KE177_Increase_Mitochondrial_dysfunction_WP5241	Mitochondrial beta-oxidation	ACADL	ECI1	ACAA2	ACADSB	HSD17B10	ECHS1	ACSL3	EHHADH	DECR1
KE177_Increase_Mitochondrial_dysfunction_WP4324	Mitochondrial complex I assembly model OXPHOS system	NDUFAF6	TMEM126B	NUBPL	TMEM186	FOXRED1	DMAC1	NDUFAF3	TMEM70	COA1	TIMMDC1	DMAC2	NDUFB11	NDUFAF4	NDUFAB1	NDUFA1	NDUFS4	NDUFB5	NDUFB3	NDUFC1	NDUFA2	NDUFS5	NDUFS2	NDUFS6	NDUFB1	NDUFS3	NDUFB6	NDUFA3	NDUFB4	NDUFB8	NDUFB2	NDUFA7	NDUFC2	NDUFA10	NDUFB10	MT-ND1	MT-ND2	MT-ND4L	MT-ND4	MT-ND5	MT-ND6	NDUFB7	NDUFV2	NDUFS1	NDUFV1	NDUFA8	NDUFV3	NDUFA6	NDUFA5	NDUFAF2	ECSIT	ACAD9	NDUFA13	NDUFA12	NDUFAF1	NDUFB9	NDUFAF7
KE177_Increase_Mitochondrial_dysfunction_WP78	TCA cycle (aka Krebs or citric acid cycle)	CS	IDH3A	SUCLG2	DLST	OGDH	SDHA	SDHB	SDHC	SDHD	DLD	FH	MDH2	IDH2	ACO2	SUCLG1	SUCLA2	IDH3B	IDH3G
KE1825_Increase_Cell_death_WP1772	Apoptosis modulation and signaling	BIRC7	BNIP3	BMF	DFFA	MAP3K5	TNFRSF10A	SEPTIN4	PTRH2	TNFRSF10C	MT-RNR2	BAG3	BCL2L10	CAPNS1	ENSG00000115760	ENSG00000164761	ENSG00000171552	TNFRSF6B	NAIP	PEA15	PTPN13	TNFRSF10B	PMAIP1	DAXX	MAP3K14	TOLLIP	PRKD1	CASP6	DFFB	ENDOG	BIRC5	BBC3	HTRA2	CYCS	APAF1	BAK1	BID	BIRC3	CASP10	CASP2	CASP7	CASP8	CASP9	CRADD	FADD	FAS	FASLG	IL1R1	IL1R2	IRAK1	TNFRSF1A	TNFRSF1B	TRADD	TRAF3	TRAF6	HSPA1A	PIDD1	RIPK1	DIABLO	BIK	HRK	TNFRSF25	CASP4	AIFM1	MIR29B1	BAD	BAX	BCL2	BCL2A1	BCL2L1	CASP3	CDKN2A	FOS	IKBKB	JUN	MAPK3	MAPK8	MYD88	NFKB1	NFKBIA	TP53	AIFM2	TNFSF10	BCL2L11	BCL2L2	BIRC2	BOK	CFLAR	MCL1	CASP1	BLK	XIAP	MADD	TNFRSF10D	MIR29B2
KE89_Synthesis_De_Novo_Fatty_Acid_FA_WP357	Fatty acid biosynthesis	ACSS2	ECH1	ACLY	MECR	ECHDC2	PECR	ECHDC1	ECHDC3	ACAA2	ECHS1	FASN	ACACB	DECR1	ACSL1	ACSL3	ACSL4	ACSL6	ACACA	PC	ACSL5	SCD	HADH
KE115_Increase_FA_Influx_WP5061	Fatty acid transporters	FABP2	DBI	FABP1	SLC27A4	CD36	ACSL4	ACSL3	ACSL1	ACSL6	ACSL5	ACSBG1	FABP3	ACSBG2	FABP7	FABP5	FABP6	FABP4	FABP9	HGNC:10995	HGNC:10996	HGNC:10997	HGNC:10999	HGNC:11000	HGNC:3555
KE471_Inhibition_FoxA2_WP5066	FOXA2 pathway	ABCC4	FOXA2	IRS1	FOXA1	PPARGC1B	FASN	INS	MLXIPL	ABCC2	ABCC3	MTTP	FOXO1	IRS2	GSTM2	GSTA1	GSTA2	APOB	SREBF1	ACACA	SLC27A5	SLCO1B1
KE474_Down_Regulation_HMGCS2_WP4718	Cholesterol metabolism with Bloch and Kandutsch-Russell pathways	ELOVL4	ELOVL2	SREBF2	SOAT2	FADS1	FASN	DHCR7	CYP51A1	MYLIP	ELOVL5	NR1H3	CYP46A1	MSMO1	SOAT1	IDI1	ACSL4	SREBF1	FDFT1	SCD	SQLE	SC5D	MVK	HMGCS1	HMGCR	DHCR24	ACOT2	ELOVL3	ACAT2	ACSL3	NR1H2	HSD17B7	HMGCS2	FADS2	CYP27A1	CH25H	LBR	EBP	NSDHL	TM7SF2	ACSL1	GGPS1	ABCG1	LSS	FDPS	PMVK	ABCA1	MVD
KE860_Decreased_Mitochondrial_Fatty_Acid_Beta_Oxidation_WP368	Mitochondrial long chain fatty acid beta-oxidation	HADHA	PECR	ACADS	ACADVL	ACSF2	CPT2	ECI1	ACADL	ACADM	SCP2	SLC25A20	CPT1A	EHHADH	ACSL1	ACSL3	ACSL4	HADH
KE1825_Increase_Cell_death_WP2513	Nanoparticle triggered regulated necrosis	RIPK3	PARP1	TNF	PLA2G4A	CASP8	TNFRSF1A	TRADD	TICAM1	RIPK1	FADD	MAPK8	FTL
KE1096_Increased_blood_uric_acid_concentration_WP4595	Urea cycle and associated pathways	SLC25A12	OTC	OAT	ARG1	ALDH4A1	CPS1	NAGS	SLC25A13	SLC25A15	GLUD1	ASS1	ASL	GPT	NOS3	NOS1	PYCR1	NOS2	GLS2	GOT2	LDHB	FH	GOT1	MDH1	MDH2
KE1306_Increase_De_novo_lipogenesis_WP236	Adipogenesis	MIF	ZMPSTE24	GATA2	LIPE	NRIP1	IRS4	ASIP	RETN	CEBPB	CTNNB1	CFD	IGF1	IL6	IL6ST	IRS1	PPARD	SLC2A4	BMP4	STAT3	STAT5A	STAT5B	TGFB1	TNF	WNT1	NCOA2	WWTR1	ID3	LMNA	PLIN1	PRLR	TWIST1	CEBPD	KLF15	OSM	DLK1	NAMPT	AGPAT2	PPARGC1A	GADD45A	AGT	E2F4	AHR	FOXC2	LPIN1	BSCL2	HMGA1	FAS	INS	LIF	GADD45B	NDN	SERPINE1	RBL1	RBL2	RXRA	RXRG	SFRP4	LPIN3	SP1	STAT2	KLF5	HNF1A	UCP1	WNT10B	WNT5B	MIXL1	NCOA1	SOCS1	NCOR1	NCOR2	LPIN2	NR1H3	CDKN1A	CEBPA	CREB1	CYP26A1	DDIT3	DVL1	E2F1	EGR2	EPAS1	FOXO1	FRZB	GATA3	GATA4	GH1	NR3C1	HIF1A	LEP	LPL	SMAD3	MEF2A	MEF2B	MEF2C	MEF2D	PCK1	PPARA	PPARG	CISD1	CYP26B1	RARA	RB1	SCD	BMP1	SREBF1	STAT1	STAT6	FZD1	IRS2	SOCS3	ADIPOQ	CELF1	PCK2	PTGIS	RORA	BMP2	PNPLA3	KLF6	TRIB3	LIFR	BMP3	NR2F1	PLIN2	CNTFR	EBF1	GDF10	GTF3A	MBNL1	SPOCK1	KLF7
KE1195_modulation_Extracellular_Matrix_Composition_WP5382	TGFB / Smad signaling	CCN2	SMAD4	YWHAG	WWTR1	SERPINE1	TGFBR3	TGFBR1	TGFBR2	SMAD3	SMAD2	SPARC	POSTN
KE1395_Liver_Cancer_WP3646	Hepatitis C and hepatocellular carcinoma	BRCA1	TGFB1	PODXL	RAC1	IL6	MYC	SMAD4	IL6R	STAT3	CXCL8	NOS2	E2F2	BIRC3	CD44	PTGS2	CTTN	BIRC5	FASLG	CASP9	COL4A2	HNF1A	MYOF	UCHL1	VAV2	CXCR1	CASP7	RRM2	MIR744	MIR155	MIR34A	MIR24-2	MIR24-1	MIR92A2	HIF1A	MAPK3	TGFBR1	MAPK8	NFKB1	CCND1	MAPK14	VEGFA	SOS1	CDKN1A	LEF1	TP53	AKT1	JAK1	FRZB	CASP3	SMAD3	BCL2L1	JUN	GRB2	PTPN11	MMP1	MIR92A1
KE2410_Increase_11_Hydroxysteroid_dehydrogenase_type_1_activity_WP2880	Glucocorticoid receptor pathway	IL11	PPP1R14C	THBD	S100P	SLC19A2	CDC42EP3	PLK2	ABHD2	SPINK13	TSC22D3	EDN2	ARL5B	ADGRF4	DNAJC15	AMIGO2	GPR153	KTN1	SERPINB9	PMP2	EPB41L4B	SRGN	SCNN1A	SEC14L1	PRRG4	CPEB4	CAVIN2	ENC1	NAV3	SERTAD2	CCL2	PDE4B	ACKR3	RGS2	B3GNT5	MGAM	PTGES3	SLC26A2	STOM	BIRC3	HSP90AA1	MFGE8	GADD45B	POU5F1	LRRC8A	PTGS2	RXRA	TGFBR3	TNFAIP3	ZIC2	CUL1	BHLHE40	DNER	TNS4	FGFBP1	CDKN1C	ALOX5AP	NR3C1	JUN	NFKB2	CCL20	SNAI2	NR1I2	NR1I3	BIRC2	ANGPTL4	ETNK2	ANKRD1	SPRY1	FGD4	AKAP13
KE149_Increase_Inflammation_WP453	Inflammatory response pathway	THBS3	IGHA2	IGHA1	VTN	IL2	IL2RA	IL2RB	IL2RG	IL4	IL5	CD28	CD80	CD86	THBS1	IL4R	TNFRSF1A	TNFRSF1B	CD40	CD40LG	COL1A1	COL1A2	COL3A1	FN1	IFNG	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	ZAP70	IL5RA
KE829_Damage_Lipid_bilayer_WP5584	Signaling lipids	PLA2G1B	MT-CO1	PTGS2	PLCB1	CYP7B1	FADS2	ALOX5	LTA4H	CYP2C8	CYP2C9	HPGD	ALOX15	ALOX12	CYP2B6	CYP7A1	EPHX2	GPX4	PTGDS	CYP4F2	CYP27A1	LTC4S	CYP8B1	PTGES	CBR1	TBXAS1	PRXL2B	PLA1A
KE839_Formation_Mallory_body_WP254	Apoptosis	TNFRSF21	GZMB	HELLS	BNIP3L	IRF5	IGF1	MYC	MAPK10	TNF	PMAIP1	TRAF1	TNFRSF10B	DFFA	DFFB	IRF1	CASP6	BBC3	APAF1	BIRC3	BIRC5	FAS	FASLG	IRF3	IRF4	IRF7	LTA	MAP3K1	NFKBIB	CYCS	BAK1	BID	TNFRSF1A	TNFRSF1B	TP73	TRAF2	TRAF3	CASP2	CASP7	CASP8	CASP9	CASP10	TRADD	RIPK1	CRADD	FADD	IRF2	PRF1	DIABLO	CASP4	TNFRSF25	HRK	SCAF11	MIR29B1	MIR29A	CDKN2A	CHUK	AKT1	IGF1R	IGF2	IKBKB	JUN	MDM2	NFKB1	NFKBIA	PIK3R1	BAD	BAX	BCL2	RELA	BCL2L1	MAP2K4	TP53	CASP3	IKBKG	TP63	BCL2L11	BIRC2	IRF6	MCL1	BCL2L2	BOK	CASP1	TNFSF10	CFLAR	XIAP	NFKBIE	MIR29B2
