 Decreased, PPAR-beta activation ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 KE233 Decreased, PPAR-gamma activation ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 KE239 Activation, Pregnane-X receptor, NR1I2 NCOA2 NRIP1 CYP4F12 NCOA1 SULT2A1 ABCC4 CYP3A7 UGT1A1 UGT1A6 DNAJC7 HSP90AA1 PPARGC1A CYP2C9 NR1I2 FOXO1 CYP3A4 CYP2C19 RXRA SRC ABCC2 ABCB1 PSMC5 ABCC3 NCOA3 SLCO1B1 CYP2B6 GSTA2 CYP3A5 UGT1A9 UGT1A4 CYP2A6 SRPX2 KE245 Activation, PXR/SXR NCOA2 NRIP1 CYP4F12 NCOA1 SULT2A1 ABCC4 CYP3A7 UGT1A1 UGT1A6 DNAJC7 HSP90AA1 PPARGC1A CYP2C9 NR1I2 FOXO1 CYP3A4 CYP2C19 RXRA SRC ABCC2 ABCB1 PSMC5 ABCC3 NCOA3 SLCO1B1 CYP2B6 GSTA2 CYP3A5 UGT1A9 UGT1A4 CYP2A6 SRPX2 KE265 Activation, Stellate cells FKBP1A SKIL MIR302A LEFTY1 CTNNB1 INHBA LIF SMAD2 SMAD3 SERPINE1 LEF1 BMP4 SPP1 STAT3 TGFB1 LEFTY2 TGFBR1 TGFBR2 TGFBR3 WNT1 FOXH1 ZNF423 SMAD7 RUNX3 FST BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD4 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG EGF SMAD5 SMAD9 ZEB2 ENG ITGB6 LTBP1 KE269 Induction, Sustained Cell Proliferation KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 MET RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA RAF1 APC MDM2 LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR PTEN NTRK1 AKT1S1 IL6R JAK2 STAT3 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 GSK3B MAPK1 NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 PIK3CA CDKN1A ELK1 MAP2K2 KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 FLT4 FLT1 PDGFRB TELO2 TTI1 KE272 Activation/Proliferation, T-cells GAB2 CD83 IL15RA RIPK2 SH2B3 VAV3 MALT1 MAP4K1 CCR5 CRK PTK2B LAT ICOS TNFRSF9 IL17A ITK LCP2 NCK1 NFATC1 NFATC2 PAK1 PDPK1 PTPN11 RAF1 REL SHC1 TGFB1 VAV1 WAS CARD11 CBLB BCL10 CD3D CD3E CD3G CD247 CD8A GRAP2 CDC42 IRF4 OPRM1 FYB1 PSTPIP1 MAP3K14 CHUK MAP3K8 CREB1 ATF2 MAPK14 AKT1 FOS GATA3 GRB2 HRAS FAS IKBKB IL1A IL1B IL6 ITPR1 JUN LCK NFKB1 NFKBIA PIK3R1 PIK3R2 PLCG1 PRKCD PRKCQ MAPK1 MAPK3 MAPK8 MAPK9 MAP2K1 MAP2K2 RELA SOS1 MAP3K7 TRAF6 ZAP70 IKBKG CBL CD28 CRKL FYN IL9 VIM SKAP1 CD4 DBNL KE277 Thyroid hormone synthesis, Decreased PRKAA1 PRKAA2 RAF1 MAP2K2 PRKCA MAP2K1 ELK1 MAPK1 MAPK3 CREB1 NFKB1 PLCD1 TPO ANO1 DUOX1 DUOX2 CLCN5 SLC26A6 ACY1 CGA SLC5A5 TG TRH TSHR RAP1B RAP1A KE281 Thyroxine (T4) in serum, Decreased PRKAA1 PRKAA2 RAF1 MAP2K2 PRKCA MAP2K1 ELK1 MAPK1 MAPK3 CREB1 NFKB1 PLCD1 TPO ANO1 DUOX1 DUOX2 CLCN5 SLC26A6 ACY1 CGA SLC5A5 TG TRH TSHR RAP1B RAP1A KE288 Activation of specific nuclear receptors, Transcriptional change CYP4A11 CYP8B1 CYP26A1 CYP4B1 ABCD2 MIR33B MIR33A ABCA1 RARA RARB RARG CYP1A2 CYP2C9 CYP2E1 CYP3A4 CYP24A1 CYP27B1 PPARA PPARD PPARG VDR NR1I2 NR1H3 ABCC2 CYP2B6 CYP7A1 ABCB1 ABCG5 ABCC3 ABCG1 ABCB11 NR1I3 NR1H4 ABCB4 ABCD3 BIRC3 ACAA1 ME1 KEAP1 SLC5A1 SLC6A4 IL12B EHHADH IL17B NCOA2 STOM ACOX1 SLC2A2 SPRY1 NRIP1 MAFF ADH7 SERPINB2 NCOA6 PTGR1 ABCC5 CBR1 FTH1 CYP4F12 HGF ZIC2 SLC2A3 TGFBR3 SREBF1 NCOA1 ESR1 TGFB2 SCD GADD45B PDGFB TGFB1 SULT2A1 SOD3 HES1 SLC2A1 TNFAIP3 EGR1 POLK ABCC4 SLC27A1 JUND BHLHE40 CDK4 BAAT MFGE8 ETNK2 SLC2A12 IGFBP1 ANKRD1 SLC7A11 DBI NRG1 CYP3A7 TGFA TGFBR2 FABP1 SLC6A20 STAT3 FASN SLC6A19 IRS2 DNER SULT1A1 POU5F1 UGT1A1 ARNT MGST1 ALAS1 SMC1A SLC7A5 ALDH3A1 AIP PTGES3 CAP2 NR3C1 PRDX1 DNAJB1 ALOX5AP LRRC8A CYP1B1 MYOF AMIGO2 FGF19 UGT1A6 DNAJC7 CES3 UGT1A7 HSP90AB1 SLC19A2 FGF13 SLC6A3 EPHA2 UGT2B7 THBD SERPINA1 FKBP5 TNS4 FGFBP1 SRXN1 GCLC GCLM PTGS2 NFKB2 HSP90AA1 GSTP1 BAX GSTT2 GGT1 EP300 GSR AHR CCL2 IL2 PPARGC1A CCND1 APOC3 CDKN1B IFNG HBEGF KAT2B NFE2L2 APOA1 GPAM IL1B CDKN1C GSTM1 TXN MYC CYP1A1 EGFR FOXO1 APOA2 CES5A G6PD SQSTM1 CYP2C19 GSTM4 JUNB CES2 GPX2 B3GNT5 JUN NQO1 SLC2A4 GSTA5 PDE4B SP1 RXRA SRC CES1 GPX3 GSTM2 TNF GSTA1 SNAI2 CUL1 AHRR SLC27A5 PSMC5 IL11 HMOX1 CDC37 CPT1A CCL20 ACADM PTPA NCOA3 NR0B2 SLCO1B1 ABCG8 CPT2 IL12A CDK1 KLK15 MAFG AGER GSTA2 EPHA3 FTL SLC10A1 PLTP SLC5A5 CYP3A5 APOA5 BIRC2 SCP2 PCK1 ANGPTL4 AKAP13 TXNRD3 TXNRD1 UGT1A9 UGT1A4 CYP2A6 PDK4 SLC6A13 SLC6A7 SLC39A9 SLC6A16 NAV3 SLC6A15 MGST2 BLVRB EPB41L4B SLC5A4 SMARCA1 SRPX2 SLC6A2 SLC39A14 SLC2A9 SCNN1A SLC39A7 CPEB4 SLC5A7 RGS2 PRDX6 SLC5A9 DNAJC15 SRGN KTN1 EDN2 SEC14L1 SLC6A8 SLC6A6 SLC6A11 SLC39A11 SLC2A11 GSTM5 GSTM3 PRRG4 SLC2A8 SLCO2B1 SLC5A6 SLC39A8 FGD4 SLC39A5 ABHD2 SLC5A2 SLC39A6 SLC39A3 SLC2A5 PGD MGST3 SLC39A1 ACKR3 PLK2 PMP2 SLC39A4 SLC39A12 SLC5A12 SLC2A13 ADGRF4 SLC5A10 SLC26A2 UGT2B4 SLC6A1 TSC22D3 GPR153 SLC5A11 CBR3 SLC2A6 IP6K3 CDC42EP3 S100P SLC6A18 SLC39A2 SLC39A13 SLC6A5 ARL5B CAVIN2 SERPINB9 GSTA4 ENC1 CES4A SLC2A14 GSTA3 GCC1 SERTAD2 SLC6A9 SLC39A10 SLC6A17 SLC2A7 SLC2A10 PPP1R14C SLC5A3 HSPA1A SPINK13 SLC5A8 SLC6A14 KE291 Accumulation, Triglyceride OSBPL5 NPC2 FABP3 LDLRAP1 ACSL6 SLC27A4 ACSL5 LPA APOA4 DBI SOAT1 SLC27A2 ACSL1 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 AGPAT1 AGPAT2 MOGAT1 GK GK2 GPD1 MOGAT3 LIPC LIPE LPL AGPAT5 AGPAT3 AGPAT4 PNPLA2 GPAM MOGAT2 GNPAT DGAT2 LIPF AGPS PLPP1 PLPP2 PLPP3 DGAT1 KE295 Induction, Upregulation of glucuronyltransferase activity PGM1 PGM2 HK1 UGT1A1 UGDH UGP2 UGT1A7 UGT1A6 UGT1A8 UGT2A2 UGT2B7 PGM3 UGT2B10 PGM5 UGT2B11 UGT2A1 UGT2B28 UGT1A5 UGT1A3 UGT2B15 UGT2B17 UGT2A3 UGT1A10 UGT1A9 UGT1A4 UGT2B4 KE327 Accumulation, Fatty acid ACSBG2 FABP7 FABP5 FABP6 FABP9 HGNC:10995 HGNC:10996 HGNC:10997 HGNC:10999 HGNC:11000 HGNC:3555 ACSL4 FABP3 ACSL3 FABP2 ACSL1 DBI FABP1 ACSL6 SLC27A4 FABP4 ACSL5 CD36 ACSBG1 ACACB ECH1 ECHDC2 ECHDC1 ECHDC3 FASN ACLY SCD ACAA2 MECR ECHS1 HADH ACACA PC ACSS2 DECR1 PECR CHKB DLD GCDH GK GK2 ACAT1 LIPC LIPE LPL PNPLA2 LIPF CPT1A CPT1B CPT2 CRAT ECI1 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL TPI1 SLC25A20 KE334 Promotion, Hepatocelluar carcinoma JAK2 IL6ST IL6R STAT3 MIR200A MIR200C MIR200B MIR21 UCA1 NFKB1 IL6 JAK1 RELA IL11 IL11RA ZEB1 JAK3 SOX4 DANCR MIR452 TCF7 NLK CHD8 PORCN SFRP1 DKK4 EZH2 DKK1 SFRP5 KLF4 LEF1 NKD1 SFRP2 NKD2 CER1 TCF7L2 TCF7L1 DKK2 WIF1 CTBP1 SENP2 SOX17 SOST CXXC4 CTBP2 CTNNBIP1 FRAT2 NOTUM CSNK2B MIR214 FRAT1 FZD10 CSNK1E CTNNB1 DVL1 DVL2 DVL3 APC LRP6 LRP5 ROR1 ROR2 WNT16 PLAU WNT4 RYK WNT1 WNT2 WNT3 WNT6 WNT7A WNT7B WNT11 WNT2B FZD5 FZD3 FOSL1 WNT5B FZD1 FZD6 FZD8 FZD9 KREMEN1 CCND2 CCND3 WNT3A MTDH SOX7 MIR18A MIR320A CSNK2A2 CSNK2A1 SFRP4 CSNK1A1 SERPINF1 CSNK2A3 FZD2 GSK3B JUN MYC CCND1 WNT5A WNT10B WNT10A AXIN1 FZD7 ELAVL1 CSNK1A1L DOCK1 MAP4K1 CRK PTK2B RAPGEF1 HGF MET PAK1 PTEN PTPN11 PXN RAF1 ELK1 FOS GAB1 GRB2 HRAS PIK3CA MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTGS2 PTK2 SOS1 SRC CRKL ITGA1 ITGB1 RAP1A RAP1B RASA1 KE344 N/A, Liver fibrosis P4HA2 PLOD1 ADAMTS2 P3H2 TMEM38B LOX P3H1 P4HA1 COLGALT1 TNFRSF11A FKBP10 PLOD2 MIA3 TNFRSF11B PPIB CRTAP P4HB IFITM5 MBTPS2 LRP6 TNFSF11 WNT1 MBTPS1 FZD1 LRP5 COL1A1 SERPINF1 ITPR1 CREB3L1 COL1A2 SERPINH1 SP7 BMP1 KE345 N/A, Liver Steatosis OSBPL5 NPC2 FABP3 LDLRAP1 ACSL6 SLC27A4 ACSL5 LPA APOA4 DBI SOAT1 SLC27A2 ACSL1 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 CEBPA COX6C COX7A1 LEP NDUFA9 PKLR SDHB SDHC SDHD VCAM1 LEPR BBC3 GSK3A IL6R INSR IRS1 MIR21 MAP3K11 MT-CO2 NDUFB10 PRKAG2 PRKAG3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 SREBF1 TGFB1 XBP1 CASP3 CASP8 COX4I2 IRS2 CDC42 SMAD7 MT-CO1 UQCRFS1 ADIPOR2 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A MT-CO3 NDUFA4 COX5A UQCR11 NDUFA11 COX6A2 UQCRQ UQCR10 NDUFS7 MT-CYB NDUFS8 UQCRB UQCRC1 UQCRC2 UQCRH COX7A2L CYC1 AKT3 BCL2L11 CYP2E1 EIF2S1 AKT1 AKT2 GSK3B FAS IKBKB IL1A IL1B FASLG IL6 CXCL8 INS JUN MAP3K5 ATF4 NFKB1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 CYCS PPARA MAPK8 MAPK9 BAK1 BAX RAC1 RELA RXRA CCL2 BID TNF TNFRSF1A TRAF2 PIK3R3 SOCS3 ADIPOQ EIF2AK3 NR1H3 DDIT3 ERN1 MLXIPL ITCH CASP7 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA13 NDUFB11 NDUFA12 SDHA NR1H4 NDUFC2-KCTD14 COX6B2 COX7B2 MLXIP COX8C UQCRHL NDUFA4L2 MLX ADIPOR1 KE352 N/A, Neurodegeneration CEBPB BDNF NTRK2 SET TARDBP LGMN SRPK2 APP MAPT MAOB AKT1 AKT2 STAT1 BACE1 PPP2CB AKT3 SNCA KE357 Cholestasis, Pathology HSD3B7 CYP7B1 CYP8B1 ATP8B1 FABP6 SLC10A2 SLCO1B3 AKR1D1 HSD17B4 SLC27A2 ABCC4 AKR1C4 BAAT CYP27A1 ABCC2 SLC27A5 CYP7A1 ABCC3 ABCB1 SLCO1B1 ABCB11 ACOX2 SCP2 SLC10A1 SLC51A SLC51B AMACR ABCB4 ABCD3 SLC22A1 SLCO1A2 TJP2 HMGCR EPHX1 LDLR RXRA SCARB1 ABCG8 ABCG5 NR1I3 NR1H4 KE373 Formation, Pro-mutagenic DNA Adducts ERCC8 ERCC6 MNAT1 GTF2H1 GTF2H3 RFC3 CDK7 CCNH GTF2H2 RFC4 GTF2H4 RFC2 RFC5 POLE2 LIG1 POLE3 POLE PCNA DDB2 ERCC5 XPC CUL4B ERCC3 POLD3 POLD2 POLE4 RAD23B RPA1 CETN2 POLD4 RPA3 RPA2 DDB1 CUL4A ERCC1 RFC1 POLD1 RBX1 ERCC2 XPA ERCC4 RAD23A GTF2H5 KE376 Increased, Induced Mutations in Critical Genes ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 POLE2 LIG1 POLE3 NEIL2 POLE MRE11 MLH1 XRCC5 MSH2 POLK PCNA DDB2 ERCC5 XPC FANCC CUL4B ERCC3 MGMT POLH RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A LIG3 PARP2 PARP1 ATM H2AX ERCC1 RFC1 POLD1 POLB RBX1 ERCC2 PMS2 BRCA2 FANCD2 XRCC4 WRN LIG4 FAN1 RAP1A PRKDC EXO1 REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 KE378 Tumorigenesis, Hepatocellular carcinoma JAK2 IL6ST IL6R STAT3 MIR200A MIR200C MIR200B MIR21 UCA1 NFKB1 IL6 JAK1 RELA IL11 IL11RA ZEB1 JAK3 SOX4 DANCR MIR452 TCF7 NLK CHD8 PORCN SFRP1 DKK4 EZH2 DKK1 SFRP5 KLF4 LEF1 NKD1 SFRP2 NKD2 CER1 TCF7L2 TCF7L1 DKK2 WIF1 CTBP1 SENP2 SOX17 SOST CXXC4 CTBP2 CTNNBIP1 FRAT2 NOTUM CSNK2B MIR214 FRAT1 FZD10 CSNK1E CTNNB1 DVL1 DVL2 DVL3 APC LRP6 LRP5 ROR1 ROR2 WNT16 PLAU WNT4 RYK WNT1 WNT2 WNT3 WNT6 WNT7A WNT7B WNT11 WNT2B FZD5 FZD3 FOSL1 WNT5B FZD1 FZD6 FZD8 FZD9 KREMEN1 CCND2 CCND3 WNT3A MTDH SOX7 MIR18A MIR320A CSNK2A2 CSNK2A1 SFRP4 CSNK1A1 SERPINF1 CSNK2A3 FZD2 GSK3B JUN MYC CCND1 WNT5A WNT10B WNT10A AXIN1 FZD7 ELAVL1 CSNK1A1L BIRC3 CD44 VAV2 FRZB UCHL1 MIR744 NOS2 E2F2 CTTN BIRC5 TGFB1 TGFBR1 CASP9 CASP3 SMAD3 PTPN11 MIR155 MIR34A MIR24-2 MIR24-1 MYOF MIR92A1 BRCA1 PTGS2 HIF1A MAPK3 MAPK8 MAPK14 VEGFA SOS1 FASLG CDKN1A RAC1 TP53 SMAD4 AKT1 CXCL8 BCL2L1 GRB2 CXCR1 CASP7 RRM2 PODXL COL4A2 HNF1A MMP1 MIR92A2 KE381 Reduced levels of BDNF EGR2 ACACB SHC4 VAV2 KSR1 RACK1 SH2B1 DLG1 SYN1 NCK2 VAV3 SH2B2 MAP3K2 CTNNB1 EGR1 EIF4EBP1 PTK2B CRTC1 SHC2 APC IRS1 JAK2 MEF2A MEF2C NCF2 NCK1 NFATC4 NGF NGFR NTRK1 NTRK2 NTRK3 PDPK1 SHC3 PRKAA1 PRKAA2 MAP2K5 BAD KIDINS220 PTPN11 PTPRF RAF1 RPS6KA1 RPS6KA3 RPS6KB1 BDNF SORT1 SHC1 NCF1 SPP1 STAT3 TIAM1 CASP3 IRS2 CDC42 IGF2BP1 CFL1 RHOG NCAM1 NTF3 DPYSL2 FRS3 DOCK3 GRIA3 KCNA3 KCNN2 MARCKS YBX1 NSF DOK5 CDKL5 BCL2L11 FRS2 CHUK CNR1 CREB1 MAPK14 CSNK2A1 EIF2S1 EIF4E ELK1 AKT1 FOXO3 FOS MTOR ALPL GRB2 GRIA1 GRIN1 GRIN2B GSK3B HRAS IKBKB JUN MAPT MAP3K1 NFKB1 NFKBIA PIK3R1 PIK3R2 PLCG1 PPP2CA PRKCD MAPK1 MAPK3 MAPK7 MAPK8 MAPK9 MAPK10 MAP2K1 MAP2K2 RAC1 RELA BMP2 SRC STAT1 TRAF6 TSC2 CAMK4 CAMK2A IKBKG CAMK1 SQSTM1 RPS6KA5 CDH2 CDK5 SIRPA EEF2 FYN GABRB3 RAB3A RASGRF1 RPS6 ADAM17 CDK5R1 EIF2S2 RANBP9 GRIP1 GRIA2 RAP1A STAT5A STAT5B CYFIP1 LINGO1 KE383 Reduced, Presynaptic release of glutamate SLC6A4 CACNA1A SLC18A3 SYT1 RIMS1 NAPA CPLX1 UNC13B SYN1 DNM1L STX1B DNM1 SNAP25 STXBP1 STX1A SLC38A1 PARK7 CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 AP2B1 CLTCL1 SLC25A4 VAMP2 RAB3A CLTA CLTC SLC18A2 ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 CAMKK2 ARC IL12B PPP1CC SLC1A2 LRRC8C CNTF GRIN3A GRIN3B DAO LTA PHGDH GLS2 DISC1 GLS GRM5 PSAT1 IL6R IL6ST IL10 INSR IRS1 LIF SMAD2 SMAD3 NGF PDHA1 PSPH BDNF SHMT1 SHMT2 SLC1A1 SLC2A1 SLC2A3 STAT3 STAT6 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 CFL1 GFAP SMAD7 SLC38A2 LRRC8A SLC1A4 CAMKK1 SLC38A5 GRM2 GRM4 GRM7 GRM8 IL10RA IL13RA1 GLUL SLC7A10 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 SLC1A6 ADCY1 ADCY3 ADCY8 CREB1 DLD AKT1 FGF2 PLCB1 FOS GOT1 GRIA1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D IFNG IFNGR1 IFNGR2 IGF1 IL1A IL1B IL1R1 IL4 IL4R IL6 IL13 JAK1 SMAD4 NFKB1 NFKB2 NOS1 PLCB2 PLCB3 PLCB4 PPP1CB PRKACA PRKCA PRKCB PRKCG MAPK1 MAPK3 BCL2 STAT1 TGFB3 TNF TNFRSF1A TNFRSF1B TRAF5 CALM1 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G SOCS3 GRM1 IL12A IL1R2 DLAT GRIA2 IL10RB PPP1CA SLC6A9 SLC38A3 LRRC8B NSMF TRPM4 LRRC8D SRR LRRC8E KE385 Decrease of synaptogenesis FMR1 NLGN1 ARC DLG1 RPH3A NLGN2 NLGN3 NLGN4X RYR2 STX1A DLG2 NRXN3 NRXN1 NRXN2 YWHAG CAMK2B CAMK2A GRIN2D CAMK2D CAMK2G GRIN2C GRIN1 GRIN2A GRIN2B MAPK1 MAPK3 TJP1 GRM1 HOMER1 DLGAP1 SYNGAP1 SHANK1 CYFIP1 CAMKK2 RPS6KA1 CCND2 NGF BDNF DIO2 CAMKK1 HNRNPL SYT2 NCAM1 PRL SYT12 HGNC:1464 HGNC:9393 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 KE386 Decrease of neuronal network function ARC UBE3A GRIN3A GRIN3B EIF4EBP1 NF1 NTRK2 PRKAG2 PRKAG3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PTEN RHEB RPS6KB1 BDNF CACNA1C GSK3B PIK3R2 PIK3R1 CAMK4 AKT3 AKT1 AKT2 MTOR GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D HRAS KRAS NRAS PIK3CA PIK3CB PIK3CD MAPK1 MAPK3 RPTOR TSC1 TSC2 CAMK2B PIK3R3 GRM1 SHANK3 DLG4 SYNGAP1 HOMER1 KE388 Overactivation, NMDARs SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE398 Activation, Dendritic Cells TNFRSF11A MR1 TLR3 RIGI IRF3 MAVS IFIH1 TLR7 IRF7 TLR8 KE425 Decrease of Thyroidal iodide PRKAA1 PRKAA2 RAF1 MAP2K2 PRKCA MAP2K1 ELK1 MAPK1 MAPK3 CREB1 NFKB1 PLCD1 TPO ANO1 DUOX1 DUOX2 CLCN5 SLC26A6 ACY1 CGA SLC5A5 TG TRH TSHR RAP1B RAP1A KE450 Suppression, VLDL secretion OSBPL5 NPC2 FABP3 LDLRAP1 ACSL6 SLC27A4 ACSL5 LPA APOA4 DBI SOAT1 SLC27A2 ACSL1 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 KE451 Inhibition, Mitochondrial fatty acid beta-oxidation EHHADH ACSL1 ACSL3 ACSL4 HADH CPT1A CPT2 ECI1 HADHA ACADL ACADM ACADS ACADVL SLC25A20 SCP2 PECR ACSF2 CHKB ACSL6 ACSL5 DLD ECHS1 GCDH GK GK2 ACAT1 LIPC LIPE LPL PNPLA2 LIPF CPT1B CRAT DECR1 GPD2 HADHB ACSS2 TPI1 KE454 Increased, Triglyceride formation AGPAT1 AGPAT2 MOGAT1 GK GK2 GPD1 MOGAT3 LIPC LIPE LPL AGPAT5 AGPAT3 AGPAT4 PNPLA2 GPAM MOGAT2 GNPAT DGAT2 LIPF AGPS PLPP1 PLPP2 PLPP3 DGAT1 KE456 Suppression, Constitutive androstane receptor, NR1l3 EHHADH CYP4A11 NCOA2 NCOA6 SULT2A1 SULT1A1 UGT1A1 NCOA1 ALAS1 UGT1A6 DNAJC7 SMC1A FOXO1 PPARGC1A CYP2C19 CYP2C9 CYP3A4 HSP90AA1 RXRA SP1 PTPA ABCC2 CYP2B6 GSTA2 ABCB1 ABCC3 UGT1A9 UGT1A4 CYP2A6 CYP3A5 NR1I3 KE457 Activation, SREBF1 NFYA CYP51A1 MBTPS2 MDH1 IDI1 SREBF1 SEC31B SAR1A FDFT1 SCD MED15 YY1 SEC23A SEC23B SQLE FGF21 GSK3A PRKAG2 KPNB1 PRKAB1 HMGCS1 HMGCR SEC24A SCAP PRKAG3 ATF6 INSIG2 NR1H2 ACLY PRKAB2 PRKAA1 CDK8 LPIN1 RBP4 SEC31A SEC24B MBTPS1 SEC24D SAR1B ACSS1 DBI PPARGC1B SEC13 LSS FDPS PRKAA2 MVD FASN RNF139 SEC24C PRKAG1 INSIG1 SREBF2 MIR33A MIR33B PRKACA SCARB1 SIRT1 CREB1 GPAM PIK3CA LDLR PPARG AKT1 AMFR CAMP LPL SP1 MTOR ACACA INS KE458 Increased, De Novo FA synthesis ACACB ECH1 ECHDC2 ECHDC1 ECHDC3 ACSL1 ACSL3 ACSL4 FASN ACSL6 ACLY ACSL5 SCD ACAA2 MECR ECHS1 HADH ACACA PC ACSS2 DECR1 PECR KE459 Increased, Liver Steatosis OSBPL5 NPC2 FABP3 LDLRAP1 ACSL6 SLC27A4 ACSL5 LPA APOA4 DBI SOAT1 SLC27A2 ACSL1 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 CHKB ACSL4 DLD ECHS1 GCDH GK GK2 HADH ACAT1 LIPC LIPE LPL PNPLA2 LIPF CPT1A CPT1B CPT2 CRAT ECI1 DECR1 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL ACSS2 TPI1 SLC25A20 ACSBG2 FABP7 FABP5 FABP6 FABP9 HGNC:10995 HGNC:10996 