KE1790_Increased_Differentiation_to_Testis_WP4842	Mammalian disorder of sexual development	FGFR2	AMH	SOX9	SRD5A1	WNT4	CTNNB1	PBX1	GATA4	SOX8	NR5A1	FST	RBFOX2	AMHR2	DMRT1	CBX2	FOXL2	SRY	PTGDS	MAPK11	FGF9	RSPO1	EMX2	WT1	INSL3	DHH
KE177_Increase_Mitochondrial_dysfunction_WP5241	Mitochondrial beta-oxidation	ACADSB	EHHADH	ACSL3	ACAA2	ECHS1	ACADL	ECI1	DECR1	HSD17B10
KE177_Increase_Mitochondrial_dysfunction_WP4324	Mitochondrial complex I assembly model OXPHOS system	NDUFB10	ECSIT	NDUFAB1	NDUFA1	NDUFS4	NDUFB5	NDUFB3	NDUFC1	NDUFA2	NDUFS5	NDUFS2	NDUFS6	NDUFB1	NDUFS3	NDUFB6	NDUFA3	NDUFB4	NDUFB8	NDUFB2	NDUFA7	NDUFC2	NDUFA10	MT-ND1	MT-ND2	MT-ND4L	MT-ND4	MT-ND5	MT-ND6	NDUFB7	NDUFV2	NDUFS1	NDUFV1	NDUFA8	NDUFV3	NDUFA6	NDUFA5	NDUFAF6	NDUFAF7	TMEM126B	NDUFAF2	NUBPL	TMEM186	FOXRED1	DMAC1	NDUFAF3	TMEM70	COA1	ACAD9	TIMMDC1	DMAC2	NDUFB11	NDUFAF4	NDUFA13	NDUFA12	NDUFAF1	NDUFB9
KE177_Increase_Mitochondrial_dysfunction_WP78	TCA cycle (aka Krebs or citric acid cycle)	IDH2	SDHB	SDHC	SDHD	ACO2	SUCLG1	SUCLA2	IDH3B	IDH3G	DLD	MDH2	CS	DLST	FH	IDH3A	OGDH	SDHA	SUCLG2
KE1825_Increase_Cell_death_WP1772	Apoptosis modulation and signaling	HTRA2	BIRC3	AIFM1	BIRC7	TNFRSF10A	BAG3	CASP10	XIAP	NAIP	BLK	PTRH2	TNFRSF10C	MT-RNR2	BIK	CRADD	ENSG00000115760	ENSG00000164761	ENSG00000171552	HRK	TNFRSF25	TNFRSF6B	CASP4	PEA15	BIRC5	BBC3	TNFRSF10B	PMAIP1	TNFRSF10D	APAF1	BAD	BCL2A1	CASP3	CASP8	CASP9	PIDD1	MIR29B1	MIR29B2	MADD	DIABLO	CASP6	DFFA	DFFB	ENDOG	BCL2L10	BCL2L2	BOK	AIFM2	TNFSF10	BCL2L11	CYCS	BAK1	BAX	BCL2	BCL2L1	BID	BMF	BNIP3	CDKN2A	CFLAR	FAS	FASLG	FOS	IKBKB	IL1R1	IRAK1	JUN	MAP3K14	MAP3K5	MAPK3	MAPK8	MCL1	MYD88	NFKB1	NFKBIA	TNFRSF1A	TNFRSF1B	TOLLIP	TRAF6	TP53	CAPNS1	CASP7	DAXX	FADD	IL1R2	TRADD	TRAF3	RIPK1	BIRC2	CASP2	PRKD1	CASP1	SEPTIN4	HSPA1A	PTPN13
KE89_Synthesis_De_Novo_Fatty_Acid_FA_WP357	Fatty acid biosynthesis	ACACB	ECH1	ECHDC2	ECHDC1	ECHDC3	ACSL1	ACSL3	ACSL4	FASN	ACSL6	ACLY	ACSL5	SCD	ACAA2	MECR	ECHS1	HADH	ACACA	PC	ACSS2	DECR1	PECR
KE115_Increase_FA_Influx_WP5061	Fatty acid transporters	ACSBG2	FABP7	FABP5	FABP6	FABP9	HGNC:10995	HGNC:10996	HGNC:10997	HGNC:10999	HGNC:11000	HGNC:3555	ACSL4	FABP3	ACSL3	FABP2	ACSL1	DBI	FABP1	ACSL6	SLC27A4	FABP4	ACSL5	CD36	ACSBG1
KE471_Inhibition_FoxA2_WP5066	FOXA2 pathway	ABCC4	FOXA2	FOXA1	PPARGC1B	IRS1	FASN	IRS2	SREBF1	FOXO1	GSTM2	GSTA1	INS	APOB	ACACA	ABCC2	SLC27A5	ABCC3	SLCO1B1	MTTP	GSTA2	MLXIPL
KE474_Down_Regulation_HMGCS2_WP4718	Cholesterol metabolism with Bloch and Kandutsch-Russell pathways	CH25H	ELOVL4	GGPS1	CYP51A1	MYLIP	SOAT1	IDI1	ACSL4	SREBF1	FDFT1	SCD	SQLE	HMGCS1	HMGCR	ACOT2	ELOVL3	ACSL3	NR1H2	ACSL1	LSS	FDPS	ABCA1	MVD	SOAT2	FASN	SREBF2	ELOVL5	FADS2	CYP27A1	FADS1	DHCR7	ELOVL2	NR1H3	CYP46A1	HMGCS2	ABCG1	MSMO1	SC5D	MVK	DHCR24	ACAT2	HSD17B7	LBR	EBP	NSDHL	TM7SF2	PMVK
KE860_Decreased_Mitochondrial_Fatty_Acid_Beta_Oxidation_WP368	Mitochondrial long chain fatty acid beta-oxidation	EHHADH	ACSL1	ACSL3	ACSL4	HADH	CPT1A	CPT2	ECI1	HADHA	ACADL	ACADM	ACADS	ACADVL	SLC25A20	SCP2	PECR	ACSF2
KE1825_Increase_Cell_death_WP2513	Nanoparticle triggered regulated necrosis	CASP8	RIPK3	TNFRSF1A	MAPK8	PLA2G4A	PARP1	TNF	TRADD	TICAM1	RIPK1	FADD	FTL
KE1096_Increased_blood_uric_acid_concentration_WP4595	Urea cycle and associated pathways	LDHB	ARG1	NOS3	ALDH4A1	NOS2	MDH1	GLS2	PYCR1	OTC	OAT	CPS1	NAGS	SLC25A15	GOT2	ASS1	ASL	GOT1	GPT	NOS1	MDH2	SLC25A12	GLUD1	FH	SLC25A13
KE1306_Increase_De_novo_lipogenesis_WP236	Adipogenesis	NCOA2	CEBPA	EGR2	GH1	ID3	LEP	MIF	RORA	NRIP1	NCOR1	CELF1	PLIN2	KLF6	CYP26A1	FRZB	BSCL2	GDF10	GTF3A	NDN	CISD1	RETN	BMP3	SPOCK1	NR2F1	PNPLA3	KLF7	NCOR2	CNTFR	LPIN3	LPIN2	CEBPB	CTNNB1	GADD45A	DVL1	EPAS1	FOXC2	LPIN1	IL6ST	IRS1	LIF	SMAD3	MEF2A	MEF2B	MEF2C	MEF2D	GADD45B	SERPINE1	TRIB3	RARA	SCD	BMP4	SREBF1	STAT3	STAT6	KLF5	TGFB1	TWIST1	WNT1	WNT5B	FZD1	MIXL1	NCOA1	IRS2	DLK1	CEBPD	EBF1	GATA4	KLF15	NR3C1	MBNL1	PCK2	PLIN1	PRLR	RBL2	E2F4	RBL1	CDKN1A	AGPAT2	PPARGC1A	CREB1	AGT	E2F1	AHR	FOXO1	GATA3	HIF1A	IGF1	FAS	IL6	INS	LIPE	LPL	ASIP	PPARA	PPARD	PPARG	PTGIS	RB1	RXRA	RXRG	SFRP4	BMP2	SLC2A4	SP1	STAT1	STAT2	TNF	UCP1	WNT10B	IRS4	SOCS1	SOCS3	ADIPOQ	NR1H3	NAMPT	ZMPSTE24	DDIT3	HMGA1	LMNA	CYP26B1	CFD	WWTR1	GATA2	LIFR	OSM	PCK1	BMP1	STAT5A	STAT5B	HNF1A
KE1195_modulation_Extracellular_Matrix_Composition_WP5382	TGFB / Smad signaling	SPARC	TGFB1	SERPINE1	CCN2	TGFBR1	TGFBR2	SMAD3	TGFBR3	SMAD2	YWHAG	SMAD4	POSTN	WWTR1
KE1395_Liver_Cancer_WP3646	Hepatitis C and hepatocellular carcinoma	BIRC3	CD44	VAV2	FRZB	UCHL1	MIR744	NOS2	E2F2	CTTN	BIRC5	TGFB1	TGFBR1	CASP9	LEF1	IL6R	CASP3	SMAD3	STAT3	PTPN11	MIR155	MIR34A	MIR24-2	MIR24-1	MYOF	MIR92A1	BRCA1	PTGS2	HIF1A	MAPK3	MAPK8	NFKB1	CCND1	MAPK14	VEGFA	SOS1	FASLG	CDKN1A	RAC1	IL6	MYC	TP53	SMAD4	AKT1	JAK1	CXCL8	BCL2L1	JUN	GRB2	CXCR1	CASP7	RRM2	PODXL	COL4A2	HNF1A	MMP1	MIR92A2
KE2410_Increase_11_Hydroxysteroid_dehydrogenase_type_1_activity_WP2880	Glucocorticoid receptor pathway	SPRY1	STOM	BIRC3	MGAM	ANKRD1	MFGE8	GADD45B	POU5F1	ETNK2	TGFBR3	TNFAIP3	ZIC2	BHLHE40	DNER	PTGES3	ALOX5AP	NR3C1	AMIGO2	LRRC8A	SLC19A2	THBD	TNS4	FGFBP1	CDKN1C	HSP90AA1	JUN	NFKB2	PDE4B	PTGS2	RXRA	CCL2	B3GNT5	NR1I2	IL11	CCL20	SNAI2	CUL1	AKAP13	BIRC2	ANGPTL4	NR1I3	CDC42EP3	PLK2	ABHD2	FGD4	SPINK13	TSC22D3	SLC26A2	EDN2	ARL5B	ADGRF4	DNAJC15	GPR153	KTN1	SERPINB9	PMP2	EPB41L4B	SRGN	ACKR3	RGS2	S100P	SCNN1A	SEC14L1	PRRG4	CPEB4	PPP1R14C	CAVIN2	ENC1	NAV3	SERTAD2
KE149_Increase_Inflammation_WP453	Inflammatory response pathway	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG
KE829_Damage_Lipid_bilayer_WP5584	Signaling lipids	CYP7B1	CYP8B1	CBR1	CYP4F2	PRXL2B	PLA2G1B	MT-CO1	PLA1A	PTGES	FADS2	ALOX5	LTA4H	CYP2C8	CYP2C9	HPGD	ALOX15	ALOX12	TBXAS1	EPHX2	PTGS2	GPX4	PTGDS	CYP27A1	LTC4S	PLCB1	CYP2B6	CYP7A1