KE2405_Increase_Hepatocellular_lipotoxicity_WP5323	Fatty acid and lipoprotein transport in hepatocytes	OSBPL5	NPC2	SLC27A4	LPA	VDAC1	DBI	LIPA	STAR	SLC27A1	SORT1	STARD3	FABP2	APOC1	FABP4	FABP1	LRP1	SOAT2	SLC27A3	APOE	LDLRAP1	ACSL6	ACSL5	APOA4	LDLR	SOAT1	ACSL1	APOB	ACSL3	ABCA1	MYLIP	APOC2	PCSK9	SCARB1	FABP3	SLC27A2
KE2408_Increase_Adipose_lipolysis_WP236	Adipogenesis	MIF	ZMPSTE24	GATA2	LIPE	NRIP1	IRS4	ASIP	RETN	CEBPB	CTNNB1	CFD	IGF1	IL6	IL6ST	IRS1	PPARD	SLC2A4	BMP4	STAT3	STAT5A	STAT5B	TGFB1	TNF	WNT1	NCOA2	WWTR1	ID3	LMNA	PLIN1	PRLR	TWIST1	CEBPD	KLF15	OSM	DLK1	NAMPT	AGPAT2	PPARGC1A	GADD45A	AGT	E2F4	AHR	FOXC2	LPIN1	BSCL2	HMGA1	FAS	INS	LIF	GADD45B	NDN	SERPINE1	RBL1	RBL2	RXRA	RXRG	SFRP4	LPIN3	SP1	STAT2	KLF5	HNF1A	UCP1	WNT10B	WNT5B	MIXL1	NCOA1	SOCS1	NCOR1	NCOR2	LPIN2	NR1H3	CDKN1A	CEBPA	CREB1	CYP26A1	DDIT3	DVL1	E2F1	EGR2	EPAS1	FOXO1	FRZB	GATA3	GATA4	GH1	NR3C1	HIF1A	LEP	LPL	SMAD3	MEF2A	MEF2B	MEF2C	MEF2D	PCK1	PPARA	PPARG	CISD1	CYP26B1	RARA	RB1	SCD	BMP1	SREBF1	STAT1	STAT6	FZD1	IRS2	SOCS3	ADIPOQ	CELF1	PCK2	PTGIS	RORA	BMP2	PNPLA3	KLF6	TRIB3	LIFR	BMP3	NR2F1	PLIN2	CNTFR	EBF1	GDF10	GTF3A	MBNL1	SPOCK1	KLF7
KE2406_Increase_Regenerative_nodule_formation_WP3932	Focal adhesion: PI3K-Akt-mTOR-signaling	LAMC3	COL4A4	ANGPT2	LAMA4	HSP90B1	COL4A6	COL5A2	PHLPP2	COL11A1	TBC1D1	COL5A3	PHLPP1	PPP2R3C	PIK3IP1	TCL1A	CAB39L	THBS4	TNR	TNN	HIF3A	CHAD	CSH1	COL6A2	PELO	PFKFB1	TNXB	THBS3	PFKFB3	PPP2R2D	EIF4E1B	THBS2	COL11A2	TCL1B	STRADA	EIF4B	PPP2R5A	PPP2R5B	PPP2R3A	PPP2R2C	PPP2R5C	LIPE	VTN	EPO	IRS4	PPP2R1B	PPP2R5E	PPP2R2B	VEGFD	VEGFB	CSF1	COL4A1	COMP	PRL	IGF1	HGF	PIK3CB	FGFR2	PDGFB	IL2RB	AKT2	PIK3R2	CSF3	RPS6KB1	IL2	FGF1	SPP1	PIK3CA	IL2RA	RPS6	FGF2	EGF	FGF7	IL2RG	IL6R	IL7R	IRS1	INSR	PIK3CD	SLC2A4	PDGFA	MTOR	ITGAL	ITGA2B	FLT4	NGFR	ELAVL1	ITGA8	GNB1	ITGB5	ITGAE	PPP2R1A	ITGB8	VWF	GNB3	PPP2R5D	PRLR	PFKFB4	GNB4	ITGB6	TEK	PFKFB2	GNG13	GNG11	GNGT1	ITGA7	THBS1	ITGA11	ITGB7	EPHA2	ITGA10	ITGA9	VEGFC	ITGAD	ITGA5	GNG3	ITGA2	GNG8	GNG4	GNB2	GNG5	GNG7	GNG2	RELN	ATF6B	OSM	OSMR	NOS2	IL4R	HSP90AA1	GSK3B	NOS1	FLT1	RAB2A	CDC37	JAK3	PPARGC1A	ATF2	RAB14	FOXA1	CASP9	COL4A2	ITGAV	ITGAX	RPTOR	IFNAR1	ANGPT1	IFNAR2	PRKAA2	NOS3	MLST8	ULK1	LPAR1	AKT1S1	IFNA7	INS	ITGB3	RAB10	EIF4E2	CRTC2	BAD	ITGA3	PIK3C2A	IBSP	TNC	KITLG	LAMA3	LAMC2	SLC2A3	CREB3L3	FGFR3	FGF10	FGF22	SREBF1	FGF4	FGFR1	FGF20	LAMB1	ITGA6	JAK2	MAPK1	HIF1A	LAMA1	FGF14	FGF9	MAPK3	TSC2	IKBKB	PPP2CB	FGF21	PIK3CG	MET	RHEB	CREB3	FGF8	COL1A1	FGF6	CDKN1B	VEGFA	GHR	PPP2CA	PDGFRB	FGF12	ITGA4	FN1	SOS1	EPAS1	AKT3	SLC2A1	CREB1	FOXO3	CDKN1A	MAP2K2	KDR	ATF4	FGF13	LAMA5	RAF1	PRKAA1	ITGB4	PIK3C2B	KRAS	NGF	PDGFRA	MDM2	LAMC1	CAB39	COL2A1	IGF1R	PDPK1	PIK3R5	AKT1	CREB3L4	PIK3R1	CREB5	EGFR	ITGB1	FOXO1	EIF4E	FGF18	KIT	CREB3L1	FGF17	ITGB2	FGFR4	FGF11	FGF19	JAK1	SLC2A2	COL1A2	TSC1	RAB8A	CHRM1	COL3A1	MAP2K1	PTK2	ITGAM	IFNB1	PTEN	LAMB2	GNG12	HRAS	RPS6KB2	GRB2	CHRM2	F2R	CREB3L2	CSF1R	RAB11B	IRS2	FGF3	EIF4EBP1	PIK3R4	FGF16	LAMA2	LAMB3	NRAS	IKBKG	ACACA	EFNA2	GYS1	GYS2	EFNA3	EFNA1	EFNA5	EFNA4	LPAR2	HSP90AB1	CSF3R	PGF	LPAR6	PDGFC	LPAR4	GNGT2	PDGFD	LPAR3	LPAR5	IL3RA	EPOR	GNG10	ANGPT4	STK11	DDIT4	COL5A1
KE2412_Increase_Hepatic_intracellular_active_glucocorticoids_WP5280	Glucocorticoid biosynthesis	CYP3A4	CYP21A2	CYP11B1	AKR1C4	SRD5A1	CYP11B2	AKR1C3	AKR1D1	AKR1C2	AKR1C1	CBR1	HSD11B1	SRD5A2	HSD11B2
KE1815_Increase_Endoplasmic_reticulum_stress_WP4925	Unfolded protein response	NFE2L2	IL1B	TNFRSF10B	PMAIP1	BID	XBP1	BBC3	EIF2S1	EIF2AK3	CASP2	ATF4	TP53	BCL2	DDIT3	MBTPS2	HSPA5	PPP1R15A	RTCB	ATF6	MBTPS1	BCL2L11	ERN1	TXNIP
KE1306_Increase_De_novo_lipogenesis_WP3965	Lipid metabolism pathway	LIPE	ACSS2	ACLY	HILPDA	AKT2	PRKAG2	PRKAR2B	PRKAR2A	PLIN1	PNPLA2	PRKAR1B	PRKAR1A	PRKAG3	PRKAB2	PRKAA2	FASN	PRKACA	PRKAB1	AKT3	PDHA1	PRKAA1	AKT1	PRKACB	PRKACG	PRKAG1	ACACA	ABHD5	ACSBG1	BCKDHA
KE1395_Liver_Cancer_WP5434	Cancer pathways	BIRC7	CKS1B	COL4A3	COL4A4	COL4A5	COL4A6	HSP90B1	LAMA4	LAMB4	LAMC3	NKX3-1	TRAF4	ZBTB17	CALML3	CALML4	CALML5	CALML6	COL4A1	EGLN1	EGLN3	EPO	FLT3LG	GNA11	GNAI2	GNAI3	KEAP1	PLD2	RPS6KA5	SMO	VEGFB	VEGFD	WNT8A	WNT8B	WNT9A	AKT2	ARHGEF1	BMP4	BRCA2	CTBP1	CTNNA2	CTNNB1	CXCL8	DDB2	EDN1	EGF	FGF1	FGFR2	FZD4	FZD5	FZD8	GLI3	GNA13	HGF	HMOX1	IGF1	IL12B	IL13	IL2	IL2RA	IL2RB	IL2RG	IL4	IL5	IL6	IL6R	IL6ST	IL7R	JUP	MAPK10	MLH1	MMP2	MSH2	MSH3	MSH6	MTOR	MYC	NFE2L2	PDGFA	PDGFB	PIK3CA	PIK3CB	PIK3CD	PIK3R2	PIM1	POLK	PPARD	RAC1	RAD51	RBX1	RHOA	ROCK1	ROCK2	RPS6KB1	SHH	SMAD4	STAT3	STAT5A	STAT5B	TCF7L1	TERC	TERT	TGFA	TGFB1	WNT1	ZBTB16	GNG5	ADCY2	ADCY4	ADCY5	ADCY7	AR	CRKL	FLT4	GNAI1	GNB1	GNB2	GNB3	GNB4	GNB5	GNG11	GNG13	GNG2	GNG3	GNG4	GNG7	GNG8	GNGT1	IL12RB1	IL12RB2	ITGA2	ITGA2B	KLK3	MITF	MST1	NCOA3	PAX8	PMAIP1	RET	TRAF1	TXNRD2	VEGFC	WNT9B	CUL2	TFG	SP1	ADCY1	ADCY8	AGT	ALK	APAF1	AXIN1	AXIN2	BAK1	BBC3	BCR	BID	BIRC3	BIRC5	CAMK2A	CAMK2B	CAMK2G	CASP7	CASP8	CASP9	CCDC6	CDH1	COL4A2	CTBP2	CTNNA1	CTNNA3	CUL1	CYCS	DLL1	DLL3	DLL4	DVL2	E2F2	E2F3	EML4	ESR1	ETS1	FADD	FAS	FASLG	FRAT1	FRAT2	FZD10	FZD3	FZD6	FZD7	GADD45A	GADD45B	GADD45G	GNAQ	HDAC1	HES1	HES5	HEY1	HEY2	HSP90AA1	IFNA1	IFNA10	IFNA13	IFNA14	IFNA16	IFNA17	IFNA21	IFNA4	IFNA5	IFNA6	IFNA7	IFNA8	IFNAR1	IFNAR2	IFNGR1	IFNGR2	IL12A	IL13RA1	IL4R	ITGAV	JAG1	JAG2	JAK3	KNG1	LPAR1	LRP5	LRP6	MAX	MMP3	NCOA1	NOS2	NOTCH3	NOTCH4	PLCB1	PLCB2	PLCB3	PLCB4	PLD1	PTGS2	RALA	RALB	RALBP1	RALGDS	RASGRP1	RASSF1	RASSF5	RXRA	RXRB	RXRG	SKP1	STAT2	TPR	TRAF2	TRAF3	TRAF5	TRAF6	WNT10A	WNT10B	WNT11	WNT16	WNT3	WNT5B	WNT7A	WNT7B	ABL1	ADCY3	ADCY6	ADCY9	AGTR1	AKT1	AKT3	APC	APC2	ARAF	ARNT	BAD	BAX	BCL2	BCL2L1	BDKRB1	BDKRB2	BRAF	CAMK2D	CASP3	CBL	CCNA1	CCNA2	CCND1	CCND2	CCND3	CCNE1	CCNE2	CDK2	CDK4	CDK6	CDKN1A	CDKN1B	CDKN2A	CDKN2B	CEBPA	CHUK	CREBBP	CRK	CSF1R	CXCL12	CXCR4	DVL1	DVL3	E2F1	EGFR	ELK1	EP300	EPAS1	ERBB2	F2	F2R	FGFR1	FGFR3	FGFR4	FH	