HGNC:10997 HGNC:10999 HGNC:11000 HGNC:3555 CD36 ACSBG1 HILPDA PRKAG2 PRKAB1 PRKAG3 ACLY PRKAB2 PDHA1 PRKAA1 PRKAA2 FASN PRKAG1 PLIN1 PRKAR2B PRKACA AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PRKAR1B ACACA ABHD5 PRKAR2A BCKDHA KE465 Increased, Fatty acid influx ACSBG2 FABP7 FABP5 FABP6 FABP9 HGNC:10995 HGNC:10996 HGNC:10997 HGNC:10999 HGNC:11000 HGNC:3555 ACSL4 FABP3 ACSL3 FABP2 ACSL1 DBI FABP1 ACSL6 SLC27A4 FABP4 ACSL5 CD36 ACSBG1 KE468 Inhibition, PPAR alpha ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 CDK4 CCND1 MYC CPT1A ACADM CDK1 KLK15 UGT1A9 KE471 Inhibition, FoxA2 ABCC4 FOXA2 FOXA1 PPARGC1B IRS1 FASN IRS2 SREBF1 FOXO1 GSTM2 GSTA1 INS APOB ACACA ABCC2 SLC27A5 ABCC3 SLCO1B1 MTTP GSTA2 MLXIPL KE474 Down Regulation, HMGCS2 CH25H ELOVL4 GGPS1 CYP51A1 MYLIP SOAT1 IDI1 ACSL4 SREBF1 FDFT1 SCD SQLE HMGCS1 HMGCR ACOT2 ELOVL3 ACSL3 NR1H2 ACSL1 LSS FDPS ABCA1 MVD SOAT2 FASN SREBF2 ELOVL5 FADS2 CYP27A1 FADS1 DHCR7 ELOVL2 NR1H3 CYP46A1 HMGCS2 ABCG1 MSMO1 SC5D MVK DHCR24 ACAT2 HSD17B7 LBR EBP NSDHL TM7SF2 PMVK KE478 Activation, NRF2 ME1 KEAP1 SLC5A1 SLC6A4 SLC2A2 MAFF CYP4A11 ADH7 PTGR1 ABCC5 CBR1 FTH1 HGF SLC2A3 TGFB2 PDGFB TGFB1 SOD3 SLC2A1 EGR1 ABCC4 SLC2A12 SLC7A11 NRG1 TGFA TGFBR2 SLC6A20 SLC6A19 UGT1A1 ALDH3A1 PRDX1 DNAJB1 UGT1A6 CES3 UGT1A7 HSP90AB1 FGF13 SLC6A3 EPHA2 UGT2B7 SERPINA1 SRXN1 GCLC GCLM HSP90AA1 GSTP1 GSTT2 GGT1 GSR PPARD HBEGF NFE2L2 GSTM1 TXN CES5A G6PD SQSTM1 GSTM4 CES2 GPX2 NQO1 SLC2A4 GSTA5 RXRA CES1 GPX3 GSTM2 GSTA1 ABCC2 HMOX1 ABCC3 MAFG AGER GSTA2 EPHA3 FTL SLC5A5 TXNRD3 TXNRD1 UGT1A9 UGT1A4 CYP2A6 SLC6A13 SLC6A7 SLC39A9 SLC6A16 SLC6A15 MGST2 BLVRB SLC5A4 SLC6A2 SLC39A14 SLC2A9 SLC39A7 SLC5A7 PRDX6 SLC5A9 SLC6A8 SLC6A6 SLC6A11 SLC39A11 SLC2A11 GSTM5 GSTM3 SLC2A8 SLC5A6 SLC39A8 SLC39A5 SLC5A2 SLC39A6 SLC39A3 SLC2A5 PGD MGST3 SLC39A1 SLC39A4 SLC39A12 SLC5A12 SLC2A13 SLC5A10 SLC6A1 SLC5A11 CBR3 SLC2A6 SLC6A18 SLC39A2 SLC39A13 SLC6A5 GSTA4 CES4A SLC2A14 GSTA3 SLC6A9 SLC39A10 SLC6A17 SLC2A7 SLC2A10 SLC5A3 HSPA1A SLC5A8 SLC6A14 CUL3 AIMP2 INSR CEBPB MAF GSK3B SRC PGAM5 EPHB2 PIK3CA PRKCA MAPK8 FYN RBX1 YES1 KE483 Activation, LXR alpha FASN SCD SREBF1 CYP3A4 RXRA NR1H3 CYP2B6 CYP7A1 ABCG5 ABCG8 KE484 Activation, AKT2 ITGA2B PPP2R3A PPP2R2C ITGA8 PPP2R5C ITGA6 PPP2R1A ITGB8 ITGA4 MYB ITGA7 EIF4E2 PPP2R1B ITGB7 ITGA10 ITGA9 PPP2R5E PPP2R2B ITGA5 PPP2R3B CSF1R LAMA2 PPP2R2A GH1 BAD HGF IBSP NGFR FGFR2 GNB5 FGFR1 ANGPT2 JAK2 PDGFB SOS2 SGK2 SGK3 GYS1 FGF21 CDK6 MET RHEB FGF8 RPS6KB1 GYS2 CCND3 FGF1 SGK1 SPP1 CCND2 FGF23 PGF TEK FLT3 CDK2 GNG13 KDR EPO RAF1 PRKAA1 CASP9 NGF CDK4 MDM2 ITGAV COL2A1 PDPK1 IFNAR1 PDGFC NTRK2 VEGFC ANGPT1 KIT IL6R FGFR4 PRKAA2 TGFA NOS3 VEGFD DDIT4 CHRM1 IRS1 PDGFD INSR PTEN VEGFB RPS6KB2 BDNF EIF4EBP1 PDGFA IFNA1 NTRK1 ITGB3 PKN2 FGF19 IL7R PRL CD19 LPAR1 BRCA1 PHLPP2 COL9A2 LAMC3 LPAR2 PPP2R5A PPP2R5B FGF22 FLT3LG LAMB4 PPP2R3C COL9A3 HSP90AB1 EFNA2 TCL1A PCK2 ANGPT4 LAMA1 FGF14 RBL2 COMP VWF COL9A1 PPP2R5D GHR THBS4 PRLR FGF12 GNB4 TNR CSF3R TNN PKN1 FGF13 CHAD GH2 CSH1 LPAR6 G6PC3 EPHA2 EFNA3 LPAR4 G6PC2 PIK3AP1 FGF17 THEM4 PKN3 FGF11 HSP90B1 IGF2 EFNA1 LPAR3 COL6A5 CCNE2 PPP2R2D EIF4E1B CHRM2 F2R EFNA5 LPAR5 IL3RA NTF3 LAMB3 COL4A6 COL6A6 CSH2 TCL1B NTF4 EFNA4 IGF1 PIK3CB LAMC2 CREB3L3 FGFR3 IL4R HSP90AA1 PHLPP1 GSK3B LAMB1 MAPK1 IL2RB MAPK3 TSC2 IKBKB PPP2CB CCNE1 AKT2 PIK3R2 PIK3CG CREB3 COL1A1 VTN NFKB1 IL2 CCND1 CDKN1B VEGFA IL4 PPP2CA FN1 SOS1 ATF2 AKT3 PIK3R3 FASLG STK11 CREB1 FOXO3 PIK3CA CDKN1A MAP2K2 ATF4 LAMA5 KRAS IL2RA PDGFRA LAMC1 RAC1 IL6 TLR4 MYC TLR2 THBS1 FGF2 FGF7 IGF1R PIK3R5 TP53 RPTOR AKT1 MCL1 CREB3L4 PIK3R1 CREB5 EGFR IL2RG EIF4E BCL2L11 PRKCA CREB3L1 IFNAR2 JAK1 COL1A2 TSC1 MLST8 MAP2K1 THBS3 PTK2 BCL2L1 PIK3CD BCL2 LAMB2 HRAS GRB2 CREB3L2 CSF1 IFNA2 MTOR NRAS CHUK ATF6B INS IKBKG PIK3R6 RELA ITGA3 FLT4 KITLG LAMA3 EIF4B FLT1 IL7 CDC37 CSF3 PDGFRB IFNA6 IFNA8 IFNA21 RPS6 EGF IFNA5 IFNA16 ITGB1 ITGA2 IFNB1 IFNA10 COL4A1 RELN ITGA1 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 TNC FGF10 FGF4 GNB1 FGF20 COL4A4 ITGB5 OSM FGF9 JAK3 FGF6 GNB3 LAMA4 ITGB6 PCK1 GNG11 GNGT1 G6PC1 ITGB4 COL4A2 ITGA11 FGF5 COL6A1 COL6A2 OSMR FGF18 GNG3 COL6A3 IL3 SYK GNGT2 GNG8 GNG4 TNXB COL4A3 GNB2 GNG12 GNG5 GNG7 THBS2 GNG2 FGF3 EPOR COL4A5 GNG10 KE486 systemic inflammation leading to hepatic steatosis ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG IL12B IL15 IL10 PDGFA TGFB1 CSF1 CSF2 IL1B IL13 CSF3 CXCL1 CXCL2 HLA-DRA HLA-DRB1 IFNB1 IL7 IL11 CD4 IL3 KE491 Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) DOCK1 MAP4K1 CRK PTK2B RAPGEF1 HGF MET PAK1 PTEN PTPN11 PXN RAF1 STAT3 ELK1 FOS GAB1 GRB2 HRAS JUN PIK3CA MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTGS2 PTK2 SOS1 SRC CRKL ITGA1 ITGB1 RAP1A RAP1B RASA1 KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA APC MDM2 LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR NTRK1 AKT1S1 IL6R JAK2 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 GSK3B NFKBIA TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 CDKN1A KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 PIK3CD RELA MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 FLT4 FLT1 PDGFRB TELO2 TTI1 KE493 Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 POLE2 LIG1 POLE3 NEIL2 POLE MRE11 MLH1 XRCC5 MSH2 POLK PCNA DDB2 ERCC5 XPC FANCC CUL4B ERCC3 MGMT POLH RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A LIG3 PARP2 PARP1 ATM H2AX ERCC1 RFC1 POLD1 POLB RBX1 ERCC2 PMS2 BRCA2 FANCD2 XRCC4 WRN LIG4 FAN1 RAP1A PRKDC EXO1 REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 TDP1 APTX PARP4 ADPRS PARPG POLG2 NEIL1 PARP3 POLG KE570 Accumulation, Damaged mitochondrial DNA ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 POLE2 LIG1 POLE3 NEIL2 POLE MRE11 MLH1 XRCC5 MSH2 POLK PCNA DDB2 ERCC5 XPC FANCC CUL4B ERCC3 MGMT POLH RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A LIG3 PARP2 PARP1 ATM H2AX ERCC1 RFC1 POLD1 POLB RBX1 ERCC2 PMS2 BRCA2 FANCD2 XRCC4 WRN LIG4 FAN1 RAP1A PRKDC EXO1 REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 KE613 Occurrence, Epileptic seizure SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE616 Occurrence, A paroxysmal depolarizing shift SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE618 Decreased, Neuronal network function in adult brain CAMKK2 ARC IL12B PPP1CC SLC1A2 LRRC8C CNTF GRIN3A GRIN3B DAO LTA PHGDH GLS2 DISC1 GLS GRM5 PSAT1 IL6R IL6ST IL10 INSR IRS1 LIF SMAD2 SMAD3 NGF PDHA1 PSPH BDNF SHMT1 SHMT2 SLC1A1 SLC2A1 SLC2A3 STAT3 STAT6 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 CFL1 GFAP SMAD7 SLC38A2 LRRC8A SLC1A4 SLC38A1 CAMKK1 SLC38A5 GRM2 GRM4 GRM7 GRM8 IL10RA IL13RA1 GLUL SLC7A10 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 SLC17A7 SLC17A6 SLC1A3 SLC1A6 ADCY1 ADCY3 ADCY8 CREB1 DLD AKT1 FGF2 PLCB1 FOS GOT1 GRIA1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D IFNG IFNGR1 IFNGR2 IGF1 IL1A IL1B IL1R1 IL4 IL4R IL6 IL13 JAK1 SMAD4 NFKB1 NFKB2 NOS1 PLCB2 PLCB3 PLCB4 PPP1CB PRKACA PRKCA PRKCB PRKCG MAPK1 MAPK3 BCL2 STAT1 TGFB3 TNF TNFRSF1A TNFRSF1B TRAF5 CALM1 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G SOCS3 GRM1 IL12A IL1R2 DLAT GRIA2 IL10RB PPP1CA SLC6A9 SLC38A3 LRRC8B NSMF TRPM4 LRRC8D SRR LRRC8E KE654 Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists CYP17A1 HSD17B1 CYP11B1 POR AKR1C4 SRD5A1 CYP3A7 HSD11B1 SRD5A2 HSD17B3 HSD17B2 AKR1C3 HSD17B4 AKR1D1 AKR1C2 HSD11B2 AKR1C1 SULT2A1 CYP3A4 HSD3B1 HSD3B2 KE664 Overwhelmed, Mitochondrial DNA repair mechanisms ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 POLE2 LIG1 POLE3 NEIL2 POLE MRE11 MLH1 XRCC5 MSH2 POLK PCNA DDB2 ERCC5 XPC FANCC CUL4B ERCC3 MGMT POLH RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A LIG3 PARP2 PARP1 ATM H2AX ERCC1 RFC1 POLD1 POLB RBX1 ERCC2 PMS2 BRCA2 FANCD2 XRCC4 WRN LIG4 FAN1 RAP1A PRKDC EXO1 REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 KE667 Binding at picrotoxin site, iGABAR chloride channel GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2B1 ABAT GAD2 GAD1 GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE669 Reduction, Neuronal synaptic inhibition SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE682 Generation, Amplified excitatory postsynaptic potential (EPSP) SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE709 Increase, Cytotoxicity (renal tubular cell) HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 MAPK14 MAPK13 MAPK11 MAPK12 TNF AKT1 KE710 Increase, Regenerative cell proliferation (tubular epithelial cells) KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 MET RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA RAF1 APC MDM2 LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR PTEN NTRK1 AKT1S1 IL6R JAK2 STAT3 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 GSK3B MAPK1 NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 PIK3CA CDKN1A ELK1 MAP2K2 KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 FLT4 FLT1 PDGFRB TELO2 TTI1 KE716 Increase, cell proliferation (hepatocytes) MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 E2F2 TGFB2 GADD45B TGFB1 CDK6 E2F3 CCND3 GADD45A CCND2 CDK2 GADD45G PCNA CDK4 MDM2 CDC25C CDC25A SMAD3 SMAD2 SFN SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 CUL1 ABL1 RBX1 SKP1 CCNA1 CCNB1 CCNB2 CDK1 PLK1 PRKDC DOCK1 MAP4K1 CRK PTK2B RAPGEF1 HGF MET PAK1 PTEN PTPN11 PXN RAF1 STAT3 ELK1 FOS GAB1 GRB2 HRAS JUN PIK3CA MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTGS2 PTK2 SOS1 SRC CRKL ITGA1 ITGB1 RAP1A RAP1B RASA1 KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA APC LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR NTRK1 AKT1S1 IL6R JAK2 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 NFKBIA TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 KRAS PDGFRA IGF1R RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 PIK3CD RELA MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 FLT4 FLT1 PDGFRB TELO2 TTI1 KE719 Increase, hepatocellular adenomas and carcinomas BIRC3 CD44 VAV2 FRZB UCHL1 MIR744 NOS2 E2F2 CTTN BIRC5 TGFB1 TGFBR1 CASP9 LEF1 IL6R CASP3 SMAD3 STAT3 PTPN11 MIR155 MIR34A MIR24-2 MIR24-1 MYOF MIR92A1 BRCA1 PTGS2 HIF1A MAPK3 MAPK8 NFKB1 CCND1 MAPK14 VEGFA SOS1 FASLG CDKN1A RAC1 IL6 MYC TP53 SMAD4 AKT1 JAK1 CXCL8 BCL2L1 JUN GRB2 CXCR1 CASP7 RRM2 PODXL COL4A2 HNF1A MMP1 MIR92A2 DANCR MIR452 TCF7 NLK CHD8 PORCN SFRP1 DKK4 EZH2 DKK1 SFRP5 KLF4 NKD1 SFRP2 NKD2 CER1 TCF7L2 TCF7L1 DKK2 WIF1 CTBP1 SENP2 SOX17 SOST CXXC4 CTBP2 CTNNBIP1 FRAT2 NOTUM CSNK2B MIR214 FRAT1 FZD10 CSNK1E CTNNB1 DVL1 DVL2 DVL3 APC LRP6 LRP5 ROR1 ROR2 WNT16 PLAU WNT4 RYK WNT1 WNT2 WNT3 WNT6 WNT7A WNT7B WNT11 WNT2B FZD5 FZD3 FOSL1 WNT5B FZD1 FZD6 FZD8 FZD9 KREMEN1 CCND2 CCND3 WNT3A MTDH SOX7 MIR18A MIR320A CSNK2A2 CSNK2A1 SFRP4 CSNK1A1 SERPINF1 CSNK2A3 FZD2 GSK3B WNT5A WNT10B WNT10A AXIN1 FZD7 ELAVL1 CSNK1A1L KE756 Hippocampal gene expression, Altered CAMKK2 RPS6KA1 CCND2 NGF BDNF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 KE757 Hippocampal anatomy, Altered CAMKK2 RPS6KA1 CCND2 NGF BDNF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 PROX1 NEUROG2 LRP6 FZD3 WNT3 WNT3A WNT7A FZD1 NEUROD1 CCND1 WNT5A KE758 Hippocampal Physiology, Altered HTRA2 ITGAM ITGAX ITGB2 AXL XIAP COLEC11 PATJ COLEC10 ATP8B3 CX3CR1 FCN1 FCN2 ATP11A CRB1 SCRIB C5AR2 CRB2 ATP11C LLGL2 MARK3 MBL2 ATP8B1 PLSCR1 SUSD4 PLSCR3 PLSCR4 ATP10A PALS1 CSMD1 C4BPA C4BPB TYRO3 C8B COLEC12 PARD6G FCN3 DEDD CD59 DLGAP5 CAP1 MARK2 APAF1 ITGAV ITGB3 MFGE8 PRKCI ATP8B2 CX3CL1 TGFB1 TGFB2 CASP3 CASP8 CASP9 C1QB MASP2 CR1 CR2 CD55 CD46 PROS1 MASP1 DIABLO C1QC C2 C3AR1 C4B C5AR1 C6 C7 C8G C9 MARK1 PARD6A C4A CASP10 MERTK GAS6 IFNG FAS FASLG MBP CYCS PRKCZ BAK1 BAX BID TGFB3 VTN CLU CFH CFI CFP CFB C1QA C1R C1S C8A CASP7 CFD PARD3 SERPING1 C3 C5 PARD6B CAMKK2 RPS6KA1 CCND2 NGF BDNF DIO2 CAMKK1 NRXN3 HNRNPL NRXN2 SYT2 NCAM1 PRL SYT12 NRXN1 HGNC:1464 HGNC:9393 CAMK2B CAMK2A MAPK1 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 KE761 Increased, Chloride conductance GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2B1 ABAT GAD2 GAD1 GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE762 Activation, ionotropic GABA Receptor chloride channel GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2B1 ABAT GAD2 GAD1 GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE767 Increase, Hyperplasia (renal tubular cells) CASP8 TGFB1 ACTA2 TNFSF11 APAF1 TRPV5 RAF1 CASP9 BRAF SMAD2 PPP3R1 FFAR3 CALCA TGFBR1 CASP3 RGN G3BP1 SEC16B BAK1 TNFRSF1A BAX MAPK1 PIK3CA SMAD4 AKT1 PTH MTOR NOS1 MCU MAP3K5 KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 MET RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA APC MDM2 LEF1 PML NTRK2 DEPTOR KIT SHC1 FGFR4 LRP5 REL PYGO1 INSR PTEN NTRK1 AKT1S1 IL6R JAK2 STAT3 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 GSK3B NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 CDKN1A ELK1 MAP2K2 KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC CHUK IKBKG AKT3 AKT2 IL6 CCND1 FLT4 FLT1 PDGFRB TELO2 TTI1 KE768 Increase, Cytotoxicity BIRC3 TNFRSF21 HELLS XIAP LTA CASP4 TNFRSF25 CRADD HRK MIR29A BBC3 APAF1 BIRC5 IRF1 IRF3 IRF5 MDM2 PMAIP1 BAD CASP3 CASP8 CASP9 TNFRSF10B MIR29B1 MIR29B2 IRF4 DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR IRF2 TRAF3 CASP7 TRADD RIPK1 FADD GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 TP73 SCAF11 KE769 Increase, Oxidative metabolism NDUFA9 ATP6AP2 NDUFB10 NDUFA4 MT-ATP6 ATP5PD ATP5MG NDUFA11 DMAC2L NDUFS7 MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO ATP5MF MTCO3P12 ATP6AP1 GZMB MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA4L2 KE770 Increase, Cytotoxicity (club cells) HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 KE771 Decrease, Serum thyroid hormone (T4/T3) PRKAA1 PRKAA2 RAF1 MAP2K2 PRKCA MAP2K1 ELK1 MAPK1 MAPK3 CREB1 NFKB1 PLCD1 TPO ANO1 DUOX1 DUOX2 CLCN5 SLC26A6 ACY1 CGA SLC5A5 TG TRH TSHR RAP1B RAP1A KE774 Increase, Preneoplastic foci (hepatocytes) KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 MET RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA RAF1 APC MDM2 LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR PTEN NTRK1 AKT1S1 IL6R JAK2 STAT3 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 GSK3B MAPK1 NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 PIK3CA CDKN1A ELK1 MAP2K2 KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 FLT4 FLT1 PDGFRB TELO2 TTI1 KE780 Increase, Cytotoxicity (epithelial cells) HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 KE783 Increase, Cytotoxicity (tubular epithelial cells) CASP8 TGFB1 ACTA2 TNFSF11 APAF1 TRPV5 RAF1 CASP9 BRAF SMAD2 PPP3R1 FFAR3 CALCA TGFBR1 CASP3 RGN G3BP1 SEC16B BAK1 TNFRSF1A BAX MAPK1 PIK3CA SMAD4 AKT1 PTH MTOR NOS1 MCU MAP3K5 HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D BAD BCL2A1 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 KE784 Increase, Hyperplasia (tubular epithelial cells) KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 MET RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA RAF1 APC MDM2 LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR PTEN NTRK1 AKT1S1 