KE839_Formation_Mallory_body_WP254	Apoptosis	BIRC3	TNFRSF21	HELLS	XIAP	LTA	CASP4	TNFRSF25	CRADD	HRK	MIR29A	BBC3	APAF1	BIRC5	IRF1	IRF3	IRF5	MDM2	PMAIP1	BAD	CASP3	CASP8	CASP9	TNFRSF10B	MIR29B1	MIR29B2	IRF4	DFFA	DFFB	IGF2	NFKBIE	DIABLO	CASP6	BCL2L2	BOK	CASP10	BCL2L11	CDKN2A	CHUK	AKT1	IGF1	IGF1R	FAS	IKBKB	FASLG	IRF6	IRF7	JUN	MCL1	MAP3K1	MYC	NFKB1	NFKBIA	NFKBIB	PIK3R1	CYCS	MAPK10	BAK1	BAX	BCL2	RELA	BCL2L1	BID	MAP2K4	BNIP3L	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF2	IKBKG	TP63	TNFSF10	CFLAR	IRF2	TRAF3	CASP7	TRADD	RIPK1	FADD	GZMB	BIRC2	PRF1	TRAF1	CASP1	CASP2	TP73	SCAF11
KE2405_Increase_Hepatocellular_lipotoxicity_WP5323	Fatty acid and lipoprotein transport in hepatocytes	OSBPL5	NPC2	FABP3	LDLRAP1	ACSL6	SLC27A4	ACSL5	LPA	APOA4	DBI	SOAT1	SLC27A2	ACSL1	SLC27A1	SORT1	FABP2	APOC1	FABP4	FABP1	LRP1	SOAT2	ACSL3	ABCA1	MYLIP	SLC27A3	PCSK9	APOE	VDAC1	LDLR	LIPA	STAR	APOB	APOC2	STARD3	SCARB1
KE2408_Increase_Adipose_lipolysis_WP236	Adipogenesis	NCOA2	CEBPA	EGR2	GH1	ID3	LEP	MIF	RORA	NRIP1	NCOR1	CELF1	PLIN2	KLF6	CYP26A1	FRZB	BSCL2	GDF10	GTF3A	NDN	CISD1	RETN	BMP3	SPOCK1	NR2F1	PNPLA3	KLF7	NCOR2	CNTFR	LPIN3	LPIN2	CEBPB	CTNNB1	GADD45A	DVL1	EPAS1	FOXC2	LPIN1	IL6ST	IRS1	LIF	SMAD3	MEF2A	MEF2B	MEF2C	MEF2D	GADD45B	SERPINE1	TRIB3	RARA	SCD	BMP4	SREBF1	STAT3	STAT6	KLF5	TGFB1	TWIST1	WNT1	WNT5B	FZD1	MIXL1	NCOA1	IRS2	DLK1	CEBPD	EBF1	GATA4	KLF15	NR3C1	MBNL1	PCK2	PLIN1	PRLR	RBL2	E2F4	RBL1	CDKN1A	AGPAT2	PPARGC1A	CREB1	AGT	E2F1	AHR	FOXO1	GATA3	HIF1A	IGF1	FAS	IL6	INS	LIPE	LPL	ASIP	PPARA	PPARD	PPARG	PTGIS	RB1	RXRA	RXRG	SFRP4	BMP2	SLC2A4	SP1	STAT1	STAT2	TNF	UCP1	WNT10B	IRS4	SOCS1	SOCS3	ADIPOQ	NR1H3	NAMPT	ZMPSTE24	DDIT3	HMGA1	LMNA	CYP26B1	CFD	WWTR1	GATA2	LIFR	OSM	PCK1	BMP1	STAT5A	STAT5B	HNF1A
KE2406_Increase_Regenerative_nodule_formation_WP3932	Focal adhesion: PI3K-Akt-mTOR-signaling	ITGAL	ITGA2B	PPP2R3A	PPP2R2C	ITGA8	PPP2R5C	ITGAE	ITGA6	RAB2A	PPP2R1A	ITGB8	ITGA4	RAB14	ITGA7	EIF4E2	PPP2R1B	ITGB7	ITGAX	ITGA10	ITGA9	PPP2R5E	PPP2R2B	ITGB2	ITGA5	SLC2A2	ITGAM	CSF1R	LAMA2	COL11A1	TBC1D1	PIK3IP1	CAB39L	PFKFB2	HIF3A	CAB39	PELO	PFKFB1	PFKFB3	RAB11B	STRADA	PFKFB4	CRTC2	BAD	NOS2	HGF	IBSP	SLC2A3	NGFR	FGFR2	SREBF1	FGFR1	ANGPT2	JAK2	PDGFB	GYS1	FGF21	MET	RHEB	FGF8	RPS6KB1	GYS2	FGF1	EPAS1	SLC2A1	SPP1	PGF	TEK	GNG13	KDR	FOXA1	EPO	RAF1	PRKAA1	CASP9	NGF	MDM2	ITGAV	COL2A1	PDPK1	IFNAR1	PDGFC	VEGFC	ANGPT1	KIT	IL6R	FGFR4	PRKAA2	NOS3	VEGFD	DDIT4	CHRM1	IRS1	PDGFD	INSR	PTEN	VEGFB	RPS6KB2	IRS2	EIF4EBP1	PDGFA	AKT1S1	ITGB3	FGF19	IL7R	PRL	LPAR1	COL11A2	PHLPP2	LAMC3	LPAR2	PPP2R5A	PPP2R5B	FGF22	PPP2R3C	HSP90AB1	EFNA2	TCL1A	ANGPT4	LAMA1	FGF14	COMP	VWF	PPP2R5D	GHR	THBS4	PRLR	FGF12	GNB4	TNR	CSF3R	TNN	FGF13	CHAD	CSH1	LPAR6	EPHA2	EFNA3	LPAR4	FGF17	FGF11	HSP90B1	EFNA1	LPAR3	PPP2R2D	EIF4E1B	CHRM2	F2R	EFNA5	LPAR5	IL3RA	LAMB3	COL4A6	TCL1B	EFNA4	FGF16	PIK3C2A	IGF1	PIK3CB	LAMC2	CREB3L3	FGFR3	IL4R	LIPE	HSP90AA1	PHLPP1	GSK3B	NOS1	LAMB1	MAPK1	IL2RB	HIF1A	MAPK3	TSC2	IKBKB	PPP2CB	AKT2	PIK3R2	PIK3CG	CREB3	COL1A1	VTN	IL2	PPARGC1A	CDKN1B	VEGFA	PPP2CA	FN1	SOS1	ATF2	AKT3	STK11	CREB1	FOXO3	PIK3CA	CDKN1A	MAP2K2	ATF4	LAMA5	PIK3C2B	IRS4	KRAS	IL2RA	PDGFRA	LAMC1	THBS1	FGF2	FGF7	IGF1R	PIK3R5	RPTOR	AKT1	CREB3L4	PIK3R1	CREB5	EGFR	IL2RG	FOXO1	EIF4E	CREB3L1	IFNAR2	JAK1	COL1A2	TSC1	MLST8	COL3A1	MAP2K1	THBS3	PTK2	PIK3CD	LAMB2	HRAS	ULK1	GRB2	SLC2A4	CREB3L2	CSF1	PIK3R4	MTOR	NRAS	ATF6B	INS	IKBKG	ACACA	ITGA3	FLT4	KITLG	LAMA3	EIF4B	ELAVL1	FLT1	CDC37	CSF3	PDGFRB	RPS6	EGF	ITGB1	ITGAD	ITGA2	IFNB1	COL4A1	RELN	IFNA7	TNC	FGF10	FGF4	GNB1	FGF20	COL5A3	COL4A4	ITGB5	RAB10	OSM	FGF9	JAK3	FGF6	GNB3	LAMA4	ITGB6	GNG11	GNGT1	COL5A1	ITGB4	COL4A2	ITGA11	COL6A2	OSMR	FGF18	GNG3	GNGT2	GNG8	RAB8A	GNG4	TNXB	GNB2	GNG12	GNG5	GNG7	THBS2	GNG2	FGF3	EPOR	COL5A2	GNG10
KE2412_Increase_Hepatic_intracellular_active_glucocorticoids_WP5280	Glucocorticoid biosynthesis	CBR1	CYP11B1	AKR1C4	SRD5A1	HSD11B1	SRD5A2	AKR1C3	AKR1D1	AKR1C2	HSD11B2	AKR1C1	CYP3A4	CYP21A2	CYP11B2
KE1815_Increase_Endoplasmic_reticulum_stress_WP4925	Unfolded protein response	MBTPS2	XBP1	BBC3	ATF6	TNFRSF10B	MBTPS1	PMAIP1	BID	NFE2L2	IL1B	ATF4	EIF2S1	TP53	BCL2L11	BCL2	EIF2AK3	DDIT3	ERN1	HSPA5	PPP1R15A	RTCB	TXNIP	CASP2
KE1306_Increase_De_novo_lipogenesis_WP3965	Lipid metabolism pathway	HILPDA	PRKAG2	PRKAB1	PRKAG3	ACLY	PRKAB2	PDHA1	PRKAA1	PRKAA2	FASN	PRKAG1	PLIN1	PRKAR2B	PRKACA	LIPE	AKT2	PRKAR1A	AKT3	AKT1	PRKACB	PRKACG	PNPLA2	PRKAR1B	ACACA	ACSS2	ABHD5	PRKAR2A	ACSBG1	BCKDHA
KE1395_Liver_Cancer_WP5434	Cancer pathways	APPL1	ARNT2	BCR	BIRC3	CEBPA	CSF1R	DCC	IL12B	IL12RB1	IL15	ITGA6	KEAP1	KLK3	LAMA2	MSH3	MSH6	RAC3	RALA	RALB	RALGDS	RUNX1	STAT4	ARHGEF11	BIRC7	CALML1	CALML2	CCDC42	CKS1B	GSTT1	GSTT2B	HEYL	HHIP	NCOA4	NKX3-1	PAX8	PLEKHG5	TERC	TFG	TPR	CSF2RA	DAPK1	DAPK2	DAPK3	F2RL3	IL12RB2	IL15RA	PTGER1	PTGER2	PTGER3	PTGER4	TERT	XIAP	APAF1	ARAF	ARNT	BAD	BBC3	BDKRB2	BIRC5	BMP4	BRAF	CASP3	CASP8	CASP9	CCDC6	CDK2	CDK4	CRK	CTBP1	CTBP2	CXCL12	CXCR4	DDB2	DLL1	DLL3	DLL4	DVL1	E2F2	EDN1	EDNRA	EDNRB	EGLN1	ELOB	EPAS1	EPO	ESR1	F2	FGF1	FGFR1	FGFR2	FGFR4	FLT3	FRAT1	FRAT2	FZD4	FZD5	FZD8	GADD45A	GADD45B	GADD45G	GNA13	GNAI1	GNB5	GNG13	HES1	HEY1	HGF	IFNA1	IFNAR1	IL6R	IL6ST	ITGAV	JAG1	JAG2	JAK2	JUP	KIT	LRP5	LRP6	MET	MLH1	MSH2	NCOA1	NOS2	NOTCH1	NOTCH2	NOTCH3	NOTCH4	NTRK1	PDGFA	PDGFB	PGF	PMAIP1	PML	POLK	PTEN	RAF1	RARA	RARB	RET	RPS6KB1	RPS6KB2	RUNX1T1	SHH	SLC2A1	SMAD2	SOS2	STAT3	STAT6	TCF7	TCF7L1	TCF7L2	TGFA	TGFB2	TGFBR1	TGFBR2	TRAF4	VEGFB	VEGFC	VEGFD	VHL	WNT7A	WNT9B	ZBTB16	RAC2	CTNNA1	EML4	HES5	IL7R	LPAR1	MECOM	MGST1	RAD51	RASSF1	RASSF5	SUFU	TPM3	ZBTB17	COL4A6	CSF2RB	CSF3R	F2R	FLT3LG	GNB4	HSP90AB1	HSP90B1	IGF2	IL13RA1	LAMA1	LAMB3	LAMB4	LAMC3	LPAR2	LPAR3	LPAR4	LPAR5	LPAR6	PLD2	RALBP1	RASGRP1	RASGRP2	RASGRP3	RASGRP4	SP1	ABL1	ADCY1	ADCY2	ADCY3	ADCY4	ADCY5	ADCY6	ADCY7	ADCY8	ADCY9	AGT	AGTR1	AKT1	AKT2	AKT3	APC	AXIN1	AXIN2	BAK1	BAX	BCL2	BCL2L1	BCL2L11	BID	BMP2	CALML3	CALML4	CALML5	CALML6	CAMK2A	CAMK2B	CAMK2D	CAMK2G	CBL	CCNA1	CCNA2	CCND1	CCND2	CCND3	CCNE1	CCNE2	CDH1	CDK6	CDKN1A	CDKN1B	CDKN2A	CDKN2B	CHUK	CREBBP	CTNNB1	CXCL8	CYCS	DVL2	DVL3	E2F1	E2F3	EGFR	ELK1	EP300	ERBB2	ETS1	FAS	FASLG	FGFR3	FN1	FOS	FOXO1	FZD1	FZD10	FZD2	FZD3	FZD6	FZD7	FZD9	GNAQ	GNAS	GRB2	GSK3B	GSTA1	GSTA5	GSTM1	GSTM2	GSTM4	GSTP1	