FLT3	FN1	FOS	FOXO1	FZD1	FZD2	FZD9	GLI1	GLI2	GNA12	GNAS	GNG12	GRB2	GSK3B	GSTA1	GSTA2	GSTA3	GSTA4	GSTA5	GSTM1	GSTM2	GSTM3	GSTM4	GSTM5	GSTO1	GSTO2	GSTP1	GSTT2	GSTT2B	HDAC2	HIF1A	HRAS	IFNA2	IFNG	IGF1R	IGF2	IKBKB	IKBKG	IL15	IL3	ITGA3	ITGA6	ITGB1	JAK1	JAK2	JUN	KIT	KITLG	KRAS	LAMA1	LAMA2	LAMA3	LAMA5	LAMB1	LAMB2	LAMB3	LAMC1	LAMC2	LEF1	MAP2K1	MAP2K2	MAPK1	MAPK3	MAPK8	MAPK9	MDM2	MET	MGST1	MGST2	MGST3	MMP1	NCOA4	NFKB1	NFKB2	NFKBIA	NOTCH1	NOTCH2	NQO1	NRAS	NTRK1	PDGFRA	PDGFRB	PIK3R1	PIK3R3	PIM2	PLCG1	PLCG2	PML	PPARG	PRKACA	PRKACB	PRKACG	PRKCA	PRKCB	PRKCG	PTCH1	PTEN	PTK2	RAC3	RAF1	RARA	RARB	RB1	RELA	RPS6KB2	RUNX1	RUNX1T1	SKP2	SLC2A1	SMAD2	SMAD3	SOS1	SOS2	SPI1	STAT1	STAT4	STAT6	SUFU	TCF7	TCF7L2	TGFB2	TGFB3	TGFBR1	TGFBR2	TP53	TXNRD1	VEGFA	VHL	WNT2	WNT2B	WNT3A	WNT4	WNT5A	WNT6	RAC2	BCL2L11	BIRC2	BMP2	EGLN2	ELOB	ELOC	ESR2	HEYL	IL23A	IL7	PTGER1	PTGER2	PTGER3	PTGER4	ARHGEF11	ARHGEF12	ARNT2	CALML1	CALML2	CCDC42	CSF2RA	CSF2RB	CSF3R	DAPK1	DAPK2	DAPK3	DCC	EDNRA	EDNRB	EPOR	F2RL3	GNG10	GNGT2	GSTT1	HHIP	HSP90AB1	IL15RA	IL3RA	IL5RA	LPAR2	LPAR3	LPAR4	LPAR5	LPAR6	MECOM	PGF	PLEKHG5	RASGRP2	RASGRP3	RASGRP4	TPM3	XIAP	APPL1	KIF7	PTCH2	TXNRD3
KE839_Formation_Mallory_body_WP183	Proteasome degradation	NEDD4	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC5	PSMD1	PSMD2	PSMD3	PSMD4	PSMD9	PSMD6	H2AX	UBC	UCHL3	PSME3	HLA-A	HLA-B	HLA-C	HLA-E	HLA-F	HLA-G	PSMB8	PSMB9	PSMB10	PSMD5	PSMD10	PSMD11	PSME1	PSME2	UBA1	UBA7	UBE2B	UBE2D1	H2AC4	UCHL1	PSMC4	PSMC6	PSMD7	PSMD8	PSMD12	PSMD13	UBE2D2	UBE2D3	IFNG	RPN1	RPN2	UBB	H2AZ1
KE134_Increase_Kupffer_cell_activation_WP530	Cytokines and inflammatory response	IL11	CSF1	CSF2	CSF3	CXCL2	IL1B	IL2	IL4	IL5	IL6	IL12B	IL13	PDGFA	TGFB1	TNF	IL1A	CXCL1	HLA-DRA	IFNB1	IFNG	IL3	IL10	IL15	CD4	HLA-DRB1	IL7
KE2119_Increase_Insulin_resistance_WP481	Insulin signaling	EGR1	SGK3	INPP4A	PPP1R3A	SGK1	SNAP23	CBLC	INPPL1	ARF6	LIPE	MAP3K5	MAPK7	IRS4	RPS6KA5	PIK3CA	AKT2	MTOR	INSR	IRS1	MAP3K4	PIK3CB	PIK3CD	PIK3R2	MAPK10	RAC1	RPS6KB1	SLC2A4	TBC1D4	SH2B2	MAP3K2	MAP4K5	RPS6KA6	GRB10	GSK3A	KIF5B	MAP3K3	PTPN1	MAP3K14	RPS6KA4	GSK3B	MAP3K1	MAP3K9	MAP3K10	MAP3K11	MYO1C	PRKAA2	MAPK13	RPS6KA1	RPS6KA2	RPS6KA3	MAPK12	SNAP25	STXBP1	MAP3K7	XBP1	SOCS1	CBLB	KIF3A	CRK	MAPK14	EIF4E	EIF4EBP1	ELK1	AKT1	FOXO1	FOXO3	FOS	GAB1	GRB2	PIK3R4	HRAS	IGF1R	IKBKB	JUN	ENPP1	PDPK1	PFKL	PFKM	PIK3C2A	PIK3C2G	PIK3C3	PIK3CG	PIK3R1	PRKAA1	PRKCA	PRKCB	PRKCD	PRKCH	PRKCI	PRKCQ	PRKCZ	MAPK1	MAPK3	MAPK4	MAPK6	MAPK8	MAPK11	MAPK9	MAP2K1	MAP2K2	MAP2K3	MAP2K5	MAP2K6	MAP2K7	PTEN	PTPN11	RAC2	RAF1	RHEB	RPS6KB2	MAP2K4	SHC1	SLC2A1	SOS1	SOS2	SRF	STX4	VAMP2	TSC1	TSC2	PIK3R3	IRS2	CBL	SOCS3	SORBS1	MAP4K1	SHC2	RAPGEF1	GYG1	GYS1	GYS2	ARF1	SHC3	SGK2	FLOT1	CAP1	EHD1	ARHGAP33	FLOT2	RHOQ	STXBP4	EHD2	MINK1	RHOJ	TRIB3	PTPRF	MAP4K2	REG1A	RRAD	STXBP2	STXBP3	MAP3K12	MAP4K3	MAP3K6	MAP3K13	CYTH3	MAP4K4	MAP3K8	GRB14	RAB4A
KE465_Increased_Fatty_acid_influx_WP5061	Fatty acid transporters	FABP2	DBI	FABP1	SLC27A4	CD36	ACSL4	ACSL3	ACSL1	ACSL6	ACSL5	ACSBG1	FABP3	ACSBG2	FABP7	FABP5	FABP6	FABP4	FABP9	HGNC:10995	HGNC:10996	HGNC:10997	HGNC:10999	HGNC:11000	HGNC:3555
KE2406_Increase_Regenerative_nodule_formation_WP428	Wnt signaling	NLK	NFATC1	ROCK2	TCF7L1	CTBP1	CTNNB1	RHOA	MYC	ROR2	PLAU	RAC1	WNT1	FZD5	FZD8	CAMK2B	CSNK2A2	CAMK2A	NFATC3	GPC4	DAAM1	CHD8	NFATC4	NFATC2	CSNK2A1	PLCB4	PORCN	SFRP4	PPP3CB	CSNK1A1	SFRP5	PPP3CC	SERPINF1	MAP3K7	PLCB2	PRICKLE1	NKD1	NKD2	DAAM2	CER1	CAMK2G	PLCB3	DKK2	VANGL2	PRICKLE2	SENP2	SOX17	SOST	CXXC4	CTBP2	CTNNBIP1	FRAT2	PLCB1	NOTUM	PPP3R2	CSNK2B	PPP3R1	CSNK2A3	FRAT1	FZD10	CSNK1E	DVL2	FZD2	GSK3B	LRP6	LRP5	ROR1	WNT16	RYK	WNT2	WNT3	WNT7A	WNT7B	WNT10B	WNT11	WNT2B	FZD3	WNT10A	WNT5B	AXIN1	FZD6	FZD7	FZD9	KREMEN1	WNT3A	MAPK9	TCF7	SFRP1	DKK4	MAPK8	DKK1	INVS	LEF1	PPP3CA	CAMK2D	SFRP2	TCF7L2	WIF1	PRKCB	VANGL1	DVL1	DVL3	APC	JUN	WNT4	PRKCA	PRKCG	CCND1	WNT5A	WNT6	FOSL1	FZD1	CCND2	CCND3
KE828_Inhibition_Phospholipase_A_WP3965	Lipid metabolism pathway	LIPE	ACSS2	ACLY	HILPDA	AKT2	PRKAG2	PRKAR2B	PRKAR2A	PLIN1	PNPLA2	PRKAR1B	PRKAR1A	PRKAG3	PRKAB2	PRKAA2	FASN	PRKACA	PRKAB1	AKT3	PDHA1	PRKAA1	AKT1	PRKACB	PRKACG	PRKAG1	ACACA	ABHD5	ACSBG1	BCKDHA
KE1271_Activation_of_TGF_signaling_WP5382	TGFB / Smad signaling	CCN2	SMAD4	YWHAG	WWTR1	SERPINE1	TGFBR3	TGFBR1	TGFBR2	SMAD3	SMAD2	SPARC	POSTN
KE1493_Increased_Pro_inflammatory_mediators_WP453	Inflammatory response pathway	THBS3	IGHA2	IGHA1	VTN	IL2	IL2RA	IL2RB	IL2RG	IL4	IL5	CD28	CD80	CD86	THBS1	IL4R	TNFRSF1A	TNFRSF1B	CD40	CD40LG	COL1A1	COL1A2	COL3A1	FN1	IFNG	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	ZAP70	IL5RA
KE831_Disturbance_Lysosomal_function_WP183	Proteasome degradation	NEDD4	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC5	PSMD1	PSMD2	PSMD3	PSMD4	PSMD9	PSMD6	H2AX	UBC	UCHL3	PSME3	HLA-A	HLA-B	HLA-C	HLA-E	HLA-F	HLA-G	PSMB8	PSMB9	PSMB10	PSMD5	PSMD10	PSMD11	PSME1	PSME2	UBA1	UBA7	UBE2B	UBE2D1	H2AC4	UCHL1	PSMC4	PSMC6	PSMD7	PSMD8	PSMD12	PSMD13	UBE2D2	UBE2D3	IFNG	RPN1	RPN2	UBB	H2AZ1
KE838_Induction_Microvesicular_fat_WP4149	White fat cell differentiation	TLE3	KLF2	GATA2	STAT5A	TCF7L1	CEBPB	STAT5B	NR2F2	KLF15	CEBPD	CTNNA1	KLF5	IRF3	IRF4	WNT10B	INS	NR1H3	SREBF1	ZNF423	GATA3	NR3C1	CREB1	EGR2	RARA	PPARG	KLF4	FOXO1	DDIT3	CEBPA	RORA	MECOM	EBF1
KE837_Occurrence_Cytoplasmic_vacuolization_kupffer_cell_WP3965	Lipid metabolism pathway	LIPE	ACSS2	ACLY	HILPDA	AKT2	PRKAG2	PRKAR2B	PRKAR2A	PLIN1	PNPLA2	PRKAR1B	PRKAR1A	PRKAG3	PRKAB2	PRKAA2	FASN	PRKACA	PRKAB1	AKT3	PDHA1	PRKAA1	AKT1	PRKACB	PRKACG	PRKAG1	ACACA	ABHD5	ACSBG1	BCKDHA
KE836_Occurrence_Cytoplasmic_vacuolization_Bile_duct_cell_WP3965	Lipid metabolism pathway	LIPE	ACSS2	ACLY	HILPDA	AKT2	PRKAG2	PRKAR2B	PRKAR2A	PLIN1	PNPLA2	PRKAR1B	PRKAR1A	PRKAG3	PRKAB2	PRKAA2	FASN	PRKACA	PRKAB1	AKT3	PDHA1	PRKAA1	AKT1	PRKACB	PRKACG	PRKAG1	ACACA	ABHD5	ACSBG1	BCKDHA
KE835_Occurrence_Ballooning_degeneration_hepatocyte_WP4925	Unfolded protein response	NFE2L2	IL1B	TNFRSF10B	PMAIP1	BID	XBP1	BBC3	EIF2S1	EIF2AK3	CASP2	ATF4	TP53	BCL2	DDIT3	MBTPS2	HSPA5	PPP1R15A	RTCB	ATF6	MBTPS1	BCL2L11	ERN1	TXNIP