IL6R JAK2 STAT3 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 GSK3B MAPK1 NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 PIK3CA CDKN1A ELK1 MAP2K2 KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 FLT4 FLT1 PDGFRB TELO2 TTI1 KE787 Increase, Regenerative cell proliferation (hepatocytes) MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 E2F2 TGFB2 GADD45B TGFB1 CDK6 E2F3 CCND3 GADD45A CCND2 CDK2 GADD45G PCNA CDK4 MDM2 CDC25C CDC25A SMAD3 SMAD2 SFN SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 CUL1 ABL1 RBX1 SKP1 CCNA1 CCNB1 CCNB2 CDK1 PLK1 PRKDC DOCK1 MAP4K1 CRK PTK2B RAPGEF1 HGF MET PAK1 PTEN PTPN11 PXN RAF1 STAT3 ELK1 FOS GAB1 GRB2 HRAS JUN PIK3CA MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTGS2 PTK2 SOS1 SRC CRKL ITGA1 ITGB1 RAP1A RAP1B RASA1 KE794 Increase, Cytotoxicity (urothelial cells) HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 KE795 Increase, Regenerative cell proliferation (urothelial cells) KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 MET RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA RAF1 APC MDM2 LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR PTEN NTRK1 AKT1S1 IL6R JAK2 STAT3 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 GSK3B MAPK1 NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 PIK3CA CDKN1A ELK1 MAP2K2 KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 FLT4 FLT1 PDGFRB TELO2 TTI1 KE819 Decreased, Glomerular filtration ILK VCL LRP6 JAG1 TGFB1 DNM1 DKK1 WNT1 PCNA ITGAV NOTCH1 NCK1 LRP5 CTNNB1 DAG1 ITGB3 YWHAQ PLAUR KRT8 CR1 CAMK2B VTN CDKN1B IRF6 CD80 PLCG1 CDKN1A CDKN1C LAMA5 TLR4 PLCE1 AKT1 PTK2 LAMB2 ITGA3 FYN VIM CTSL TLN1 ITGB1 CLDN1 CDH2 AGRN MME PAX2 COL4A4 MYH9 NPHS2 PODXL ACTN4 ITGB4 LMX1B TRPC6 SMARCAL1 SCARB2 PTPRO MYO1E NPHS1 COL4A3 SYNPO CD151 WT1 COL4A5 CD2AP INF2 FAT1 KIRREL2 MKI67 KIRREL3 UTRN LIMS1 PARVA MT-TL1 KE821 Decreased, Sodium reabsorption SLC9A3 SLC5A1 SLC2A2 SLC22A7 ATP6V1H SLC4A4 SLC7A8 ATP6V1D CA2 ATP6V0A4 SLC16A10 SLC22A2 ATP6V1A ATP6V1B1 ATP6V0B ATP6V1E1 SLC34A1 ATP6V1G1 FXYD2 SLC47A1 ATP1B1 SLC22A8 SLC13A3 SLC4A2 CA4 SLC22A11 SLC20A2 SLC47A2 ATP6V0C SLC22A6 SLC34A3 SLC7A9 SLC1A1 SLC2A1 ABCC4 SLC3A1 CLTRN SLC7A7 SLC6A20 SLC3A2 SLC6A19 SLC36A2 ATP6V0E1 SLC12A4 ATP6V1C1 ATP1A1 AQP1 ATP6V1F ABCC2 ABCB1 SLC5A5 ABCG2 ATP6V0D2 SLC26A6 SLC5A2 SLC6A18 SLC5A8 KE831 Disturbance, Lysosomal function PRKAG2 PRKAB1 PRKAG3 PRKAB2 PRKAA1 DEPTOR PRKAA2 PRKAG1 AKT1S1 RB1CC1 PIK3C3 AMBRA1 BECN1 ATG14 RPTOR MLST8 ULK1 PIK3R4 MTOR ATG9A ATG5 ATG16L1 ATG101 MAP1LC3B ATG3 ATG12 WIPI2 ATG13 ATG7 UVRAG KE835 Occurrence, Ballooning degeneration (hepatocyte) MBTPS2 XBP1 BBC3 ATF6 TNFRSF10B MBTPS1 PMAIP1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 DDIT3 ERN1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE836 Occurrence, Cytoplasmic vacuolization (Bile duct cell) PRKAG2 PRKAB1 PRKAG3 PRKAB2 PRKAA1 DEPTOR PRKAA2 PRKAG1 AKT1S1 RB1CC1 PIK3C3 AMBRA1 BECN1 ATG14 RPTOR MLST8 ULK1 PIK3R4 MTOR ATG9A ATG5 ATG16L1 ATG101 MAP1LC3B ATG3 ATG12 WIPI2 ATG13 ATG7 UVRAG KE837 Occurrence, Cytoplasmic vacuolization (kupffer cell) PRKAG2 PRKAB1 PRKAG3 PRKAB2 PRKAA1 DEPTOR PRKAA2 PRKAG1 AKT1S1 RB1CC1 PIK3C3 AMBRA1 BECN1 ATG14 RPTOR MLST8 ULK1 PIK3R4 MTOR ATG9A ATG5 ATG16L1 ATG101 MAP1LC3B ATG3 ATG12 WIPI2 ATG13 ATG7 UVRAG KE838 Induction, Microvesicular fat EHHADH ACSL1 ACSL3 ACSL4 HADH CPT1A CPT2 ECI1 HADHA ACADL ACADM ACADS SLC25A20 ACADVL HADHB SCP2 PECR ACSF2 SLC22A5 KE839 Formation, Mallory body UBC UBE2D2 PSMD11 UBA1 HLA-B HLA-E HLA-F HLA-G UCHL1 UBE2D3 HLA-A NEDD4 UBB UBE2D1 H2AC4 UCHL3 PSME3 HLA-H PSMB8 PSMB9 PSMB10 PSMD5 PSMD10 PSME1 PSME2 RPN1 RPN2 UBA7 H2AX H2AZ1 IFNG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD7 PSMD8 PSMD9 PSMD12 PSMD13 PSMD6 UBE2B HLA-C KE840 Formation, Liver fibrosis P4HA2 PLOD1 ADAMTS2 P3H2 TMEM38B LOX P3H1 P4HA1 COLGALT1 TNFRSF11A FKBP10 PLOD2 MIA3 TNFRSF11B PPIB CRTAP P4HB IFITM5 MBTPS2 LRP6 TNFSF11 WNT1 MBTPS1 FZD1 LRP5 COL1A1 SERPINF1 ITPR1 CREB3L1 COL1A2 SERPINH1 SP7 BMP1 KE850 Induction, CYP1A2/CYP1A5 NRIP1 KLF6 NCOR2 HPGDS PLAGL1 RAF1 CDK2 ESR1 FGF21 ARNT NF1 RET AIP CYP1B1 NCOA7 PSRC1 KRAS MAP2K1 HRAS NRAS CDKN1A CDKN1B CYP1A1 CYP1A2 NQO1 E2F1 EGFR AHR EP300 GCLC HSP90AA1 LPL MYC NFE2L2 NFKB1 MAPK1 PTGS2 RB1 RELA CCL1 SRC TNF VEGFA CD36 CDC37 AHRR CYP39A1 CYP7B1 CYP8B1 CYP4A11 CYP26A1 CYP3A43 CYP2C18 CYP4A22 CYP2S1 CYP4F2 CYP4F12 CYP4F8 CYP4B1 CYP51A1 POR CYP19A1 CYP17A1 CYP3A7 CYP11B1 CYB5A CYP2W1 CYP26C1 CYB5R4 CYB5R3 CYB5B CYP20A1 CYP2G1P CYP2J2 CYP4V2 CYP2U1 CYB5R1 CYB5R2 CYP4F11 CYP4F22 CYP4Z1 CYP4X1 CYP27C1 CYP2F1 CYP2A13 CYP2A7 CYP24A1 CYP2D6 CYP27B1 CYP2E1 CYP27A1 CYP2C9 CYP2C8 CYP11A1 CYP3A4 CYP2C19 CYP11B2 CYP2R1 CYP26B1 CYP46A1 CYP7A1 CYP2B6 CYP3A5 CYP2A6 CYP4F3 KE851 Decrease of GABAergic interneurons GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2B1 ABAT GAD2 GAD1 GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE853 Changes/Inhibition, Cellular Homeostasis and Apoptosis HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 TNFRSF21 HELLS LTA MIR29A IRF1 IRF3 IRF5 MDM2 IRF4 IGF2 NFKBIE CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 IRF2 GZMB PRF1 TRAF1 TP73 SCAF11 KE854 Alterations, Cellular proliferation / hyperplasia MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 E2F2 TGFB2 GADD45B TGFB1 CDK6 E2F3 CCND3 GADD45A CCND2 CDK2 GADD45G PCNA CDK4 MDM2 CDC25C CDC25A SMAD3 SMAD2 SFN SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 CUL1 ABL1 RBX1 SKP1 CCNA1 CCNB1 CCNB2 CDK1 PLK1 PRKDC KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 MET RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA RAF1 APC LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR PTEN NTRK1 AKT1S1 IL6R JAK2 STAT3 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 MAPK1 NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 PIK3CA ELK1 MAP2K2 KRAS PDGFRA IGF1R RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 FLT4 FLT1 PDGFRB TELO2 TTI1 KE856 Formation, Hepatocellular and Bile duct tumors DANCR MIR452 TCF7 NLK CHD8 PORCN SFRP1 DKK4 EZH2 DKK1 SFRP5 KLF4 LEF1 NKD1 SFRP2 NKD2 CER1 TCF7L2 TCF7L1 DKK2 WIF1 CTBP1 SENP2 SOX17 SOST CXXC4 CTBP2 CTNNBIP1 FRAT2 NOTUM CSNK2B MIR214 FRAT1 FZD10 CSNK1E CTNNB1 DVL1 DVL2 DVL3 APC LRP6 LRP5 ROR1 ROR2 WNT16 PLAU WNT4 RYK WNT1 WNT2 WNT3 WNT6 WNT7A WNT7B WNT11 WNT2B FZD5 FZD3 FOSL1 WNT5B FZD1 FZD6 FZD8 FZD9 KREMEN1 CCND2 CCND3 WNT3A MTDH SOX7 MIR18A MIR320A CSNK2A2 CSNK2A1 SFRP4 CSNK1A1 SERPINF1 CSNK2A3 FZD2 GSK3B JUN MYC CCND1 WNT5A WNT10B WNT10A AXIN1 FZD7 ELAVL1 CSNK1A1L KE860 Decreased, Mitochondrial Fatty Acid Beta Oxidation CHKB ACSL1 ACSL3 ACSL4 ACSL6 ACSL5 DLD ECHS1 GCDH GK GK2 HADH ACAT1 LIPC LIPE LPL PNPLA2 LIPF CPT1A CPT1B CPT2 CRAT ECI1 DECR1 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL ACSS2 TPI1 SLC25A20 EHHADH SCP2 PECR ACSF2 KE870 Increase, Cell Proliferation MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 E2F2 TGFB2 GADD45B TGFB1 CDK6 E2F3 CCND3 GADD45A CCND2 CDK2 GADD45G PCNA CDK4 MDM2 CDC25C CDC25A SMAD3 SMAD2 SFN SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 CUL1 ABL1 RBX1 SKP1 CCNA1 CCNB1 CCNB2 CDK1 PLK1 PRKDC KE875 Binding of agonist, Ionotropic glutamate receptors CAMKK2 ARC IL12B PPP1CC SLC1A2 LRRC8C CNTF GRIN3A GRIN3B DAO LTA PHGDH GLS2 DISC1 GLS GRM5 PSAT1 IL6R IL6ST IL10 INSR IRS1 LIF SMAD2 SMAD3 NGF PDHA1 PSPH BDNF SHMT1 SHMT2 SLC1A1 SLC2A1 SLC2A3 STAT3 STAT6 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 CFL1 GFAP SMAD7 SLC38A2 LRRC8A SLC1A4 SLC38A1 CAMKK1 SLC38A5 GRM2 GRM4 GRM7 GRM8 IL10RA IL13RA1 GLUL SLC7A10 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 SLC17A7 SLC17A6 SLC1A3 SLC1A6 ADCY1 ADCY3 ADCY8 CREB1 DLD AKT1 FGF2 PLCB1 FOS GOT1 GRIA1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D IFNG IFNGR1 IFNGR2 IGF1 IL1A IL1B IL1R1 IL4 IL4R IL6 IL13 JAK1 SMAD4 NFKB1 NFKB2 NOS1 PLCB2 PLCB3 PLCB4 PPP1CB PRKACA PRKCA PRKCB PRKCG MAPK1 MAPK3 BCL2 STAT1 TGFB3 TNF TNFRSF1A TNFRSF1B TRAF5 CALM1 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G SOCS3 GRM1 IL12A IL1R2 DLAT GRIA2 IL10RB PPP1CA SLC6A9 SLC38A3 LRRC8B NSMF TRPM4 LRRC8D SRR LRRC8E KE878 Inhibition, SREBP1c NFYA CYP51A1 MBTPS2 MDH1 IDI1 SREBF1 SEC31B SAR1A FDFT1 SCD MED15 YY1 SEC23A SEC23B SQLE FGF21 GSK3A PRKAG2 KPNB1 PRKAB1 HMGCS1 HMGCR SEC24A SCAP PRKAG3 ATF6 INSIG2 NR1H2 ACLY PRKAB2 PRKAA1 CDK8 LPIN1 RBP4 SEC31A SEC24B MBTPS1 SEC24D SAR1B ACSS1 DBI PPARGC1B SEC13 LSS FDPS PRKAA2 MVD FASN RNF139 SEC24C PRKAG1 INSIG1 SREBF2 MIR33A MIR33B PRKACA SCARB1 SIRT1 CREB1 GPAM PIK3CA LDLR PPARG AKT1 AMFR CAMP LPL SP1 MTOR ACACA INS KE881 Increased, Triglyceride AGPAT1 AGPAT2 MOGAT1 GK GK2 GPD1 MOGAT3 LIPC LIPE LPL AGPAT5 AGPAT3 AGPAT4 PNPLA2 GPAM MOGAT2 GNPAT DGAT2 LIPF AGPS PLPP1 PLPP2 PLPP3 DGAT1 OSBPL5 NPC2 FABP3 LDLRAP1 ACSL6 SLC27A4 ACSL5 LPA APOA4 DBI SOAT1 SLC27A2 ACSL1 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 KE887 Inhibition, NADH-ubiquinone oxidoreductase (complex I) COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 MT-CO2 NDUFB10 COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF UCP1 SLC25A4 SLC25A5 SLC25A6 NDUFA13 MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA12 SDHA KE888 Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) NDUFB10 ECSIT NDUFAB1 NDUFA1 NDUFS4 NDUFB5 NDUFB3 NDUFC1 NDUFA2 NDUFS5 NDUFS2 NDUFS6 NDUFB1 NDUFS3 NDUFB6 NDUFA3 NDUFB4 NDUFB8 NDUFB2 NDUFA7 NDUFC2 NDUFA10 MT-ND1 MT-ND2 MT-ND4L MT-ND4 MT-ND5 MT-ND6 NDUFB7 NDUFV2 NDUFS1 NDUFV1 NDUFA8 NDUFV3 NDUFA6 NDUFA5 NDUFAF6 NDUFAF7 TMEM126B NDUFAF2 NUBPL TMEM186 FOXRED1 DMAC1 NDUFAF3 TMEM70 COA1 ACAD9 TIMMDC1 DMAC2 NDUFB11 NDUFAF4 NDUFA13 NDUFA12 NDUFAF1 NDUFB9 KE889 Proteostasis, impaired UBC UBE2D2 PSMD11 UBA1 HLA-B HLA-E HLA-F HLA-G UCHL1 UBE2D3 HLA-A NEDD4 UBB UBE2D1 H2AC4 UCHL3 PSME3 HLA-H PSMB8 PSMB9 PSMB10 PSMD5 PSMD10 PSME1 PSME2 RPN1 RPN2 UBA7 H2AX H2AZ1 IFNG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD7 PSMD8 PSMD9 PSMD12 PSMD13 PSMD6 UBE2B HLA-C HSPA7 PFDN4 PFDN1 PFDN5 PFDN2 VBP1 PFDN6 DNAJB1P1 HSP90AA2P KE890 Degeneration of dopaminergic neurons of the nigrostriatal pathway CEBPB BDNF NTRK2 SET TARDBP LGMN SRPK2 APP MAPT MAOB AKT1 AKT2 STAT1 BACE1 PPP2CB AKT3 SNCA KE896 Parkinsonian motor deficits LRRK2 HTRA2 ATXN2 MIR409 UBA1 UBE2L3 UCHL1 MIR485 MIR1224 MIR1294 MIR4448 SYT11 MIR128-2 MIR19B2 MIR338 MIR375 MIR26B MIR34C MIR128-1 MIR34B APAF1 MIR16-2 MIR212 MIR26A1 MIR26A2 CASP3 CASP9 MIRLET7G MIR18A PARK7 MIR195 MIR19A MIR19B1 MIR30A UBE2J1 MIR503 SNCAIP MIR370 MIR127 SLC6A3 CASP6 CCNE2 UBB GPR37 SEPTIN5 UBA7 UBE2G1 UBE2G2 UBE2L6 UBE2J2 MAPK14 DDC PRKN CYCS MAPK11 MAPK13 MAPK12 PINK1 TH CCNE1 SNCA CASP7 MIR30E CASP2 MIR433 MIR136 MIR873 EPRS1 MIR10A MIR132 MIR431 KE898 Disruption, Lysosome PRKAG2 PRKAB1 PRKAG3 PRKAB2 PRKAA1 DEPTOR PRKAA2 PRKAG1 AKT1S1 RB1CC1 PIK3C3 AMBRA1 BECN1 ATG14 RPTOR MLST8 ULK1 PIK3R4 MTOR ATG9A ATG5 ATG16L1 ATG101 MAP1LC3B ATG3 ATG12 WIPI2 ATG13 ATG7 UVRAG KE902 Inflammation, Liver ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG IL12B IL15 IL10 PDGFA TGFB1 CSF1 CSF2 IL1B IL13 CSF3 CXCL1 CXCL2 HLA-DRA HLA-DRB1 IFNB1 IL7 IL11 CD4 IL3 KE926 Oxidation, Glutathione (To be considered with MIE) GSTA5 G6PD GGT5 OPLAH GCLC GCLM GPX1 GPX2 GPX3 GPX4 ANPEP GSR GSS GSTA1 GSTM1 GSTM2 GSTT2 IDH1 GGT1 KE941 Activation, EGFR CSK RALA RALB RALGDS VAV2 CAV2 BCAR1 GAB2 STAM2 STAMBP EPS8 EPN1 SH3KBP1 LIMK2 MYBL2 PEBP1 ASAP1 PTPN12 PTPRR EPS15L1 ATXN2 SYNJ1 SH2D2A HGS REPS2 USP6NL IQSEC1 STMN1 STAM PLSCR1 NCK2 ERRFI1 PIAS3 VAV3 MAP3K2 MAP4K1 CRK DNM1 EIF4EBP1 ELK4 PTK2B FOSB CBLC GRB10 INPPL1 JAK2 JUND MEF2A MEF2C MEF2D MAP3K4 MT-CO2 NCK1 NOS3 PAK1 PCNA PDPK1 PRKCI MAPK4 MAP2K5 PTEN PTPN11 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 SHC1 SOS2 BRAF STAT3 AURKA STXBP1 TWIST1 VAV1 CBLB IQGAP1 DOK2 CDC42 CFL1 NEDD4 PXDN RALBP1 PLD2 RIN1 SPRY2 EPS15 SH3GL2 CREB1 MAPK14 AP2B1 E2F1 EGFR ELK1 ERBB2 AKT1 FOXO1 FOS MTOR RICTOR GAB1 GJA1 GRB2 HRAS JAK1 JUN ARF6 KRAS MAP3K1 MAP3K3 ATF1 PLCE1 PIK3C2B PIK3R1 PIK3R2 PLCG1 PLD1 PRKCA PRKCB PRKCD PRKCZ MAPK1 MAPK7 MAPK8 MAPK9 MAP2K1 MAP2K2 PTK2 RAB5A RAC1 ROCK1 SOS1 SP1 SRC STAT1 CAMK2A CAV1 CBL USP8 RPS6KA5 CRKL EGF ABL1 INPP5D NCOA3 ITCH ABI1 TNK2 FOXO4 NDUFA13 RAP1A RASA1 STAT5A STAT5B ARHGEF1 AP2M1 AP2S1 AP2A1 NEDD8 SH3GL3 PTPN5 PTK6 KE959 Increased, Free serum thyroxine (T4) ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 PFKFB2 PAX8 AQP7 SLC16A10 TTF2 TTF1 TSHB NPPB BAD KDM1A RPS6KA6 FGFR1 FGF21 RHEB RPS6KB1 NPY THRA RAF1 CASP9 MDM2 TBC1D4 ITGAV NOTCH1 WNT4 SHH CTNNB1 AKT1S1 DIO2 ITGB3 PRKG2 MAP4K5 NPR1 MGLL MC4R PLIN1 ADRB3 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 RPS6 PRDM16 TPO SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 ZNF516 KLB KDM3B KE960 Increased, Uptake of thyroxine into tissue ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 PFKFB2 PAX8 AQP7 SLC16A10 TTF2 TTF1 TSHB NPPB BAD KDM1A RPS6KA6 FGFR1 FGF21 RHEB RPS6KB1 NPY THRA RAF1 CASP9 MDM2 TBC1D4 ITGAV NOTCH1 WNT4 SHH CTNNB1 AKT1S1 DIO2 ITGB3 PRKG2 MAP4K5 NPR1 MGLL MC4R PLIN1 ADRB3 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 RPS6 PRDM16 TPO SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 ZNF516 KLB KDM3B KE961 Increased, Clearance of thyroxine from serum ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 PFKFB2 PAX8 AQP7 SLC16A10 TTF2 TTF1 TSHB NPPB BAD KDM1A RPS6KA6 FGFR1 FGF21 RHEB RPS6KB1 NPY THRA RAF1 CASP9 MDM2 TBC1D4 ITGAV NOTCH1 WNT4 SHH CTNNB1 AKT1S1 DIO2 ITGB3 PRKG2 MAP4K5 NPR1 MGLL MC4R PLIN1 ADRB3 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 RPS6 PRDM16 TPO SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 ZNF516 KLB KDM3B KE1012 Increased, Inhibitory postsynaptic potential SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1014 Induction, Somatic muscle paralysis DMD NEB TNNI1 ACTC1 TNNI3 TNNT2 MYL9 MYBPC1 MYBPC2 MYBPC3 MYH3 MYH8 TMOD1 TNNC2 TNNC1 TNNI2 TNNT1 TNNT3 MYOM1 ACTN2 ACTN3 ACTA2 TTN MYL2 TPM1 TPM2 TPM3 TPM4 MYH6 ACTA1 MYL3 MYL1 TCAP ACTG1 VIM DES ACTN4 MYL4 KE1015 Increased, Neuronal synaptic inhibition SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1096 Increased, blood uric acid concentration PPAT MAT2A GRM5 RRM2B GART PFAS PAICS TPMT MOCOS PNP HPRT1 ADA APRT IMPDH1 AMPD1 ADSS2 ADSL ATIC XDH PRPS1 AOX1 DGUOK ITPA KE1097 Occurrence, renal proximal tubular necrosis CISD1 NCOA4 SLC11A2 SLC40A1 FTH1 PRNP NOX1 ACSL4 FDFT1 SLC1A5 HMGCR CTH ACSL3 POR SAT1 SLC7A11 AKR1C2 ACSL1 CBS ACSL6 CYBB SLC3A2 COQ2 AKR1C1 AKR1C3 PCBP2 ACSL5 SLC38A1 BACH1 AIFM2 CHMP5 LPCAT3 GCH1 IREB2 SAT2 PCBP1 CHMP6 FTMT DPP4 GCLC GCLM VDAC3 NOX4 GSS MAP1LC3A TP53 VDAC2 GPX4 ALOX15 ATG5 TF HMOX1 HSPB1 STEAP3 MAP1LC3B ATG7 CP TFRC FTL TXNRD1 SLC39A14 SLC39A8 PHKG2 MAP1LC3C KE1103 Inhibition, Cyclooxygenase 1 activity TBXA2R ACAA1 EHHADH ACOX1 CYP4A11 AKR1B1 ACOX3 PTGR1 PTGFR PTGR2 PRXL2B CYP4A22 PTGDR PTGDR2 CYP4F2 CYP4F12 PTGIR PLA2G5 PLA2G4B TBXAS1 PTGS2 PTGS1 PTGDS PPARD PLA2G4A PTGIS PTGES HPGD PPARG ACOX2 PLA2G6 KE1104 Decreased, Prostaglandin F2alpha concentration, plasma ANXA2 TBXA2R ANXA8 ANXA3 ANXA4 PTGFRN SCGB1A1 HPGDS PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR S100A6 CBR1 AKR1B1 S100A10 ABCC4 PPARGC1B AKR1C1 AKR1C2 EDN1 EDNRA EDNRB HSD11B1 HSD11B2 PTGIR SOX9 AKR1C3 ANXA1 PRL PPARGC1A CYP11A1 HPGD MITF PLA2G4A PPARG PTGDS PTGIS PTGS1 PTGS2 TBXAS1 PTGES ANXA5 ANXA6 KE1115 Increase, Reactive oxygen species NOX5 MT1X NFIX NOX1 NOX3 CYBB SOD3 TXN2 MGST1 UGT1A6 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT HMOX1 SOD2 TXNRD2 TXNRD1 CUL3 IPCEF1 KEAP1 CHEK1 PIP GSX1 ATR NOS2 ICAM1 RHEB CDK2 MDM2 PTEN MAP2K3 MAP2K4 PTGS2 SIRT1 RPS6KA5 IKBKB CCNE1 MAPK8 IL1A ATF2 CREB1 PIK3CA CDKN1A IL6 TP53 AKT1 FOXO1 PINK1 TSC1 CXCL8 BCL2L1 BCL2 MAP3K5 MTOR TNF IKBKG NRF1 KE1171 Increase, Clonal Expansion of Altered Hepatic Foci KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 MET RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA RAF1 APC MDM2 LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR PTEN NTRK1 AKT1S1 IL6R JAK2 STAT3 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 GSK3B MAPK1 NFKBIA MAPK3 TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 SOS1 PIK3CA CDKN1A ELK1 MAP2K2 KRAS PDGFRA MYC IGF1R TP53 RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 MAP2K1 PTK2 FOS PIK3CD RELA HRAS JUN GRB2 SRC MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 CCND1 FLT4 FLT1 PDGFRB TELO2 TTI1 KE1172 Increased activation, Nuclear factor kappa B (NF-kB) AJUBA TIFA UBE2N UBE2V1 PRKCZ IL1A SQSTM1 TRAF6 IRAK1 NFKB1 KE1177 Decreased, Ionotropic GABA receptor chloride channel conductance SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 GABBR2 GABBR1 ALDH9A1 GAD2 AP2S1 AP2M1 GPHN KE1194 Increase, DNA damage CHEK1 ATR HUS1B RAD17 CHEK2 RRM2B CASP8 SESN1 GADD45B BBC3 CDK6 CCND3 GADD45A CCND2 TP53AIP1 APAF1 TNFRSF10B CDK2 GADD45G CASP9 DDB2 CDK4 MDM2 PML PMAIP1 CDC25C CDC25A CASP3 SFN MRE11 PIDD1 RAD52 RAD51 SMC1A RAD50 NBN BRCA1 RAD1 RPA2 RAD9A CCNE2 ATRIP CCNB3 TLK1 BID FAS BAX E2F1 CCNE1 CCND1 CDKN1B CDKN1A RB1 TP53 AKT1 TLK2 ATM CYCS H2AX CREB1 MYC ABL1 CCNB1 FANCD2 CCNB2 CDK5 CDK1 RFC1 PRKDC KE1195 modulation, Extracellular Matrix Composition SPARC TGFB1 SERPINE1 CCN2 TGFBR1 TGFBR2 SMAD3 TGFBR3 SMAD2 YWHAG SMAD4 POSTN WWTR1 KE1197 Activation, Fibroblasts IL12B SKIL GREM1 SFTPC TERC CYSLTR2 TERT ATP11A SFTPA1 PTX3 HGF EDN1 PDGFB MMP9 BMP7 TIMP1 TGFB1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 CEBPB PDGFA SMAD7 CCR2 ELMOD2 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 CXCL2 HMOX1 CSF3 EGF KE1198 Activation, Macrophages ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 KE1214 Altered gene expression specific to CAR activation, Hepatocytes EHHADH CYP4A11 NCOA2 NCOA6 SULT2A1 SULT1A1 UGT1A1 NCOA1 ALAS1 UGT1A6 DNAJC7 SMC1A FOXO1 PPARGC1A CYP2C19 CYP2C9 CYP3A4 HSP90AA1 RXRA SP1 PTPA ABCC2 CYP2B6 GSTA2 ABCB1 ABCC3 UGT1A9 UGT1A4 CYP2A6 CYP3A5 NR1I3 KE1218 Opening of calcium channel, Calcium influx ORAI1 FKBP1A GJA3 CACNA1A CASQ1 GJA5 CALR ATP1B1 FXYD2 GJB6 GJC2 GJB2 GNB5 CHRM1 ADRA1A ADRB1 GNAI1 SFN ATP2B1 ATP2B2 ATP2B3 GNG13 RGS10 RYR2 RYR3 SLC8A1 CACNA1C YWHAQ GJB1 GRK5 GRK6 CHRM2 GNB4 RGS1 YWHAB PLN GJA4 RGS4 YWHAE YWHAG YWHAH YWHAZ CACNA1B CHRM3 CHRM4 CHRM5 ADRB3 GJA8 ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB2 ADCY4 GJA1 GNAQ GNAS ITPR1 ITPR2 ITPR3 ARRB1 ARRB2 ATP2A2 PLCB3 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ RYR1 CACNB1 CALM1 CALM2 CALM3 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G CAMK1 ADRA1D ADRA1B GNAO1 ATP2A3 CACNA1D CACNA1S RGS9 GNA11 GNAI2 GNAI3 GNAZ GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG11 GNGT1 KCNJ3 GNG2 PRKAR2A PRKD1 GNG12 GNG8 STIM2 GJC1 GJB4 GJB3 GJB5 ANXA6 KCNB1 KCNJ5 ATP1A4 ATP1B2 ATP1B3 GJD2 SLC8A3 CACNA1E GJA9 CASQ2 RGS19 RGS14 PKIG RGS17 GRK4 PKIA PKIB RGS2 RGS3 RGS7 RGS16 RGS18 CACNB3 RGS5 RGS20 RGS11 RGS6 KE1223 Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea CD38 MYLK RHOA ROCK1 ITPR3 ROCK2 GNAQ PPP1R14A MYL1 IL13 ADRB2 PLCB1 RYR1 GDI1 PPP1CB CALM1 KE1262 Apoptosis HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 TNFRSF21 HELLS LTA MIR29A IRF1 IRF3 IRF5 MDM2 IRF4 IGF2 NFKBIE CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 IRF2 GZMB PRF1 TRAF1 TP73 SCAF11 KE1263 Necrosis CASP8 RIPK3 TNFRSF1A MAPK8 PLA2G4A PARP1 TNF TRADD TICAM1 RIPK1 FADD FTL KE1270 Inactivation of PPARγ ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 KE1271 Increase, Transforming growth factor-beta signaling SPARC TGFB1 SERPINE1 CCN2 TGFBR1 TGFBR2 SMAD3 TGFBR3 SMAD2 YWHAG SMAD4 POSTN WWTR1 FKBP1A SKIL MIR302A LEFTY1 CTNNB1 INHBA LIF LEF1 BMP4 SPP1 STAT3 LEFTY2 WNT1 FOXH1 ZNF423 SMAD7 RUNX3 FST BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG EGF SMAD5 SMAD9 ZEB2 ENG ITGB6 LTBP1 KE1275 Collagen Deposition P4HA2 PLOD1 ADAMTS2 P3H2 TMEM38B LOX P3H1 P4HA1 COLGALT1 TNFRSF11A FKBP10 PLOD2 MIA3 TNFRSF11B PPIB CRTAP P4HB IFITM5 MBTPS2 LRP6 TNFSF11 WNT1 MBTPS1 FZD1 LRP5 COL1A1 SERPINF1 ITPR1 CREB3L1 COL1A2 SERPINH1 SP7 BMP1 GPI PGM1 PHGDH GLS LDHA SLC2A1 FGFR1 FGFR4 SLC16A1 PSPH SLC1A5 PSAT1 LPAR1 UGDH PYCR1 GCK ALDH18A1 UGP2 P4HA3 P3H3 P3H4 LOXL2 CD36 PLCG1 RHOA GLUD1 KE1283 Activation, TGF-beta pathway LOX GREM1 LOXL1 TGFB1 TGFBR1 TGFBR2 SMAD3 SMAD2 LOXL2 MAPK9 MAPK8 BMPR1A MAPK14 SMAD4 BMPR2 LOXL4 BMP1 FKBP1A SKIL MIR302A LEFTY1 CTNNB1 INHBA LIF SERPINE1 LEF1 BMP4 SPP1 STAT3 LEFTY2 TGFBR3 WNT1 FOXH1 ZNF423 SMAD7 RUNX3 FST BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD6 NFKB1 MAPK3 STAT1 TFE3 THBS1 TNF RUNX2 NOG EGF SMAD5 SMAD9 ZEB2 ENG ITGB6 LTBP1 KE1284 Up Regulation, SREBF2 NFYA CYP51A1 MBTPS2 MDH1 IDI1 SREBF1 SEC31B SAR1A FDFT1 SCD MED15 YY1 SEC23A SEC23B SQLE FGF21 GSK3A PRKAG2 KPNB1 PRKAB1 HMGCS1 HMGCR SEC24A SCAP PRKAG3 ATF6 INSIG2 NR1H2 ACLY PRKAB2 PRKAA1 CDK8 LPIN1 RBP4 SEC31A SEC24B MBTPS1 SEC24D SAR1B ACSS1 DBI PPARGC1B SEC13 LSS FDPS PRKAA2 MVD FASN RNF139 SEC24C PRKAG1 INSIG1 SREBF2 MIR33A MIR33B PRKACA SCARB1 SIRT1 CREB1 GPAM PIK3CA LDLR PPARG AKT1 AMFR CAMP LPL SP1 MTOR ACACA INS SIRT6 ABCA1 PPARGC1A PPARA NR1H3 KE1285 Up Regulation, Unsaturated fatty acid ACACB ECH1 ECHDC2 ECHDC1 ECHDC3 ACSL1 ACSL3 ACSL4 FASN ACSL6 ACLY ACSL5 SCD ACAA2 MECR ECHS1 HADH ACACA PC ACSS2 DECR1 PECR ACOX1 ACOX3 ACOT2 PLA2G5 PLA2G4B ELOVL5 PLA2G4A FADS2 FADS1 ELOVL2 PLA2G6 ACOT1 ELOVL1 ELOVL3 ELOVL6 SCD5 KE1287 Glutathione synthesis GSTA5 G6PD GGT5 OPLAH GCLC GCLM GPX1 GPX2 GPX3 GPX4 ANPEP GSR GSS GSTA1 GSTM1 GSTM2 GSTT2 IDH1 GGT1 KE1289 Perturbation of cholesterol CYP51A1 FDFT1 FDPS HMGCR HMGCS1 IDI1 LSS MVD SQLE DHCR7 PMVK MVK NSDHL MSMO1 SC5D SIRT6 SREBF1 MED15 SREBF2 MIR33B MIR33A ABCA1 FASN PRKAA1 SCD SIRT1 PPARGC1A LDLR PPARA MTOR NR1H3 MYLIP OSBPL5 SOAT1 APOA4 NPC2 LRP1 APOC1 SORT1 FABP2 SAR1B LDLRAP1 SLC27A4 PCSK9 LPA NPC1L1 SCARB1 APOB CETP LIPA APOC3 APOA1 APOE STARD3 CD36 CYP27A1 STAR APOA2 LIPC LPL DGAT1 LCAT VDAC1 APOC2 APOH ABCG5 MTTP CYP7A1 ABCG8 ABCB11 TSPO VAPA LIPG DHCR24 ACAT2 ANGPTL8 MGAT1 HSD17B7 ANGPTL3 CIDEB LBR EBP TM7SF2 LRPAP1 NPC1 PLTP KE1290 Glutathione homeostasis GSTA5 G6PD GGT5 OPLAH GCLC GCLM GPX1 GPX2 GPX3 GPX4 ANPEP GSR GSS GSTA1 GSTM1 GSTM2 GSTT2 IDH1 GGT1 KE1292 Activation, JNK CACNA1G CACNG1 RRAS2 CACNA1A CACNA2D1 CACNB2 RAC3 LRRK2 MRAS LAMTOR3 PTPRR TAOK2 MAPK8IP2 FLNC FLNB DUSP10 STMN1 PPP5C HSPA2 HSPA6 HSPA1B HSPA1L RAPGEF2 DUSP16 DUSP9 TAOK3 MAPK8IP3 DUSP8 PPP5D1P DUSP7 MAP3K20 PPM1A FGFR2 NFATC3 ARAF FGF21 FGF8 FGF1 FGF23 RRAS NGF NTRK2 CACNA1C ELK4 FGFR4 RPS6KA4 MAP4K2 NF1 PDGFA MAP3K2 MAP4K1 CRK GADD45A FGFR1 JUND MEF2C MAP3K4 MAP3K11 NFATC1 NTRK1 PAK1 PAK2 PDGFB NLK PPP3CA PPP3CB PPP3R1 PPP3R2 MAP2K5 RAC2 RAF1 RASA2 RPS6KA3 BDNF SOS2 BRAF TGFB1 TGFB2 TGFBR1 TGFBR2 MAP3K12 CASP3 MAP4K3 MAP3K6 MAP3K13 MAP4K4 CDC42 STK4 MAPK8IP1 DUSP2 FGF19 RASGRP2 FGF22 FGF14 PLA2G4C FGF12 FGF13 RASGRP3 FGF17 PLA2G4D FGF11 PLA2G4F RASGRP4 NTF3 PLA2G4E NTF4 PLA2G4B RASGRP1 RASGRF2 STK3 CACNA1B FGF16 TAOK1 CDC25B CACNG8 CACNG2 PPM1B CACNA2D2 CACNG5 CACNG4 CACNG7 CACNG6 CACNA2D4 CACNA2D3 CACNB4 CACNG3 PTPN7 MAP3K14 TNFRSF1A CACNB1 FGFR3 NFKB2 MKNK2 RELB SOS1 PLA2G4A FGF2 FGF7 PRKACB PRKCA PRKACG RELA HRAS MAPK11 CHUK AKT3 TAB1 MAP3K8 ATF2 MAPK14 EGFR ELK1 AKT1 AKT2 TAB2 FOS GRB2 FAS IKBKB IL1A IL1B IL1R1 FASLG JUN KRAS ARRB1 ARRB2 MAPT MAP3K1 MAP3K5 MYC ATF4 NFKB1 NRAS PPP3CC PRKACA PRKCD PRKCG MAPK1 MAPK3 MAPK7 MAPK8 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP2K7 RAC1 MAPK12 MAP2K4 SRF MAP3K7 TGFB3 TNF TP53 TRAF2 TRAF6 IKBKG MKNK1 RPS6KA5 MAPKAPK2 RASGRF1 CACNA1S CACNA1F PDGFRB CACNA1D CRKL DAXX DDIT3 DUSP1 DUSP4 DUSP6 EGF NR4A1 HSPA8 HSPB1 MAX ECSIT IL1R2 MAPKAPK5 CD14 FGF10 FGF4 FGF20 FGF9 FGF6 FGF5 FGF18 GNG12 FGF3 FLNA GNA12 RAP1A RAP1B RASA1 CACNA1E CACNA1I DUSP3 MAPKAPK3 CACNB3 HSPA1A PTPN5 CACNA1H KE1299 Activation, AKT ITGA2B PPP2R3A PPP2R2C ITGA8 PPP2R5C ITGA6 PPP2R1A ITGB8 ITGA4 MYB ITGA7 EIF4E2 PPP2R1B ITGB7 ITGA10 ITGA9 PPP2R5E PPP2R2B ITGA5 PPP2R3B CSF1R LAMA2 PPP2R2A GH1 BAD HGF IBSP NGFR FGFR2 GNB5 FGFR1 ANGPT2 JAK2 PDGFB SOS2 SGK2 SGK3 GYS1 FGF21 CDK6 MET RHEB FGF8 RPS6KB1 GYS2 CCND3 FGF1 SGK1 SPP1 CCND2 FGF23 PGF TEK FLT3 CDK2 GNG13 KDR EPO RAF1 PRKAA1 CASP9 NGF CDK4 MDM2 ITGAV COL2A1 PDPK1 IFNAR1 PDGFC NTRK2 VEGFC ANGPT1 KIT IL6R FGFR4 PRKAA2 TGFA NOS3 VEGFD DDIT4 CHRM1 IRS1 PDGFD INSR PTEN VEGFB RPS6KB2 BDNF EIF4EBP1 PDGFA IFNA1 NTRK1 ITGB3 PKN2 FGF19 IL7R PRL CD19 LPAR1 BRCA1 PHLPP2 COL9A2 LAMC3 LPAR2 PPP2R5A PPP2R5B FGF22 FLT3LG LAMB4 PPP2R3C COL9A3 HSP90AB1 EFNA2 TCL1A PCK2 ANGPT4 LAMA1 FGF14 RBL2 COMP VWF COL9A1 PPP2R5D GHR THBS4 PRLR FGF12 GNB4 TNR CSF3R TNN PKN1 FGF13 CHAD GH2 CSH1 LPAR6 G6PC3 EPHA2 EFNA3 LPAR4 G6PC2 PIK3AP1 FGF17 THEM4 PKN3 FGF11 HSP90B1 IGF2 EFNA1 LPAR3 COL6A5 CCNE2 PPP2R2D EIF4E1B CHRM2 F2R EFNA5 LPAR5 IL3RA NTF3 LAMB3 COL4A6 COL6A6 CSH2 TCL1B NTF4 EFNA4 IGF1 PIK3CB LAMC2 CREB3L3 FGFR3 IL4R HSP90AA1 PHLPP1 GSK3B LAMB1 MAPK1 IL2RB MAPK3 TSC2 IKBKB PPP2CB CCNE1 AKT2 PIK3R2 PIK3CG CREB3 COL1A1 VTN NFKB1 IL2 CCND1 CDKN1B VEGFA IL4 PPP2CA FN1 SOS1 ATF2 AKT3 PIK3R3 FASLG STK11 CREB1 FOXO3 PIK3CA CDKN1A MAP2K2 ATF4 LAMA5 KRAS IL2RA PDGFRA LAMC1 RAC1 IL6 TLR4 MYC TLR2 THBS1 FGF2 FGF7 IGF1R PIK3R5 TP53 RPTOR AKT1 MCL1 CREB3L4 PIK3R1 CREB5 EGFR IL2RG EIF4E BCL2L11 PRKCA CREB3L1 IFNAR2 JAK1 COL1A2 TSC1 MLST8 MAP2K1 THBS3 PTK2 BCL2L1 PIK3CD BCL2 LAMB2 HRAS GRB2 CREB3L2 CSF1 IFNA2 MTOR NRAS CHUK ATF6B INS IKBKG PIK3R6 RELA ITGA3 FLT4 KITLG LAMA3 EIF4B FLT1 IL7 CDC37 CSF3 PDGFRB IFNA6 IFNA8 IFNA21 RPS6 EGF IFNA5 IFNA16 ITGB1 ITGA2 IFNB1 IFNA10 COL4A1 RELN ITGA1 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 TNC FGF10 FGF4 GNB1 FGF20 COL4A4 ITGB5 OSM FGF9 JAK3 FGF6 GNB3 LAMA4 ITGB6 PCK1 GNG11 GNGT1 G6PC1 ITGB4 COL4A2 ITGA11 FGF5 COL6A1 COL6A2 OSMR FGF18 GNG3 COL6A3 IL3 SYK GNGT2 GNG8 GNG4 TNXB COL4A3 GNB2 GNG12 GNG5 GNG7 THBS2 GNG2 FGF3 EPOR COL4A5 GNG10 KE1300 Activation, mTORC1 FKBP1A RRAGC IDI1 CDC42 ULK2 RHEB PRKAG2 RPS6KB1 PRKAB1 PRKAG3 PRKAB2 PRKAA1 PRKAA2 DDIT4 PRKAG1 EIF4EBP1 AKT1S1 HMGCR TSC2 MAPKAP1 RAC1 RPTOR AKT1 PRKCA RICTOR TSC1 MLST8 ULK1 MTOR PRR5L RRAGA RRAGD RRAGB ULK3 DDIT4L PRR5 KE1306 Increase, De novo lipogenesis HILPDA PRKAG2 PRKAB1 PRKAG3 ACLY PRKAB2 PDHA1 PRKAA1 PRKAA2 FASN PRKAG1 PLIN1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA ACSS2 ABHD5 PRKAR2A ACSBG1 BCKDHA KE1310 Activation, PI3K ITGA2B PPP2R3A PPP2R2C ITGA8 PPP2R5C ITGA6 PPP2R1A ITGB8 ITGA4 MYB ITGA7 EIF4E2 PPP2R1B ITGB7 ITGA10 ITGA9 PPP2R5E PPP2R2B ITGA5 PPP2R3B CSF1R LAMA2 PPP2R2A GH1 BAD HGF IBSP NGFR FGFR2 GNB5 FGFR1 ANGPT2 JAK2 PDGFB SOS2 SGK2 SGK3 GYS1 FGF21 CDK6 MET RHEB FGF8 RPS6KB1 GYS2 CCND3 FGF1 SGK1 SPP1 CCND2 FGF23 PGF TEK FLT3 CDK2 GNG13 KDR EPO RAF1 PRKAA1 CASP9 NGF CDK4 MDM2 ITGAV COL2A1 PDPK1 IFNAR1 PDGFC NTRK2 VEGFC ANGPT1 KIT IL6R FGFR4 PRKAA2 TGFA NOS3 VEGFD DDIT4 CHRM1 IRS1 PDGFD INSR PTEN VEGFB RPS6KB2 BDNF EIF4EBP1 PDGFA IFNA1 NTRK1 ITGB3 PKN2 FGF19 IL7R PRL CD19 LPAR1 BRCA1 PHLPP2 COL9A2 LAMC3 LPAR2 PPP2R5A PPP2R5B FGF22 FLT3LG LAMB4 PPP2R3C COL9A3 HSP90AB1 EFNA2 TCL1A PCK2 ANGPT4 LAMA1 FGF14 RBL2 COMP VWF COL9A1 PPP2R5D GHR THBS4 PRLR FGF12 GNB4 TNR CSF3R TNN PKN1 FGF13 CHAD GH2 CSH1 LPAR6 G6PC3 EPHA2 EFNA3 LPAR4 G6PC2 PIK3AP1 FGF17 THEM4 PKN3 FGF11 HSP90B1 IGF2 EFNA1 LPAR3 COL6A5 CCNE2 PPP2R2D EIF4E1B CHRM2 F2R EFNA5 LPAR5 IL3RA NTF3 LAMB3 COL4A6 COL6A6 CSH2 TCL1B NTF4 EFNA4 IGF1 PIK3CB LAMC2 CREB3L3 FGFR3 IL4R HSP90AA1 PHLPP1 GSK3B LAMB1 MAPK1 IL2RB MAPK3 TSC2 IKBKB PPP2CB CCNE1 AKT2 PIK3R2 PIK3CG CREB3 COL1A1 VTN NFKB1 IL2 CCND1 CDKN1B VEGFA IL4 PPP2CA FN1 SOS1 ATF2 AKT3 PIK3R3 FASLG STK11 CREB1 FOXO3 PIK3CA CDKN1A MAP2K2 ATF4 LAMA5 KRAS IL2RA PDGFRA LAMC1 RAC1 IL6 TLR4 MYC TLR2 THBS1 FGF2 FGF7 IGF1R PIK3R5 TP53 RPTOR AKT1 MCL1 CREB3L4 PIK3R1 CREB5 EGFR IL2RG EIF4E BCL2L11 PRKCA CREB3L1 IFNAR2 JAK1 COL1A2 TSC1 MLST8 MAP2K1 THBS3 PTK2 BCL2L1 PIK3CD BCL2 LAMB2 HRAS GRB2 CREB3L2 CSF1 IFNA2 MTOR NRAS CHUK ATF6B INS IKBKG PIK3R6 RELA ITGA3 FLT4 KITLG LAMA3 EIF4B FLT1 IL7 CDC37 CSF3 PDGFRB IFNA6 IFNA8 IFNA21 RPS6 EGF IFNA5 IFNA16 ITGB1 ITGA2 IFNB1 IFNA10 COL4A1 RELN ITGA1 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 TNC FGF10 FGF4 GNB1 FGF20 COL4A4 ITGB5 OSM FGF9 JAK3 FGF6 GNB3 LAMA4 ITGB6 PCK1 GNG11 GNGT1 G6PC1 ITGB4 COL4A2 ITGA11 FGF5 COL6A1 COL6A2 OSMR FGF18 GNG3 COL6A3 IL3 SYK GNGT2 GNG8 GNG4 TNXB COL4A3 GNB2 GNG12 GNG5 GNG7 THBS2 GNG2 FGF3 EPOR COL4A5 GNG10 PIK3C2A PIK3C2B PIK3C2G PIK3R4 KE1339 Increase, intracellular calcium ORAI1 FKBP1A GJA3 CACNA1A CASQ1 GJA5 CALR ATP1B1 FXYD2 GJB6 GJC2 GJB2 GNB5 CHRM1 ADRA1A ADRB1 GNAI1 SFN ATP2B1 ATP2B2 ATP2B3 GNG13 RGS10 RYR2 RYR3 SLC8A1 CACNA1C YWHAQ GJB1 GRK5 GRK6 CHRM2 GNB4 RGS1 YWHAB PLN GJA4 RGS4 YWHAE YWHAG YWHAH YWHAZ CACNA1B CHRM3 CHRM4 CHRM5 ADRB3 GJA8 ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRB2 ADCY4 GJA1 GNAQ GNAS ITPR1 ITPR2 ITPR3 ARRB1 ARRB2 ATP2A2 PLCB3 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKCZ RYR1 CACNB1 CALM1 CALM2 CALM3 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G CAMK1 ADRA1D ADRA1B GNAO1 ATP2A3 CACNA1D CACNA1S RGS9 GNA11 GNAI2 GNAI3 GNAZ GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG11 GNGT1 KCNJ3 GNG2 PRKAR2A PRKD1 GNG12 GNG8 STIM2 GJC1 GJB4 GJB3 GJB5 ANXA6 KCNB1 KCNJ5 ATP1A4 ATP1B2 ATP1B3 GJD2 SLC8A3 CACNA1E GJA9 CASQ2 RGS19 RGS14 PKIG RGS17 GRK4 PKIA PKIB RGS2 RGS3 RGS7 RGS16 RGS18 CACNB3 RGS5 RGS20 RGS11 RGS6 KE1349 Activated, presynaptic neuron 1 SLC6A4 CACNA1A SLC18A3 SYT1 RIMS1 NAPA CPLX1 UNC13B SYN1 DNM1L STX1B DNM1 SNAP25 STXBP1 STX1A SLC38A1 PARK7 CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 AP2B1 CLTCL1 SLC25A4 VAMP2 RAB3A CLTA CLTC SLC18A2 ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE1350 Increased, glutamate CAMKK2 ARC IL12B PPP1CC SLC1A2 LRRC8C CNTF GRIN3A GRIN3B DAO LTA PHGDH GLS2 DISC1 GLS GRM5 PSAT1 IL6R IL6ST IL10 INSR IRS1 LIF SMAD2 SMAD3 NGF PDHA1 PSPH BDNF SHMT1 SHMT2 SLC1A1 SLC2A1 SLC2A3 STAT3 STAT6 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 CFL1 GFAP SMAD7 SLC38A2 LRRC8A SLC1A4 SLC38A1 CAMKK1 SLC38A5 GRM2 GRM4 GRM7 GRM8 IL10RA IL13RA1 GLUL SLC7A10 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 SLC17A7 SLC17A6 SLC1A3 SLC1A6 ADCY1 ADCY3 ADCY8 CREB1 DLD AKT1 FGF2 PLCB1 FOS GOT1 GRIA1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D