GSTT2	HDAC1	HDAC2	HIF1A	HRAS	HSP90AA1	IFNA2	IFNAR2	IFNG	IFNGR1	IFNGR2	IGF1	IGF1R	IKBKB	IKBKG	IL13	IL2	IL23A	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	IL6	JAK1	JUN	KRAS	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LEF1	MAP2K1	MAP2K2	MAPK1	MAPK10	MAPK3	MAPK8	MAPK9	MDM2	MITF	MMP2	MTOR	MYC	NFE2L2	NFKB1	NFKB2	NFKBIA	NQO1	NRAS	PDGFRA	PIK3CA	PIK3CB	PIK3CD	PIK3R1	PIK3R2	PIK3R3	PLCB1	PLCB2	PLCB3	PLCB4	PLCG1	PLCG2	PLD1	PPARD	PPARG	PRKACA	PRKACB	PRKACG	PRKCA	PRKCB	PRKCG	PTGS2	PTK2	RAC1	RB1	RELA	RHOA	ROCK1	ROCK2	RPS6KA5	RXRA	RXRB	RXRG	SKP2	SMAD3	SMAD4	SOS1	SPI1	STAT1	STAT2	TGFB1	TGFB3	TP53	TRAF2	TRAF5	TRAF6	VEGFA	WNT1	WNT10A	WNT10B	WNT11	WNT16	WNT2	WNT2B	WNT3	WNT3A	WNT4	WNT5A	WNT5B	WNT6	WNT7B	APC2	AR	BRCA2	CASP7	COL4A1	CRKL	CUL1	CUL2	EGF	ELOC	ESR2	FADD	FLT4	GSTA2	GSTO1	GSTO2	HMOX1	IFNA10	IFNA13	IFNA14	IFNA16	IFNA17	IFNA21	IFNA4	IFNA5	IFNA6	IFNA7	IFNA8	IL12A	IL7	ITGA2	ITGA2B	ITGA3	ITGB1	KITLG	LAMA3	MAX	MST1	NCOA3	PDGFRB	PIM1	PIM2	RBX1	SKP1	TRAF3	GNG5	ALK	ARHGEF1	BDKRB1	BIRC2	COL4A2	COL4A3	COL4A4	COL4A5	EGLN2	EGLN3	EPOR	FH	GLI1	GLI2	GLI3	GNA11	GNA12	GNAI2	GNAI3	GNB1	GNB2	GNB3	GNG10	GNG11	GNG12	GNG2	GNG3	GNG4	GNG7	GNG8	GNGT1	GNGT2	HEY2	IL3	IL3RA	JAK3	KNG1	LAMA4	MMP1	MMP3	PTCH1	SMO	STAT5A	STAT5B	TRAF1	TXNRD1	TXNRD2	TXNRD3	WNT8A	WNT8B	WNT9A	ARHGEF12	CTNNA2	CTNNA3	GSTA3	GSTA4	GSTM3	GSTM5	KIF7	MGST2	MGST3	PTCH2
KE839_Formation_Mallory_body_WP183	Proteasome degradation	UBC	UBE2D2	PSMD11	UBA1	HLA-B	HLA-E	HLA-F	HLA-G	UCHL1	UBE2D3	HLA-A	NEDD4	UBB	UBE2D1	H2AC4	UCHL3	PSME3	HLA-H	PSMB8	PSMB9	PSMB10	PSMD5	PSMD10	PSME1	PSME2	RPN1	RPN2	UBA7	H2AX	H2AZ1	IFNG	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD2	PSMD3	PSMD4	PSMD7	PSMD8	PSMD9	PSMD12	PSMD13	PSMD6	UBE2B	HLA-C
KE134_Increase_Kupffer_cell_activation_WP530	Cytokines and inflammatory response	IL12B	IL15	IL10	PDGFA	TGFB1	CSF1	CSF2	IFNG	IL1A	IL1B	IL2	IL4	IL5	IL6	IL13	TNF	CSF3	CXCL1	CXCL2	HLA-DRA	HLA-DRB1	IFNB1	IL7	IL11	CD4	IL3
KE2119_Increase_Insulin_resistance_WP481	Insulin signaling	SGK2	FLOT1	CAP1	SORBS1	SH2B2	MAP3K2	EHD1	KIF3A	MAP4K5	MAP4K1	ARHGAP33	CRK	EGR1	EIF4EBP1	FLOT2	RHOQ	CBLC	SGK3	STXBP4	SHC2	RPS6KA6	GRB10	GRB14	RAPGEF1	GSK3A	GYG1	GYS1	GYS2	EHD2	INPP4A	INPPL1	INSR	IRS1	ARF1	KIF5B	MAP3K4	MAP3K9	MAP3K10	MAP3K11	MYO1C	MINK1	ENPP1	PDPK1	PFKL	PFKM	PIK3C3	SHC3	PPP1R3A	PRKAA1	PRKAA2	PRKCI	MAPK4	MAPK6	MAP2K5	PTEN	RHOJ	PTPN1	TRIB3	PTPN11	PTPRF	RAB4A	MAP4K2	RAC2	RAF1	REG1A	RHEB	RPS6KA1	RPS6KA2	RPS6KA3	RPS6KB1	RPS6KB2	RRAD	SGK1	SHC1	SLC2A1	SNAP25	SOS2	STX4	STXBP1	STXBP2	STXBP3	XBP1	MAP3K12	MAP4K3	IRS2	CBLB	SNAP23	RPS6KA4	MAP3K6	MAP3K13	CYTH3	MAP4K4	TBC1D4	PIK3CA	MAP3K8	MAPK14	EIF4E	ELK1	AKT1	AKT2	FOXO1	FOXO3	FOS	MTOR	GAB1	GRB2	GSK3B	PIK3R4	HRAS	IGF1R	IKBKB	JUN	ARF6	LIPE	MAP3K1	MAP3K3	MAP3K5	PIK3C2A	PIK3C2G	PIK3CB	PIK3CD	PIK3CG	PIK3R1	PIK3R2	PRKCA	PRKCB	PRKCD	PRKCH	PRKCQ	PRKCZ	MAPK1	MAPK3	MAPK7	MAPK8	MAPK11	MAPK9	MAPK10	MAPK13	MAP2K1	MAP2K2	MAP2K3	MAP2K6	MAP2K7	RAC1	MAPK12	MAP2K4	SLC2A4	SOS1	SRF	VAMP2	MAP3K7	TSC1	TSC2	IRS4	PIK3R3	SOCS1	CBL	MAP3K14	SOCS3	RPS6KA5
KE465_Increased_Fatty_acid_influx_WP5061	Fatty acid transporters	ACSBG2	FABP7	FABP5	FABP6	FABP9	HGNC:10995	HGNC:10996	HGNC:10997	HGNC:10999	HGNC:11000	HGNC:3555	ACSL4	FABP3	ACSL3	FABP2	ACSL1	DBI	FABP1	ACSL6	SLC27A4	FABP4	ACSL5	CD36	ACSBG1
KE2406_Increase_Regenerative_nodule_formation_WP428	Wnt signaling	NFATC3	GPC4	TCF7	NLK	DAAM1	CHD8	NFATC4	NFATC2	PORCN	SFRP1	DKK4	PPP3CB	DKK1	INVS	SFRP5	NFATC1	LEF1	PPP3CA	PRICKLE1	NKD1	SFRP2	NKD2	DAAM2	CER1	TCF7L2	TCF7L1	DKK2	WIF1	CTBP1	VANGL2	PRICKLE2	SENP2	SOX17	SOST	CXXC4	VANGL1	CTBP2	CTNNBIP1	FRAT2	NOTUM	PPP3R2	CSNK2B	PPP3R1	FRAT1	FZD10	CSNK1E	CTNNB1	DVL1	DVL2	DVL3	APC	LRP6	LRP5	ROR1	ROR2	WNT16	PLAU	WNT4	RYK	WNT1	WNT2	WNT3	WNT6	WNT7A	WNT7B	WNT11	WNT2B	FZD5	FZD3	FOSL1	WNT5B	FZD1	FZD6	FZD8	FZD9	KREMEN1	CCND2	CCND3	WNT3A	MAPK9	CAMK2B	CSNK2A2	CAMK2A	CSNK2A1	PLCB4	SFRP4	MAPK8	CSNK1A1	PPP3CC	SERPINF1	ROCK2	MAP3K7	PLCB2	CAMK2D	CAMK2G	PLCB3	PRKCB	PLCB1	CSNK2A3	FZD2	GSK3B	JUN	RHOA	MYC	PRKCA	PRKCG	RAC1	CCND1	WNT5A	WNT10B	WNT10A	AXIN1	FZD7
KE828_Inhibition_Phospholipase_A_WP3965	Lipid metabolism pathway	HILPDA	PRKAG2	PRKAB1	PRKAG3	ACLY	PRKAB2	PDHA1	PRKAA1	PRKAA2	FASN	PRKAG1	PLIN1	PRKAR2B	PRKACA	LIPE	AKT2	PRKAR1A	AKT3	AKT1	PRKACB	PRKACG	PNPLA2	PRKAR1B	ACACA	ACSS2	ABHD5	PRKAR2A	ACSBG1	BCKDHA
KE1271_Activation_of_TGF_signaling_WP5382	TGFB / Smad signaling	SPARC	TGFB1	SERPINE1	CCN2	TGFBR1	TGFBR2	SMAD3	TGFBR3	SMAD2	YWHAG	SMAD4	POSTN	WWTR1
KE1493_Increased_Pro_inflammatory_mediators_WP453	Inflammatory response pathway	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG
KE831_Disturbance_Lysosomal_function_WP183	Proteasome degradation	UBC	UBE2D2	PSMD11	UBA1	HLA-B	HLA-E	HLA-F	HLA-G	UCHL1	UBE2D3	HLA-A	NEDD4	UBB	UBE2D1	H2AC4	UCHL3	PSME3	HLA-H	PSMB8	PSMB9	PSMB10	PSMD5	PSMD10	PSME1	PSME2	RPN1	RPN2	UBA7	H2AX	H2AZ1	IFNG	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD2	PSMD3	PSMD4	PSMD7	PSMD8	PSMD9	PSMD12	PSMD13	PSMD6	UBE2B	HLA-C
KE838_Induction_Microvesicular_fat_WP4149	White fat cell differentiation	RORA	EGR2	CEBPA	SREBF1	KLF5	IRF3	RARA	KLF4	TCF7L1	CEBPB	CTNNA1	MECOM	ZNF423	NR3C1	KLF2	IRF4	KLF15	EBF1	NR2F2	CEBPD	GATA3	CREB1	PPARG	FOXO1	WNT10B	INS	NR1H3	TLE3	DDIT3	STAT5A	STAT5B	GATA2
KE837_Occurrence_Cytoplasmic_vacuolization_kupffer_cell_WP3965	Lipid metabolism pathway	HILPDA	PRKAG2	PRKAB1	PRKAG3	ACLY	PRKAB2	PDHA1	PRKAA1	PRKAA2	FASN	PRKAG1	PLIN1	PRKAR2B	PRKACA	LIPE	AKT2	PRKAR1A	AKT3	AKT1	PRKACB	PRKACG	PNPLA2	PRKAR1B	ACACA	ACSS2	ABHD5	PRKAR2A	ACSBG1	BCKDHA
KE836_Occurrence_Cytoplasmic_vacuolization_Bile_duct_cell_WP3965	Lipid metabolism pathway	HILPDA	PRKAG2	PRKAB1	PRKAG3	ACLY	PRKAB2	PDHA1	PRKAA1	PRKAA2	FASN	PRKAG1	PLIN1	PRKAR2B	PRKACA	LIPE	AKT2	PRKAR1A	AKT3	AKT1	PRKACB	PRKACG	PNPLA2	PRKAR1B	ACACA	ACSS2	ABHD5	PRKAR2A	ACSBG1	BCKDHA