KE831_Disturbance_Lysosomal_function_WP4923	Autophagy	ATG3	UVRAG	ATG16L1	ATG101	WIPI2	PRKAG2	MTOR	RB1CC1	ATG13	ATG9A	AMBRA1	PRKAG3	BECN1	ATG14	PRKAB2	RPTOR	ATG12	DEPTOR	PRKAA2	MLST8	ULK1	AKT1S1	ATG5	PIK3C3	PRKAB1	PRKAA1	MAP1LC3B	PRKAG1	PIK3R4	ATG7
KE833_Occurrence_Cytoplasmic_vacuolization_hepatocyte_WP3965	Lipid metabolism pathway	LIPE	ACSS2	ACLY	HILPDA	AKT2	PRKAG2	PRKAR2B	PRKAR2A	PLIN1	PNPLA2	PRKAR1B	PRKAR1A	PRKAG3	PRKAB2	PRKAA2	FASN	PRKACA	PRKAB1	AKT3	PDHA1	PRKAA1	AKT1	PRKACB	PRKACG	PRKAG1	ACACA	ABHD5	ACSBG1	BCKDHA
KE1262_Apoptosis_WP254	Apoptosis	TNFRSF21	GZMB	HELLS	BNIP3L	IRF5	IGF1	MYC	MAPK10	TNF	PMAIP1	TRAF1	TNFRSF10B	DFFA	DFFB	IRF1	CASP6	BBC3	APAF1	BIRC3	BIRC5	FAS	FASLG	IRF3	IRF4	IRF7	LTA	MAP3K1	NFKBIB	CYCS	BAK1	BID	TNFRSF1A	TNFRSF1B	TP73	TRAF2	TRAF3	CASP2	CASP7	CASP8	CASP9	CASP10	TRADD	RIPK1	CRADD	FADD	IRF2	PRF1	DIABLO	CASP4	TNFRSF25	HRK	SCAF11	MIR29B1	MIR29A	CDKN2A	CHUK	AKT1	IGF1R	IGF2	IKBKB	JUN	MDM2	NFKB1	NFKBIA	PIK3R1	BAD	BAX	BCL2	RELA	BCL2L1	MAP2K4	TP53	CASP3	IKBKG	TP63	BCL2L11	BIRC2	IRF6	MCL1	BCL2L2	BOK	CASP1	TNFSF10	CFLAR	XIAP	NFKBIE	MIR29B2
KE1967_Pyroptosis_WP453	Inflammatory response pathway	THBS3	IGHA2	IGHA1	VTN	IL2	IL2RA	IL2RB	IL2RG	IL4	IL5	CD28	CD80	CD86	THBS1	IL4R	TNFRSF1A	TNFRSF1B	CD40	CD40LG	COL1A1	COL1A2	COL3A1	FN1	IFNG	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	ZAP70	IL5RA
KE2009_Activation_of_inflammation_pathway_WP453	Inflammatory response pathway	THBS3	IGHA2	IGHA1	VTN	IL2	IL2RA	IL2RB	IL2RG	IL4	IL5	CD28	CD80	CD86	THBS1	IL4R	TNFRSF1A	TNFRSF1B	CD40	CD40LG	COL1A1	COL1A2	COL3A1	FN1	IFNG	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	ZAP70	IL5RA
KE870_Increase_Cell_Proliferation_WP179	Cell cycle	SMC3	ZBTB17	BUB3	CDC20	CDKN2D	ESPL1	RBX1	TGFB1	PCNA	CDK7	CCNH	MYC	SMAD4	ATM	ATR	PRKDC	CHEK1	DBF4	ORC1	ORC6	CDC7	ORC2	ORC4	ORC3	ORC5	SFN	YWHAQ	YWHAB	YWHAE	YWHAG	YWHAH	YWHAZ	SMC1B	STAG2	PTTG1	RAD21	E2F2	CUL1	SMC1A	MCM2	MCM6	RBL1	GSK3B	CDC45	CDC6	GADD45B	MCM5	RBL2	MCM4	MCM3	E2F3	SKP1	TFDP2	HDAC1	GADD45A	GADD45G	E2F5	CCNB1	CDC25C	WEE1	MCM7	PLK1	CDK1	CCNE2	HDAC2	TFDP1	E2F4	CHEK2	CDC27	ANAPC4	CDC14A	CDC14B	ANAPC5	CDC23	FZR1	MAD2L2	STAG1	PKMYT1	ANAPC13	CDC16	ANAPC11	CCNB3	ANAPC1	ANAPC10	BUB1	ANAPC2	ANAPC7	WEE2	PTTG2	TGFB2	ABL1	EP300	E2F1	CCNE1	CDK6	CCND1	CDKN1B	CCND3	CCND2	TGFB3	CDKN2C	CDK2	CDKN1A	CDKN1C	CCNA1	CDK4	MDM2	RB1	TP53	CCNA2	CDKN2B	CDKN2A	CDC25A	SMAD3	SMAD2	SKP2	MAD1L1	CDC25B	TTK	CCNB2
KE1493_Increased_Pro_inflammatory_mediators_WP530	Cytokines and inflammatory response	IL11	CSF1	CSF2	CSF3	CXCL2	IL1B	IL2	IL4	IL5	IL6	IL12B	IL13	PDGFA	TGFB1	TNF	IL1A	CXCL1	HLA-DRA	IFNB1	IFNG	IL3	IL10	IL15	CD4	HLA-DRB1	IL7
KE1492_Tissue_resident_cell_activation_WP560	TGF-beta receptor signaling	CTNNB1	EGF	SMAD4	SMAD7	SKIL	BMP4	SPP1	STAT3	TGFB1	TNF	WNT1	ENG	FKBP1A	BAMBI	ITGB6	LTBP1	SMAD5	SMAD9	SKI	TFE3	TGIF1	THBS1	ZFYVE9	CREBBP	LIF	SMAD6	SERPINE1	TGFBR3	FOXH1	NOG	ZEB2	MIR302A	FST	LEFTY1	EP300	ZNF423	FOS	HRAS	IFNG	INHBA	JAK1	JUN	SMAD1	SMAD2	SMAD3	NFKB1	LEF1	MAPK3	MAPK9	STAT1	LEFTY2	TGFBR1	TGFBR2	RUNX2	RUNX3
KE1494_Leukocyte_recruitment_activation_WP4542	Leukocyte-intrinsic Hippo pathway functions	RHOA	FOXP3	RAC1	RAP1A	FOXO6	NDRG1	YWHAQ	STK38L	FYB1	WWTR1	ITGAL	MST1	MOB1A	RAB13	SAV1	STK3	TEAD4	TEAD3	FERMT3	KNSTRN	YAP1	CCR7	LATS2	PRDM1	TEAD1	RASSF5	TEAD2	LATS1	MAPK14	FOXO1	FOXO3	LPL	MIR21	FOXO4	CD19
KE265_Activation_Stellate_cells_WP560	TGF-beta receptor signaling	CTNNB1	EGF	SMAD4	SMAD7	SKIL	BMP4	SPP1	STAT3	TGFB1	TNF	WNT1	ENG	FKBP1A	BAMBI	ITGB6	LTBP1	SMAD5	SMAD9	SKI	TFE3	TGIF1	THBS1	ZFYVE9	CREBBP	LIF	SMAD6	SERPINE1	TGFBR3	FOXH1	NOG	ZEB2	MIR302A	FST	LEFTY1	EP300	ZNF423	FOS	HRAS	IFNG	INHBA	JAK1	JUN	SMAD1	SMAD2	SMAD3	NFKB1	LEF1	MAPK3	MAPK9	STAT1	LEFTY2	TGFBR1	TGFBR2	RUNX2	RUNX3
KE68_Accumulation_Collagen_WP560	TGF-beta receptor signaling	CTNNB1	EGF	SMAD4	SMAD7	SKIL	BMP4	SPP1	STAT3	TGFB1	TNF	WNT1	ENG	FKBP1A	BAMBI	ITGB6	LTBP1	SMAD5	SMAD9	SKI	TFE3	TGIF1	THBS1	ZFYVE9	CREBBP	LIF	SMAD6	SERPINE1	TGFBR3	FOXH1	NOG	ZEB2	MIR302A	FST	LEFTY1	EP300	ZNF423	FOS	HRAS	IFNG	INHBA	JAK1	JUN	SMAD1	SMAD2	SMAD3	NFKB1	LEF1	MAPK3	MAPK9	STAT1	LEFTY2	TGFBR1	TGFBR2	RUNX2	RUNX3
KE898_Disruption_Lysosome_WP4923	Autophagy	ATG3	UVRAG	ATG16L1	ATG101	WIPI2	PRKAG2	MTOR	RB1CC1	ATG13	ATG9A	AMBRA1	PRKAG3	BECN1	ATG14	PRKAB2	RPTOR	ATG12	DEPTOR	PRKAA2	MLST8	ULK1	AKT1S1	ATG5	PIK3C3	PRKAB1	PRKAA1	MAP1LC3B	PRKAG1	PIK3R4	ATG7
KE898_Disruption_Lysosome_WP183	Proteasome degradation	NEDD4	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC5	PSMD1	PSMD2	PSMD3	PSMD4	PSMD9	PSMD6	H2AX	UBC	UCHL3	PSME3	HLA-A	HLA-B	HLA-C	HLA-E	HLA-F	HLA-G	PSMB8	PSMB9	PSMB10	PSMD5	PSMD10	PSMD11	PSME1	PSME2	UBA1	UBA7	UBE2B	UBE2D1	H2AC4	UCHL1	PSMC4	PSMC6	PSMD7	PSMD8	PSMD12	PSMD13	UBE2D2	UBE2D3	IFNG	RPN1	RPN2	UBB	H2AZ1
KE1539_Endocytotic_lysosomal_uptake_WP4655	Cytosolic DNA-sensing pathway	RIPK3	TREX1	AIM2	CCL4L2	IL1B	IL6	CCL5	CCL4	POLR3B	POLR3E	POLR2E	POLR3H	POLR3G	POLR3GL	POLR3F	POLR2K	POLR3A	POLR3K	POLR2H	POLR3D	POLR1C	POLR2L	POLR3C	POLR1D	ZBP1	CASP10	CASP8	CYLD	MAVS	RNF125	TRADD	NFKBIB	RIGI	TRIM25	IRF3	RIPK1	ATG12	IL18	NLRX1	ADAR	CGAS	FADD	CXCL10	TBK1	STING1	IRF7	ISG15	IKBKE	IFNA1	IFNA4	IFNA5	IFNA6	IFNA7	IFNA8	IFNA10	IFNA13	IFNA14	IFNA16	IFNA17	IFNA21	ATG5	NFKBIA	IKBKB	IL33	RELA	CHUK	IKBKG	IFNA2	IFNB1	NFKB1	PYCARD	CASP1	POLR2F
KE1501_Increased_extracellular_matrix_deposition_WP560	TGF-beta receptor signaling	CTNNB1	EGF	SMAD4	SMAD7	SKIL	BMP4	SPP1	STAT3	TGFB1	TNF	WNT1	ENG	FKBP1A	BAMBI	ITGB6	LTBP1	SMAD5	SMAD9	SKI	TFE3	TGIF1	THBS1	ZFYVE9	CREBBP	LIF	SMAD6	SERPINE1	TGFBR3	FOXH1	NOG	ZEB2	MIR302A	FST	LEFTY1	EP300	ZNF423	FOS	HRAS	IFNG	INHBA	JAK1	JUN	SMAD1	SMAD2	SMAD3	NFKB1	LEF1	MAPK3	MAPK9	STAT1	LEFTY2	TGFBR1	TGFBR2	RUNX2	RUNX3