IFNG IFNGR1 IFNGR2 IGF1 IL1A IL1B IL1R1 IL4 IL4R IL6 IL13 JAK1 SMAD4 NFKB1 NFKB2 NOS1 PLCB2 PLCB3 PLCB4 PPP1CB PRKACA PRKCA PRKCB PRKCG MAPK1 MAPK3 BCL2 STAT1 TGFB3 TNF TNFRSF1A TNFRSF1B TRAF5 CALM1 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G SOCS3 GRM1 IL12A IL1R2 DLAT GRIA2 IL10RB PPP1CA SLC6A9 SLC38A3 LRRC8B NSMF TRPM4 LRRC8D SRR LRRC8E KE1352 Activated, voltage-gated sodium channel WEE1 SCN4A MAPK8IP2 NEDD4L PTPRN SCN1B PDCD10 SCN2A SCN7A RNF121 SCN1A SCN2B SCN3A SCNM1 NFASC SCN3B PRRT2 SCN11A SCN9A SCN4B SCN5A SCN10A SCN8A RACK1 JAK2 NEDD4 FGF14 FGF12 FGF13 CAMK2A PSEN1 GSK3B AKT1 BACE1 CALM1 TNF FYN KE1353 Binding to voltage-gated sodium channel WEE1 SCN4A MAPK8IP2 NEDD4L PTPRN SCN1B PDCD10 SCN2A SCN7A RNF121 SCN1A SCN2B SCN3A SCNM1 NFASC SCN3B PRRT2 SCN11A SCN9A SCN4B SCN5A SCN10A SCN8A RACK1 JAK2 NEDD4 FGF14 FGF12 FGF13 CAMK2A PSEN1 GSK3B AKT1 BACE1 CALM1 TNF FYN KE1355 Activated, membrane depolarization SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1362 Increased, hippocampal hyperdepolarization SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1363 Increased, epilepsy SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1365 Increase, Apoptosis HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 TNFRSF21 HELLS LTA MIR29A IRF1 IRF3 IRF5 MDM2 IRF4 IGF2 NFKBIE CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 IRF2 GZMB PRF1 TRAF1 TP73 SCAF11 KE1391 Activation of Cyp2E1 CYP39A1 CYP7B1 CYP8B1 CYP4A11 CYP26A1 CYP3A43 CYP2C18 CYP4A22 CYP2S1 CYP4F2 CYP4F12 CYP4F8 CYP4B1 CYP51A1 POR CYP19A1 CYP17A1 CYP3A7 CYP11B1 CYB5A CYP1B1 CYP2W1 CYP26C1 CYB5R4 CYB5R3 CYB5B CYP20A1 CYP2G1P CYP2J2 CYP4V2 CYP2U1 CYB5R1 CYB5R2 CYP4F11 CYP4F22 CYP4Z1 CYP4X1 CYP27C1 CYP2F1 CYP2A13 CYP2A7 CYP24A1 CYP2D6 CYP27B1 CYP2E1 CYP27A1 CYP2C9 CYP2C8 CYP11A1 CYP1A1 CYP1A2 CYP3A4 CYP2C19 CYP11B2 CYP2R1 CYP26B1 CYP46A1 CYP7A1 CYP2B6 CYP3A5 CYP2A6 CYP4F3 KE1392 Increase, Oxidative Stress BAD MAP3K9 CDC42 GADD45A APAF1 PCNA CASP9 CASP3 C1QB CR2 NFKBIE C1QC C2 C3AR1 C5AR1 C4B TDP2 BAG4 TNFRSF1B BAK1 MAP2K4 MAP3K1 NFKB1 MAPK10 CDKN1B CDKN1A TRAF2 CDKN1C MAPK13 BCL2 CYCS TRAF6 TNF TRAF3 C1R C1QA C1S TRAF1 TNK2 C5 NOX5 MT1X NFIX NOX1 NOX3 CYBB SOD3 TXN2 MGST1 UGT1A6 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NOX4 SOD1 SP1 XDH CAT HMOX1 SOD2 TXNRD2 TXNRD1 CUL3 IPCEF1 KEAP1 CHEK1 PIP GSX1 ATR NOS2 ICAM1 RHEB CDK2 MDM2 PTEN MAP2K3 PTGS2 SIRT1 RPS6KA5 IKBKB CCNE1 MAPK8 IL1A ATF2 CREB1 PIK3CA IL6 TP53 AKT1 FOXO1 PINK1 TSC1 CXCL8 BCL2L1 MAP3K5 MTOR IKBKG NRF1 KE1393 Hepatocytotoxicity HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 KE1394 Induction, persistent proliferation/sustained proliferation MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 E2F2 TGFB2 GADD45B TGFB1 CDK6 E2F3 CCND3 GADD45A CCND2 CDK2 GADD45G PCNA CDK4 MDM2 CDC25C CDC25A SMAD3 SMAD2 SFN SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 CUL1 ABL1 RBX1 SKP1 CCNA1 CCNB1 CCNB2 CDK1 PLK1 PRKDC DOCK1 MAP4K1 CRK PTK2B RAPGEF1 HGF MET PAK1 PTEN PTPN11 PXN RAF1 STAT3 ELK1 FOS GAB1 GRB2 HRAS JUN PIK3CA MAPK1 MAPK3 MAPK8 MAP2K1 MAP2K2 PTGS2 PTK2 SOS1 SRC CRKL ITGA1 ITGB1 RAP1A RAP1B RASA1 KSR1 CSF1R RETN GAREM2 NGFR FGFR2 LRP6 TCF3 FGFR1 RUNX1T1 ULK2 SOS2 SALL4 RHEB ZBTB16 BCL9 TEK FLT3 WNT1 KDR RARA APC LEF1 PML NTRK2 DEPTOR KIT BRAF SHC1 FGFR4 LRP5 REL PYGO1 INSR NTRK1 AKT1S1 IL6R JAK2 CTNNB1 FZD6 JUP EPHA2 NFKBIE PIK3CB FGFR3 NFKBIA TSC2 IKBKB PIK3CG NFKB1 PPARD CSNK1A1 KRAS PDGFRA IGF1R RPTOR EGFR FOXO1 TSC1 MLST8 AXIN2 PIK3CD RELA MTOR CHUK IKBKG AKT3 AKT1 AKT2 IL6 FLT4 FLT1 PDGFRB TELO2 TTI1 KE1395 Liver Cancer BIRC3 CD44 VAV2 FRZB UCHL1 MIR744 NOS2 E2F2 CTTN BIRC5 TGFB1 TGFBR1 CASP9 LEF1 IL6R CASP3 SMAD3 STAT3 PTPN11 MIR155 MIR34A MIR24-2 MIR24-1 MYOF MIR92A1 BRCA1 PTGS2 HIF1A MAPK3 MAPK8 NFKB1 CCND1 MAPK14 VEGFA SOS1 FASLG CDKN1A RAC1 IL6 MYC TP53 SMAD4 AKT1 JAK1 CXCL8 BCL2L1 JUN GRB2 CXCR1 CASP7 RRM2 PODXL COL4A2 HNF1A MMP1 MIR92A2 KE1413 Reduced, presynaptic neuron 2 activity SLC6A4 CACNA1A SLC18A3 SYT1 RIMS1 NAPA CPLX1 UNC13B SYN1 DNM1L STX1B DNM1 SNAP25 STXBP1 STX1A SLC38A1 PARK7 CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 AP2B1 CLTCL1 SLC25A4 VAMP2 RAB3A CLTA CLTC SLC18A2 ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE1414 Decreased, GABA ADHFE1 AKR7A2 GLS GLS2 DPEP1 MAOB ABAT GAD2 PON3 GAD1 ALDH5A1 KE1415 Reduced, GABA-A receptor activation GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2B1 ABAT GAD2 GAD1 GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE1417 NFE2/Nrf2 repression ME1 KEAP1 SLC5A1 SLC6A4 SLC2A2 MAFF CYP4A11 ADH7 PTGR1 ABCC5 CBR1 FTH1 HGF SLC2A3 TGFB2 PDGFB TGFB1 SOD3 SLC2A1 EGR1 ABCC4 SLC2A12 SLC7A11 NRG1 TGFA TGFBR2 SLC6A20 SLC6A19 UGT1A1 ALDH3A1 PRDX1 DNAJB1 UGT1A6 CES3 UGT1A7 HSP90AB1 FGF13 SLC6A3 EPHA2 UGT2B7 SERPINA1 SRXN1 GCLC GCLM HSP90AA1 GSTP1 GSTT2 GGT1 GSR PPARD HBEGF NFE2L2 GSTM1 TXN CES5A G6PD SQSTM1 GSTM4 CES2 GPX2 NQO1 SLC2A4 GSTA5 RXRA CES1 GPX3 GSTM2 GSTA1 ABCC2 HMOX1 ABCC3 MAFG AGER GSTA2 EPHA3 FTL SLC5A5 TXNRD3 TXNRD1 UGT1A9 UGT1A4 CYP2A6 SLC6A13 SLC6A7 SLC39A9 SLC6A16 SLC6A15 MGST2 BLVRB SLC5A4 SLC6A2 SLC39A14 SLC2A9 SLC39A7 SLC5A7 PRDX6 SLC5A9 SLC6A8 SLC6A6 SLC6A11 SLC39A11 SLC2A11 GSTM5 GSTM3 SLC2A8 SLC5A6 SLC39A8 SLC39A5 SLC5A2 SLC39A6 SLC39A3 SLC2A5 PGD MGST3 SLC39A1 SLC39A4 SLC39A12 SLC5A12 SLC2A13 SLC5A10 SLC6A1 SLC5A11 CBR3 SLC2A6 SLC6A18 SLC39A2 SLC39A13 SLC6A5 GSTA4 CES4A SLC2A14 GSTA3 SLC6A9 SLC39A10 SLC6A17 SLC2A7 SLC2A10 SLC5A3 HSPA1A SLC5A8 SLC6A14 CUL3 AIMP2 INSR CEBPB MAF GSK3B SRC PGAM5 EPHB2 PIK3CA PRKCA MAPK8 FYN RBX1 YES1 KE1421 Activated, LXR FASN SCD SREBF1 CYP3A4 RXRA NR1H3 CYP2B6 CYP7A1 ABCG5 ABCG8 KE1422 Reduced, PPARalpha ACAA1 EHHADH CYP8B1 CYP4A11 SLC27A1 CDK4 DBI FABP1 CCND1 APOC3 APOA1 MYC APOA2 RXRA PPARA NR1H3 CPT1A ACADM CPT2 CYP7A1 CDK1 KLK15 PLTP APOA5 SCP2 UGT1A9 ME1 UBC ACOX1 ILK OLR1 AQP7 SORBS1 SCD FABP3 PDPK1 ACSL1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 PPARD PPARG FADS2 CD36 CYP27A1 RXRG LPL ADIPOQ GK RXRB SLC27A5 HMGCS2 PCK1 ANGPTL4 MMP1 KE1439 Systemic acute phase response ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 KE1445 Increase, Lipid peroxidation CISD1 NCOA4 SLC11A2 SLC40A1 FTH1 PRNP NOX1 ACSL4 FDFT1 SLC1A5 HMGCR CTH ACSL3 POR SAT1 SLC7A11 AKR1C2 ACSL1 CBS ACSL6 CYBB SLC3A2 COQ2 AKR1C1 AKR1C3 PCBP2 ACSL5 SLC38A1 BACH1 AIFM2 CHMP5 LPCAT3 GCH1 IREB2 SAT2 PCBP1 CHMP6 FTMT DPP4 GCLC GCLM VDAC3 NOX4 GSS MAP1LC3A TP53 VDAC2 GPX4 ALOX15 ATG5 TF HMOX1 HSPB1 STEAP3 MAP1LC3B ATG7 CP TFRC FTL TXNRD1 SLC39A14 SLC39A8 PHKG2 MAP1LC3C KE1456 Increase, Differentiation of fibroblasts IL12B SKIL GREM1 SFTPC TERC CYSLTR2 TERT ATP11A SFTPA1 PTX3 HGF EDN1 PDGFB MMP9 BMP7 TIMP1 TGFB1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 CEBPB PDGFA SMAD7 CCR2 ELMOD2 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 CXCL2 HMOX1 CSF3 EGF KE1458 Pulmonary fibrosis IL12B SKIL GREM1 SFTPC TERC CYSLTR2 TERT ATP11A SFTPA1 PTX3 HGF EDN1 PDGFB MMP9 BMP7 TIMP1 TGFB1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 CEBPB PDGFA SMAD7 CCR2 ELMOD2 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 CXCL2 HMOX1 CSF3 EGF KE1468 Activation, Latent Transforming Growth Factor Beta 1 FKBP1A SKIL MIR302A LEFTY1 CTNNB1 INHBA LIF SMAD2 SMAD3 SERPINE1 LEF1 BMP4 SPP1 STAT3 TGFB1 LEFTY2 TGFBR1 TGFBR2 TGFBR3 WNT1 FOXH1 ZNF423 SMAD7 RUNX3 FST BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD4 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG EGF SMAD5 SMAD9 ZEB2 ENG ITGB6 LTBP1 KE1469 Activation, Transforming Growth Factor beta pathway FKBP1A SKIL MIR302A LEFTY1 CTNNB1 INHBA LIF SMAD2 SMAD3 SERPINE1 LEF1 BMP4 SPP1 STAT3 TGFB1 LEFTY2 TGFBR1 TGFBR2 TGFBR3 WNT1 FOXH1 ZNF423 SMAD7 RUNX3 FST BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD4 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG EGF SMAD5 SMAD9 ZEB2 ENG ITGB6 LTBP1 KE1487 Binding, Thiol/seleno-proteins involved in protection against oxidative stress NOX5 MT1X NFIX NOX1 NOX3 CYBB SOD3 TXN2 MGST1 UGT1A6 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT HMOX1 SOD2 TXNRD2 TXNRD1 KE1488 Glutamate dyshomeostasis CAMKK2 ARC IL12B PPP1CC SLC1A2 LRRC8C CNTF GRIN3A GRIN3B DAO LTA PHGDH GLS2 DISC1 GLS GRM5 PSAT1 IL6R IL6ST IL10 INSR IRS1 LIF SMAD2 SMAD3 NGF PDHA1 PSPH BDNF SHMT1 SHMT2 SLC1A1 SLC2A1 SLC2A3 STAT3 STAT6 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 CFL1 GFAP SMAD7 SLC38A2 LRRC8A SLC1A4 SLC38A1 CAMKK1 SLC38A5 GRM2 GRM4 GRM7 GRM8 IL10RA IL13RA1 GLUL SLC7A10 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 SLC17A7 SLC17A6 SLC1A3 SLC1A6 ADCY1 ADCY3 ADCY8 CREB1 DLD AKT1 FGF2 PLCB1 FOS GOT1 GRIA1 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D IFNG IFNGR1 IFNGR2 IGF1 IL1A IL1B IL1R1 IL4 IL4R IL6 IL13 JAK1 SMAD4 NFKB1 NFKB2 NOS1 PLCB2 PLCB3 PLCB4 PPP1CB PRKACA PRKCA PRKCB PRKCG MAPK1 MAPK3 BCL2 STAT1 TGFB3 TNF TNFRSF1A TNFRSF1B TRAF5 CALM1 CAMK4 CAMK2A CAMK2B CAMK2D CAMK2G SOCS3 GRM1 IL12A IL1R2 DLAT GRIA2 IL10RB PPP1CA SLC6A9 SLC38A3 LRRC8B NSMF TRPM4 LRRC8D SRR LRRC8E KE1489 N/A, Steatohepatisis CEBPA COX6C COX7A1 LEP NDUFA9 PKLR SDHB SDHC SDHD VCAM1 LEPR BBC3 GSK3A IL6R INSR IRS1 MIR21 MAP3K11 MT-CO2 NDUFB10 PRKAG2 PRKAG3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 SREBF1 TGFB1 XBP1 CASP3 CASP8 COX4I2 IRS2 CDC42 SMAD7 MT-CO1 UQCRFS1 ADIPOR2 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A MT-CO3 NDUFA4 COX5A UQCR11 NDUFA11 COX6A2 UQCRQ UQCR10 NDUFS7 MT-CYB NDUFS8 UQCRB UQCRC1 UQCRC2 UQCRH COX7A2L CYC1 AKT3 BCL2L11 CYP2E1 EIF2S1 AKT1 AKT2 GSK3B FAS IKBKB IL1A IL1B FASLG IL6 CXCL8 INS JUN MAP3K5 ATF4 NFKB1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 CYCS PPARA MAPK8 MAPK9 BAK1 BAX RAC1 RELA RXRA CCL2 BID TNF TNFRSF1A TRAF2 PIK3R3 SOCS3 ADIPOQ EIF2AK3 NR1H3 DDIT3 ERN1 MLXIPL ITCH CASP7 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA13 NDUFB11 NDUFA12 SDHA NR1H4 NDUFC2-KCTD14 COX6B2 COX7B2 MLXIP COX8C UQCRHL NDUFA4L2 MLX ADIPOR1 IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG KE1493 Increased Pro-inflammatory mediators ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D CNTF CCL23 CTF1 CCL28 LTA CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 CX3CL1 MMP9 CCL22 CCL17 TGFB1 CXCL12 IL17A SPP1 LIF EPO IL10 CXCL9 IL18 CXCL10 CXCL11 IFNA1 TNFSF13B IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1B IL37 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CCL11 CCL13 CSF1 IFNA2 CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 NFKB1 CCL26 CXCL2 IL11 IL7 CSF3 AREG CCL20 IFNA6 IFNA8 CXCL6 IL22 IL33 CCL21 IFNA21 IL21 IL9 IFNA5 IFNA16 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A IFNB1 IFNA10 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 OSM IL26 MMP3 TNFSF13 IL3 MMP1 IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IL2RA IL2RB IL2RG IL4R IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG PDGFA HLA-DRA HLA-DRB1 CD4 KE1494 Leukocyte recruitment/activation ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 TEAD4 TEAD3 MIR21 FOXP3 PRDM1 TEAD1 TEAD2 LATS1 YWHAQ RASSF5 CD19 LATS2 MOB1A SAV1 STK3 CCR7 STK38L FOXO6 FYB1 RAB13 FERMT3 KNSTRN YAP1 MAPK14 FOXO1 FOXO3 RHOA LPL RAC1 NDRG1 MST1 WWTR1 FOXO4 RAP1A KE1496 Increased, secretion of proinflammatory mediators IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D CNTF CCL23 CTF1 CCL28 LTA CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 CX3CL1 MMP9 CCL22 CCL17 TGFB1 CXCL12 IL17A SPP1 LIF EPO IL10 CXCL9 IL18 CXCL10 CXCL11 IFNA1 TNFSF13B IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1A IL1B IL37 IL6 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 TNF CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 NFKB1 CCL26 CXCL2 IL11 IL7 CSF3 AREG CCL20 IFNA6 IFNA8 CXCL6 IL22 IL33 CCL21 IFNA21 IL21 IL9 IFNA5 IFNA16 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A IFNB1 IFNA10 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 OSM IL26 MMP3 TNFSF13 IL3 MMP1 KE1497 Increased, recruitment of inflammatory cells ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 KE1501 Increased, extracellular matrix deposition P4HA2 ADAMTS2 GPI P4HA1 PGM1 PLOD1 PHGDH GLS LDHA SLC2A1 FGFR1 FGFR4 SLC16A1 PSPH SLC1A5 PSAT1 LPAR1 UGDH PYCR1 GCK ALDH18A1 UGP2 P4HA3 P3H3 P3H4 LOXL2 CD36 PLCG1 RHOA SERPINH1 GLUD1 BMP1 MMP24 MMP21 MMP10 MMP11 MMP15 MMP16 MMP17 MMP19 MMP27 MMP23B MMP20 MMP8 MMP9 MMP13 MMP14 TIMP1 TIMP2 TIMP4 MMP12 MMP23A MMP26 BSG TCF20 MMP2 TNF MMP28 MMP25 MMP1 MMP3 MMP7 TIMP3 FKBP1A SKIL MIR302A LEFTY1 CTNNB1 INHBA LIF SMAD2 SMAD3 SERPINE1 LEF1 BMP4 SPP1 STAT3 TGFB1 LEFTY2 TGFBR1 TGFBR2 TGFBR3 WNT1 FOXH1 ZNF423 SMAD7 RUNX3 FST BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD4 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 RUNX2 NOG EGF SMAD5 SMAD9 ZEB2 ENG ITGB6 LTBP1 KE1508 CYP2E1 Activation CYP39A1 CYP7B1 CYP8B1 CYP4A11 CYP26A1 CYP3A43 CYP2C18 CYP4A22 CYP2S1 CYP4F2 CYP4F12 CYP4F8 CYP4B1 CYP51A1 POR CYP19A1 CYP17A1 CYP3A7 CYP11B1 CYB5A CYP1B1 CYP2W1 CYP26C1 CYB5R4 CYB5R3 CYB5B CYP20A1 CYP2G1P CYP2J2 CYP4V2 CYP2U1 CYB5R1 CYB5R2 CYP4F11 CYP4F22 CYP4Z1 CYP4X1 CYP27C1 CYP2F1 CYP2A13 CYP2A7 CYP24A1 CYP2D6 CYP27B1 CYP2E1 CYP27A1 CYP2C9 CYP2C8 CYP11A1 CYP1A1 CYP1A2 CYP3A4 CYP2C19 CYP11B2 CYP2R1 CYP26B1 CYP46A1 CYP7A1 CYP2B6 CYP3A5 CYP2A6 CYP4F3 KE1511 Lipid Peroxidation CISD1 NCOA4 SLC11A2 SLC40A1 FTH1 PRNP NOX1 ACSL4 FDFT1 SLC1A5 HMGCR CTH ACSL3 POR SAT1 SLC7A11 AKR1C2 ACSL1 CBS ACSL6 CYBB SLC3A2 COQ2 AKR1C1 AKR1C3 PCBP2 ACSL5 SLC38A1 BACH1 AIFM2 CHMP5 LPCAT3 GCH1 IREB2 SAT2 PCBP1 CHMP6 FTMT DPP4 GCLC GCLM VDAC3 NOX4 GSS MAP1LC3A TP53 VDAC2 GPX4 ALOX15 ATG5 TF HMOX1 HSPB1 STEAP3 MAP1LC3B ATG7 CP TFRC FTL TXNRD1 SLC39A14 SLC39A8 PHKG2 MAP1LC3C KE1512 Unfolded Protein Response MBTPS2 XBP1 BBC3 ATF6 TNFRSF10B MBTPS1 PMAIP1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 DDIT3 ERN1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE1513 General Apoptosis BIRC3 TNFRSF21 HELLS XIAP LTA CASP4 TNFRSF25 CRADD HRK MIR29A BBC3 APAF1 BIRC5 IRF1 IRF3 IRF5 MDM2 PMAIP1 BAD CASP3 CASP8 CASP9 TNFRSF10B MIR29B1 MIR29B2 IRF4 DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR IRF2 TRAF3 CASP7 TRADD RIPK1 FADD GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 TP73 SCAF11 KE1527 Increase, Cell membrane depolarization SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1528 Fatty Acid Beta Oxidation, Decreased CHKB ACSL1 ACSL3 ACSL4 ACSL6 ACSL5 DLD ECHS1 GCDH GK GK2 HADH ACAT1 LIPC LIPE LPL PNPLA2 LIPF CPT1A CPT1B CPT2 CRAT ECI1 DECR1 GPD2 HADHA HADHB ACADL ACADM ACADS ACADVL ACSS2 TPI1 SLC25A20 KE1538 Decreased protection against oxidative stress NOX5 MT1X NFIX NOX1 NOX3 CYBB SOD3 TXN2 MGST1 UGT1A6 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT HMOX1 SOD2 TXNRD2 TXNRD1 KE1541 Mitochondrial Complex I inhibition NDUFB10 ECSIT NDUFAB1 NDUFA1 NDUFS4 NDUFB5 NDUFB3 NDUFC1 NDUFA2 NDUFS5 NDUFS2 NDUFS6 NDUFB1 NDUFS3 NDUFB6 NDUFA3 NDUFB4 NDUFB8 NDUFB2 NDUFA7 NDUFC2 NDUFA10 MT-ND1 MT-ND2 MT-ND4L MT-ND4 MT-ND5 MT-ND6 NDUFB7 NDUFV2 NDUFS1 NDUFV1 NDUFA8 NDUFV3 NDUFA6 NDUFA5 NDUFAF6 NDUFAF7 TMEM126B NDUFAF2 NUBPL TMEM186 FOXRED1 DMAC1 NDUFAF3 TMEM70 COA1 ACAD9 TIMMDC1 