KE835_Occurrence_Ballooning_degeneration_hepatocyte_WP4925	Unfolded protein response	MBTPS2	XBP1	BBC3	ATF6	TNFRSF10B	MBTPS1	PMAIP1	BID	NFE2L2	IL1B	ATF4	EIF2S1	TP53	BCL2L11	BCL2	EIF2AK3	DDIT3	ERN1	HSPA5	PPP1R15A	RTCB	TXNIP	CASP2
KE831_Disturbance_Lysosomal_function_WP4923	Autophagy	PRKAG2	PRKAB1	PRKAG3	PRKAB2	PRKAA1	DEPTOR	PRKAA2	PRKAG1	AKT1S1	RB1CC1	PIK3C3	AMBRA1	BECN1	ATG14	RPTOR	MLST8	ULK1	PIK3R4	MTOR	ATG9A	ATG5	ATG16L1	ATG101	MAP1LC3B	ATG3	ATG12	WIPI2	ATG13	ATG7	UVRAG
KE833_Occurrence_Cytoplasmic_vacuolization_hepatocyte_WP3965	Lipid metabolism pathway	HILPDA	PRKAG2	PRKAB1	PRKAG3	ACLY	PRKAB2	PDHA1	PRKAA1	PRKAA2	FASN	PRKAG1	PLIN1	PRKAR2B	PRKACA	LIPE	AKT2	PRKAR1A	AKT3	AKT1	PRKACB	PRKACG	PNPLA2	PRKAR1B	ACACA	ACSS2	ABHD5	PRKAR2A	ACSBG1	BCKDHA
KE1262_Apoptosis_WP254	Apoptosis	BIRC3	TNFRSF21	HELLS	XIAP	LTA	CASP4	TNFRSF25	CRADD	HRK	MIR29A	BBC3	APAF1	BIRC5	IRF1	IRF3	IRF5	MDM2	PMAIP1	BAD	CASP3	CASP8	CASP9	TNFRSF10B	MIR29B1	MIR29B2	IRF4	DFFA	DFFB	IGF2	NFKBIE	DIABLO	CASP6	BCL2L2	BOK	CASP10	BCL2L11	CDKN2A	CHUK	AKT1	IGF1	IGF1R	FAS	IKBKB	FASLG	IRF6	IRF7	JUN	MCL1	MAP3K1	MYC	NFKB1	NFKBIA	NFKBIB	PIK3R1	CYCS	MAPK10	BAK1	BAX	BCL2	RELA	BCL2L1	BID	MAP2K4	BNIP3L	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF2	IKBKG	TP63	TNFSF10	CFLAR	IRF2	TRAF3	CASP7	TRADD	RIPK1	FADD	GZMB	BIRC2	PRF1	TRAF1	CASP1	CASP2	TP73	SCAF11
KE1967_Pyroptosis_WP453	Inflammatory response pathway	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG
KE2009_Activation_of_inflammation_pathway_WP453	Inflammatory response pathway	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG
KE870_Increase_Cell_Proliferation_WP179	Cell cycle	MCM2	MCM6	MCM5	MCM4	MCM3	SKP2	WEE1	MCM7	ATR	CHEK1	CDKN2C	CDKN2D	CDC16	CDK7	CCNH	CDKN2B	BUB1	CHEK2	E2F2	TGFB2	GADD45B	TGFB1	CDK6	E2F3	CCND3	GADD45A	CCND2	CDK2	GADD45G	PCNA	CDK4	MDM2	CDC25C	CDC25A	SMAD3	SMAD2	SFN	SMC1A	MAD2L2	ZBTB17	E2F5	YWHAQ	CDC20	RBL2	CCNE2	YWHAB	MAD1L1	CDC27	DBF4	ANAPC4	SMC1B	CDC14A	RBL1	CDC14B	ORC1	ANAPC5	ORC6	CDC45	CDC6	CDC23	CDC7	CDC25B	STAG2	FZR1	SMC3	TTK	TFDP2	ORC2	ORC4	STAG1	PKMYT1	ANAPC13	ORC3	ESPL1	ANAPC11	CCNB3	BUB3	ANAPC10	PTTG1	RAD21	ORC5	ANAPC2	ANAPC7	TFDP1	E2F4	WEE2	PTTG2	YWHAE	YWHAG	YWHAH	YWHAZ	GSK3B	EP300	E2F1	CCNE1	CCND1	CDKN1B	HDAC1	TGFB3	CDKN1A	CDKN1C	MYC	RB1	TP53	SMAD4	CCNA2	CDKN2A	ATM	ANAPC1	HDAC2	CUL1	ABL1	RBX1	SKP1	CCNA1	CCNB1	CCNB2	CDK1	PLK1	PRKDC
KE1493_Increased_Pro_inflammatory_mediators_WP530	Cytokines and inflammatory response	IL12B	IL15	IL10	PDGFA	TGFB1	CSF1	CSF2	IFNG	IL1A	IL1B	IL2	IL4	IL5	IL6	IL13	TNF	CSF3	CXCL1	CXCL2	HLA-DRA	HLA-DRB1	IFNB1	IL7	IL11	CD4	IL3
KE1492_Tissue_resident_cell_activation_WP560	TGF-beta receptor signaling	FKBP1A	SKIL	MIR302A	LEFTY1	CTNNB1	INHBA	LIF	SMAD2	SMAD3	SERPINE1	LEF1	BMP4	SPP1	STAT3	TGFB1	LEFTY2	TGFBR1	TGFBR2	TGFBR3	WNT1	FOXH1	ZNF423	SMAD7	RUNX3	FST	BAMBI	SKI	TGIF1	ZFYVE9	CREBBP	EP300	FOS	HRAS	IFNG	JAK1	JUN	SMAD1	SMAD4	SMAD6	NFKB1	MAPK3	MAPK9	STAT1	TFE3	THBS1	TNF	RUNX2	NOG	EGF	SMAD5	SMAD9	ZEB2	ENG	ITGB6	LTBP1
KE1494_Leukocyte_recruitment_activation_WP4542	Leukocyte-intrinsic Hippo pathway functions	ITGAL	TEAD4	TEAD3	MIR21	FOXP3	PRDM1	TEAD1	TEAD2	LATS1	YWHAQ	RASSF5	CD19	LATS2	MOB1A	SAV1	STK3	CCR7	STK38L	FOXO6	FYB1	RAB13	FERMT3	KNSTRN	YAP1	MAPK14	FOXO1	FOXO3	RHOA	LPL	RAC1	NDRG1	MST1	WWTR1	FOXO4	RAP1A
KE265_Activation_Stellate_cells_WP560	TGF-beta receptor signaling	FKBP1A	SKIL	MIR302A	LEFTY1	CTNNB1	INHBA	LIF	SMAD2	SMAD3	SERPINE1	LEF1	BMP4	SPP1	STAT3	TGFB1	LEFTY2	TGFBR1	TGFBR2	TGFBR3	WNT1	FOXH1	ZNF423	SMAD7	RUNX3	FST	BAMBI	SKI	TGIF1	ZFYVE9	CREBBP	EP300	FOS	HRAS	IFNG	JAK1	JUN	SMAD1	SMAD4	SMAD6	NFKB1	MAPK3	MAPK9	STAT1	TFE3	THBS1	TNF	RUNX2	NOG	EGF	SMAD5	SMAD9	ZEB2	ENG	ITGB6	LTBP1
KE68_Accumulation_Collagen_WP560	TGF-beta receptor signaling	FKBP1A	SKIL	MIR302A	LEFTY1	CTNNB1	INHBA	LIF	SMAD2	SMAD3	SERPINE1	LEF1	BMP4	SPP1	STAT3	TGFB1	LEFTY2	TGFBR1	TGFBR2	TGFBR3	WNT1	FOXH1	ZNF423	SMAD7	RUNX3	FST	BAMBI	SKI	TGIF1	ZFYVE9	CREBBP	EP300	FOS	HRAS	IFNG	JAK1	JUN	SMAD1	SMAD4	SMAD6	NFKB1	MAPK3	MAPK9	STAT1	TFE3	THBS1	TNF	RUNX2	NOG	EGF	SMAD5	SMAD9	ZEB2	ENG	ITGB6	LTBP1
KE898_Disruption_Lysosome_WP4923	Autophagy	PRKAG2	PRKAB1	PRKAG3	PRKAB2	PRKAA1	DEPTOR	PRKAA2	PRKAG1	AKT1S1	RB1CC1	PIK3C3	AMBRA1	BECN1	ATG14	RPTOR	MLST8	ULK1	PIK3R4	MTOR	ATG9A	ATG5	ATG16L1	ATG101	MAP1LC3B	ATG3	ATG12	WIPI2	ATG13	ATG7	UVRAG
KE898_Disruption_Lysosome_WP183	Proteasome degradation	UBC	UBE2D2	PSMD11	UBA1	HLA-B	HLA-E	HLA-F	HLA-G	UCHL1	UBE2D3	HLA-A	NEDD4	UBB	UBE2D1	H2AC4	UCHL3	PSME3	HLA-H	PSMB8	PSMB9	PSMB10	PSMD5	PSMD10	PSME1	PSME2	RPN1	RPN2	UBA7	H2AX	H2AZ1	IFNG	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD2	PSMD3	PSMD4	PSMD7	PSMD8	PSMD9	PSMD12	PSMD13	PSMD6	UBE2B	HLA-C
KE1539_Endocytotic_lysosomal_uptake_WP4655	Cytosolic DNA-sensing pathway	POLR3B	POLR3E	POLR3H	POLR3K	AIM2	POLR3D	POLR3G	POLR3GL	POLR3F	POLR3C	CASP8	MAVS	RIGI	IRF3	IL18	CGAS	CXCL10	STING1	IFNA1	ADAR	RIPK3	CASP10	CYLD	RNF125	TRIM25	ZBP1	POLR3A	TREX1	POLR2E	POLR2F	NFKBIA	IKBKB	NFKBIB	IL1B	IL6	POLR2K	NLRX1	POLR2H	POLR1C	RELA	POLR2L	TBK1	IRF7	POLR1D	ISG15	CHUK	IKBKG	CCL5	CCL4	CCL4L2	IFNA2	NFKB1	ATG5	TRADD	IL33	RIPK1	ATG12	FADD	IKBKE	IFNA4	IFNA5	IFNA6	IFNA7	IFNA8	IFNA10	IFNA13	IFNA14	IFNA16	IFNA17	IFNA21	IFNB1	PYCARD	CASP1
KE1501_Increased_extracellular_matrix_deposition_WP560	TGF-beta receptor signaling	FKBP1A	SKIL	MIR302A	LEFTY1	CTNNB1	INHBA	LIF	SMAD2	SMAD3	SERPINE1	LEF1	BMP4	SPP1	STAT3	TGFB1	LEFTY2	TGFBR1	TGFBR2	TGFBR3	WNT1	FOXH1	ZNF423	SMAD7	RUNX3	FST	BAMBI	SKI	TGIF1	ZFYVE9	CREBBP	EP300	FOS	HRAS	IFNG	JAK1	JUN	SMAD1	SMAD4	SMAD6	NFKB1	MAPK3	MAPK9	STAT1	TFE3	THBS1	TNF	RUNX2	NOG	EGF	SMAD5	SMAD9	ZEB2	ENG	ITGB6	LTBP1
KE1501_Increased_extracellular_matrix_deposition_WP428	Wnt signaling	NFATC3	GPC4	TCF7	NLK	DAAM1	CHD8	NFATC4	NFATC2	PORCN	SFRP1	DKK4	PPP3CB	DKK1	INVS	SFRP5	NFATC1	LEF1	PPP3CA	PRICKLE1	NKD1	SFRP2	NKD2	DAAM2	CER1	TCF7L2	TCF7L1	DKK2	WIF1	CTBP1	VANGL2	PRICKLE2	SENP2	SOX17	SOST	CXXC4	VANGL1	CTBP2	CTNNBIP1	FRAT2	NOTUM	PPP3R2	CSNK2B	PPP3R1	FRAT1	FZD10	CSNK1E	CTNNB1	DVL1	DVL2	DVL3	APC	LRP6	LRP5	ROR1	ROR2	WNT16	PLAU	WNT4	RYK	WNT1	WNT2	WNT3	WNT6	WNT7A	WNT7B	WNT11	WNT2B	FZD5	FZD3	FOSL1	WNT5B	FZD1	FZD6	FZD8	FZD9	KREMEN1	CCND2	CCND3	WNT3A	MAPK9	CAMK2B	CSNK2A2	CAMK2A	CSNK2A1	PLCB4	SFRP4	MAPK8	CSNK1A1	PPP3CC	SERPINF1	ROCK2	MAP3K7	PLCB2	CAMK2D	CAMK2G	PLCB3	PRKCB	PLCB1	CSNK2A3	FZD2	GSK3B	JUN	RHOA	MYC	PRKCA	PRKCG	RAC1	CCND1	WNT5A	WNT10B	WNT10A	AXIN1	FZD7