KE1501_Increased_extracellular_matrix_deposition_WP428	Wnt signaling	NLK	NFATC1	ROCK2	TCF7L1	CTBP1	CTNNB1	RHOA	MYC	ROR2	PLAU	RAC1	WNT1	FZD5	FZD8	CAMK2B	CSNK2A2	CAMK2A	NFATC3	GPC4	DAAM1	CHD8	NFATC4	NFATC2	CSNK2A1	PLCB4	PORCN	SFRP4	PPP3CB	CSNK1A1	SFRP5	PPP3CC	SERPINF1	MAP3K7	PLCB2	PRICKLE1	NKD1	NKD2	DAAM2	CER1	CAMK2G	PLCB3	DKK2	VANGL2	PRICKLE2	SENP2	SOX17	SOST	CXXC4	CTBP2	CTNNBIP1	FRAT2	PLCB1	NOTUM	PPP3R2	CSNK2B	PPP3R1	CSNK2A3	FRAT1	FZD10	CSNK1E	DVL2	FZD2	GSK3B	LRP6	LRP5	ROR1	WNT16	RYK	WNT2	WNT3	WNT7A	WNT7B	WNT10B	WNT11	WNT2B	FZD3	WNT10A	WNT5B	AXIN1	FZD6	FZD7	FZD9	KREMEN1	WNT3A	MAPK9	TCF7	SFRP1	DKK4	MAPK8	DKK1	INVS	LEF1	PPP3CA	CAMK2D	SFRP2	TCF7L2	WIF1	PRKCB	VANGL1	DVL1	DVL3	APC	JUN	WNT4	PRKCA	PRKCG	CCND1	WNT5A	WNT6	FOSL1	FZD1	CCND2	CCND3
KE1743_Increase_plasma_Ang_II_WP4756	Renin-angiotensin-aldosterone system (RAAS)	CALML3	CALML4	CALML5	CALML6	HSD3B1	CALM1	CMA1	ATF1	ATF6B	CALM2	CALM3	STAR	CAMK1D	CAMK1G	ATF2	CAMK1	CAMK2A	CAMK2B	CAMK2G	CAMK4	GNAQ	ITPR1	ITPR2	ITPR3	PLCB2	ACE	AGT	AGTR2	REN	ATF4	CAMK2D	CREB1	CREB3	CREB3L1	CREB3L2	CREB3L3	CREB3L4	CREB5	CYP11A1	CYP11B2	CYP21A2	AGTR1	HSD3B2	CTSG
KE459_Increased_Liver_Steatosis_WP143	Fatty acid beta-oxidation	HADHA	HADHB	CRAT	GPD2	LIPE	ACSS2	ACADS	ACADVL	CPT2	ECI1	ACADL	ACADM	PNPLA2	SLC25A20	ECHS1	ACAT1	CPT1A	DECR1	DLD	ACSL1	ACSL3	ACSL4	ACSL6	LIPC	LPL	ACSL5	TPI1	CHKB	CPT1B	GCDH	GK2	HADH	GK	LIPF
KE1740_Induced_dysregulation_of_ACE2_WP554	ACE inhibitor pathway	ATP6AP2	CMA1	TGFB1	ACE	AGT	AGTR2	KNG1	NOS3	REN	CYP11B2	AGTR1	ACE2	BDKRB1	BDKRB2	MAS1	CTSG	NR3C2
KE1852_Increased_Ang_II_type_1_receptor_AT1R_WP5036	Angiotensin II receptor type 1 pathway	IL11	TGFB1	CCN2	IL6ST	SMAD4	IL11RA	F12	SP1	RACK1	AGT	MAPK1	HIF1A	TGFBR1	ACTA2	COL1A1	MAP2K6	RRAS	JUND	RAF1	AGTR1	TGFBR2	COL1A2	SMAD3	PTPN11	NOX4	ACE2	MAS1	PDGFD
KE459_Increased_Liver_Steatosis_WP5061	Fatty acid transporters	FABP2	DBI	FABP1	SLC27A4	CD36	ACSL4	ACSL3	ACSL1	ACSL6	ACSL5	ACSBG1	FABP3	ACSBG2	FABP7	FABP5	FABP6	FABP4	FABP9	HGNC:10995	HGNC:10996	HGNC:10997	HGNC:10999	HGNC:11000	HGNC:3555
KE459_Increased_Liver_Steatosis_WP3965	Lipid metabolism pathway	LIPE	ACSS2	ACLY	HILPDA	AKT2	PRKAG2	PRKAR2B	PRKAR2A	PLIN1	PNPLA2	PRKAR1B	PRKAR1A	PRKAG3	PRKAB2	PRKAA2	FASN	PRKACA	PRKAB1	AKT3	PDHA1	PRKAA1	AKT1	PRKACB	PRKACG	PRKAG1	ACACA	ABHD5	ACSBG1	BCKDHA
KE1489_N_A_Steatohepatisis_WP453	Inflammatory response pathway	THBS3	IGHA2	IGHA1	VTN	IL2	IL2RA	IL2RB	IL2RG	IL4	IL5	CD28	CD80	CD86	THBS1	IL4R	TNFRSF1A	TNFRSF1B	CD40	CD40LG	COL1A1	COL1A2	COL3A1	FN1	IFNG	LAMA5	LAMB1	LAMB2	LAMC1	LAMC2	LCK	ZAP70	IL5RA
KE2407_Increase_Cirrhosis_WP5382	TGFB / Smad signaling	CCN2	SMAD4	YWHAG	WWTR1	SERPINE1	TGFBR3	TGFBR1	TGFBR2	SMAD3	SMAD2	SPARC	POSTN
KE18_Activation_AhR_WP2873	Aryl hydrocarbon receptor pathway	TGFB1	IL2	CAP2	IL12B	NFE2L2	POLK	IL1B	TNF	AHRR	HSP90AA1	NCOA1	SLC7A5	CDC37	AHR	ALDH3A1	AIP	PTGES3	HES1	IL17B	MYOF	IGFBP1	IL12A	CES3	SERPINB2	MGST1	BAX	EP300	CDKN1B	IFNG	JUND	CYP1B1	CYP1A1	CYP1A2	EGFR	UGT1A6	JUNB	JUN	NQO1	SRC	UGT1A9	UGT1A1	GSTA2	UGT1A7	UGT1A4	ARNT
KE122_Increase_Glucocorticoid_receptor_activation_WP2880	Glucocorticoid receptor pathway	IL11	PPP1R14C	THBD	S100P	SLC19A2	CDC42EP3	PLK2	ABHD2	SPINK13	TSC22D3	EDN2	ARL5B	ADGRF4	DNAJC15	AMIGO2	GPR153	KTN1	SERPINB9	PMP2	EPB41L4B	SRGN	SCNN1A	SEC14L1	PRRG4	CPEB4	CAVIN2	ENC1	NAV3	SERTAD2	CCL2	PDE4B	ACKR3	RGS2	B3GNT5	MGAM	PTGES3	SLC26A2	STOM	BIRC3	HSP90AA1	MFGE8	GADD45B	POU5F1	LRRC8A	PTGS2	RXRA	TGFBR3	TNFAIP3	ZIC2	CUL1	BHLHE40	DNER	TNS4	FGFBP1	CDKN1C	ALOX5AP	NR3C1	JUN	NFKB2	CCL20	SNAI2	NR1I2	NR1I3	BIRC2	ANGPTL4	ETNK2	ANKRD1	SPRY1	FGD4	AKAP13
KE1271_Increase_Transforming_growth_factor_beta_signaling_WP560	TGF-beta receptor signaling	CTNNB1	EGF	SMAD4	SMAD7	SKIL	BMP4	SPP1	STAT3	TGFB1	TNF	WNT1	ENG	FKBP1A	BAMBI	ITGB6	LTBP1	SMAD5	SMAD9	SKI	TFE3	TGIF1	THBS1	ZFYVE9	CREBBP	LIF	SMAD6	SERPINE1	TGFBR3	FOXH1	NOG	ZEB2	MIR302A	FST	LEFTY1	EP300	ZNF423	FOS	HRAS	IFNG	INHBA	JAK1	JUN	SMAD1	SMAD2	SMAD3	NFKB1	LEF1	MAPK3	MAPK9	STAT1	LEFTY2	TGFBR1	TGFBR2	RUNX2	RUNX3
KE40_Mitochondrial_ATP_production_decreased_WP5239	Lac-Phe pathway	ABCC5	CNDP2
KE40_Mitochondrial_ATP_production_decreased_WP5241	Mitochondrial beta-oxidation	ACADL	ECI1	ACAA2	ACADSB	HSD17B10	ECHS1	ACSL3	EHHADH	DECR1
KE570_Accumulation_Damaged_mitochondrial_DNA_WP4946	DNA repair pathways, full network	RAD52	LIG3	REV3L	BRCA1	ERCC1	MNAT1	MRE11	RFC1	PNKP	ERCC8	RFC2	RAD51	POLD1	NTHL1	POLB	XRCC1	MLH1	UNG	POLD3	XRCC5	PALB2	MSH2	RBX1	POLE2	APEX1	POLI	MPG	NBN	ERCC2	LIG1	RPA3	POLD2	RAD51C	NEIL3	GTF2H1	GTF2H3	RFC5	FANCE	MSH3	RAD50	OGG1	WDR48	POLE4	FANCL	MSH6	RAP1A	RPA2	RAD23B	POLK	PMS2	POLM	SMUG1	MBD4	PARP2	FAAP24	RPA1	TERF2	PCNA	MUTYH	RFC3	CDK7	CCNH	DDB2	ERCC5	REV1	BRIP1	XPA	TDG	BRCA2	CUL4A	FANCI	PARP1	FANCD2	GTF2H2	CETN2	POLE3	ATM	CHEK1	XRCC4	DCLRE1C	NEIL2	XPC	FANCC	CUL4B	USP1	ERCC3	RFC4	WRN	POLL	DDB1	FEN1	APEX2	CENPX	MGMT	POLH	EXO1	LIG4	ATR	CENPS	POLD4	ERCC4	POLE	RAD23A	FANCB	FANCF	FAAP100	NHEJ1	FANCA	FANCM	H2AX	HMGB1	XRCC6	RAD54B	FAN1	GTF2H4	FANCG	ERCC6	PRKDC	GTF2H5
KE664_Overwhelmed_Mitochondrial_DNA_repair_mechanisms_WP4946	DNA repair pathways, full network	RAD52	LIG3	REV3L	BRCA1	ERCC1	MNAT1	MRE11	RFC1	PNKP	ERCC8	RFC2	RAD51	POLD1	NTHL1	POLB	XRCC1	MLH1	UNG	POLD3	XRCC5	PALB2	MSH2	RBX1	POLE2	APEX1	POLI	MPG	NBN	ERCC2	LIG1	RPA3	POLD2	RAD51C	NEIL3	GTF2H1	GTF2H3	RFC5	FANCE	MSH3	RAD50	OGG1	WDR48	POLE4	FANCL	MSH6	RAP1A	RPA2	RAD23B	POLK	PMS2	POLM	SMUG1	MBD4	PARP2	FAAP24	RPA1	TERF2	PCNA	MUTYH	RFC3	CDK7	CCNH	DDB2	ERCC5	REV1	BRIP1	XPA	TDG	BRCA2	CUL4A	FANCI	PARP1	FANCD2	GTF2H2	CETN2	POLE3	ATM	CHEK1	XRCC4	DCLRE1C	NEIL2	XPC	FANCC	CUL4B	USP1	ERCC3	RFC4	WRN	POLL	DDB1	FEN1	APEX2	CENPX	MGMT	POLH	EXO1	LIG4	ATR	CENPS	POLD4	ERCC4	POLE	RAD23A	FANCB	FANCF	FAAP100	NHEJ1	FANCA	FANCM	H2AX	HMGB1	XRCC6	RAD54B	FAN1	GTF2H4	FANCG	ERCC6	PRKDC	GTF2H5
KE1825_Increase_Cell_death_WP4923	Autophagy	ATG3	UVRAG	ATG16L1	ATG101	WIPI2	PRKAG2	MTOR	RB1CC1	ATG13	ATG9A	AMBRA1	PRKAG3	BECN1	ATG14	PRKAB2	RPTOR	ATG12	DEPTOR	PRKAA2	MLST8	ULK1	AKT1S1	ATG5	PIK3C3	PRKAB1	PRKAA1	MAP1LC3B	PRKAG1	PIK3R4	ATG7
KE40_Mitochondrial_ATP_production_decreased_WP5049	Glycolysis in senescence	G6PD	PKM	PGK1	GAPDH	LDHA	RB1	TP53	ALDOC	HK1	ENO1	PRKAA1