DMAC2 NDUFB11 NDUFAF4 NDUFA13 NDUFA12 NDUFAF1 NDUFB9 KE1548 Necrotic Tissue CASP8 RIPK3 TNFRSF1A MAPK8 PLA2G4A PARP1 TNF TRADD TICAM1 RIPK1 FADD FTL BIRC3 TNFRSF21 HELLS XIAP LTA CASP4 TNFRSF25 CRADD HRK MIR29A BBC3 APAF1 BIRC5 IRF1 IRF3 IRF5 MDM2 PMAIP1 BAD CASP3 CASP9 TNFRSF10B MIR29B1 MIR29B2 IRF4 DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR IRF2 TRAF3 CASP7 GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 TP73 SCAF11 KE1556 Increase, lung cancer BAD E2F2 CASP8 RARB ARAF GADD45B SOS2 CDK6 E2F3 GADD45A POLK GADD45G RAF1 CASP9 DDB2 CDK4 BRAF TGFA CASP3 STAT3 HGF KIF5B MET PDPK1 RET RASSF1 STK4 CRABP2 EML4 CRABP1 FHIT RASSF5 VEGFR2 BID BAK1 PIK3CB BAX MAPK1 E2F1 MAPK3 AKT2 CCND1 SOS1 AKT3 FOXO3 PIK3CA PLCG1 CDKN1A PRKCG MAP2K2 KRAS RB1 TP53 ERBB2 AKT1 RXRG EGFR CDKN2A PRKCA PRKCB MAP2K1 PIK3CD CYCS HRAS RXRA PLCG2 RXRB NRAS GRB2 EGF KIF5A KIF5C JAK3 STAT5A ALK STAT5B BIRC3 ITGA6 ITGA2B LAMA2 BIRC7 CKS1B CDKN2B CKS2 BIRC8 NOS2 TRAF4 APAF1 CDK2 ITGAV PTEN ZBTB17 LAMB4 CCNE2 LAMC3 COL4A6 LAMA1 LAMB3 PTGS2 TRAF5 NFKBIA IKBKB NFKBIB CCNE1 CDKN1B PIK3R3 TRAF2 CDKN1C MYC BCL2L1 BCL2 RELA TRAF6 CHUK IKBKG FN1 LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 NFKB1 PIK3R1 PIK3R2 PTK2 SKP1 MAX TRAF3 COL4A1 ITGA2 ITGA3 ITGB1 LAMA3 TRAF1 BIRC2 COL4A3 COL4A5 COL4A2 COL4A4 LAMA4 KE1575 Activation, Caspase 8 pathway BIRC3 TNFRSF21 HELLS XIAP LTA CASP4 TNFRSF25 CRADD HRK MIR29A BBC3 APAF1 BIRC5 IRF1 IRF3 IRF5 MDM2 PMAIP1 BAD CASP3 CASP8 CASP9 TNFRSF10B MIR29B1 MIR29B2 IRF4 DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR IRF2 TRAF3 CASP7 TRADD RIPK1 FADD GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 TP73 SCAF11 KE1579 Increase, proinflammatory mediators (TNFalpha) FBXW11 BIRC3 SELE NSMAF KSR1 CYBA NOX1 APAF1 RFK BAD MAP4K2 RAF1 REL TNFAIP3 CASP3 CASP8 CASP9 TRAP1 RIPK3 NOXO1 GLUL KSR2 NFKBIE DIABLO OTUD7B PTPRCAP PYGL SMPD2 MADD TANK TAB1 CHUK RFFL MAP3K8 CREBBP CSNK2A1 AKT1 TAB2 TAB3 GRB2 TBK1 HRAS HSP90AA1 IKBKB IL6 JUN KRAS MAP3K1 MAP3K3 MAP3K5 NFKB1 NFKB2 NFKBIA NFKBIB NRAS PPP2CA PRKCZ MAPK1 MAPK3 MAPK8 MAPK9 MAP2K3 MAP2K6 MAP2K7 PSMD2 BAX RAC1 BCL2L1 CCL2 BID MAP2K4 SOS1 MAP3K7 TNF TNFRSF1A TNFRSF1B TRAF2 TXN IKBKG CFLAR MAP3K14 CDC37 SKP1 CASP7 CUL1 TRADD RIPK1 FADD BTRC BIRC2 PLK1 TRAF1 IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D CNTF CCL23 CTF1 CCL28 LTA CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 CX3CL1 MMP9 CCL22 CCL17 TGFB1 CXCL12 IL17A SPP1 LIF EPO IL10 CXCL9 IL18 CXCL10 CXCL11 IFNA1 TNFSF13B IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 CCL7 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1A IL1B IL37 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 CCL26 CXCL2 IL11 IL7 CSF3 AREG CCL20 IFNA6 IFNA8 CXCL6 IL22 IL33 CCL21 IFNA21 IL21 IL9 IFNA5 IFNA16 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A IFNB1 IFNA10 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 OSM IL26 MMP3 TNFSF13 IL3 MMP1 KE1581 Disturbance in microtubule dynamic instability STMN1 AURKB TRIO CDC42 MARK2 DVL1 MAP1B APC PAK1 WNT3A TIAM1 STAT3 PTEN NTRK1 NTRK2 NTRK3 F2RL2 MAPRE1 PTPRA PHLDB2 TPPP TESK2 CLASP1 DPYSL2 PARD6A MARK1 CLIP1 KIF2C TAOK1 SPRED1 ROCK1 PRKACA GSK3B EPHB2 RAC1 AKT1 CAMK4 PRKCA GNAQ MAPKAPK2 MAPT SRC ABL1 CDK1 LIMK1 DIAPH1 RHO CFL2 KE1585 Proteasomal dysfunction UBC UBE2D2 PSMD11 UBA1 HLA-B HLA-E HLA-F HLA-G UCHL1 UBE2D3 HLA-A NEDD4 UBB UBE2D1 H2AC4 UCHL3 PSME3 HLA-H PSMB8 PSMB9 PSMB10 PSMD5 PSMD10 PSME1 PSME2 RPN1 RPN2 UBA7 H2AX H2AZ1 IFNG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD7 PSMD8 PSMD9 PSMD12 PSMD13 PSMD6 UBE2B HLA-C KE1587 Fibroproliferative airway lesions IL12B SKIL GREM1 SFTPC TERC CYSLTR2 TERT ATP11A SFTPA1 PTX3 HGF EDN1 PDGFB MMP9 BMP7 TIMP1 TGFB1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 CEBPB PDGFA SMAD7 CCR2 ELMOD2 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 CXCL2 HMOX1 CSF3 EGF KE1605 Accumulation of misfolded proteins MBTPS2 XBP1 BBC3 ATF6 TNFRSF10B MBTPS1 PMAIP1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 DDIT3 ERN1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE1607 Increase, Necrosis CASP8 RIPK3 TNFRSF1A MAPK8 PLA2G4A PARP1 TNF TRADD TICAM1 RIPK1 FADD FTL CISD1 NCOA4 SLC11A2 SLC40A1 FTH1 PRNP NOX1 ACSL4 FDFT1 SLC1A5 HMGCR CTH ACSL3 POR SAT1 SLC7A11 AKR1C2 ACSL1 CBS ACSL6 CYBB SLC3A2 COQ2 AKR1C1 AKR1C3 PCBP2 ACSL5 SLC38A1 BACH1 AIFM2 CHMP5 LPCAT3 GCH1 IREB2 SAT2 PCBP1 CHMP6 FTMT DPP4 GCLC GCLM VDAC3 NOX4 GSS MAP1LC3A TP53 VDAC2 GPX4 ALOX15 ATG5 TF HMOX1 HSPB1 STEAP3 MAP1LC3B ATG7 CP TFRC TXNRD1 SLC39A14 SLC39A8 PHKG2 MAP1LC3C KE1623 Occurrence, Focal Seizure WEE1 SCN4A MAPK8IP2 NEDD4L PTPRN SCN1B PDCD10 SCN2A SCN7A RNF121 SCN1A SCN2B SCN3A SCNM1 NFASC SCN3B PRRT2 SCN11A SCN9A SCN4B SCN5A SCN10A SCN8A RACK1 JAK2 NEDD4 FGF14 FGF12 FGF13 CAMK2A PSEN1 GSK3B AKT1 BACE1 CALM1 TNF FYN KE1632 Increase in reactive oxygen and nitrogen species (RONS) ATP1A1 UQCRFS1 COA3 AS3MT CAT SOD1 VDAC1 GSTO1 SDHA MT-ND1 KE1633 Increase in inflammation IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG IL12B IL15 IL10 PDGFA TGFB1 CSF1 CSF2 IL1A IL1B IL6 IL13 TNF CSF3 CXCL1 CXCL2 HLA-DRA HLA-DRB1 IFNB1 IL7 IL11 CD4 IL3 KE1635 Increase, DNA strand breaks CHEK1 ACTL6A HSF1 ATR TERF2 RIF1 KAT5 RAD17 RNF8 CHEK2 TP53BP1 MDC1 APAF1 LATS1 PCNA CDC25C CASP3 MRE11 CASP9 MDM2 NBN RAD52 RAD51 SMC1A RAD50 DCLRE1C RASSF1 RAD9A BRCA1 STK3 SMC3 ATF2 ATM TP53 PARP1 H2AX YAP1 BID E2F1 BAX BAK1 CDKN2A TRAF6 ABL1 BRCA2 CDK5 UPF1 FANCD2 BLM PRKDC TRIM28 NABP2 TP73 MCPH1 EXO1 ERCC8 MSH3 MSH6 ERCC6 MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 POLE2 LIG1 POLE3 NEIL2 POLE MLH1 XRCC5 MSH2 POLK DDB2 ERCC5 XPC FANCC CUL4B ERCC3 MGMT POLH POLD3 APEX1 POLD2 POLE4 RAD23B POLM RPA1 TDG CETN2 USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B RPA3 RPA2 DDB1 HMGB1 CUL4A LIG3 PARP2 ERCC1 RFC1 POLD1 POLB RBX1 ERCC2 PMS2 XRCC4 WRN LIG4 FAN1 RAP1A REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 KE1656 Antagonism, Thyroid Receptor ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 PFKFB2 PAX8 AQP7 SLC16A10 TTF2 TTF1 TSHB NPPB BAD KDM1A RPS6KA6 FGFR1 FGF21 RHEB RPS6KB1 NPY THRA RAF1 CASP9 MDM2 TBC1D4 ITGAV NOTCH1 WNT4 SHH CTNNB1 AKT1S1 DIO2 ITGB3 PRKG2 MAP4K5 NPR1 MGLL MC4R PLIN1 ADRB3 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 RPS6 PRDM16 TPO SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 ZNF516 KLB KDM3B KE1668 Frustrated phagocytosis ITGB2 VAV2 RAC3 ITGAM TREM2 ARPC1B SIGLEC7 CYBA NCF4 HCK PTPN6 NCF2 RAC2 VAV3 VAV1 NCF1 CYBB LAT C1QB NCKAP1L TREM1 C1QC LYN FCGR1A FCER1G PIK3C2A PIK3CB PIK3C3 PIK3R2 PIK3CG PIK3R3 PIK3CA RAC1 PIK3R1 PIK3CD PLCG2 PIK3R6 C1QA TYROBP SYK KE1669 Increased, DNA damage and mutation ERCC8 MSH3 MSH6 TERF2 CHEK1 ATR ERCC6 MNAT1 GTF2H1 GTF2H3 SMUG1 RFC3 CDK7 CCNH FANCI GTF2H2 RFC4 GTF2H4 RFC2 RFC5 WDR48 POLE2 LIG1 POLE3 NEIL2 POLE MRE11 MLH1 XRCC5 MSH2 POLK PCNA DDB2 ERCC5 XPC FANCC CUL4B ERCC3 MGMT POLH RAD52 RAD51 POLD3 APEX1 NBN POLD2 RAD50 POLE4 RAD23B POLM RPA1 TDG CETN2 DCLRE1C USP1 POLL POLD4 NHEJ1 XRCC6 RAD54B BRCA1 RPA3 RPA2 DDB1 HMGB1 CUL4A LIG3 PARP2 PARP1 ATM H2AX ERCC1 RFC1 POLD1 POLB RBX1 ERCC2 PMS2 BRCA2 FANCD2 XRCC4 WRN LIG4 FAN1 RAP1A PRKDC EXO1 REV3L PNKP NTHL1 XRCC1 UNG PALB2 POLI MPG RAD51C NEIL3 FANCE OGG1 FANCL MBD4 FAAP24 MUTYH REV1 BRIP1 XPA FEN1 APEX2 CENPX CENPS ERCC4 RAD23A FANCB FANCF FAAP100 FANCA FANCM FANCG GTF2H5 HUS1B RAD17 CHEK2 RRM2B CASP8 SESN1 GADD45B BBC3 CDK6 CCND3 GADD45A CCND2 TP53AIP1 APAF1 TNFRSF10B CDK2 GADD45G CASP9 CDK4 MDM2 PML PMAIP1 CDC25C CDC25A CASP3 SFN PIDD1 SMC1A RAD1 RAD9A CCNE2 ATRIP CCNB3 TLK1 BID FAS BAX E2F1 CCNE1 CCND1 CDKN1B CDKN1A RB1 TP53 AKT1 TLK2 CYCS CREB1 MYC ABL1 CCNB1 CCNB2 CDK5 CDK1 KE1670 Lung cancer BAD E2F2 CASP8 RARB ARAF GADD45B SOS2 CDK6 E2F3 GADD45A POLK GADD45G RAF1 CASP9 DDB2 CDK4 BRAF TGFA CASP3 STAT3 HGF KIF5B MET PDPK1 RET RASSF1 STK4 CRABP2 EML4 CRABP1 FHIT RASSF5 VEGFR2 BID BAK1 PIK3CB BAX MAPK1 E2F1 MAPK3 AKT2 CCND1 SOS1 AKT3 FOXO3 PIK3CA PLCG1 CDKN1A PRKCG MAP2K2 KRAS RB1 TP53 ERBB2 AKT1 RXRG EGFR CDKN2A PRKCA PRKCB MAP2K1 PIK3CD CYCS HRAS RXRA PLCG2 RXRB NRAS GRB2 EGF KIF5A KIF5C JAK3 STAT5A ALK STAT5B BIRC3 ITGA6 ITGA2B LAMA2 BIRC7 CKS1B CDKN2B CKS2 BIRC8 NOS2 TRAF4 APAF1 CDK2 ITGAV PTEN ZBTB17 LAMB4 CCNE2 LAMC3 COL4A6 LAMA1 LAMB3 PTGS2 TRAF5 NFKBIA IKBKB NFKBIB CCNE1 CDKN1B PIK3R3 TRAF2 CDKN1C MYC BCL2L1 BCL2 RELA TRAF6 CHUK IKBKG FN1 LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 NFKB1 PIK3R1 PIK3R2 PTK2 SKP1 MAX TRAF3 COL4A1 ITGA2 ITGA3 ITGB1 LAMA3 TRAF1 BIRC2 COL4A3 COL4A5 COL4A2 COL4A4 LAMA4 KE1708 Th17 cell migration and inflammation induction IL17F IL17C IL17B IL17D IL25 CEBPB IL17A JAK2 STAT3 CEBPD IL17RA IL17RC IL17RD AKT1 GSK3B IKBKB JAK1 NFKB1 NFKBIB PIK3CA MAPK1 MAPK3 RELA SP1 MAP3K7 TRAF6 IKBKG MAP3K14 TRAF3 TRAF3IP2 IL17RE IL17RB RORA TBX21 NR1D1 RUNX1 NFIL3 IL21R IL27RA IL27 FOXP3 TGFB1 TGFBR1 NFATC1 RARA PPP3CA CD3G IL6R STAT6 CD3D SMAD2 CD247 CD3E HLA-DMA LAT IRF4 IFNGR1 PRKCQ IL4R HSP90AA1 HIF1A NFKBIA TYK2 AHR GATA3 MAPK8 IL2 IL23A IFNG MAPK14 IL4 ZAP70 STAT1 PLCG1 IL1B IL2RA IL6 FOS JUN LCK SOCS3 RXRA MTOR CD4 IL22 BMAL1 CLOCK IL21 CRY1 STAT5A RORC PER1 IL23R KE1738 SARS-CoV-2 cell entry TMPRSS4 SLC6A19 NRP1 ACE2 TLR7 TMPRSS2 FURIN SCARB1 ACAT1 CTSL KE1740 Induced dysregulation of ACE2 ATP6AP2 NOS3 ACE2 BDKRB2 TGFB1 NR3C2 CMA1 CTSG CYP11B2 ACE AGT AGTR1 AGTR2 REN KNG1 BDKRB1 MAS1 KE1743 Increase plasma Ang II ATF1 ATF2 ATF4 ATF6B CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CYP11A1 CYP11B2 CYP21A2 GNAQ HSD3B1 HSD3B2 ITPR1 ITPR2 ITPR3 PLCB2 STAR CMA1 CTSG ACE AGT AGTR1 AGTR2 REN KE1750 Increased inflammatory immune responses ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG KE1770 Decrease, Mitochondrial membrane potential COX6C COX7A1 NDUFA9 SDHB SDHC SDHD SURF1 MT-CO2 NDUFB10 COX11 MT-CO1 UQCRFS1 COX17 COX4I1 COX5B COX6A1 COX6B1 COX7A2 COX7B COX7C COX8A COX15 MT-CO3 NDUFA4 COX5A ATP5PD ATP5MG UQCR11 NDUFA11 COX6A2 UQCRQ DMAC2L UQCR10 NDUFS7 MT-ATP6 MT-ATP8 MT-CYB MT-ND3 NDUFS8 ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5F1E ATP5PB ATP5MC1 ATP5MC2 ATP5MC3 ATP5ME ATP5PF ATP5PO SCO1 UCP2 UCP3 UQCRB UQCRC1 UQCRC2 UQCRH SLC25A14 COX7A2L ATP5IF1 SLC25A27 ATP5MF UCP1 SLC25A4 SLC25A5 SLC25A6 NDUFA13 MT-ND1 MT-ND2 MT-ND4 MT-ND4L MT-ND5 MT-ND6 NDUFA1 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA10 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFV1 NDUFS4 NDUFS5 NDUFS6 NDUFV2 NDUFV3 NDUFA12 SDHA KE1788 Status epilepticus SLC1A2 STIM1 PDIA2 P4HB ARC MBD5 ORAI1 GRIN3B GRIN3A CRTC1 SLC1A1 GLS2 SLC7A11 NRG1 STAT3 GRM5 ERBB4 GRM3 NRXN3 HDAC10 EFNB2 SDCBP GRM4 FFAR1 GLUL GRM2 GRM8 GRM7 CABIN1 SLC32A1 SLC1A6 GRIK5 SH3GL2 CPEB3 SLC6A12 GABRR2 SUMO1 GRIA3 ARHGEF9 SNX14 ATAD1 CACNG8 SNX27 C1QL2 GABRR1 FRMPD3 GRIK4 GRIA4 ZFYVE27 NPTN LHFPL4 UBQLN4 SYVN1 SLC1A7 GRIK3 GRIK2 C1QL3 CACNG2 GRIK1 NETO2 AP2A2 GABRR3 NWD1 ADARB1 SLC1A3 CREBBP AP2B1 CAMK2A MAPK1 MAPK3 GRIN2D PPP2CA STAT1 HDAC1 GAD1 PRKCA GRIA1 GNAQ GRIN2C MAP2K1 GRIN1 PLCB1 ABAT GRIN2A SRC GRIN2B GABRA3 GABRA1 GABRP GABRE GABRA4 GAPDH GRM6 GABRG2 NR4A1 SLC12A5 MAP1LC3B GABRA6 GABRB2 GABRA2 GRM1 GABRG1 GABRB1 GABRB3 KIF5C CDH2 GABRG3 GABRA5 GABRD GABRQ GNA11 GRIA2 DLG4 HOMER1 GRIP1 SLC6A13 PICK1 DLGAP3 SLC6A8 SLC6A11 SLC6A1 AP2A1 SLC6A6 KE1790 Increased, Differentiation to Testis FGFR2 AMH SOX9 SRD5A1 WNT4 CTNNB1 PBX1 GATA4 SOX8 NR5A1 FST RBFOX2 AMHR2 DMRT1 CBX2 FOXL2 SRY PTGDS MAPK11 FGF9 RSPO1 EMX2 WT1 INSL3 DHH KE1795 Latent Transforming growth Factor beta expression FKBP1A SKIL MIR302A LEFTY1 CTNNB1 INHBA LIF SMAD2 SMAD3 SERPINE1 LEF1 BMP4 SPP1 STAT3 TGFB1 LEFTY2 TGFBR1 TGFBR2 TGFBR3 WNT1 FOXH1 ZNF423 SMAD7 RUNX3 FST BAMBI SKI TGIF1 ZFYVE9 CREBBP EP300 FOS HRAS IFNG JAK1 JUN SMAD1 SMAD4 SMAD6 NFKB1 MAPK3 MAPK9 STAT1 TFE3 THBS1 TNF RUNX2 NOG EGF SMAD5 SMAD9 ZEB2 ENG ITGB6 LTBP1 KE1812 Increase, Cytochrome c release BIRC3 TNFRSF21 HELLS XIAP LTA CASP4 TNFRSF25 CRADD HRK MIR29A BBC3 APAF1 BIRC5 IRF1 IRF3 IRF5 MDM2 PMAIP1 BAD CASP3 CASP8 CASP9 TNFRSF10B MIR29B1 MIR29B2 IRF4 DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR IRF2 TRAF3 CASP7 TRADD RIPK1 FADD GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 TP73 SCAF11 KE1815 Increase, Endoplasmic reticulum stress MBTPS2 XBP1 BBC3 ATF6 TNFRSF10B MBTPS1 PMAIP1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 DDIT3 ERN1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE1816 Mitochondrial dysfunction EMPTY HSPA9 HTRA2 AFG3L2 AIFM1 XPNPEP3 PLEK USP9X HSPD1 TRAK1 DNM1L SLC25A46 MICOS13 AGK MIPEP TIMM50 MICU1 CLPP TIMM8A YME1L1 PPA2 CLPB PMPCA MFF SFXN4 ATAD3A SPG7 DNAJC19 PAM16 GDAP1L1 GFER LONP1 UBXN1 OXA1L PYCR3 COQ5 NPLOC4 RTN4IP1 UFD1 PYCR2 MSTO1 UBXN6 TMEM126A OPA3 SACS COQ3 C1QBP TXN2 PYCR1 MFN2 PINK1 STAT2 PRKN OPA1 VCP MCL1 MFN1 MARCHF5 PMPCB PITRM1 TIMMDC1 TXNRD2 KE1817 Apoptotic cell death HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 TNFRSF21 HELLS LTA MIR29A IRF1 IRF3 IRF5 MDM2 IRF4 IGF2 NFKBIE CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TNF TRAF2 IKBKG TP63 IRF2 GZMB PRF1 TRAF1 TP73 SCAF11 KE1818 Immune cell activation GAB2 CD83 IL15RA RIPK2 SH2B3 VAV3 MALT1 MAP4K1 CCR5 CRK PTK2B LAT ICOS TNFRSF9 IL17A ITK LCP2 NCK1 NFATC1 NFATC2 PAK1 PDPK1 PTPN11 RAF1 REL SHC1 TGFB1 VAV1 WAS CARD11 CBLB BCL10 CD3D CD3E CD3G CD247 CD8A GRAP2 CDC42 IRF4 OPRM1 FYB1 PSTPIP1 MAP3K14 CHUK MAP3K8 CREB1 ATF2 MAPK14 AKT1 FOS GATA3 GRB2 HRAS FAS IKBKB IL1A IL1B IL6 ITPR1 JUN LCK NFKB1 NFKBIA PIK3R1 PIK3R2 PLCG1 PRKCD PRKCQ MAPK1 MAPK3 MAPK8 MAPK9 MAP2K1 MAP2K2 RELA SOS1 MAP3K7 TRAF6 ZAP70 IKBKG CBL CD28 CRKL FYN IL9 VIM SKAP1 CD4 DBNL KE1819 IFNγ signaling GBP1 HLA-B OAS1 IRF9 CYBB ICAM1 CXCL10 IRF1 JAK2 CXCL9 NOS2 EIF2AK2 PTPN11 REG1A IRF4 IFIT2 PSMB9 TAP1 IFNA2 IFNG IFNGR1 IFNGR2 IL1B JAK1 PRKCD SPI1 STAT1 STAT2 H4C14 SOCS1 SOCS3 ISG15 IFI6 IFNB1 IRF2 IRF8 CIITA KE1820 Immune mediated hepatitis IL12B IL15 IL10 PDGFA TGFB1 CSF1 CSF2 IFNG IL1A IL1B IL2 IL4 IL5 IL6 IL13 TNF CSF3 CXCL1 CXCL2 HLA-DRA HLA-DRB1 IFNB1 IL7 IL11 CD4 IL3 KE1825 Increase, Cell death HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 RIPK3 PLA2G4A PARP1 TNF TICAM1 FTL PRKAG2 PRKAB1 PRKAG3 PRKAB2 PRKAA1 DEPTOR PRKAA2 PRKAG1 AKT1S1 RB1CC1 PIK3C3 AMBRA1 BECN1 ATG14 RPTOR MLST8 ULK1 PIK3R4 MTOR ATG9A ATG5 ATG16L1 ATG101 MAP1LC3B ATG3 ATG12 WIPI2 ATG13 ATG7 UVRAG TNFRSF21 HELLS LTA MIR29A IRF1 IRF3 IRF5 MDM2 IRF4 IGF2 NFKBIE CHUK AKT1 IGF1 IGF1R IRF6 IRF7 MAP3K1 MYC NFKBIB PIK3R1 MAPK10 RELA MAP2K4 BNIP3L TRAF2 IKBKG TP63 IRF2 GZMB PRF1 TRAF1 TP73 SCAF11 KE1829 Altered, Thyroid hormone-dependent gene expression ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 PFKFB2 PAX8 AQP7 SLC16A10 TTF2 TTF1 TSHB NPPB BAD KDM1A RPS6KA6 FGFR1 FGF21 RHEB RPS6KB1 NPY THRA RAF1 CASP9 MDM2 TBC1D4 ITGAV NOTCH1 WNT4 SHH CTNNB1 AKT1S1 DIO2 ITGB3 PRKG2 MAP4K5 NPR1 MGLL MC4R PLIN1 ADRB3 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 RPS6 PRDM16 TPO SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 ZNF516 KLB KDM3B KE1841 Encephalitis NOS2 MT-CO2 MT-CO1 ASCC1 NFKBIA MAPK8 MAPK14 TLR4 FOS RELA JUN MTOR CHUK KE1842 