KE1743_Increase_plasma_Ang_II_WP4756	Renin-angiotensin-aldosterone system (RAAS)	ATF1	ATF2	ATF4	ATF6B	CALM1	CALM2	CALM3	CALML3	CALML4	CALML5	CALML6	CAMK1	CAMK1D	CAMK1G	CAMK2A	CAMK2B	CAMK2D	CAMK2G	CAMK4	CREB1	CREB3	CREB3L1	CREB3L2	CREB3L3	CREB3L4	CREB5	CYP11A1	CYP11B2	CYP21A2	GNAQ	HSD3B1	HSD3B2	ITPR1	ITPR2	ITPR3	PLCB2	STAR	CMA1	CTSG	ACE	AGT	AGTR1	AGTR2	REN
KE459_Increased_Liver_Steatosis_WP143	Fatty acid beta-oxidation	CHKB	ACSL1	ACSL3	ACSL4	ACSL6	ACSL5	DLD	ECHS1	GCDH	GK	GK2	HADH	ACAT1	LIPC	LIPE	LPL	PNPLA2	LIPF	CPT1A	CPT1B	CPT2	CRAT	ECI1	DECR1	GPD2	HADHA	HADHB	ACADL	ACADM	ACADS	ACADVL	ACSS2	TPI1	SLC25A20
KE1740_Induced_dysregulation_of_ACE2_WP554	ACE inhibitor pathway	ATP6AP2	NOS3	ACE2	BDKRB2	TGFB1	NR3C2	CMA1	CTSG	CYP11B2	ACE	AGT	AGTR1	AGTR2	REN	KNG1	BDKRB1	MAS1
KE1852_Increased_Ang_II_type_1_receptor_AT1R_WP5036	Angiotensin II receptor type 1 pathway	RACK1	TGFB1	TGFBR1	ACTA2	CCN2	RRAS	JUND	RAF1	IL6ST	TGFBR2	SMAD3	PDGFD	PTPN11	ACE2	MAPK1	HIF1A	COL1A1	MAP2K6	SMAD4	AGTR1	COL1A2	SP1	NOX4	AGT	IL11	IL11RA	F12	MAS1
KE459_Increased_Liver_Steatosis_WP5061	Fatty acid transporters	ACSBG2	FABP7	FABP5	FABP6	FABP9	HGNC:10995	HGNC:10996	HGNC:10997	HGNC:10999	HGNC:11000	HGNC:3555	ACSL4	FABP3	ACSL3	FABP2	ACSL1	DBI	FABP1	ACSL6	SLC27A4	FABP4	ACSL5	CD36	ACSBG1
KE459_Increased_Liver_Steatosis_WP3965	Lipid metabolism pathway	HILPDA	PRKAG2	PRKAB1	PRKAG3	ACLY	PRKAB2	PDHA1	PRKAA1	PRKAA2	FASN	PRKAG1	PLIN1	PRKAR2B	PRKACA	LIPE	AKT2	PRKAR1A	AKT3	AKT1	PRKACB	PRKACG	PNPLA2	PRKAR1B	ACACA	ACSS2	ABHD5	PRKAR2A	ACSBG1	BCKDHA
KE1489_N_A_Steatohepatisis_WP453	Inflammatory response pathway	IGHA2	IGHA1	COL1A1	COL1A2	COL3A1	FN1	IFNG	IL2	IL2RA	IL2RB	IL2RG	IL4	IL4R	IL5	IL5RA	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	THBS1	THBS3	TNFRSF1A	TNFRSF1B	VTN	ZAP70	CD28	CD80	CD86	CD40	CD40LG
KE2407_Increase_Cirrhosis_WP5382	TGFB / Smad signaling	SPARC	TGFB1	SERPINE1	CCN2	TGFBR1	TGFBR2	SMAD3	TGFBR3	SMAD2	YWHAG	SMAD4	POSTN	WWTR1
KE18_Activation_AhR_WP2873	Aryl hydrocarbon receptor pathway	IL12B	IL17B	SERPINB2	NCOA1	TGFB1	HES1	POLK	JUND	IGFBP1	UGT1A1	ARNT	MGST1	SLC7A5	ALDH3A1	AIP	PTGES3	CAP2	CYP1B1	MYOF	UGT1A6	CES3	UGT1A7	HSP90AA1	BAX	EP300	AHR	IL2	CDKN1B	IFNG	NFE2L2	IL1B	CYP1A1	CYP1A2	EGFR	JUNB	JUN	NQO1	SRC	TNF	AHRR	CDC37	IL12A	GSTA2	UGT1A9	UGT1A4
KE122_Increase_Glucocorticoid_receptor_activation_WP2880	Glucocorticoid receptor pathway	SPRY1	STOM	BIRC3	MGAM	ANKRD1	MFGE8	GADD45B	POU5F1	ETNK2	TGFBR3	TNFAIP3	ZIC2	BHLHE40	DNER	PTGES3	ALOX5AP	NR3C1	AMIGO2	LRRC8A	SLC19A2	THBD	TNS4	FGFBP1	CDKN1C	HSP90AA1	JUN	NFKB2	PDE4B	PTGS2	RXRA	CCL2	B3GNT5	NR1I2	IL11	CCL20	SNAI2	CUL1	AKAP13	BIRC2	ANGPTL4	NR1I3	CDC42EP3	PLK2	ABHD2	FGD4	SPINK13	TSC22D3	SLC26A2	EDN2	ARL5B	ADGRF4	DNAJC15	GPR153	KTN1	SERPINB9	PMP2	EPB41L4B	SRGN	ACKR3	RGS2	S100P	SCNN1A	SEC14L1	PRRG4	CPEB4	PPP1R14C	CAVIN2	ENC1	NAV3	SERTAD2
KE1271_Increase_Transforming_growth_factor_beta_signaling_WP560	TGF-beta receptor signaling	FKBP1A	SKIL	MIR302A	LEFTY1	CTNNB1	INHBA	LIF	SMAD2	SMAD3	SERPINE1	LEF1	BMP4	SPP1	STAT3	TGFB1	LEFTY2	TGFBR1	TGFBR2	TGFBR3	WNT1	FOXH1	ZNF423	SMAD7	RUNX3	FST	BAMBI	SKI	TGIF1	ZFYVE9	CREBBP	EP300	FOS	HRAS	IFNG	JAK1	JUN	SMAD1	SMAD4	SMAD6	NFKB1	MAPK3	MAPK9	STAT1	TFE3	THBS1	TNF	RUNX2	NOG	EGF	SMAD5	SMAD9	ZEB2	ENG	ITGB6	LTBP1
KE40_Mitochondrial_ATP_production_decreased_WP5239	Lac-Phe pathway	ABCC5	CNDP2
KE40_Mitochondrial_ATP_production_decreased_WP5241	Mitochondrial beta-oxidation	ACADSB	EHHADH	ACSL3	ACAA2	ECHS1	ACADL	ECI1	DECR1	HSD17B10
KE570_Accumulation_Damaged_mitochondrial_DNA_WP4946	DNA repair pathways, full network	ERCC8	MSH3	MSH6	TERF2	CHEK1	ATR	ERCC6	MNAT1	GTF2H1	GTF2H3	SMUG1	RFC3	CDK7	CCNH	FANCI	GTF2H2	RFC4	GTF2H4	RFC2	RFC5	WDR48	POLE2	LIG1	POLE3	NEIL2	POLE	MRE11	MLH1	XRCC5	MSH2	POLK	PCNA	DDB2	ERCC5	XPC	FANCC	CUL4B	ERCC3	MGMT	POLH	RAD52	RAD51	POLD3	APEX1	NBN	POLD2	RAD50	POLE4	RAD23B	POLM	RPA1	TDG	CETN2	DCLRE1C	USP1	POLL	POLD4	NHEJ1	XRCC6	RAD54B	BRCA1	RPA3	RPA2	DDB1	HMGB1	CUL4A	LIG3	PARP2	PARP1	ATM	H2AX	ERCC1	RFC1	POLD1	POLB	RBX1	ERCC2	PMS2	BRCA2	FANCD2	XRCC4	WRN	LIG4	FAN1	RAP1A	PRKDC	EXO1	REV3L	PNKP	NTHL1	XRCC1	UNG	PALB2	POLI	MPG	RAD51C	NEIL3	FANCE	OGG1	FANCL	MBD4	FAAP24	MUTYH	REV1	BRIP1	XPA	FEN1	APEX2	CENPX	CENPS	ERCC4	RAD23A	FANCB	FANCF	FAAP100	FANCA	FANCM	FANCG	GTF2H5
KE664_Overwhelmed_Mitochondrial_DNA_repair_mechanisms_WP4946	DNA repair pathways, full network	ERCC8	MSH3	MSH6	TERF2	CHEK1	ATR	ERCC6	MNAT1	GTF2H1	GTF2H3	SMUG1	RFC3	CDK7	CCNH	FANCI	GTF2H2	RFC4	GTF2H4	RFC2	RFC5	WDR48	POLE2	LIG1	POLE3	NEIL2	POLE	MRE11	MLH1	XRCC5	MSH2	POLK	PCNA	DDB2	ERCC5	XPC	FANCC	CUL4B	ERCC3	MGMT	POLH	RAD52	RAD51	POLD3	APEX1	NBN	POLD2	RAD50	POLE4	RAD23B	POLM	RPA1	TDG	CETN2	DCLRE1C	USP1	POLL	POLD4	NHEJ1	XRCC6	RAD54B	BRCA1	RPA3	RPA2	DDB1	HMGB1	CUL4A	LIG3	PARP2	PARP1	ATM	H2AX	ERCC1	RFC1	POLD1	POLB	RBX1	ERCC2	PMS2	BRCA2	FANCD2	XRCC4	WRN	LIG4	FAN1	RAP1A	PRKDC	EXO1	REV3L	PNKP	NTHL1	XRCC1	UNG	PALB2	POLI	MPG	RAD51C	NEIL3	FANCE	OGG1	FANCL	MBD4	FAAP24	MUTYH	REV1	BRIP1	XPA	FEN1	APEX2	CENPX	CENPS	ERCC4	RAD23A	FANCB	FANCF	FAAP100	FANCA	FANCM	FANCG	GTF2H5
KE1825_Increase_Cell_death_WP4923	Autophagy	PRKAG2	PRKAB1	PRKAG3	PRKAB2	PRKAA1	DEPTOR	PRKAA2	PRKAG1	AKT1S1	RB1CC1	PIK3C3	AMBRA1	BECN1	ATG14	RPTOR	MLST8	ULK1	PIK3R4	MTOR	ATG9A	ATG5	ATG16L1	ATG101	MAP1LC3B	ATG3	ATG12	WIPI2	ATG13	ATG7	UVRAG
KE40_Mitochondrial_ATP_production_decreased_WP5049	Glycolysis in senescence	PKM	PGK1	LDHA	PRKAA1	RB1	TP53	G6PD	GAPDH	ALDOC	ENO1