KE178_Mitochondrial_electron_transport_chain_disrupted_WP111	Electron transport chain: OXPHOS system in mitochondria	NDUFA13	COX17	ATP5PD	ATP5MG	UQCR11	NDUFA11	COX4I1	COX5B	COX6A1	COX6A2	COX6B1	COX6C	COX7A1	COX7A2	COX7B	COX7C	COX11	COX15	UQCRQ	DMAC2L	SLC25A4	SLC25A5	SLC25A6	UQCR10	NDUFS7	MT-ATP6	MT-ATP8	MT-CO1	MT-CO3	MT-CYB	MT-ND1	MT-ND2	MT-ND3	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	NDUFA1	NDUFA2	NDUFA3	NDUFA4	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA9	NDUFA10	NDUFAB1	NDUFB1	NDUFB2	NDUFB3	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB9	NDUFB10	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFS8	NDUFV2	NDUFV3	ATP5F1A	ATP5F1B	ATP5F1C	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP5PO	NDUFA12	SCO1	SDHA	SDHB	SDHC	SDHD	SURF1	UCP1	UCP2	UCP3	UQCRB	UQCRC1	UQCRC2	UQCRFS1	UQCRH	SLC25A14	COX7A2L	ATP5IF1	SLC25A27	ATP5MF	COX8A	MT-CO2	COX5A
KE55_Increase_Cell_injury_death_WP254	Apoptosis	TNFRSF21	GZMB	HELLS	BNIP3L	IRF5	IGF1	MYC	MAPK10	TNF	PMAIP1	TRAF1	TNFRSF10B	DFFA	DFFB	IRF1	CASP6	BBC3	APAF1	BIRC3	BIRC5	FAS	FASLG	IRF3	IRF4	IRF7	LTA	MAP3K1	NFKBIB	CYCS	BAK1	BID	TNFRSF1A	TNFRSF1B	TP73	TRAF2	TRAF3	CASP2	CASP7	CASP8	CASP9	CASP10	TRADD	RIPK1	CRADD	FADD	IRF2	PRF1	DIABLO	CASP4	TNFRSF25	HRK	SCAF11	MIR29B1	MIR29A	CDKN2A	CHUK	AKT1	IGF1R	IGF2	IKBKB	JUN	MDM2	NFKB1	NFKBIA	PIK3R1	BAD	BAX	BCL2	RELA	BCL2L1	MAP2K4	TP53	CASP3	IKBKG	TP63	BCL2L11	BIRC2	IRF6	MCL1	BCL2L2	BOK	CASP1	TNFSF10	CFLAR	XIAP	NFKBIE	MIR29B2
KE149_Increase_Inflammation_WP530	Cytokines and inflammatory response	IL11	CSF1	CSF2	CSF3	CXCL2	IL1B	IL2	IL4	IL5	IL6	IL12B	IL13	PDGFA	TGFB1	TNF	IL1A	CXCL1	HLA-DRA	IFNB1	IFNG	IL3	IL10	IL15	CD4	HLA-DRB1	IL7
KE1825_Increase_Cell_death_WP254	Apoptosis	TNFRSF21	GZMB	HELLS	BNIP3L	IRF5	IGF1	MYC	MAPK10	TNF	PMAIP1	TRAF1	TNFRSF10B	DFFA	DFFB	IRF1	CASP6	BBC3	APAF1	BIRC3	BIRC5	FAS	FASLG	IRF3	IRF4	IRF7	LTA	MAP3K1	NFKBIB	CYCS	BAK1	BID	TNFRSF1A	TNFRSF1B	TP73	TRAF2	TRAF3	CASP2	CASP7	CASP8	CASP9	CASP10	TRADD	RIPK1	CRADD	FADD	IRF2	PRF1	DIABLO	CASP4	TNFRSF25	HRK	SCAF11	MIR29B1	MIR29A	CDKN2A	CHUK	AKT1	IGF1R	IGF2	IKBKB	JUN	MDM2	NFKB1	NFKBIA	PIK3R1	BAD	BAX	BCL2	RELA	BCL2L1	MAP2K4	TP53	CASP3	IKBKG	TP63	BCL2L11	BIRC2	IRF6	MCL1	BCL2L2	BOK	CASP1	TNFSF10	CFLAR	XIAP	NFKBIE	MIR29B2
KE1392_Oxidative_Stress_WP408	Oxidative stress response	NOX3	NFE2L2	HMOX1	MAPK10	XDH	TXNRD2	SOD2	SOD3	GPX1	SP1	NOX1	CYBB	MAPK14	CYP1A1	NQO1	FOS	GCLC	GPX3	GSR	GSTT2	JUNB	MAOA	MGST1	NFKB1	NOX4	UGT1A6	SOD1	TXNRD1	CAT	NOX5	TXN2	MT1X	NFIX
KE1194_Increase_DNA_damage_WP707	DNA damage response	TLK2	HUS1B	RAD52	BRCA1	RRM2B	RAD51	RAD50	RPA2	DDB2	FANCD2	ATM	CHEK1	ATR	H2AX	PRKDC	MRE11	MYC	NBN	RFC1	TP53AIP1	TNFRSF10B	PMAIP1	SFN	BID	FAS	CASP8	SMC1A	SESN1	GADD45B	BBC3	RAD1	GADD45A	APAF1	GADD45G	CASP9	CCNB1	RAD17	CDC25C	CDK1	CYCS	RAD9A	CCNE2	CHEK2	TLK1	PIDD1	ATRIP	CCNB3	BAX	ABL1	E2F1	CCNE1	CDK6	CCND1	CDKN1B	CCND3	CCND2	CDK2	CDKN1A	CDK4	MDM2	RB1	PML	TP53	AKT1	CDC25A	CASP3	CREB1	CDK5	CCNB2
KE1365_Increase_Apoptosis_WP254	Apoptosis	TNFRSF21	GZMB	HELLS	BNIP3L	IRF5	IGF1	MYC	MAPK10	TNF	PMAIP1	TRAF1	TNFRSF10B	DFFA	DFFB	IRF1	CASP6	BBC3	APAF1	BIRC3	BIRC5	FAS	FASLG	IRF3	IRF4	IRF7	LTA	MAP3K1	NFKBIB	CYCS	BAK1	BID	TNFRSF1A	TNFRSF1B	TP73	TRAF2	TRAF3	CASP2	CASP7	CASP8	CASP9	CASP10	TRADD	RIPK1	CRADD	FADD	IRF2	PRF1	DIABLO	CASP4	TNFRSF25	HRK	SCAF11	MIR29B1	MIR29A	CDKN2A	CHUK	AKT1	IGF1R	IGF2	IKBKB	JUN	MDM2	NFKB1	NFKBIA	PIK3R1	BAD	BAX	BCL2	RELA	BCL2L1	MAP2K4	TP53	CASP3	IKBKG	TP63	BCL2L11	BIRC2	IRF6	MCL1	BCL2L2	BOK	CASP1	TNFSF10	CFLAR	XIAP	NFKBIE	MIR29B2
KE177_Increase_Mitochondrial_dysfunction_WP623	Oxidative phosphorylation	MTCO3P12	ATP6AP2	GZMB	NDUFA4L2	ATP6AP1	MT-ATP6	ATP5PD	ATP5MG	NDUFA11	DMAC2L	NDUFS7	MT-ND1	MT-ND2	MT-ND3	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	NDUFA2	NDUFA3	NDUFA4	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA9	NDUFA10	NDUFAB1	NDUFB1	NDUFB2	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB9	NDUFB10	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFS8	NDUFV2	NDUFV3	ATP5F1A	ATP5F1B	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP5PO	ATP5MF
KE1392_Increase_Oxidative_Stress_WP5477	Molecular pathway for oxidative stress	KEAP1	RPS6KA5	MAP3K5	PINK1	HMOX1	NFE2L2	PIK3CA	IL6	CHEK1	CXCL8	ATR	MTOR	TNF	CUL3	SOD2	NOS2	PTGS2	SIRT1	NRF1	ATF2	IPCEF1	PIP	GSX1	NOX1	MAP2K3	MAP2K4	ICAM1	IKBKB	CCNE1	RHEB	MAPK8	NFKB1	MAPK14	IL1A	CREB1	CDK2	CDKN1A	MDM2	TP53	AKT1	FOXO1	TSC1	FOS	BCL2L1	BCL2	PTEN	NQO1	IKBKG	CAT
KE1115_Increase_Reactive_oxygen_species_WP5477	Molecular pathway for oxidative stress	KEAP1	RPS6KA5	MAP3K5	PINK1	HMOX1	NFE2L2	PIK3CA	IL6	CHEK1	CXCL8	ATR	MTOR	TNF	CUL3	SOD2	NOS2	PTGS2	SIRT1	NRF1	ATF2	IPCEF1	PIP	GSX1	NOX1	MAP2K3	MAP2K4	ICAM1	IKBKB	CCNE1	RHEB	MAPK8	NFKB1	MAPK14	IL1A	CREB1	CDK2	CDKN1A	MDM2	TP53	AKT1	FOXO1	TSC1	FOS	BCL2L1	BCL2	PTEN	NQO1	IKBKG	CAT
KE1103_Inhibition_Cyclooxygenase_1_activity_WP4719	Eicosanoid metabolism via cyclooxygenases (COX)	TBXA2R	PTGFR	PTGDR	PPARD	PLA2G4A	PLA2G5	PLA2G6	PTGDR2	PTGS2	ACAA1	AKR1B1	ACOX3	PTGR1	PTGDS	EHHADH	PTGR2	ACOX1	CYP4A22	HPGD	ACOX2	CYP4F2	CYP4F12	CYP4A11	PPARG	TBXAS1	PTGS1	PTGIS	PTGES	PRXL2B	PTGIR	PLA2G4B
KE281_Thyroxine_T4_in_serum_Decreased_WP1981	Thyroxine (thyroid hormone) production	ANO1	DUOX1	CLCN5	SLC26A6	RAP1A	DUOX2	ACY1	SLC5A5	TG	TPO	TRH	TSHR	PLCD1	PRKAA2	CGA	MAP2K2	PRKAA1	PRKCA	MAP2K1	ELK1	MAPK1	MAPK3	RAF1	CREB1	NFKB1	RAP1B
KE9_Activation_5HT2c_WP5239	Lac-Phe pathway	ABCC5	CNDP2
KE926_Oxidation_Glutathione_To_be_considered_with_MIE_WP100	Glutathione metabolism	OPLAH	G6PD	GPX1	GSTA5	GGT1	GGT5	GCLC	GCLM	GPX2	GPX3	GPX4	GSR	GSS	GSTA1	GSTM1	GSTM2	GSTT2	IDH1	ANPEP