Prolonged TLR9 activation TIFA IL12B OTUD5 RBCK1 MBL2 ZMYND11 BTK PTPN6 TNFAIP3 MIR155 IFNA1 IFNAR1 CXCL10 IRF3 IRF5 MIR98 CXCL9 TLR7 TLR9 CXCL11 SPP1 TLR3 CASP8 TMED7 MIRLET7E CISH TREM1 SFTPA2 MIRLET7I TLR1 TLR5 TLR6 LY96 TICAM2 CYLD RNF216 USP7 TAB2 IRAK2 TLR4 TLR2 SMAD6 TAB3 SQSTM1 MYD88 SOCS1 MIR146A AKT3 TAB1 CHUK MAP3K8 MAPK14 AKT1 AKT2 FOS PIK3R5 TBK1 IFNA2 IFNAR2 IKBKB IL1B IL6 CXCL8 IRAK1 IRF7 JUN NFKB1 NFKB2 NFKBIA IRAK4 TLR8 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 TOLLIP MAPK1 MAPK3 MAPK8 MAPK11 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP2K7 RAC1 RELA MAPK12 CCL3 CCL4 CCL5 MAP2K4 MLST8 STAT1 MAP3K7 TNF TRAF6 PIK3R3 IKBKG CD80 CD86 CD40 IRAK3 TICAM1 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IL12A LBP TRAF3 RIPK1 FADD CD14 IKBKE SYK PLK1 RNF41 TIRAP SARM1 RNF31 CUEDC2 CTNNAL1 SFTPD CD180 TRAFD1 PELI2 FBXW5 PELI3 SIGIRR PELI1 MIR105-1 KE1844 systemic inflammatory response syndrome ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 KE1846 Thrombosis and Disseminated Intravascular Coagulation F7 SERPINB2 F11 SERPINE1 PLAU F2 PLAT PLG F9 VWF F3 F10 F13B SERPINF2 F8 F5 FGG FGA FGB F12 KLKB1 KLK1 KE1847 Increased SARS-CoV-2 production TMPRSS4 SLC6A19 NRP1 ACE2 TLR7 TMPRSS2 FURIN SCARB1 ACAT1 CTSL KE1848 Toll Like Receptor (TLR) Dysregulation IRF3 TLR3 TLR7 TLR9 REL TLR1 TLR5 TLR6 TICAM2 NFKB2 TOLLIP MAPK1 TLR8 IKBKB NFKB1 TLR4 TLR2 MYD88 TRAF6 TBK1 IRAK1 IRF7 IRAK4 CHUK IKBKG RELA RELB TICAM1 TRAF3 IKBKE TIRAP KE1851 Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) ATF1 ATF2 ATF4 ATF6B CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CYP11A1 CYP11B2 CYP21A2 GNAQ HSD3B1 HSD3B2 ITPR1 ITPR2 ITPR3 PLCB2 STAR CMA1 CTSG ACE AGT AGTR1 AGTR2 REN RACK1 TGFB1 TGFBR1 ACTA2 CCN2 RRAS JUND RAF1 IL6ST TGFBR2 SMAD3 PDGFD PTPN11 ACE2 MAPK1 HIF1A COL1A1 MAP2K6 SMAD4 COL1A2 SP1 NOX4 IL11 IL11RA F12 MAS1 KE1852 Increased Ang II type 1 receptor (AT1R) RACK1 TGFB1 TGFBR1 ACTA2 CCN2 RRAS JUND RAF1 IL6ST TGFBR2 SMAD3 PDGFD PTPN11 ACE2 MAPK1 HIF1A COL1A1 MAP2K6 SMAD4 AGTR1 COL1A2 SP1 NOX4 AGT IL11 IL11RA F12 MAS1 KE1853 Hyperactivation of ACE/Ang-II/AT1R axis ATF1 ATF2 ATF4 ATF6B CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREB5 CYP11A1 CYP11B2 CYP21A2 GNAQ HSD3B1 HSD3B2 ITPR1 ITPR2 ITPR3 PLCB2 STAR CMA1 CTSG ACE AGT AGTR1 AGTR2 REN RACK1 TGFB1 TGFBR1 ACTA2 CCN2 RRAS JUND RAF1 IL6ST TGFBR2 SMAD3 PDGFD PTPN11 ACE2 MAPK1 HIF1A COL1A1 MAP2K6 SMAD4 COL1A2 SP1 NOX4 IL11 IL11RA F12 MAS1 KE1854 Dysregulation, ACE2 expression and activity ACE2 NOS3 SERPINE1 BDKRB2 NPR1 CYP24A1 RHOA ROCK1 NOS1 MAPK1 NFKB1 VDR CYP3A4 PRKG1 TNF IL1A IL1B ACE AGT AGTR1 AGTR2 REN CPN1 F12 SERPING1 KLKB1 KLK1 KNG1 BDKRB1 RACK1 TGFB1 TGFBR1 ACTA2 CCN2 RRAS JUND RAF1 IL6ST TGFBR2 SMAD3 PDGFD PTPN11 HIF1A COL1A1 MAP2K6 SMAD4 COL1A2 SP1 NOX4 IL11 IL11RA MAS1 KE1857 Platelet-neutrophil interactions, Increased SELE VCAM1 SELPLG ICAM1 TGFB2 TGFB1 TLR7 CD40 CD40LG CCL2 TGFB3 IL1B CCL5 TLR4 TLR2 PF4 SELP KE1868 Hyperinflammation IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D CNTF CCL23 CTF1 CCL28 LTA CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 CX3CL1 MMP9 CCL22 CCL17 TGFB1 CXCL12 IL17A SPP1 LIF EPO IL10 CXCL9 IL18 CXCL10 CXCL11 IFNA1 TNFSF13B IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1A IL1B IL37 IL6 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 TNF CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 NFKB1 CCL26 CXCL2 IL11 IL7 CSF3 AREG CCL20 IFNA6 IFNA8 CXCL6 IL22 IL33 CCL21 IFNA21 IL21 IL9 IFNA5 IFNA16 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A IFNB1 IFNA10 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 OSM IL26 MMP3 TNFSF13 IL3 MMP1 KE1869 Diminished protective oxidative stress response NOX5 MT1X NFIX NOX1 NOX3 CYBB SOD3 TXN2 MGST1 UGT1A6 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT HMOX1 SOD2 TXNRD2 TXNRD1 KE1897 increased MyD88 activation TIFA UBE2N UBE2V1 TLR7 TLR9 TLR1 TLR5 TLR6 TLR10 TLR8 NFKB1 IL1A TLR4 TLR2 MYD88 TRAF6 IRAK1 JUN KE1900 increased platelet surface TLR9 expression TIFA IL12B OTUD5 RBCK1 MBL2 ZMYND11 BTK PTPN6 TNFAIP3 MIR155 IFNA1 IFNAR1 CXCL10 IRF3 IRF5 MIR98 CXCL9 TLR7 TLR9 CXCL11 SPP1 TLR3 CASP8 TMED7 MIRLET7E CISH TREM1 SFTPA2 MIRLET7I TLR1 TLR5 TLR6 LY96 TICAM2 CYLD RNF216 USP7 TAB2 IRAK2 TLR4 TLR2 SMAD6 TAB3 SQSTM1 MYD88 SOCS1 MIR146A AKT3 TAB1 CHUK MAP3K8 MAPK14 AKT1 AKT2 FOS PIK3R5 TBK1 IFNA2 IFNAR2 IKBKB IL1B IL6 CXCL8 IRAK1 IRF7 JUN NFKB1 NFKB2 NFKBIA IRAK4 TLR8 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 TOLLIP MAPK1 MAPK3 MAPK8 MAPK11 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP2K7 RAC1 RELA MAPK12 CCL3 CCL4 CCL5 MAP2K4 MLST8 STAT1 MAP3K7 TNF TRAF6 PIK3R3 IKBKG CD80 CD86 CD40 IRAK3 TICAM1 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IL12A LBP TRAF3 RIPK1 FADD CD14 IKBKE SYK PLK1 RNF41 TIRAP SARM1 RNF31 CUEDC2 CTNNAL1 SFTPD CD180 TRAFD1 PELI2 FBXW5 PELI3 SIGIRR PELI1 MIR105-1 KE1901 Interferon-I antiviral response, antagonized by SARS-CoV-2 OAS1 OAS3 TREML4 EIF2AK2 MAVS RIGI IFIH1 IRF3 IFNAR1 TLR7 IRF9 TLR3 ACE2 TLR9 TMPRSS2 TLR6 TYK2 OAS2 STAT1 IFNAR2 JAK1 STAT2 MYD88 TRAF6 TBK1 IRF7 IRAK4 TLR4 TLR2 TRAF3 IKBKE KE1908 Cilia Beat Frequency, Decreased MKS1 SPATA7 CRX DYNC2I2 IFT43 BBS9 BBS2 GLIS2 DYNC2I1 LCA5 BBS7 BBS4 CCDC40 NEK8 BBS5 LZTFL1 IFT122 INTU ANKS6 TTC8 ANKS3 IQCB1 BBS1 IFT140 XPNPEP3 CEP290 DYNLT2B BBIP1 ZMYND10 KATNIP CNGB1 DNAAF6 POMGNT1 KIZ RPGRIP1 EFHC1 ARL2BP RP1 ODAD1 DNAH11 RSPH4A MAK DNAH6 NEK2 CENPF DDX59 TRIM32 DNAL1 TTLL5 DNAI1 USP9X DNAAF11 ATXN10 NEK1 POC1B AK7 PLK4 NME7 DCDC2 TBC1D32 CEP78 CCNO DNAAF1 CFAP418 HYDIN RAB28 PKD1L1 CFAP298 CCDC28B RSPH1 CFAP410 POC1A DNAAF5 DNAAF2 TUB CFAP52 DNAAF19 DNAAF3 ODAD2 TAPT1 FAM161A PKHD1 DNAI2 CFAP53 GALNT11 PCARE NME9 RP1L1 TOPORS ODAD3 HYLS1 CNGA1 ODAD4 MCIDAS DNAAF4 CCNQ CCDC39 SPAG1 RSPH3 RSPH9 DNAJB13 ZIC2 NPHP3 INVS OFD1 CC2D2A EVC PIBF1 KIAA0586 RP2 ZNF423 RPGRIP1L CSPP1 CEP41 SUFU B9D1 UNC119 CEP164 CILK1 RAB23 ARL6 CEP104 WDR35 TCTN3 B9D2 MKKS TTBK2 NPHP4 DYNC2LI1 ARL3 WDPCP NPHP1 INPP5E TMEM138 SCLT1 TMEM237 WDR19 TMEM67 C2CD3 TCTN2 CEP120 ARL13B EVC2 CEP83 CEP19 TMEM107 BBS10 BBS12 TMEM17 TMEM216 DYNC2H1 CPLANE1 KIAA0753 TCTN1 TMEM231 SDCCAG8 TULP1 PDE6D ADCY6 PIK3R4 PKD1 NEK9 OCRL AHI1 IFT80 GLI2 IFT27 IFT52 CLUAP1 GLI3 IFT57 PKD2 IFT81 TTC21B SMO IFT172 CCDC65 GAS8 FLCN DRC1 TRAF3IP1 ALMS1 GPR161 KIF7 KE1909 Mucociliary Clearance, Decreased MKS1 SPATA7 CRX DYNC2I2 IFT43 BBS9 BBS2 GLIS2 DYNC2I1 LCA5 BBS7 BBS4 CCDC40 NEK8 BBS5 LZTFL1 IFT122 INTU ANKS6 TTC8 ANKS3 IQCB1 BBS1 IFT140 XPNPEP3 CEP290 DYNLT2B BBIP1 ZMYND10 KATNIP CNGB1 DNAAF6 POMGNT1 KIZ RPGRIP1 EFHC1 ARL2BP RP1 ODAD1 DNAH11 RSPH4A MAK DNAH6 NEK2 CENPF DDX59 TRIM32 DNAL1 TTLL5 DNAI1 USP9X DNAAF11 ATXN10 NEK1 POC1B AK7 PLK4 NME7 DCDC2 TBC1D32 CEP78 CCNO DNAAF1 CFAP418 HYDIN RAB28 PKD1L1 CFAP298 CCDC28B RSPH1 CFAP410 POC1A DNAAF5 DNAAF2 TUB CFAP52 DNAAF19 DNAAF3 ODAD2 TAPT1 FAM161A PKHD1 DNAI2 CFAP53 GALNT11 PCARE NME9 RP1L1 TOPORS ODAD3 HYLS1 CNGA1 ODAD4 MCIDAS DNAAF4 CCNQ CCDC39 SPAG1 RSPH3 RSPH9 DNAJB13 ZIC2 NPHP3 INVS OFD1 CC2D2A EVC PIBF1 KIAA0586 RP2 ZNF423 RPGRIP1L CSPP1 CEP41 SUFU B9D1 UNC119 CEP164 CILK1 RAB23 ARL6 CEP104 WDR35 TCTN3 B9D2 MKKS TTBK2 NPHP4 DYNC2LI1 ARL3 WDPCP NPHP1 INPP5E TMEM138 SCLT1 TMEM237 WDR19 TMEM67 C2CD3 TCTN2 CEP120 ARL13B EVC2 CEP83 CEP19 TMEM107 BBS10 BBS12 TMEM17 TMEM216 DYNC2H1 CPLANE1 KIAA0753 TCTN1 TMEM231 SDCCAG8 TULP1 PDE6D ADCY6 PIK3R4 PKD1 NEK9 OCRL AHI1 IFT80 GLI2 IFT27 IFT52 CLUAP1 GLI3 IFT57 PKD2 IFT81 TTC21B SMO IFT172 CCDC65 GAS8 FLCN DRC1 TRAF3IP1 ALMS1 GPR161 KIF7 KE1912 Motile Cilia Number/Length, Decreased DYNLL1 DYNC2I2 DYNC2I1 DYNLT1 DYNLT2B IFT43 TTC8 BBS5 BBS9 LZTFL1 MKS1 BBS7 IFT122 BBS1 BBS2 BBS4 CEP97 FUZ IFT140 KIF3A DYNC2LI1 DYNC2H1 ARL6 KIF3B TTC23 KATNB1 PIBF1 CEP43 RABL2A RABL2B CEP20 SCLT1 EVC2 CIBAR1 TTBK2 CEP120 SASS6 BBS12 TMEM17 ARL13B EVC CEP162 CILK1 KIFAP3 IQCE RPGRIP1L CDK20 CBY1 C2CD3 TCTN3 B9D1 TEDC1 ARL3 WDPCP CEP83 TUBD1 TUBE1 TMEM216 RAB23 CEP192 INPP5E WDR35 CC2D2A WDR19 TRAPPC11 CPLANE1 TULP3 CPLANE2 TMEM231 TCTN1 BBS10 TXNDC15 TCTN2 CEP76 TEDC2 ARMC9 CEP44 MKKS TMEM107 EFCAB7 OFD1 CEP19 FBF1 CEP295 TMEM67 CEP104 KIAA0753 MIB1 IFT74 IFT27 IFT52 IFT56 IFT57 IFT81 IFT172 IFT70B TRAF3IP1 TTC21B CLUAP1 IFT25 IFT46 IFT80 IFT88 IFT20 SPATA7 CRX GLIS2 LCA5 CCDC40 NEK8 INTU ANKS6 ANKS3 IQCB1 XPNPEP3 CEP290 BBIP1 ZMYND10 KATNIP CNGB1 DNAAF6 POMGNT1 KIZ RPGRIP1 EFHC1 ARL2BP RP1 ODAD1 DNAH11 RSPH4A MAK DNAH6 NEK2 CENPF DDX59 TRIM32 DNAL1 TTLL5 DNAI1 USP9X DNAAF11 ATXN10 NEK1 POC1B AK7 PLK4 NME7 DCDC2 TBC1D32 CEP78 CCNO DNAAF1 CFAP418 HYDIN RAB28 PKD1L1 CFAP298 CCDC28B RSPH1 CFAP410 POC1A DNAAF5 DNAAF2 TUB CFAP52 DNAAF19 DNAAF3 ODAD2 TAPT1 FAM161A PKHD1 DNAI2 CFAP53 GALNT11 PCARE NME9 RP1L1 TOPORS ODAD3 HYLS1 CNGA1 ODAD4 MCIDAS DNAAF4 CCNQ CCDC39 SPAG1 RSPH3 RSPH9 DNAJB13 ZIC2 NPHP3 INVS KIAA0586 RP2 ZNF423 CSPP1 CEP41 SUFU UNC119 CEP164 B9D2 NPHP4 NPHP1 TMEM138 TMEM237 SDCCAG8 TULP1 PDE6D ADCY6 PIK3R4 PKD1 NEK9 OCRL AHI1 GLI2 GLI3 PKD2 SMO CCDC65 GAS8 FLCN DRC1 ALMS1 GPR161 KIF7 KE1917 Altered gene expression, NRF2 dependent antioxidant pathway AIMP2 KEAP1 SLC7A11 CEBPB MAF NQO1 EPHB2 GCLC GCLM NFE2L2 PIK3CA PRKCA MAPK8 GSTA2 HMOX1 KE1922 Increased, Reactive metabolites production SULT2B1 HS3ST2 CYP39A1 GLYAT GLYATL2 GLYATL1 CYP7B1 CYP8B1 CYP26A1 GSTT2B GSTZ1 CYP3A43 AKR1B1 CYP2C18 AKR1A1 CYP2S1 NAT1 CYP4F2 CYP4F12 CYP4F8 SULT1C2 AKR7A2 CHST3 CHST14 CYP4B1 CYP51A1 SULT2A1 AKR1D1 BAAT CYP19A1 CYP17A1 AKR1C2 CYP3A7 CYP11B1 AKR1C1 AKR1C3 SULT1A1 AKR1C4 GPX5 UGT1A1 MGST1 NDST1 CYP1B1 NAT2 UGT1A6 CHST11 CHST1 CHST6 UGT1A7 SULT1E1 UGT2B7 GAL3ST4 UGT2A2 EPHX1 CYP2W1 TPMT HNMT CYP26C1 HS3ST1 CYP20A1 HS3ST3B1 FMO5 CYP2J2 CHST12 HS6ST1 NDST4 CYP4V2 CHST7 HS2ST1 HS3ST3A1 CYP2U1 NDST3 NDST2 HS6ST2 CYP4F11 CYP4F22 CHST13 HS6ST3 CYP4Z1 CYP4X1 CYP27C1 CYP2F1 CYP2A13 CYP2A7 FMO1 KCNAB2 FMO4 NAT14 FMO2 NAT9 NAA40 CHST10 NAA50 CHST8 SULT4A1 UGT2A3 UGT2B28 NAT10 CHST5 SULT6B1 GSTCD NAA30 CHST4 NAT8 HS3ST6 AKR7A3 NNMT KCNAB1 KCNAB3 NAA20 SULT1B1 UGT2A1 CHST2 GAL3ST3 HS3ST4 SULT1C3 UGT2B15 SULT1A2 GSTK1 GPX1P1 UGT2B17 AKR1B10 SULT1C4 SLX1A-SULT1A3 SULT1A4 UGT2B11 NAA80 HS3ST5 UGT1A5 UGT1A3 CHST9 CYP24A1 GSTP1 COMT GSTT2 CYP2D6 GSS GSR CYP27B1 EPHX2 CYP2E1 GSTM1 CYP27A1 CYP2C9 CYP2C8 CYP11A1 CYP1A1 CYP1A2 CYP3A4 CYP2C19 GPX4 GSTM4 GPX2 CYP11B2 GSTA5 NAT8L CYP2R1 GPX3 GSTM2 INMT GSTA1 CYP21A2 CYP26B1 CYP46A1 GSTO2 GSTO1 CYP7A1 CYP2B6 GSTA2 FMO3 CYP3A5 CYP2A6 UGT1A10 UGT1A9 UGT1A4 MGST2 GAL3ST1 GSTM5 GSTM3 MGST3 GAL3ST2 UGT2B4 GSTA4 GSTA3 CYP4F3 KE1923 Altered gene expression, P53 dependent apoptosis pathway CX3CL1 RRM2B MLH1 TRAF4 TIGAR XRCC5 SESN1 ULK2 AURKA ICAM1 MSH2 BBC3 SERPINE1 PRKAG2 NANOG PRKAB1 ULBP1 PERP CCNG1 TP53I3 PRKAG3 NCF2 GADD45A SLC2A1 TP53AIP1 APAF1 TNFRSF10B POLK CDK2 LIF IRF5 SAT1 SESN2 ULBP2 PRKAB2 PRKAA1 PCNA DDB2 ERCC5 GLS2 DRAM1 PML PMAIP1 NOTCH1 SLC7A11 XPC DEPTOR FANCC CDC25C BTG2 ALDH4A1 PRKAA2 TP53INP1 E2F7 DDIT4 CPT1C ADORA2B MGMT POLH SMR3B PTEN ZMAT3 TNFRSF10D SFN RPRM PIDD1 FUCA1 ADGRB1 PRKAG1 SIVA1 AKT1S1 SERPINB5 MIR34C MIR200C MIR34B IRF9 ACAD11 MIR145 SCO2 MIR34A CDC25A FAS BAX TSC2 CCNE1 CCL2 FASLG CDKN1A THBS1 RPTOR MLST8 ULK1 ISG15 MTOR TNF GPX1 KE1933 Increased, Interleukin-6 production ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 KE1944 Synaptic dysfunction SLC6A4 CACNA1A SLC18A3 SYT1 RIMS1 NAPA CPLX1 UNC13B SYN1 DNM1L STX1B DNM1 SNAP25 STXBP1 STX1A SLC38A1 PARK7 CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 AP2B1 CLTCL1 SLC25A4 VAMP2 RAB3A CLTA CLTC SLC18A2 ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE1945 Dysfunctional Autophagy PRKAG2 PRKAB1 PRKAG3 PRKAB2 PRKAA1 DEPTOR PRKAA2 PRKAG1 AKT1S1 RB1CC1 PIK3C3 AMBRA1 BECN1 ATG14 RPTOR MLST8 ULK1 PIK3R4 MTOR ATG9A ATG5 ATG16L1 ATG101 MAP1LC3B ATG3 ATG12 WIPI2 ATG13 ATG7 UVRAG KE1977 Disruption of sodium channel gating kinetics WEE1 SCN4A MAPK8IP2 NEDD4L PTPRN SCN1B PDCD10 SCN2A SCN7A RNF121 SCN1A SCN2B SCN3A SCNM1 NFASC SCN3B PRRT2 SCN11A SCN9A SCN4B SCN5A SCN10A SCN8A RACK1 JAK2 NEDD4 FGF14 FGF12 FGF13 CAMK2A PSEN1 GSK3B AKT1 BACE1 CALM1 TNF FYN KE1995 Abnormal lipid metabolism CYP4A11 CYP8B1 CYP26A1 CYP4B1 ABCD2 MIR33B MIR33A ABCA1 RARA RARB RARG CYP1A2 CYP2C9 CYP2E1 CYP3A4 CYP24A1 CYP27B1 PPARA PPARD PPARG VDR NR1I2 NR1H3 ABCC2 CYP2B6 CYP7A1 ABCB1 ABCG5 ABCC3 ABCG1 ABCB11 NR1I3 NR1H4 ABCB4 ABCD3 HILPDA PRKAG2 PRKAB1 PRKAG3 ACLY PRKAB2 PDHA1 PRKAA1 PRKAA2 FASN PRKAG1 PLIN1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA ACSS2 ABHD5 PRKAR2A ACSBG1 BCKDHA KE2005 Altered neurotransmission in development SLC6A4 CACNA1A SLC18A3 SYT1 RIMS1 NAPA CPLX1 UNC13B SYN1 DNM1L STX1B DNM1 SNAP25 STXBP1 STX1A SLC38A1 PARK7 CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 AP2B1 CLTCL1 SLC25A4 VAMP2 RAB3A CLTA CLTC SLC18A2 ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE2009 Activation of inflammation pathway IL12B IL15 IL10 PDGFA TGFB1 CSF1 CSF2 IFNG IL1A IL1B IL2 IL4 IL5 IL6 IL13 TNF CSF3 CXCL1 CXCL2 HLA-DRA HLA-DRB1 IFNB1 IL7 IL11 CD4 IL3 IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IL2RA IL2RB IL2RG IL4R IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG KE2010 Pulmonary inflammation IGHA2 IGHA1 COL1A1 COL1A2 COL3A1 FN1 IFNG IL2 IL2RA IL2RB IL2RG IL4 IL4R IL5 IL5RA LAMA5 LAMB1 LAMB2 LAMC1 LAMC2 LCK THBS1 THBS3 TNFRSF1A TNFRSF1B VTN ZAP70 CD28 CD80 CD86 CD40 CD40LG KE2012 Fibroblast proliferation and differentiation IL12B SKIL GREM1 SFTPC TERC CYSLTR2 TERT ATP11A SFTPA1 PTX3 HGF EDN1 PDGFB MMP9 BMP7 TIMP1 TGFB1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 CEBPB PDGFA SMAD7 CCR2 ELMOD2 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 CXCL2 HMOX1 CSF3 EGF KE2013 Airway remodeling IL12B SKIL GREM1 SFTPC TERC CYSLTR2 TERT ATP11A SFTPA1 PTX3 HGF EDN1 PDGFB MMP9 BMP7 TIMP1 TGFB1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 CEBPB PDGFA SMAD7 CCR2 ELMOD2 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B IL6 FGF2 FGF7 CSF2 IL13 CXCL8 CCL11 TNF CCL5 CCL4 CCL3 CXCL2 HMOX1 CSF3 EGF KE2017 Endoplasmic reticulum stress MBTPS2 XBP1 BBC3 ATF6 TNFRSF10B MBTPS1 PMAIP1 BID NFE2L2 IL1B ATF4 EIF2S1 TP53 BCL2L11 BCL2 EIF2AK3 DDIT3 ERN1 HSPA5 PPP1R15A RTCB TXNIP CASP2 KE2029 protein-coupled estrogen receptor 1 (GPER) activation ESR1 BRAF GPER1 MAPK1 MAP2K1 CHUK CREB1 MAPK14 ELK1 AKT1 FOS GNAS IKBKB JUN NFKB1 PIK3CA PRKACA MAPK9 BCL2 SP1 IKBKG GNB1 GNGT1 KE2031 Releasing, Apoptosis-Inducing Factor (AIF) HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 PRF1 KE2036 Activation of metabotropic glutamate receptor GRM3 GRM5 GABBR1 GRM2 GRM4 GRM7 GRM8 GPRC5B GPRC5D GPRC5C CASR GPRC5A GABBR2 GRM1 GRM6 KE2039 Inhibition GABAA receptor GABBR2 GABBR1 ALDH9A1 SLC32A1 AP2A2 AP2B1 ABAT GAD2 GAD1 GABRA3 GABRA1 GABRP GABRE GABRA4 GABRG2 GABRB2 GABRA2 GABRG1 GABRB1 GABRB3 GABRG3 GABRA5 GABRD GABRQ GABRA6 AP2S1 SLC6A11 AP2M1 GPHN AP2A1 SLC6A1 KE2086 Airway inflammation ITGA4 ITGAL ITGB2 VCAM1 SELPLG ICAM1 C6 C7 IL1A IL6 CXCL8 TNF ITGB1 SELP KNG1 C3 C5 IL12B SKIL GREM1 SFTPC TERC CYSLTR2 TERT ATP11A SFTPA1 PTX3 HGF EDN1 PDGFB MMP9 BMP7 TIMP1 TGFB1 CALCA FGF1 