KE178_Mitochondrial_electron_transport_chain_disrupted_WP111	Electron transport chain: OXPHOS system in mitochondria	COX6C	COX7A1	NDUFA9	SDHB	SDHC	SDHD	SURF1	MT-CO2	NDUFB10	COX11	MT-CO1	UQCRFS1	COX17	COX4I1	COX5B	COX6A1	COX6B1	COX7A2	COX7B	COX7C	COX8A	COX15	MT-CO3	NDUFA4	COX5A	ATP5PD	ATP5MG	UQCR11	NDUFA11	COX6A2	UQCRQ	DMAC2L	UQCR10	NDUFS7	MT-ATP6	MT-ATP8	MT-CYB	MT-ND3	NDUFS8	ATP5F1A	ATP5F1B	ATP5F1C	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP5PO	SCO1	UCP2	UCP3	UQCRB	UQCRC1	UQCRC2	UQCRH	SLC25A14	COX7A2L	ATP5IF1	SLC25A27	ATP5MF	UCP1	SLC25A4	SLC25A5	SLC25A6	NDUFA13	MT-ND1	MT-ND2	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	NDUFA1	NDUFA2	NDUFA3	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA10	NDUFAB1	NDUFB1	NDUFB2	NDUFB3	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB9	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFV2	NDUFV3	NDUFA12	SDHA
KE55_Increase_Cell_injury_death_WP254	Apoptosis	BIRC3	TNFRSF21	HELLS	XIAP	LTA	CASP4	TNFRSF25	CRADD	HRK	MIR29A	BBC3	APAF1	BIRC5	IRF1	IRF3	IRF5	MDM2	PMAIP1	BAD	CASP3	CASP8	CASP9	TNFRSF10B	MIR29B1	MIR29B2	IRF4	DFFA	DFFB	IGF2	NFKBIE	DIABLO	CASP6	BCL2L2	BOK	CASP10	BCL2L11	CDKN2A	CHUK	AKT1	IGF1	IGF1R	FAS	IKBKB	FASLG	IRF6	IRF7	JUN	MCL1	MAP3K1	MYC	NFKB1	NFKBIA	NFKBIB	PIK3R1	CYCS	MAPK10	BAK1	BAX	BCL2	RELA	BCL2L1	BID	MAP2K4	BNIP3L	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF2	IKBKG	TP63	TNFSF10	CFLAR	IRF2	TRAF3	CASP7	TRADD	RIPK1	FADD	GZMB	BIRC2	PRF1	TRAF1	CASP1	CASP2	TP73	SCAF11
KE149_Increase_Inflammation_WP530	Cytokines and inflammatory response	IL12B	IL15	IL10	PDGFA	TGFB1	CSF1	CSF2	IFNG	IL1A	IL1B	IL2	IL4	IL5	IL6	IL13	TNF	CSF3	CXCL1	CXCL2	HLA-DRA	HLA-DRB1	IFNB1	IL7	IL11	CD4	IL3
KE1825_Increase_Cell_death_WP254	Apoptosis	BIRC3	TNFRSF21	HELLS	XIAP	LTA	CASP4	TNFRSF25	CRADD	HRK	MIR29A	BBC3	APAF1	BIRC5	IRF1	IRF3	IRF5	MDM2	PMAIP1	BAD	CASP3	CASP8	CASP9	TNFRSF10B	MIR29B1	MIR29B2	IRF4	DFFA	DFFB	IGF2	NFKBIE	DIABLO	CASP6	BCL2L2	BOK	CASP10	BCL2L11	CDKN2A	CHUK	AKT1	IGF1	IGF1R	FAS	IKBKB	FASLG	IRF6	IRF7	JUN	MCL1	MAP3K1	MYC	NFKB1	NFKBIA	NFKBIB	PIK3R1	CYCS	MAPK10	BAK1	BAX	BCL2	RELA	BCL2L1	BID	MAP2K4	BNIP3L	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF2	IKBKG	TP63	TNFSF10	CFLAR	IRF2	TRAF3	CASP7	TRADD	RIPK1	FADD	GZMB	BIRC2	PRF1	TRAF1	CASP1	CASP2	TP73	SCAF11
KE1392_Oxidative_Stress_WP408	Oxidative stress response	NOX5	MT1X	NFIX	NOX1	NOX3	CYBB	SOD3	TXN2	MGST1	UGT1A6	NFE2L2	MAPK14	CYP1A1	NQO1	FOS	GCLC	GPX1	GPX3	GSR	GSTT2	JUNB	MAOA	NFKB1	NOX4	MAPK10	SOD1	SP1	XDH	CAT	HMOX1	SOD2	TXNRD2	TXNRD1
KE1194_Increase_DNA_damage_WP707	DNA damage response	CHEK1	ATR	HUS1B	RAD17	CHEK2	RRM2B	CASP8	SESN1	GADD45B	BBC3	CDK6	CCND3	GADD45A	CCND2	TP53AIP1	APAF1	TNFRSF10B	CDK2	GADD45G	CASP9	DDB2	CDK4	MDM2	PML	PMAIP1	CDC25C	CDC25A	CASP3	SFN	MRE11	PIDD1	RAD52	RAD51	SMC1A	RAD50	NBN	BRCA1	RAD1	RPA2	RAD9A	CCNE2	ATRIP	CCNB3	TLK1	BID	FAS	BAX	E2F1	CCNE1	CCND1	CDKN1B	CDKN1A	RB1	TP53	AKT1	TLK2	ATM	CYCS	H2AX	CREB1	MYC	ABL1	CCNB1	FANCD2	CCNB2	CDK5	CDK1	RFC1	PRKDC
KE1365_Increase_Apoptosis_WP254	Apoptosis	BIRC3	TNFRSF21	HELLS	XIAP	LTA	CASP4	TNFRSF25	CRADD	HRK	MIR29A	BBC3	APAF1	BIRC5	IRF1	IRF3	IRF5	MDM2	PMAIP1	BAD	CASP3	CASP8	CASP9	TNFRSF10B	MIR29B1	MIR29B2	IRF4	DFFA	DFFB	IGF2	NFKBIE	DIABLO	CASP6	BCL2L2	BOK	CASP10	BCL2L11	CDKN2A	CHUK	AKT1	IGF1	IGF1R	FAS	IKBKB	FASLG	IRF6	IRF7	JUN	MCL1	MAP3K1	MYC	NFKB1	NFKBIA	NFKBIB	PIK3R1	CYCS	MAPK10	BAK1	BAX	BCL2	RELA	BCL2L1	BID	MAP2K4	BNIP3L	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF2	IKBKG	TP63	TNFSF10	CFLAR	IRF2	TRAF3	CASP7	TRADD	RIPK1	FADD	GZMB	BIRC2	PRF1	TRAF1	CASP1	CASP2	TP73	SCAF11
KE177_Increase_Mitochondrial_dysfunction_WP623	Oxidative phosphorylation	NDUFA9	ATP6AP2	NDUFB10	NDUFA4	MT-ATP6	ATP5PD	ATP5MG	NDUFA11	DMAC2L	NDUFS7	MT-ND3	NDUFS8	ATP5F1A	ATP5F1B	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP5PO	ATP5MF	MTCO3P12	ATP6AP1	GZMB	MT-ND1	MT-ND2	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	NDUFA2	NDUFA3	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA10	NDUFAB1	NDUFB1	NDUFB2	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB9	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFV2	NDUFV3	NDUFA4L2
KE1392_Increase_Oxidative_Stress_WP5477	Molecular pathway for oxidative stress	CUL3	IPCEF1	KEAP1	CHEK1	PIP	GSX1	ATR	NOS2	NOX1	ICAM1	RHEB	CDK2	MDM2	PTEN	MAP2K3	MAP2K4	PTGS2	SIRT1	RPS6KA5	IKBKB	CCNE1	MAPK8	NFKB1	MAPK14	IL1A	ATF2	NFE2L2	CREB1	CAT	PIK3CA	CDKN1A	IL6	TP53	AKT1	FOXO1	PINK1	TSC1	CXCL8	FOS	BCL2L1	BCL2	NQO1	MAP3K5	MTOR	TNF	IKBKG	HMOX1	NRF1	SOD2
KE1115_Increase_Reactive_oxygen_species_WP5477	Molecular pathway for oxidative stress	CUL3	IPCEF1	KEAP1	CHEK1	PIP	GSX1	ATR	NOS2	NOX1	ICAM1	RHEB	CDK2	MDM2	PTEN	MAP2K3	MAP2K4	PTGS2	SIRT1	RPS6KA5	IKBKB	CCNE1	MAPK8	NFKB1	MAPK14	IL1A	ATF2	NFE2L2	CREB1	CAT	PIK3CA	CDKN1A	IL6	TP53	AKT1	FOXO1	PINK1	TSC1	CXCL8	FOS	BCL2L1	BCL2	NQO1	MAP3K5	MTOR	TNF	IKBKG	HMOX1	NRF1	SOD2
KE1103_Inhibition_Cyclooxygenase_1_activity_WP4719	Eicosanoid metabolism via cyclooxygenases (COX)	TBXA2R	ACAA1	EHHADH	ACOX1	CYP4A11	AKR1B1	ACOX3	PTGR1	PTGFR	PTGR2	PRXL2B	CYP4A22	PTGDR	PTGDR2	CYP4F2	CYP4F12	PTGIR	PLA2G5	PLA2G4B	TBXAS1	PTGS2	PTGS1	PTGDS	PPARD	PLA2G4A	PTGIS	PTGES	HPGD	PPARG	ACOX2	PLA2G6
KE281_Thyroxine_T4_in_serum_Decreased_WP1981	Thyroxine (thyroid hormone) production	PRKAA1	PRKAA2	RAF1	MAP2K2	PRKCA	MAP2K1	ELK1	MAPK1	MAPK3	CREB1	NFKB1	PLCD1	TPO	ANO1	DUOX1	DUOX2	CLCN5	SLC26A6	ACY1	CGA	SLC5A5	TG	TRH	TSHR	RAP1B	RAP1A
KE9_Activation_5HT2c_WP5239	Lac-Phe pathway	ABCC5	CNDP2
KE926_Oxidation_Glutathione_To_be_considered_with_MIE_WP100	Glutathione metabolism	GSTA5	G6PD	GGT5	OPLAH	GCLC	GCLM	GPX1	GPX2	GPX3	GPX4	ANPEP	GSR	GSS	GSTA1	GSTM1	GSTM2	GSTT2	IDH1	GGT1