KE105_Inhibition_Mitochondrial_Electron_Transport_Chain_Complexes_WP111	Electron transport chain: OXPHOS system in mitochondria	NDUFA13	COX17	ATP5PD	ATP5MG	UQCR11	NDUFA11	COX4I1	COX5B	COX6A1	COX6A2	COX6B1	COX6C	COX7A1	COX7A2	COX7B	COX7C	COX11	COX15	UQCRQ	DMAC2L	SLC25A4	SLC25A5	SLC25A6	UQCR10	NDUFS7	MT-ATP6	MT-ATP8	MT-CO1	MT-CO3	MT-CYB	MT-ND1	MT-ND2	MT-ND3	MT-ND4	MT-ND4L	MT-ND5	MT-ND6	NDUFA1	NDUFA2	NDUFA3	NDUFA4	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA9	NDUFA10	NDUFAB1	NDUFB1	NDUFB2	NDUFB3	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB9	NDUFB10	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFV1	NDUFS4	NDUFS5	NDUFS6	NDUFS8	NDUFV2	NDUFV3	ATP5F1A	ATP5F1B	ATP5F1C	ATP5F1D	ATP5F1E	ATP5PB	ATP5MC1	ATP5MC2	ATP5MC3	ATP5ME	ATP5PF	ATP5PO	NDUFA12	SCO1	SDHA	SDHB	SDHC	SDHD	SURF1	UCP1	UCP2	UCP3	UQCRB	UQCRC1	UQCRC2	UQCRFS1	UQCRH	SLC25A14	COX7A2L	ATP5IF1	SLC25A27	ATP5MF	COX8A	MT-CO2	COX5A
KE819_Decreased_Glomerular_filtration_WP2572	Primary focal segmental glomerulosclerosis (FSGS)	COL4A4	MYH9	COL4A3	COL4A5	PLAUR	VTN	NPHS2	PLCE1	NPHS1	MME	FYN	TGFB1	CD80	WNT1	PODXL	PCNA	CTNNB1	PAX2	YWHAQ	LMX1B	CDH2	SCARB2	KRT8	CAMK2B	LRP6	JAG1	DNM1	CTSL	SMARCAL1	ITGAV	NCK1	LRP5	CLDN1	ILK	CR1	ITGB3	ITGA3	VIM	VCL	DKK1	CDKN1B	PLCG1	CDKN1A	CDKN1C	LAMA5	ITGB4	TLR4	AKT1	NOTCH1	ITGB1	PTK2	LAMB2	CD151	WT1	IRF6	AGRN	FAT1	KIRREL2	ACTN4	TLN1	TRPC6	MKI67	KIRREL3	PTPRO	UTRN	MYO1E	LIMS1	SYNPO	PARVA	CD2AP	INF2	MT-TL1	DAG1
KE177_Increase_Mitochondrial_dysfunction_WP5507	Mitochondrial carrier deficiency associated with shuttle disturbances	SLC25A13	SLC25A12	GLUD1	GOT2	SLC25A22
KE1104_Decreased_Prostaglandin_F2alpha_concentration_plasma_WP98	Prostaglandin synthesis and regulation	ANXA1	PRL	PTGDR	PTGFR	TBXA2R	ABCC4	EDN1	MITF	PLA2G4A	ANXA6	PPARGC1A	PPARGC1B	ANXA2	PTGS2	CYP11A1	AKR1C1	AKR1C2	HPGD	PPARG	PTGDS	S100A6	SOX9	AKR1C3	AKR1B1	ANXA5	HSD11B1	HSD11B2	PTGER1	PTGER2	PTGER3	PTGER4	PTGIS	PTGS1	TBXAS1	CBR1	PTGES	EDNRA	EDNRB	PTGIR	HPGDS	ANXA3	ANXA4	PTGFRN	S100A10	SCGB1A1	ANXA8
KE40_Mitochondrial_ATP_production_decreased_WP391	Mitochondrial gene expression	MTERF3	MTERF1	GABPB1	PPARGC1A	PPARGC1B	ESRRA	PPRC1	GABPA	NRF1	TFB1M	TFB2M	SP1	TFAM	CAMK4	MYEF2	POLRMT	CREB1	PPP3CA	HCFC1
KE1105_Occurrence_renal_ischemia_WP4298	Acute viral myocarditis	AIF1	FYN	MMP9	TGFB1	IL12B	CD80	IL6	PARP1	STAT3	CCR3	CD55	DMD	TNF	EDN1	IL2	ITGAL	RASA1	PABPC1	SGCG	CHRAC1	EIF4G2	EIF4G1	CAAP1	CASP6	BNIP2	ABL2	DFFA	SGCB	ENDOG	DFFB	KRT8	SGCD	MICA	CASP8	GSK3B	CD40LG	CAV1	CASP2	CASP9	CCR5	CASP7	ILK	IL12A	PTCRA	CYCS	SOCS1	TICAM1	BID	NOS1	CD4	ACTB	NFKB2	BAX	ABL1	MAPK1	MAPK3	CCND1	IFNG	STAT1	SOS1	CREB1	CXCR4	RAC2	IL10	TLR4	AKT1	PIK3R1	ITGB2	JAK1	CASP3	TLR3	RAC3	BCL2L1	BCL2	TLR5	LAMA2	SRC	HLA-DMA	PYCARD	CXADR	CASP1	SGCA	DAG1	MYH6	NOD2
KE50_Increase_Ca_intracellular_WP254	Apoptosis	TNFRSF21	GZMB	HELLS	BNIP3L	IRF5	IGF1	MYC	MAPK10	TNF	PMAIP1	TRAF1	TNFRSF10B	DFFA	DFFB	IRF1	CASP6	BBC3	APAF1	BIRC3	BIRC5	FAS	FASLG	IRF3	IRF4	IRF7	LTA	MAP3K1	NFKBIB	CYCS	BAK1	BID	TNFRSF1A	TNFRSF1B	TP73	TRAF2	TRAF3	CASP2	CASP7	CASP8	CASP9	CASP10	TRADD	RIPK1	CRADD	FADD	IRF2	PRF1	DIABLO	CASP4	TNFRSF25	HRK	SCAF11	MIR29B1	MIR29A	CDKN2A	CHUK	AKT1	IGF1R	IGF2	IKBKB	JUN	MDM2	NFKB1	NFKBIA	PIK3R1	BAD	BAX	BCL2	RELA	BCL2L1	MAP2K4	TP53	CASP3	IKBKG	TP63	BCL2L11	BIRC2	IRF6	MCL1	BCL2L2	BOK	CASP1	TNFSF10	CFLAR	XIAP	NFKBIE	MIR29B2
KE709_Increase_Cytotoxicity_renal_tubular_cell_WP4864	Host-pathogen interaction of human coronaviruses - apoptosis	TNF	BID	CASP8	BBC3	FASLG	APAF1	CASP9	MAPK13	CASP7	FADD	MAPK12	BAD	BAX	MAPK14	CASP3	BCL2L1	BCL2	MAPK11	AKT1	MCL1	BCL2L11
KE1096_Increased_blood_uric_acid_concentration_WP497	Urea cycle and metabolism of amino groups	OTC	OAT	ARG1	CKM	ODC1	CKB	SRM	CPS1	GATM	SMS	ARG2	ACY1	GAMT	PYCR3	NAGS	SARDH	GLUD1	ASS1	ASL	PYCR1	ALDH18A1
KE1283_Activation_TGF_beta_pathway_WP560	TGF-beta receptor signaling	CTNNB1	EGF	SMAD4	SMAD7	SKIL	BMP4	SPP1	STAT3	TGFB1	TNF	WNT1	ENG	FKBP1A	BAMBI	ITGB6	LTBP1	SMAD5	SMAD9	SKI	TFE3	TGIF1	THBS1	ZFYVE9	CREBBP	LIF	SMAD6	SERPINE1	TGFBR3	FOXH1	NOG	ZEB2	MIR302A	FST	LEFTY1	EP300	ZNF423	FOS	HRAS	IFNG	INHBA	JAK1	JUN	SMAD1	SMAD2	SMAD3	NFKB1	LEF1	MAPK3	MAPK9	STAT1	LEFTY2	TGFBR1	TGFBR2	RUNX2	RUNX3
KE227_Activation_PPAR_WP2878	PPAR-alpha pathway	MYC	SCP2	ACADM	SLC27A1	DBI	CPT2	FABP1	KLK15	CDK1	RXRA	NR1H3	ACAA1	PLTP	CPT1A	CCND1	APOA5	APOC3	EHHADH	APOA1	CDK4	APOA2	CYP7A1	CYP8B1	PPARA	CYP4A11	UGT1A9
KE269_Induction_Sustained_Cell_Proliferation_WP5475	Hallmark of cancer: sustaining proliferative signaling	ULK2	BCL9	KSR1	PYGO1	GAREM2	RETN	PIK3CB	FGFR2	TCF3	ZBTB16	PPARD	PIK3CA	WNT1	MYC	INSR	PIK3CD	MTOR	AKT2	IL6	IL6R	STAT3	CTNNB1	JUP	FLT4	NGFR	TEK	EPHA2	NTRK2	REL	LRP6	GSK3B	FLT1	CSNK1A1	RPTOR	DEPTOR	LRP5	MLST8	AXIN2	AKT1S1	FZD6	FGFR3	FGFR1	RUNX1T1	MAPK1	SOS2	NFKBIA	MAPK3	TSC2	IKBKB	PIK3CG	MET	RHEB	NFKB1	PDGFRB	SOS1	FLT3	CDKN1A	ELK1	MAP2K2	KDR	RARA	RAF1	KRAS	PDGFRA	APC	MDM2	LEF1	IGF1R	PML	TP53	EGFR	FOXO1	KIT	BRAF	SHC1	FGFR4	TSC1	MAP2K1	PTK2	FOS	PTEN	RELA	HRAS	JUN	GRB2	CSF1R	SRC	NTRK1	CHUK	IKBKG	AKT3	AKT1	JAK2	CCND1	SALL4	TELO2	TTI1	NFKBIE
KE1632_Increase_in_reactive_oxygen_and_nitrogen_species_RONS_WP5233	Arsenic metabolism and reactive oxygen species generation	ATP1A1	COA3	AS3MT	VDAC1	SDHA	UQCRFS1	MT-ND1	SOD1	GSTO1	CAT
KE1528_Fatty_Acid_Beta_Oxidation_Decreased_WP143	Fatty acid beta-oxidation	HADHA	HADHB	CRAT	GPD2	LIPE	ACSS2	ACADS	ACADVL	CPT2	ECI1	ACADL	ACADM	PNPLA2	SLC25A20	ECHS1	ACAT1	CPT1A	DECR1	DLD	ACSL1	ACSL3	ACSL4	ACSL6	LIPC	LPL	ACSL5	TPI1	CHKB	CPT1B	GCDH	GK2	HADH	GK	LIPF
KE188_Neuroinflammation_WP4919	Neuroinflammation	ASCC1	MTOR	NOS2	MT-CO1	NFKBIA	MAPK8	MAPK14	TLR4	FOS	RELA	JUN	MT-CO2	CHUK
KE188_Neuroinflammation_WP5485	Post-COVID neuroinflammation	TNF	IL1B	IL4	IL6	HMGB1	CXCL8	CCL11	IL2	FURIN	TMPRSS2	TLR3	IL1A	GFAP	IL12A	IL18	TLR8	TLR7	TLR4	IFNA2	IFNG	IL10	MAPK1	ACE2
KE889_Proteostasis_impaired_WP4918	Cellular proteostasis	PFDN4	PFDN1	PFDN5	PFDN2	VBP1	PFDN6	DNAJB1P1	HSP90AA2P	HSPA7
KE55_Increase_Cell_injury_death_WP2507	Nanomaterial induced apoptosis	CASP6	ENDOG	BID	FAS	BAK1	CASP8	HTRA2	FASLG	APAF1	CASP9	CASP7	FADD	CYCS	AIFM1	PRF1	DIABLO	BAX	CASP3	BCL2	CFLAR