CCN2 SPP1 PLAU TGFA MECP2 CEBPB PDGFA SMAD7 CCR2 ELMOD2 CCR3 SFTPA2 SERPINA1 ELN DSP STN1 MUC5B MT2A FAM13A PARN DPP9 RTEL1 IGF1 MMP2 CMA1 CCL2 IL4 IL5 NFE2L2 IL1B FGF2 FGF7 CSF2 IL13 CCL11 CCL5 CCL4 CCL3 CXCL2 HMOX1 CSF3 EGF KE2093 Brain thyroid hormone (T4/T3) decreased ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 PFKFB2 PAX8 AQP7 SLC16A10 TTF2 TTF1 TSHB NPPB BAD KDM1A RPS6KA6 FGFR1 FGF21 RHEB RPS6KB1 NPY THRA RAF1 CASP9 MDM2 TBC1D4 ITGAV NOTCH1 WNT4 SHH CTNNB1 AKT1S1 DIO2 ITGB3 PRKG2 MAP4K5 NPR1 MGLL MC4R PLIN1 ADRB3 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 RPS6 PRDM16 TPO SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 ZNF516 KLB KDM3B KE2094 Abnormal, neuroblast migration ILK RHOD MYL12B RAF1 PDPK1 NCK1 WNT4 RYK EPHB1 MET RRAS TRPC1 NRP1 SLIT2 CDC42 CXCL12 SHH NGEF ROBO1 CFL1 SLIT1 SLIT3 RGMA EPHA2 EFNA1 PARD6A PLXNA1 MAPK1 HRAS FZD3 GSK3B PRKCA WNT5A PRKCZ RAC1 ROCK1 BMPR1B BMPR2 SRC ABL1 CDK5 FYN PARD3 NTN3 NTN4 SEMA6C LRRC4C GDF7 SEMA5B SEMA7A BOC LRIG2 PTCH1 CXCR4 ROBO2 DPYSL2 FES GNAI1 ITGB1 RASA1 DCC SEMA3A ARHGEF12 SRGAP2 ENAH ROBO3 NTNG2 ABLIM3 L1CAM EFNB1 UNC5D DPYSL5 KE2097 Increase, Pro-Inflammatory Mediators IL17F IL12B IL17C IL17B IL19 TSLP IL15 IL25 IL17D CNTF CCL23 CTF1 CCL28 LTA CCL24 PF4V1 CCL25 XCL1 XCL2 IFNK IL20 IL24 PPBP IFNW1 CXCL17 IL27 IL31 CX3CL1 MMP9 CCL22 CCL17 TGFB1 CXCL12 IL17A SPP1 LIF EPO IL10 CXCL9 IL18 CXCL10 CXCL11 IFNA1 TNFSF13B IFNL1 IFNL2 IFNL3 EBI3 CXCL14 CCL19 CCL7 CCL2 CCL8 CCL1 IL2 IL23A IFNG VEGFA IL4 IL5 IL1A IL1B IL37 IL6 IL36G IL1RN IL36A IL36RN IL36B IL1F10 CXCL13 CSF2 IL13 CXCL8 CCL11 CCL13 CSF1 IFNA2 TNF CCL5 CCL16 CCL4 CCL18 CCL15 CCL4L2 CCL3L3 CCL14 CCL3 NFKB1 CCL26 CXCL2 IL11 IL7 CSF3 AREG CCL20 IFNA6 IFNA8 CXCL6 IL22 IL33 CCL21 IFNA21 IL21 IL9 IFNA5 IFNA16 CXCL16 CXCL3 CXCL5 PF4 CXCL1 IL12A IFNB1 IFNA10 CCL27 IFNA7 IFNA14 IFNA13 IFNA17 IFNA4 OSM IL26 MMP3 TNFSF13 IL3 MMP1 KE2098 Increase, Abnormal Neural Remodeling HTRA2 ITGAM ITGAX ITGB2 AXL XIAP COLEC11 PATJ COLEC10 ATP8B3 CX3CR1 FCN1 FCN2 ATP11A CRB1 SCRIB C5AR2 CRB2 ATP11C LLGL2 MARK3 MBL2 ATP8B1 PLSCR1 SUSD4 PLSCR3 PLSCR4 ATP10A PALS1 CSMD1 C4BPA C4BPB TYRO3 C8B COLEC12 PARD6G FCN3 DEDD CD59 DLGAP5 CAP1 MARK2 APAF1 ITGAV ITGB3 MFGE8 PRKCI ATP8B2 CX3CL1 TGFB1 TGFB2 CASP3 CASP8 CASP9 C1QB MASP2 CR1 CR2 CD55 CD46 PROS1 MASP1 DIABLO C1QC C2 C3AR1 C4B C5AR1 C6 C7 C8G C9 MARK1 PARD6A C4A CASP10 MERTK GAS6 IFNG FAS FASLG MBP CYCS PRKCZ BAK1 BAX BID TGFB3 VTN CLU CFH CFI CFP CFB C1QA C1R C1S C8A CASP7 CFD PARD3 SERPING1 C3 C5 PARD6B KE2107 Hypomyelination CNTF PLP1 MOG SOX6 PDGFB BMP4 LIF SOX9 ASCL1 SHH MAG OMG SOX10 OLIG2 OLIG1 SOX8 NKX2-6 NKX2-2 CNP MYT1 MBP TNF IL1B IGF1 FGF2 BMP2 CXCL1 CXCL2 SOX5 GLI2 KE2110 Disrupted binding, laminin-beta1-integrin receptors with laminin CAPN9 CAPN11 CAPN10 CSK DOCK1 CAPN7 ILK ITGA6 ITGA2B ITGA4 ITGA5 ITGA7 ITGA9 ITGAE ITGAL ITGAM ITGAX ITGB2 ITGB7 ITGB8 RAC3 TNS1 CAPN5 VASP VAV2 ZYX CAPN3 CAPNS1 CAPN6 ITGA10 ITGA8 MYLK2 CAV2 CAV3 BCAR1 GIT2 MYPN MIR34C PAK4 VAV3 SORBS1 CRK RAPGEF1 ITGAV ARAF ITGB3 PAK1 PAK2 PAK3 PDPK1 SHC3 MAPK4 MAPK6 MAP2K5 PAK6 PXN RAC2 RAF1 SHC1 BRAF VCL CDC42 AKT3 AKT1 AKT2 GRB2 HRAS PIK3R2 MAPK1 MAPK7 MAPK10 MAP2K1 MAP2K2 MAP2K3 MAP2K6 PTK2 RAC1 ROCK1 MAPK12 SOS1 SRC CAV1 ROCK2 FYN ITGA1 ITGA2 ITGA3 ITGAD ITGB1 TLN1 CAPN1 CAPN2 ITGA11 ITGB4 ITGB5 ITGB6 RAP1A RAP1B RHO SELENOP ARHGEF7 KE2111 Decreased, neural progenitor cell adhesion to laminin CAPN9 CAPN11 CAPN10 CSK DOCK1 CAPN7 ILK ITGA6 ITGA2B ITGA4 ITGA5 ITGA7 ITGA9 ITGAE ITGAL ITGAM ITGAX ITGB2 ITGB7 ITGB8 RAC3 TNS1 CAPN5 VASP VAV2 ZYX CAPN3 CAPNS1 CAPN6 ITGA10 ITGA8 MYLK2 CAV2 CAV3 BCAR1 GIT2 MYPN MIR34C PAK4 VAV3 SORBS1 CRK RAPGEF1 ITGAV ARAF ITGB3 PAK1 PAK2 PAK3 PDPK1 SHC3 MAPK4 MAPK6 MAP2K5 PAK6 PXN RAC2 RAF1 SHC1 BRAF VCL CDC42 AKT3 AKT1 AKT2 GRB2 HRAS PIK3R2 MAPK1 MAPK7 MAPK10 MAP2K1 MAP2K2 MAP2K3 MAP2K6 PTK2 RAC1 ROCK1 MAPK12 SOS1 SRC CAV1 ROCK2 FYN ITGA1 ITGA2 ITGA3 ITGAD ITGB1 TLN1 CAPN1 CAPN2 ITGA11 ITGB4 ITGB5 ITGB6 RAP1A RAP1B RHO SELENOP ARHGEF7 KE2115 Altered, cholesterol metabolism CYP51A1 FDFT1 FDPS HMGCR HMGCS1 IDI1 LSS MVD SQLE DHCR7 PMVK MVK NSDHL MSMO1 SC5D CYP39A1 CYP8B1 HSD3B7 SULT2B1 CYP7B1 CH25H GPR183 UGT3A1 IL17D IL17F IL25 IL17C IL17B AKR1C4 AKR1D1 BAAT SLC27A2 INSIG1 ESR1 HSD11B1 ACOT2 NR1H2 HSD11B2 SULT2A1 IL17A CYP27A1 CYP3A4 NR1I2 EPHX2 LBP SLC27A5 CYP7A1 ESR2 CYP46A1 ACOX2 AMACR DBP SCP2 RORC ACOT7 ACOT8 EBP ACOT6 ACOT1 THEM5 ACOT4 ACOT11 ACOT12 ACOT13 ACOT9 KE2116 Decreased, oligodendrocyte differentiation CNTF PLP1 MOG SOX6 PDGFB BMP4 LIF SOX9 ASCL1 SHH MAG OMG SOX10 OLIG2 OLIG1 SOX8 NKX2-6 NKX2-2 CNP MYT1 MBP TNF IL1B IGF1 FGF2 BMP2 CXCL1 CXCL2 SOX5 GLI2 EGR2 ID4 ZBTB33 CHD8 NFATC2 ID2 TCF7L2 SOX2 PTPRZ1 NFIA CSPG4 HES5 NKX6-1 TMEM98 CNTN1 PTN LGI1 MYRF DUSP15 CHD7 ZNF24 OPALIN ZNF488 PDGFRA WNT10A PRKCA SMAD1 ZEB2 RELN BMP1 SOX11 KE2119 Increase, Insulin resistance SGK2 FLOT1 CAP1 SORBS1 SH2B2 MAP3K2 EHD1 KIF3A MAP4K5 MAP4K1 ARHGAP33 CRK EGR1 EIF4EBP1 FLOT2 RHOQ CBLC SGK3 STXBP4 SHC2 RPS6KA6 GRB10 GRB14 RAPGEF1 GSK3A GYG1 GYS1 GYS2 EHD2 INPP4A INPPL1 INSR IRS1 ARF1 KIF5B MAP3K4 MAP3K9 MAP3K10 MAP3K11 MYO1C MINK1 ENPP1 PDPK1 PFKL PFKM PIK3C3 SHC3 PPP1R3A PRKAA1 PRKAA2 PRKCI MAPK4 MAPK6 MAP2K5 PTEN RHOJ PTPN1 TRIB3 PTPN11 PTPRF RAB4A MAP4K2 RAC2 RAF1 REG1A RHEB RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 RPS6KB2 RRAD SGK1 SHC1 SLC2A1 SNAP25 SOS2 STX4 STXBP1 STXBP2 STXBP3 XBP1 MAP3K12 MAP4K3 IRS2 CBLB SNAP23 RPS6KA4 MAP3K6 MAP3K13 CYTH3 MAP4K4 TBC1D4 PIK3CA MAP3K8 MAPK14 EIF4E ELK1 AKT1 AKT2 FOXO1 FOXO3 FOS MTOR GAB1 GRB2 GSK3B PIK3R4 HRAS IGF1R IKBKB JUN ARF6 LIPE MAP3K1 MAP3K3 MAP3K5 PIK3C2A PIK3C2G PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PRKCA PRKCB PRKCD PRKCH PRKCQ PRKCZ MAPK1 MAPK3 MAPK7 MAPK8 MAPK11 MAPK9 MAPK10 MAPK13 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP2K7 RAC1 MAPK12 MAP2K4 SLC2A4 SOS1 SRF VAMP2 MAP3K7 TSC1 TSC2 IRS4 PIK3R3 SOCS1 CBL MAP3K14 SOCS3 RPS6KA5 KE2151 Disruption, neurotransmitter release SLC6A4 CACNA1A SLC18A3 SYT1 RIMS1 NAPA CPLX1 UNC13B SYN1 DNM1L STX1B DNM1 SNAP25 STXBP1 STX1A SLC38A1 PARK7 CACNA1B NSF SLC1A3 SLC17A6 SLC32A1 SYP SLC17A7 UNC13A AP2A2 AP2B1 CLTCL1 SLC25A4 VAMP2 RAB3A CLTA CLTC SLC18A2 ATP1A2 SLC18A1 STX2 UNC13C CPLX2 SLC22A3 SYN2 STX3 SLC17A8 CLN8 SYN3 CPLX3 AP2S1 DNM2 AP2M1 AP2A1 DNM3 KE2188 Activation, caspases BIRC3 TNFRSF21 HELLS XIAP LTA CASP4 TNFRSF25 CRADD HRK MIR29A BBC3 APAF1 BIRC5 IRF1 IRF3 IRF5 MDM2 PMAIP1 BAD CASP3 CASP8 CASP9 TNFRSF10B MIR29B1 MIR29B2 IRF4 DFFA DFFB IGF2 NFKBIE DIABLO CASP6 BCL2L2 BOK CASP10 BCL2L11 CDKN2A CHUK AKT1 IGF1 IGF1R FAS IKBKB FASLG IRF6 IRF7 JUN MCL1 MAP3K1 MYC NFKB1 NFKBIA NFKBIB PIK3R1 CYCS MAPK10 BAK1 BAX BCL2 RELA BCL2L1 BID MAP2K4 BNIP3L TNF TNFRSF1A TNFRSF1B TP53 TRAF2 IKBKG TP63 TNFSF10 CFLAR IRF2 TRAF3 CASP7 TRADD RIPK1 FADD GZMB BIRC2 PRF1 TRAF1 CASP1 CASP2 TP73 SCAF11 KE2195 Increase, CNS Neural cell death HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 KE2202 Altered expression of cell cycle genes MCM2 MCM6 MCM5 MCM4 MCM3 SKP2 WEE1 MCM7 ATR CHEK1 CDKN2C CDKN2D CDC16 CDK7 CCNH CDKN2B BUB1 CHEK2 E2F2 TGFB2 GADD45B TGFB1 CDK6 E2F3 CCND3 GADD45A CCND2 CDK2 GADD45G PCNA CDK4 MDM2 CDC25C CDC25A SMAD3 SMAD2 SFN SMC1A MAD2L2 ZBTB17 E2F5 YWHAQ CDC20 RBL2 CCNE2 YWHAB MAD1L1 CDC27 DBF4 ANAPC4 SMC1B CDC14A RBL1 CDC14B ORC1 ANAPC5 ORC6 CDC45 CDC6 CDC23 CDC7 CDC25B STAG2 FZR1 SMC3 TTK TFDP2 ORC2 ORC4 STAG1 PKMYT1 ANAPC13 ORC3 ESPL1 ANAPC11 CCNB3 BUB3 ANAPC10 PTTG1 RAD21 ORC5 ANAPC2 ANAPC7 TFDP1 E2F4 WEE2 PTTG2 YWHAE YWHAG YWHAH YWHAZ GSK3B EP300 E2F1 CCNE1 CCND1 CDKN1B HDAC1 TGFB3 CDKN1A CDKN1C MYC RB1 TP53 SMAD4 CCNA2 CDKN2A ATM ANAPC1 HDAC2 CUL1 ABL1 RBX1 SKP1 CCNA1 CCNB1 CCNB2 CDK1 PLK1 PRKDC KE2208 Aberrant, synaptic formation and plasticity FMR1 NLGN1 ARC DLG1 RPH3A NLGN2 NLGN3 NLGN4X RYR2 STX1A DLG2 NRXN3 NRXN1 NRXN2 YWHAG CAMK2B CAMK2A GRIN2D CAMK2D CAMK2G GRIN2C GRIN1 GRIN2A GRIN2B MAPK1 MAPK3 TJP1 GRM1 HOMER1 DLGAP1 SYNGAP1 SHANK1 CYFIP1 CAMKK2 RPS6KA1 CCND2 NGF BDNF DIO2 CAMKK1 HNRNPL SYT2 NCAM1 PRL SYT12 HGNC:1464 HGNC:9393 RPS6KA5 PPARGC1A MAPK14 CAMK4 PRKCA BCL2 DRD1 CALM1 CREB1 KE2216 Binding of antagonist to thyroid hormone receptor ACTL6B SIRT6 SLCO1C1 THRB AGRP MAFA SLC16A2 PFKFB2 PAX8 AQP7 SLC16A10 TTF2 TTF1 TSHB NPPB BAD KDM1A RPS6KA6 FGFR1 FGF21 RHEB RPS6KB1 NPY THRA RAF1 CASP9 MDM2 TBC1D4 ITGAV NOTCH1 WNT4 SHH CTNNB1 AKT1S1 DIO2 ITGB3 PRKG2 MAP4K5 NPR1 MGLL MC4R PLIN1 ADRB3 GSK3B TSC2 CREB3 UCP1 PPARGC1A POMC SOS1 ATF2 AKT3 PIK3CA ITPR2 PPARG TP53 RPTOR FOXO1 TSC1 FRS2 MLST8 HRAS GRB2 RXRA SRC MTOR ADCY3 ADCY8 MAPK1 MAP2K1 PRKACA MAPK14 PNPLA2 RPS6 PRDM16 TPO SLC5A5 DUOX2 TSHR TRH DIO3 DIO1 TG IYD SLC26A4 NHSL1 SECISBP2L DUOXA2 ZNF516 KLB KDM3B KE2217 Binding of antagonist to glucocorticoid hormone receptor SPRY1 STOM BIRC3 MGAM ANKRD1 MFGE8 GADD45B POU5F1 ETNK2 TGFBR3 TNFAIP3 ZIC2 BHLHE40 DNER PTGES3 ALOX5AP NR3C1 AMIGO2 LRRC8A SLC19A2 THBD TNS4 FGFBP1 CDKN1C HSP90AA1 JUN NFKB2 PDE4B PTGS2 RXRA CCL2 B3GNT5 NR1I2 IL11 CCL20 SNAI2 CUL1 AKAP13 BIRC2 ANGPTL4 NR1I3 CDC42EP3 PLK2 ABHD2 FGD4 SPINK13 TSC22D3 SLC26A2 EDN2 ARL5B ADGRF4 DNAJC15 GPR153 KTN1 SERPINB9 PMP2 EPB41L4B SRGN ACKR3 RGS2 S100P SCNN1A SEC14L1 PRRG4 CPEB4 PPP1R14C CAVIN2 ENC1 NAV3 SERTAD2 KE2218 Binding of (ant)agonist to liver X receptor FASN SCD SREBF1 CYP3A4 RXRA NR1H3 CYP2B6 CYP7A1 ABCG5 ABCG8 KE2220 Antagonism, Glucocorticoid hormone receptor SPRY1 STOM BIRC3 MGAM ANKRD1 MFGE8 GADD45B POU5F1 ETNK2 TGFBR3 TNFAIP3 ZIC2 BHLHE40 DNER PTGES3 ALOX5AP NR3C1 AMIGO2 LRRC8A SLC19A2 THBD TNS4 FGFBP1 CDKN1C HSP90AA1 JUN NFKB2 PDE4B PTGS2 RXRA CCL2 B3GNT5 NR1I2 IL11 CCL20 SNAI2 CUL1 AKAP13 BIRC2 ANGPTL4 NR1I3 CDC42EP3 PLK2 ABHD2 FGD4 SPINK13 TSC22D3 SLC26A2 EDN2 ARL5B ADGRF4 DNAJC15 GPR153 KTN1 SERPINB9 PMP2 EPB41L4B SRGN ACKR3 RGS2 S100P SCNN1A SEC14L1 PRRG4 CPEB4 PPP1R14C CAVIN2 ENC1 NAV3 SERTAD2 KE2221 Altered Liver X receptor activity FASN SCD SREBF1 CYP3A4 RXRA NR1H3 CYP2B6 CYP7A1 ABCG5 ABCG8 KE2223 Reduced number of oligodendrocytes EGR2 ID4 ZBTB33 SOX6 CHD8 NFATC2 ID2 BMP4 SOX9 ASCL1 TCF7L2 SHH SOX2 SOX10 MAG PTPRZ1 NFIA CSPG4 OLIG1 HES5 OLIG2 SOX8 NKX6-1 TMEM98 CNTN1 PTN LGI1 MYRF NKX2-2 DUSP15 CHD7 ZNF24 NKX2-6 MYT1 OPALIN ZNF488 PDGFRA WNT10A FGF2 PRKCA SMAD1 MBP SOX5 ZEB2 RELN GLI2 BMP1 SOX11 KE2224 Dysregulation of transcriptional expression within PPAR signaling network ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 KE2225 Disrupted Lipid Storage HILPDA PRKAG2 PRKAB1 PRKAG3 ACLY PRKAB2 PDHA1 PRKAA1 PRKAA2 FASN PRKAG1 PLIN1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA ACSS2 ABHD5 PRKAR2A ACSBG1 BCKDHA OSBPL5 NPC2 FABP3 LDLRAP1 ACSL6 SLC27A4 ACSL5 LPA APOA4 DBI SOAT1 SLC27A2 ACSL1 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 KE2226 Stressor binding PPAR isoforms ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 KE2227 Disrupted PPAR isoform nuclear signaling ACAA1 ME1 EHHADH UBC ACOX1 ILK CYP8B1 CYP4A11 OLR1 AQP7 SORBS1 SCD FABP3 SLC27A1 PDPK1 ACSL1 DBI FABP1 SLC27A4 CPT1C FABP4 PCK2 PLIN1 UCP1 APOC3 PPARD APOA1 PPARG FADS2 CD36 CYP27A1 RXRG APOA2 LPL ADIPOQ RXRA PPARA GK RXRB NR1H3 SLC27A5 HMGCS2 CPT2 CYP7A1 PLTP APOA5 SCP2 PCK1 ANGPTL4 MMP1 KE2232 Antagonism, Retinoic acid receptors RARA RARB RARG RXRA RXRB RXRG ADH1A ADH4 ALDH1A1 SULT2B1 CYP26A1 RBP4 SULT1A1 CRABP1 CRABP2 RDH10 LRAT RDH12 AWAT2 SDR16C5 BCO1 RPE65 RDH8 RBP1 RDH5 RBP7 RETSAT RBP2 BCO2 DHRS3 CYP2E1 NPC1L1 LPL MAPK1 DGAT1 CD36 SCARB1 CYP26B1 ABCG5 ABCG8 RLBP1 ALDH1A2 ALDH1A3 KE2233 Decreased, ERαβ heterodimers ACOX1 ESR1 STAT3 CYP1B1 GPAM CYP1A1 CYP1A2 JUN SP1 PPARA NR0B2 PCK1 PDK4 KE2265 Oligodendrocyte death, increased HTRA2 BIRC3 AIFM1 BIRC7 TNFRSF10A BAG3 CASP10 XIAP NAIP BLK PTRH2 TNFRSF10C MT-RNR2 BIK CRADD ENSG00000115760 ENSG00000164761 ENSG00000171552 HRK TNFRSF25 TNFRSF6B CASP4 PEA15 BIRC5 BBC3 TNFRSF10B PMAIP1 TNFRSF10D APAF1 BAD BCL2A1 CASP3 CASP8 CASP9 PIDD1 MIR29B1 MIR29B2 MADD DIABLO CASP6 DFFA DFFB ENDOG BCL2L10 BCL2L2 BOK AIFM2 TNFSF10 BCL2L11 CYCS BAK1 BAX BCL2 BCL2L1 BID BMF BNIP3 CDKN2A CFLAR FAS FASLG FOS IKBKB IL1R1 IRAK1 JUN MAP3K14 MAP3K5 MAPK3 MAPK8 MCL1 MYD88 NFKB1 NFKBIA TNFRSF1A TNFRSF1B TOLLIP TRAF6 TP53 CAPNS1 CASP7 DAXX FADD IL1R2 TRADD TRAF3 RIPK1 BIRC2 CASP2 PRKD1 CASP1 SEPTIN4 HSPA1A PTPN13 KE2299 Altered, Redox Homeostasis NOX5 MT1X NFIX NOX1 NOX3 CYBB SOD3 TXN2 MGST1 UGT1A6 NFE2L2 MAPK14 CYP1A1 NQO1 FOS GCLC GPX1 GPX3 GSR GSTT2 JUNB MAOA NFKB1 NOX4 MAPK10 SOD1 SP1 XDH CAT HMOX1 SOD2 TXNRD2 TXNRD1 KE2300 Disruption, Glucolipid metabolism HILPDA PRKAG2 PRKAB1 PRKAG3 ACLY PRKAB2 PDHA1 PRKAA1 PRKAA2 FASN PRKAG1 PLIN1 PRKAR2B PRKACA LIPE AKT2 PRKAR1A AKT3 AKT1 PRKACB PRKACG PNPLA2 PRKAR1B ACACA ACSS2 ABHD5 PRKAR2A ACSBG1 BCKDHA ENO2 ENO3 FBP1 ALDOA ALDOB GPI HK3 LDHB LDHC PGK2 PKLR SLC2A2 PGAM1 HK1 LDHA MDH1 PFKL PFKM PGK1 PKM SLC2A1 SLC2A3 GCK PGAM2 MPC1 DLD GOT1 GOT2 PC SLC2A4 GAPDH ENO1 ALDOC HK2 MDH2 TPI1 DLAT G6PC1 PCK1 PFKP MPC2 SLC2A5 FBP2 LDHAL6B KE2336 Increase, SREBF1 NFYA CYP51A1 MBTPS2 MDH1 IDI1 SREBF1 SEC31B SAR1A FDFT1 SCD MED15 YY1 SEC23A SEC23B SQLE FGF21 GSK3A PRKAG2 KPNB1 PRKAB1 HMGCS1 HMGCR SEC24A SCAP PRKAG3 ATF6 INSIG2 NR1H2 ACLY PRKAB2 PRKAA1 CDK8 LPIN1 RBP4 SEC31A SEC24B MBTPS1 SEC24D SAR1B ACSS1 DBI PPARGC1B SEC13 LSS FDPS PRKAA2 MVD FASN RNF139 SEC24C PRKAG1 INSIG1 SREBF2 MIR33A MIR33B PRKACA SCARB1 SIRT1 CREB1 GPAM PIK3CA LDLR PPARG AKT1 AMFR CAMP LPL SP1 MTOR ACACA INS KE2405 Increase, Hepatocellular lipotoxicity OSBPL5 NPC2 FABP3 LDLRAP1 ACSL6 SLC27A4 ACSL5 LPA APOA4 DBI SOAT1 SLC27A2 ACSL1 SLC27A1 SORT1 FABP2 APOC1 FABP4 FABP1 LRP1 SOAT2 ACSL3 ABCA1 MYLIP SLC27A3 PCSK9 APOE VDAC1 LDLR LIPA STAR APOB APOC2 STARD3 SCARB1 KE2408 Increase, Adipose lipolysis NCOA2 CEBPA EGR2 GH1 ID3 LEP MIF RORA NRIP1 NCOR1 CELF1 PLIN2 KLF6 CYP26A1 FRZB BSCL2 GDF10 GTF3A NDN CISD1 RETN BMP3 SPOCK1 NR2F1 PNPLA3 KLF7 NCOR2 CNTFR LPIN3 LPIN2 CEBPB CTNNB1 GADD45A DVL1 EPAS1 FOXC2 LPIN1 IL6ST IRS1 LIF SMAD3 MEF2A MEF2B MEF2C MEF2D GADD45B SERPINE1 TRIB3 RARA SCD BMP4 SREBF1 STAT3 STAT6 KLF5 TGFB1 TWIST1 WNT1 WNT5B FZD1 MIXL1 NCOA1 IRS2 DLK1 CEBPD EBF1 GATA4 KLF15 NR3C1 MBNL1 PCK2 PLIN1 PRLR RBL2 E2F4 RBL1 CDKN1A AGPAT2 PPARGC1A CREB1 AGT E2F1 AHR FOXO1 GATA3 HIF1A IGF1 FAS IL6 INS LIPE LPL ASIP PPARA PPARD PPARG PTGIS RB1 RXRA RXRG SFRP4 BMP2 SLC2A4 SP1 STAT1 STAT2 TNF UCP1 WNT10B IRS4 SOCS1 SOCS3 ADIPOQ NR1H3 NAMPT ZMPSTE24 DDIT3 HMGA1 LMNA CYP26B1 CFD WWTR1 GATA2 LIFR OSM PCK1 BMP1 STAT5A STAT5B HNF1A KE2410 Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity SPRY1 STOM BIRC3 MGAM ANKRD1 MFGE8 GADD45B POU5F1 ETNK2 TGFBR3 TNFAIP3 ZIC2 BHLHE40 DNER PTGES3 ALOX5AP NR3C1 AMIGO2 LRRC8A SLC19A2 THBD TNS4 FGFBP1 CDKN1C HSP90AA1 JUN NFKB2 PDE4B PTGS2 RXRA CCL2 B3GNT5 NR1I2 IL11 CCL20 SNAI2 CUL1 AKAP13 BIRC2 ANGPTL4 NR1I3 CDC42EP3 PLK2 ABHD2 FGD4 SPINK13 TSC22D3 SLC26A2 EDN2 ARL5B ADGRF4 DNAJC15 GPR153 KTN1 SERPINB9 PMP2 EPB41L4B SRGN ACKR3 RGS2 S100P SCNN1A SEC14L1 PRRG4 CPEB4 PPP1R14C CAVIN2 ENC1 NAV3 SERTAD2 KE2412 Increase, Hepatic intracellular active glucocorticoids CBR1 CYP11B1 AKR1C4 SRD5A1 HSD11B1 SRD5A2 AKR1C3 AKR1D1 AKR1C2 HSD11B2 AKR1C1 CYP3A4 CYP21A2 CYP11B2