KE105_Inhibition_Mitochondrial_Electron_Transport_Chain_Complexes_WP111	Electron transport chain: OXPHOS system in mitochondria	COX6C	COX7A1	NDUFA9	SDHB	SDHC	SDHD	SURF1	MT-CO2	NDUFB10	COX11	MT-CO1	UQCRFS1	COX17	COX4I1	COX5B	COX6A1	COX6B1	COX7A2	COX7B	COX7C	COX8A	COX15	MT-CO3	NDUFA4	COX5A	ATP5PD	ATP5MG	UQCR11	NDUFA11	COX6A2	UQCRQ	DMAC2L	UQCR10	NDUFS7	MT-ATP6	MT-ATP8	MT-CYB	MT-ND3	NDUFS8	ATP5F1A	ATP5F1B	ATP5F1C	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP5PO	SCO1	UCP2	UCP3	UQCRB	UQCRC1	UQCRC2	UQCRH	SLC25A14	COX7A2L	ATP5IF1	SLC25A27	ATP5MF	UCP1	SLC25A4	SLC25A5	SLC25A6	NDUFA13	MT-ND1	MT-ND2	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	NDUFA1	NDUFA2	NDUFA3	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA10	NDUFAB1	NDUFB1	NDUFB2	NDUFB3	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB9	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFV2	NDUFV3	NDUFA12	SDHA
KE819_Decreased_Glomerular_filtration_WP2572	Primary focal segmental glomerulosclerosis (FSGS)	ILK	VCL	LRP6	JAG1	TGFB1	DNM1	DKK1	WNT1	PCNA	ITGAV	NOTCH1	NCK1	LRP5	CTNNB1	DAG1	ITGB3	YWHAQ	PLAUR	KRT8	CR1	CAMK2B	VTN	CDKN1B	IRF6	CD80	PLCG1	CDKN1A	CDKN1C	LAMA5	TLR4	PLCE1	AKT1	PTK2	LAMB2	ITGA3	FYN	VIM	CTSL	TLN1	ITGB1	CLDN1	CDH2	AGRN	MME	PAX2	COL4A4	MYH9	NPHS2	PODXL	ACTN4	ITGB4	LMX1B	TRPC6	SMARCAL1	SCARB2	PTPRO	MYO1E	NPHS1	COL4A3	SYNPO	CD151	WT1	COL4A5	CD2AP	INF2	FAT1	KIRREL2	MKI67	KIRREL3	UTRN	LIMS1	PARVA	MT-TL1
KE177_Increase_Mitochondrial_dysfunction_WP5507	Mitochondrial carrier deficiency associated with shuttle disturbances	GOT2	SLC25A13	SLC25A12	GLUD1	SLC25A22
KE1104_Decreased_Prostaglandin_F2alpha_concentration_plasma_WP98	Prostaglandin synthesis and regulation	ANXA2	TBXA2R	ANXA8	ANXA3	ANXA4	PTGFRN	SCGB1A1	HPGDS	PTGDR	PTGER1	PTGER2	PTGER3	PTGER4	PTGFR	S100A6	CBR1	AKR1B1	S100A10	ABCC4	PPARGC1B	AKR1C1	AKR1C2	EDN1	EDNRA	EDNRB	HSD11B1	HSD11B2	PTGIR	SOX9	AKR1C3	ANXA1	PRL	PPARGC1A	CYP11A1	HPGD	MITF	PLA2G4A	PPARG	PTGDS	PTGIS	PTGS1	PTGS2	TBXAS1	PTGES	ANXA5	ANXA6
KE40_Mitochondrial_ATP_production_decreased_WP391	Mitochondrial gene expression	GABPA	GABPB1	TFAM	PPRC1	HCFC1	MTERF3	TFB1M	POLRMT	TFB2M	MTERF1	PPARGC1B	PPP3CA	PPARGC1A	CREB1	SP1	CAMK4	ESRRA	NRF1	MYEF2
KE1105_Occurrence_renal_ischemia_WP4298	Acute viral myocarditis	ITGAL	SGCA	IL12B	ITGB2	ILK	RAC3	LAMA2	DMD	CASP8	PABPC1	MMP9	TGFB1	EIF4G1	CXCR4	RAC2	CASP9	IL10	CCR5	CASP3	TLR3	STAT3	DAG1	HLA-DMA	EDN1	AIF1	SGCG	CHRAC1	EIF4G2	CAAP1	CASP6	BNIP2	ABL2	CXADR	DFFA	SGCB	ENDOG	DFFB	KRT8	SGCD	PTCRA	CCR3	TLR5	CD55	MYH6	NFKB2	GSK3B	BAX	MAPK1	CD40LG	MAPK3	CAV1	CCND1	IFNG	STAT1	SOS1	CREB1	CD80	IL6	TLR4	AKT1	PARP1	PIK3R1	JAK1	BCL2L1	BCL2	CYCS	SOCS1	SRC	TNF	BID	NOS1	NOD2	IL2	CD4	FYN	ACTB	ABL1	CASP7	IL12A	TICAM1	PYCARD	CASP2	RASA1	MICA	CASP1
KE50_Increase_Ca_intracellular_WP254	Apoptosis	BIRC3	TNFRSF21	HELLS	XIAP	LTA	CASP4	TNFRSF25	CRADD	HRK	MIR29A	BBC3	APAF1	BIRC5	IRF1	IRF3	IRF5	MDM2	PMAIP1	BAD	CASP3	CASP8	CASP9	TNFRSF10B	MIR29B1	MIR29B2	IRF4	DFFA	DFFB	IGF2	NFKBIE	DIABLO	CASP6	BCL2L2	BOK	CASP10	BCL2L11	CDKN2A	CHUK	AKT1	IGF1	IGF1R	FAS	IKBKB	FASLG	IRF6	IRF7	JUN	MCL1	MAP3K1	MYC	NFKB1	NFKBIA	NFKBIB	PIK3R1	CYCS	MAPK10	BAK1	BAX	BCL2	RELA	BCL2L1	BID	MAP2K4	BNIP3L	TNF	TNFRSF1A	TNFRSF1B	TP53	TRAF2	IKBKG	TP63	TNFSF10	CFLAR	IRF2	TRAF3	CASP7	TRADD	RIPK1	FADD	GZMB	BIRC2	PRF1	TRAF1	CASP1	CASP2	TP73	SCAF11
KE709_Increase_Cytotoxicity_renal_tubular_cell_WP4864	Host-pathogen interaction of human coronaviruses - apoptosis	BAD	CASP8	BBC3	APAF1	CASP9	CASP3	BID	BAX	MAPK14	FASLG	MCL1	BCL2L11	MAPK13	BCL2L1	BCL2	MAPK11	MAPK12	TNF	AKT1	CASP7	FADD
KE1096_Increased_blood_uric_acid_concentration_WP497	Urea cycle and metabolism of amino groups	GATM	GAMT	PYCR3	CKM	ARG1	SARDH	PYCR1	ALDH18A1	OTC	OAT	CPS1	NAGS	ASS1	ASL	CKB	GLUD1	ARG2	ACY1	ODC1	SRM	SMS
KE1283_Activation_TGF_beta_pathway_WP560	TGF-beta receptor signaling	FKBP1A	SKIL	MIR302A	LEFTY1	CTNNB1	INHBA	LIF	SMAD2	SMAD3	SERPINE1	LEF1	BMP4	SPP1	STAT3	TGFB1	LEFTY2	TGFBR1	TGFBR2	TGFBR3	WNT1	FOXH1	ZNF423	SMAD7	RUNX3	FST	BAMBI	SKI	TGIF1	ZFYVE9	CREBBP	EP300	FOS	HRAS	IFNG	JAK1	JUN	SMAD1	SMAD4	SMAD6	NFKB1	MAPK3	MAPK9	STAT1	TFE3	THBS1	TNF	RUNX2	NOG	EGF	SMAD5	SMAD9	ZEB2	ENG	ITGB6	LTBP1
KE227_Activation_PPAR_WP2878	PPAR-alpha pathway	ACAA1	EHHADH	CYP8B1	CYP4A11	SLC27A1	CDK4	DBI	FABP1	CCND1	APOC3	APOA1	MYC	APOA2	RXRA	PPARA	NR1H3	CPT1A	ACADM	CPT2	CYP7A1	CDK1	KLK15	PLTP	APOA5	SCP2	UGT1A9
KE269_Induction_Sustained_Cell_Proliferation_WP5475	Hallmark of cancer: sustaining proliferative signaling	KSR1	CSF1R	RETN	GAREM2	NGFR	FGFR2	LRP6	TCF3	FGFR1	RUNX1T1	ULK2	SOS2	SALL4	MET	RHEB	ZBTB16	BCL9	TEK	FLT3	WNT1	KDR	RARA	RAF1	APC	MDM2	LEF1	PML	NTRK2	DEPTOR	KIT	BRAF	SHC1	FGFR4	LRP5	REL	PYGO1	INSR	PTEN	NTRK1	AKT1S1	IL6R	JAK2	STAT3	CTNNB1	FZD6	JUP	EPHA2	NFKBIE	PIK3CB	FGFR3	GSK3B	MAPK1	NFKBIA	MAPK3	TSC2	IKBKB	PIK3CG	NFKB1	PPARD	CSNK1A1	SOS1	PIK3CA	CDKN1A	ELK1	MAP2K2	KRAS	PDGFRA	MYC	IGF1R	TP53	RPTOR	EGFR	FOXO1	TSC1	MLST8	AXIN2	MAP2K1	PTK2	FOS	PIK3CD	RELA	HRAS	JUN	GRB2	SRC	MTOR	CHUK	IKBKG	AKT3	AKT1	AKT2	IL6	CCND1	FLT4	FLT1	PDGFRB	TELO2	TTI1
KE1632_Increase_in_reactive_oxygen_and_nitrogen_species_RONS_WP5233	Arsenic metabolism and reactive oxygen species generation	ATP1A1	UQCRFS1	COA3	AS3MT	CAT	SOD1	VDAC1	GSTO1	SDHA	MT-ND1
KE1528_Fatty_Acid_Beta_Oxidation_Decreased_WP143	Fatty acid beta-oxidation	CHKB	ACSL1	ACSL3	ACSL4	ACSL6	ACSL5	DLD	ECHS1	GCDH	GK	GK2	HADH	ACAT1	LIPC	LIPE	LPL	PNPLA2	LIPF	CPT1A	CPT1B	CPT2	CRAT	ECI1	DECR1	GPD2	HADHA	HADHB	ACADL	ACADM	ACADS	ACADVL	ACSS2	TPI1	SLC25A20
KE188_Neuroinflammation_WP4919	Neuroinflammation	NOS2	MT-CO2	MT-CO1	ASCC1	NFKBIA	MAPK8	MAPK14	TLR4	FOS	RELA	JUN	MTOR	CHUK
KE188_Neuroinflammation_WP5485	Post-COVID neuroinflammation	TLR3	IL10	IL18	ACE2	TLR7	GFAP	TMPRSS2	HMGB1	FURIN	TLR4	TNF	IFNA2	IFNG	IL1A	IL1B	IL4	IL6	CXCL8	MAPK1	CCL11	IL2	TLR8	IL12A
KE889_Proteostasis_impaired_WP4918	Cellular proteostasis	HSPA7	PFDN4	PFDN1	PFDN5	PFDN2	VBP1	PFDN6	DNAJB1P1	HSP90AA2P
KE55_Increase_Cell_injury_death_WP2507	Nanomaterial induced apoptosis	HTRA2	AIFM1	CASP8	APAF1	CASP9	CASP3	CASP6	ENDOG	DIABLO	CFLAR	BID	FAS	BAK1	BAX	FASLG	BCL2	CYCS	CASP7	FADD	PRF1
KE111_Agonism_Estrogen_receptor_WP2881	Estrogen receptor pathway	ACOX1	ESR1	STAT3	CYP1B1	GPAM	CYP1A1	CYP1A2	JUN	SP1	PPARA	NR0B2	PCK1	PDK4