KE111_Agonism_Estrogen_receptor_WP2881	Estrogen receptor pathway	STAT3	NR0B2	ESR1	SP1	PCK1	CYP1B1	CYP1A1	CYP1A2	ACOX1	JUN	PPARA	GPAM	PDK4
KE10_Acetylcholine_accumulation_in_synapses_WP528	Acetylcholine synthesis	PDHA2	ACHE	PDHA1	PEMT	CHAT	CHKA	PCYT1A
KE12_Acetylcholinesterase_AchE_Inhibition_WP1602	Nicotine effect on dopaminergic neurons	CHRNA3	CHRNA4	CHRNA5	CHRNB2	DRD3	DRD4	KCNK3	KCNK9	PPP1R1B	CHRNA6	ADCY2	DRD2	GNAI1	GNB1	GNG2	SLC18A2	PPP1CA	DDC	PRKACA	TH	CDK5
KE79_Inhibition_Cyclooxygenase_activity_WP4719	Eicosanoid metabolism via cyclooxygenases (COX)	TBXA2R	PTGFR	PTGDR	PPARD	PLA2G4A	PLA2G5	PLA2G6	PTGDR2	PTGS2	ACAA1	AKR1B1	ACOX3	PTGR1	PTGDS	EHHADH	PTGR2	ACOX1	CYP4A22	HPGD	ACOX2	CYP4F2	CYP4F12	CYP4A11	PPARG	TBXAS1	PTGS1	PTGIS	PTGES	PRXL2B	PTGIR	PLA2G4B
KE468_Inhibition_PPAR_alpha_WP2878	PPAR-alpha pathway	MYC	SCP2	ACADM	SLC27A1	DBI	CPT2	FABP1	KLK15	CDK1	RXRA	NR1H3	ACAA1	PLTP	CPT1A	CCND1	APOA5	APOC3	EHHADH	APOA1	CDK4	APOA2	CYP7A1	CYP8B1	PPARA	CYP4A11	UGT1A9
KE87_Release_Cytokine_WP530	Cytokines and inflammatory response	IL11	CSF1	CSF2	CSF3	CXCL2	IL1B	IL2	IL4	IL5	IL6	IL12B	IL13	PDGFA	TGFB1	TNF	IL1A	CXCL1	HLA-DRA	IFNB1	IFNG	IL3	IL10	IL15	CD4	HLA-DRB1	IL7
KE28_Reduction_Angiogenesis_WP1539	Angiogenesis	PDGFB	MMP9	FGF2	FGFR2	PIK3CA	FLT1	NOS3	CREBBP	TEK	ANGPT1	TIMP2	MAPK1	TIMP3	PLCG1	AKT1	SMAD1	SRC	MAPK14	HIF1A	KDR	ARNT	VEGFA	PDGFRA	PTK2
KE2336_Increase_SREBF1_WP22	IL9 signaling	IL2RG	PIK3R2	STAT3	STAT5A	STAT5B	JAK3	IL9R	GRB2	JAK1	PIK3R1	MAPK1	MAPK3	MAP2K1	MAP2K2	STAT1	IL9	CDK9
KE2072_Increase_Mitochondrial_swelling_WP5241	Mitochondrial beta-oxidation	ACADL	ECI1	ACAA2	ACADSB	HSD17B10	ECHS1	ACSL3	EHHADH	DECR1
KE654_KE_654_Decreased_testosterone_by_the_fetal_Leydig_cells_Activation_by_other_glucocorticoid_receptor_agonists_WP49	IL2 signaling	NMI	IL2RA	FYN	IL2	IL2RB	IL2RG	MYC	RPS6	RPS6KB1	STAT3	STAT5A	STAT5B	CRKL	PTK2B	JAK3	MAPT	SYK	HRAS	CISH	AKT1	FOXO3	FOS	GRB2	JAK1	JUN	LCK	PIK3R1	MAPK1	MAPK3	MAP2K1	MAP2K2	PTPN11	RAF1	BCL2	RPS6KB2	SHC1	SOS1	STAT1	CBL	CCND2	SOCS3	GAB2
KE25_KE_25_Agonism_Androgen_receptor_WP272	Blood clotting cascade	F7	F9	F3	F13B	SERPINF2	F8	F5	F11	PLG	F10	FGG	FGA	FGB	PLAU	VWF	SERPINE1	F12	KLKB1	KLK1	SERPINB2	PLAT	F2
KE17_KE_17_Altered_gene_expression_AHR_nuclear_translocator_ARNT_dependent_pathway_WP2882	Nuclear receptors meta-pathway	IL11	SLC6A4	EGR1	SLC6A20	SLC6A19	PPP1R14C	SLC6A13	SLC6A7	SLC6A16	SLC6A15	BLVRB	SLC5A4	SLC2A9	PRDX6	SLC5A9	DNAJB1	SLC2A11	SLC2A8	SLC5A6	SLC5A12	SLC2A13	SLC5A10	SLC5A11	CBR3	SLC2A6	CES4A	SLC2A14	SLC6A17	SLC2A7	SLC2A10	SLC5A3	SLC6A14	KEAP1	PSMC5	PRDX1	PTPA	TXN	THBD	NRIP1	CES1	SRXN1	SLC6A2	S100P	SLC6A5	NAV3	EPB41L4B	SMARCA1	SRPX2	SCNN1A	CPEB4	SLC19A2	DNAJC15	SRGN	KTN1	EDN2	SEC14L1	PRRG4	AMIGO2	ABHD2	PLK2	PMP2	ADGRF4	TSC22D3	GPR153	CDC42EP3	ARL5B	DNAJC7	CAVIN2	SERPINB9	ENC1	GCC1	SERTAD2	SPINK13	HGF	HMOX1	PDGFB	TGFB1	CCL2	IL2	PPARD	CAP2	IL12B	NFE2L2	POLK	ABCC4	IL1B	MYC	TGFA	STAT3	SLC2A4	SERPINA1	TNF	SLC5A5	KAT2B	ABCC5	SCP2	RGS2	ACADM	NCOA3	SLC27A1	SLC6A8	NR0B2	SLC6A11	NCOA2	SLC6A3	EPHA2	ACKR3	DBI	SLC6A1	CPT2	FABP1	KLK15	B3GNT5	PDE4B	MAFF	SOD3	SLC5A2	SLC6A18	SLC5A8	BIRC3	ZIC2	CUL1	AHRR	TGFBR3	SMC1A	PTGS2	HSP90AA1	NCOA1	ESR1	GADD45B	SLC7A5	CDC37	AHR	ALDH3A1	PPARGC1A	AIP	PTGES3	HES1	IL17B	SLC6A6	BHLHE40	LRRC8A	MYOF	MFGE8	SLC2A12	IGFBP1	STOM	SLC26A2	NRG1	G6PD	SQSTM1	IL12A	FASN	CDK1	CES3	SP1	RXRA	DNER	SLC6A9	SERPINB2	AGER	HSPA1A	POU5F1	ALAS1	TNS4	FGFBP1	SLC39A4	GCLC	ABCB4	MGST1	NR1H4	SNAI2	ABCC2	GCLM	NR1H3	EPHA3	SLC2A3	ACAA1	ME1	SREBF1	ABCB11	NFKB2	GSTP1	ABCB1	MGST2	FTL	BAX	TGFB2	SCD	GSTT2	GGT1	EP300	PLTP	SLC39A14	GSR	SULT2A1	CYP3A5	PTGR1	ABCC3	CPT1A	CCND1	APOA5	APOC3	CDKN1B	VDR	IFNG	HBEGF	NR3C1	EHHADH	CCL20	SLC2A1	APOA1	TNFAIP3	PCK1	FGF13	CDKN1C	JUND	ALOX5AP	GSTM1	GSTM5	GSTM3	CDK4	BAAT	CYP1B1	ABCG5	CYP2C9	SLC39A8	CYP1A1	CYP1A2	SLC2A5	MGST3	NR1I3	ABCG8	NR1I2	EGFR	FOXO1	SLC7A11	UGT2B4	APOA2	CYP3A4	CYP3A7	ACOX1	FGF19	TGFBR2	SLC2A2	CYP2C19	UGT1A6	CYP7A1	FTH1	GSTM4	GSTA4	JUNB	UGT2B7	GSTA3	GPX2	JUN	CYP8B1	NQO1	GSTA5	IRS2	CYP4F12	PPARA	CYP4A11	SULT1A1	SRC	CYP2B6	TXNRD1	GPX3	GSTM2	UGT1A9	UGT1A1	GSTA1	GSTA2	UGT1A7	UGT1A4	CYP2A6	ARNT	SLC27A5	SLC5A1	SLC10A1	BIRC2	GPAM	SLCO1B1	ETNK2	CBR1	ANGPTL4	MAFG	FKBP5	HSP90AB1	SLCO2B1	ANKRD1	IP6K3	PDK4	FGD4	PGD	CES5A	SPRY1	CES2	TXNRD3	NCOA6	SLC39A9	SLC39A7	SLC5A7	SLC39A11	SLC39A5	SLC39A6	SLC39A3	SLC39A1	SLC39A12	SLC39A2	SLC39A13	AKAP13	ADH7	SLC39A10
KE17_KE_17_Altered_gene_expression_AHR_nuclear_translocator_ARNT_dependent_pathway_WP2289	Drug induction of bile acid pathway	ABCC4	ABCC2	CYP3A4	CYP7A1	ABCB1	BAAT	SULT2A1	VDR	ABCB11	ABCC3	NR1I2	NR1I3	NR1H4	SLCO1B1	SLC51B	SLC51A	SLC10A1
KE25_KE_25_Agonism_Androgen_receptor_WP138	Androgen receptor signaling	PIAS3	PRDX1	PIAS4	ZMIZ1	PIAS2	CTNNB1	TLE5	FHL2	RHOA	SMAD4	PIK3R2	RAC1	ROCK1	BRCA1	STAT3	ROCK2	CDC42	STUB1	CARM1	NCOA2	DSTN	KAT7	PARK7	DAXX	ETV5	FKBP4	PATZ1	ZNF318	SIN3A	PSMC3IP	KLK3	AR	RHOB	LIMK2	BAG1	RAN	RLN1	RNF4	RNF6	EFCAB6	TGFB1I1	TGIF1	NR2C2	UBE2I	SUMO1	CALR	NCOA3	NR0B2	PLPP1	KAT2B	BMF	RNF14	RACK1	CREBBP	KDM1A	SIRT1	GSK3B	HDAC1	RAD9A	SMARCE1	SP1	UBE3A	PIAS1	CAV1	NCOA1	NCOR1	NCOR2	CDKN1A	KAT5	CREB1	EGFR	EP300	AKT1	FOXO1	FLNA	JUN	SMAD3	MDM2	PIK3R1	PAK6	PTEN	PTK2	RB1	CCND1	RELA	SRC	NCOA4	RUNX2	CCNE1
KE25_KE_25_Agonism_Androgen_receptor_WP2263	Androgen receptor network in prostate cancer	SPINK1	ERG	F13B	HSD17B1	HSD17B3	ACTL6A	KLK2	EIF4E1B	HSD3B1	HSD17B2	PIK3CA	SPRY2	ABCC4	HGF	MYC	RAP1A	STAT3	CHEK1	BRCA1	MTOR	MSH2	MRE11	MSH6	PRKDC	ATM	ATR	RAD50	NDRG1	CRKL	PTK2B	KLK3	AR	ATF1	ACTL6B	RASA1	CPN1	PLK1	RICTOR	FOXA1	SMARCC2	SP1	ARID1A	CHEK2	CDK1	CASP9	CASP8	RPTOR	BARD1	ETV4	NOXA1	CDKN1B	MAPK14	CDKN1A	CDKN2B	CDKN2A	CDC25A	MIR21	CRK	CYP17A1	DOCK1	EIF4EBP1	ELK1	FOS	GAB1	GRB2	HRAS	JUN	PAK1	HSD17B7	MAPK1	MAPK3	MAPK8	MAP2K1	MAP2K2	PTEN	PTPN11	PXN	RAF1	SOS1	MMP1	TP53	RB1	BCL2	CDK4	JAK1	CCND1	CDK2	AKT1	STAT1	CASP3	TSC2	SMAD3	MDM2	E2F1	BAX	RHEB	SMAD2	TSC1	BAD	MAP4K1	RAPGEF1	HSD3B2	HSD17B4	RAP1B	BLM	FKBP5	CDC25B	SPRY1	ARID1B	SMARCA4	SMARCC1	SMARCD1	SMARCD2	SMARCD3