KE10_Acetylcholine_accumulation_in_synapses_WP528	Acetylcholine synthesis	CHAT	PEMT	CHKA	PCYT1A	PDHA1	ACHE	PDHA2
KE12_Acetylcholinesterase_AchE_Inhibition_WP1602	Nicotine effect on dopaminergic neurons	GNAI1	ADCY2	DDC	DRD2	PRKACA	TH	PPP1R1B	CDK5	CHRNA3	CHRNA4	CHRNA5	CHRNB2	DRD3	DRD4	GNB1	KCNK3	KCNK9	GNG2	PPP1CA	SLC18A2	CHRNA6
KE79_Inhibition_Cyclooxygenase_activity_WP4719	Eicosanoid metabolism via cyclooxygenases (COX)	TBXA2R	ACAA1	EHHADH	ACOX1	CYP4A11	AKR1B1	ACOX3	PTGR1	PTGFR	PTGR2	PRXL2B	CYP4A22	PTGDR	PTGDR2	CYP4F2	CYP4F12	PTGIR	PLA2G5	PLA2G4B	TBXAS1	PTGS2	PTGS1	PTGDS	PPARD	PLA2G4A	PTGIS	PTGES	HPGD	PPARG	ACOX2	PLA2G6
KE468_Inhibition_PPAR_alpha_WP2878	PPAR-alpha pathway	ACAA1	EHHADH	CYP8B1	CYP4A11	SLC27A1	CDK4	DBI	FABP1	CCND1	APOC3	APOA1	MYC	APOA2	RXRA	PPARA	NR1H3	CPT1A	ACADM	CPT2	CYP7A1	CDK1	KLK15	PLTP	APOA5	SCP2	UGT1A9
KE87_Release_Cytokine_WP530	Cytokines and inflammatory response	IL12B	IL15	IL10	PDGFA	TGFB1	CSF1	CSF2	IFNG	IL1A	IL1B	IL2	IL4	IL5	IL6	IL13	TNF	CSF3	CXCL1	CXCL2	HLA-DRA	HLA-DRB1	IFNB1	IL7	IL11	CD4	IL3
KE28_Reduction_Angiogenesis_WP1539	Angiogenesis	TIMP2	PDGFB	MMP9	NOS3	FGFR2	KDR	ARNT	TEK	ANGPT1	MAPK1	PLCG1	FGF2	AKT1	SMAD1	SRC	CREBBP	MAPK14	HIF1A	PIK3CA	VEGFA	PDGFRA	PTK2	FLT1	TIMP3
KE2336_Increase_SREBF1_WP22	IL9 signaling	IL9R	STAT3	GRB2	IL2RG	JAK1	PIK3R1	PIK3R2	MAPK1	MAPK3	MAP2K1	MAP2K2	STAT1	CDK9	IL9	JAK3	STAT5A	STAT5B
KE2072_Increase_Mitochondrial_swelling_WP5241	Mitochondrial beta-oxidation	ACADSB	EHHADH	ACSL3	ACAA2	ECHS1	ACADL	ECI1	DECR1	HSD17B10
KE654_KE_654_Decreased_testosterone_by_the_fetal_Leydig_cells_Activation_by_other_glucocorticoid_receptor_agonists_WP49	IL2 signaling	GAB2	NMI	PTK2B	PTPN11	RAF1	RPS6KB1	RPS6KB2	SHC1	STAT3	CCND2	CISH	IL2RA	HRAS	AKT1	FOXO3	FOS	GRB2	IL2	IL2RB	IL2RG	JAK1	JUN	LCK	MAPT	MYC	PIK3R1	MAPK1	MAPK3	MAP2K1	MAP2K2	BCL2	SOS1	STAT1	CBL	SOCS3	CRKL	FYN	RPS6	JAK3	STAT5A	STAT5B	SYK
KE25_KE_25_Agonism_Androgen_receptor_WP272	Blood clotting cascade	F7	SERPINB2	F11	SERPINE1	PLAU	F2	PLAT	PLG	F9	VWF	F3	F10	F13B	SERPINF2	F8	F5	FGG	FGA	FGB	F12	KLKB1	KLK1
KE17_KE_17_Altered_gene_expression_AHR_nuclear_translocator_ARNT_dependent_pathway_WP2882	Nuclear receptors meta-pathway	BIRC3	ACAA1	ME1	KEAP1	SLC5A1	SLC6A4	IL12B	EHHADH	IL17B	NCOA2	STOM	ACOX1	SLC2A2	SPRY1	CYP8B1	NRIP1	MAFF	CYP4A11	ADH7	SERPINB2	NCOA6	PTGR1	ABCC5	CBR1	FTH1	CYP4F12	HGF	ZIC2	SLC2A3	TGFBR3	SREBF1	NCOA1	ESR1	TGFB2	SCD	GADD45B	PDGFB	TGFB1	SULT2A1	SOD3	HES1	SLC2A1	TNFAIP3	EGR1	POLK	ABCC4	SLC27A1	JUND	BHLHE40	CDK4	BAAT	MFGE8	ETNK2	SLC2A12	IGFBP1	ANKRD1	SLC7A11	DBI	NRG1	CYP3A7	TGFA	TGFBR2	FABP1	SLC6A20	STAT3	FASN	SLC6A19	IRS2	DNER	SULT1A1	POU5F1	UGT1A1	ARNT	MGST1	ALAS1	SMC1A	SLC7A5	ALDH3A1	AIP	PTGES3	CAP2	NR3C1	PRDX1	DNAJB1	ALOX5AP	LRRC8A	CYP1B1	MYOF	AMIGO2	FGF19	UGT1A6	DNAJC7	CES3	UGT1A7	HSP90AB1	SLC19A2	FGF13	SLC6A3	EPHA2	UGT2B7	THBD	SERPINA1	FKBP5	TNS4	FGFBP1	SRXN1	GCLC	GCLM	PTGS2	NFKB2	HSP90AA1	GSTP1	BAX	GSTT2	GGT1	EP300	GSR	AHR	CCL2	IL2	PPARGC1A	CCND1	APOC3	CDKN1B	VDR	IFNG	PPARD	HBEGF	KAT2B	NFE2L2	APOA1	GPAM	IL1B	CDKN1C	GSTM1	TXN	MYC	CYP2C9	CYP1A1	CYP1A2	NR1I2	EGFR	FOXO1	APOA2	CES5A	G6PD	CYP3A4	SQSTM1	CYP2C19	GSTM4	JUNB	CES2	GPX2	B3GNT5	JUN	NQO1	SLC2A4	GSTA5	PDE4B	SP1	RXRA	PPARA	SRC	CES1	GPX3	GSTM2	TNF	GSTA1	SNAI2	ABCC2	NR1H3	CUL1	AHRR	SLC27A5	ABCB1	PSMC5	IL11	HMOX1	CDC37	ABCC3	CPT1A	CCL20	ACADM	PTPA	NCOA3	NR0B2	SLCO1B1	ABCG5	ABCG8	CPT2	CYP7A1	IL12A	CDK1	KLK15	MAFG	CYP2B6	AGER	GSTA2	NR1H4	EPHA3	ABCB11	FTL	SLC10A1	PLTP	SLC5A5	CYP3A5	APOA5	BIRC2	SCP2	PCK1	NR1I3	ANGPTL4	AKAP13	TXNRD3	TXNRD1	UGT1A9	UGT1A4	CYP2A6	PDK4	ABCB4	SLC6A13	SLC6A7	SLC39A9	SLC6A16	NAV3	SLC6A15	MGST2	BLVRB	EPB41L4B	SLC5A4	SMARCA1	SRPX2	SLC6A2	SLC39A14	SLC2A9	SCNN1A	SLC39A7	CPEB4	SLC5A7	RGS2	PRDX6	SLC5A9	DNAJC15	SRGN	KTN1	EDN2	SEC14L1	SLC6A8	SLC6A6	SLC6A11	SLC39A11	SLC2A11	GSTM5	GSTM3	PRRG4	SLC2A8	SLCO2B1	SLC5A6	SLC39A8	FGD4	SLC39A5	ABHD2	SLC5A2	SLC39A6	SLC39A3	SLC2A5	PGD	MGST3	SLC39A1	ACKR3	PLK2	PMP2	SLC39A4	SLC39A12	SLC5A12	SLC2A13	ADGRF4	SLC5A10	SLC26A2	UGT2B4	SLC6A1	TSC22D3	GPR153	SLC5A11	CBR3	SLC2A6	IP6K3	CDC42EP3	S100P	SLC6A18	SLC39A2	SLC39A13	SLC6A5	ARL5B	CAVIN2	SERPINB9	GSTA4	ENC1	CES4A	SLC2A14	GSTA3	GCC1	SERTAD2	SLC6A9	SLC39A10	SLC6A17	SLC2A7	SLC2A10	PPP1R14C	SLC5A3	HSPA1A	SPINK13	SLC5A8	SLC6A14
KE17_KE_17_Altered_gene_expression_AHR_nuclear_translocator_ARNT_dependent_pathway_WP2289	Drug induction of bile acid pathway	ABCC4	BAAT	SULT2A1	CYP3A4	VDR	NR1I2	SLCO1B1	ABCC2	CYP7A1	ABCB1	ABCC3	SLC51B	SLC51A	SLC10A1	ABCB11	NR1I3	NR1H4
KE25_KE_25_Agonism_Androgen_receptor_WP138	Androgen receptor signaling	NCOA2	KAT5	KLK3	UBE3A	NCOR1	NCOA4	NCOR2	LIMK2	ZMIZ1	RACK1	CALR	UBE2I	PIAS3	CTNNB1	FHL2	KDM1A	RHOB	SMAD3	MDM2	PAK6	PTEN	STAT3	PIAS1	NCOA1	CDC42	STUB1	PARK7	PRDX1	TGFB1I1	RAD9A	BRCA1	SMARCE1	SUMO1	PSMC3IP	TGIF1	DSTN	KAT7	FKBP4	PATZ1	ZNF318	PIAS4	BAG1	RNF4	RNF6	EFCAB6	PIAS2	RNF14	CDKN1A	CREB1	CREBBP	EGFR	EP300	AKT1	FOXO1	SIRT1	GSK3B	HDAC1	JUN	RHOA	SMAD4	PIK3R1	PIK3R2	PTK2	RAC1	RB1	CCND1	RELA	ROCK1	SP1	SRC	CAV1	RUNX2	PLPP1	KAT2B	CCNE1	BMF	ROCK2	DAXX	ETV5	SIN3A	AR	NCOA3	NR0B2	CARM1	FLNA	NR2C2	RLN1	TLE5	RAN
KE25_KE_25_Agonism_Androgen_receptor_WP2263	Androgen receptor network in prostate cancer	SPRY1	DOCK1	KLK3	ACTL6B	ARID1B	SMARCA4	SMARCC1	SMARCC2	SMARCD1	SMARCD2	SMARCD3	ARID1A	ACTL6A	CHEK1	MSH6	ATR	CDKN2B	CHEK2	CDC25A	MIR21	ABCC4	MAP4K1	CRK	CYP17A1	EIF4EBP1	PTK2B	RAPGEF1	HGF	FOXA1	HSD17B1	HSD17B3	HSD17B2	HSD17B4	PAK1	PTEN	PTPN11	PXN	RAF1	STAT3	CDK4	CDK2	CASP3	MSH2	MRE11	CASP9	SMAD3	MDM2	CASP8	RHEB	SMAD2	BAD	RAD50	F13B	EIF4E1B	BRCA1	CDC25B	SPRY2	ETV4	FKBP5	SPINK1	NOXA1	BARD1	CDKN1B	MAPK14	PIK3CA	CDKN1A	CDKN2A	ELK1	ERG	FOS	RICTOR	GAB1	GRB2	HRAS	HSD3B1	HSD3B2	JUN	MYC	ATF1	MAPK1	MAPK3	MAPK8	MAP2K1	MAP2K2	SOS1	SP1	TP53	RB1	BCL2	JAK1	CCND1	AKT1	STAT1	MTOR	TSC2	E2F1	BAX	ATM	RPTOR	TSC1	CPN1	NDRG1	CRKL	AR	KLK2	CDK1	PLK1	HSD17B7	RAP1A	RAP1B	RASA1	MMP1	BLM	PRKDC