# molAOP Builder GMT export
# resource: KE-REACTOME-CENTRIC
# export-revision: e07468f8ed7dbfde
# source-fingerprint: 13:a7a1ca254da13e94630e2051549c6572|reactome_gene_annotations.json:1185374:1785757638122606378
# confidence: minimum high
# generated: 2026-09-05T04:02:42+00:00
# Lines beginning with # are provenance, not gene sets.
KE55	Increase, Cell injury/death	BIRC2	BIRC3	CASP8	CYLD	FADD	IKBKE	MIB2	OPTN	OTUD1	OTUD7B	RBCK1	RIPK1	RNF31	SHARPIN	SPATA2	TBK1	TNF	TNFAIP3	TNFRSF1A	TRADD	TRAF2	UL36	USP2	USP21	USP4	XIAP
KE177	Increase, Mitochondrial dysfunction	ACAD9	BCS1L	CMC1	COA1	COA3	COA5	COQ10A	COQ10B	COX11	COX14	COX15	COX16	COX17	COX18	COX19	COX20	COX4I1	COX4I2	COX5A	COX5B	COX6A1	COX6A2	COX6B1	COX6B2	COX6C	COX7A1	COX7A2	COX7A2L	COX7B	COX7C	COX8A	COX8C	COXFA4	CYC1	CYCS	DMAC1	DMAC2	ECSIT	ETFA	ETFB	ETFDH	FOXRED1	FXN	GOT1	GOT2	HCCS	HIGD1A	HIGD1C	HIGD2A	HSCB	HSPA9	ISCU	LETM1	LYRM2	LYRM4	LYRM7	MDH1	MDH2	MT-CO1	MT-CO2	MT-CO3	MT-CYB	MT-ND1	MT-ND2	MT-ND3	MT-ND4	MT-ND5	MT-ND6	NDUFA1	NDUFA10	NDUFA11	NDUFA12	NDUFA13	NDUFA2	NDUFA3	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA9	NDUFAB1	NDUFAF1	NDUFAF2	NDUFAF3	NDUFAF4	NDUFAF5	NDUFAF6	NDUFAF7	NDUFAF8	NDUFB1	NDUFB10	NDUFB11	NDUFB2	NDUFB3	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB9	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFS4	NDUFS5	NDUFS6	NDUFS7	NDUFS8	NDUFV1	NDUFV2	NDUFV3	NFS1	NUBPL	OXA1L	PET100	PET117	PNKD	PYURF	RAB5IF	SCO1	SCO2	SDHA	SDHB	SDHC	SDHD	SFXN4	SLC25A11	SLC25A12	SLC25A13	SLC25A18	SLC25A22	SMIM20	SURF1	TACO1	TIMM21	TIMMDC1	TMEM126A	TMEM126B	TMEM177	TMEM186	TMEM223	TRAP1	TTC19	UQCC1	UQCC2	UQCC3	UQCC5	UQCC6	UQCR10	UQCR11	UQCRB	UQCRC1	UQCRC2	UQCRFS1	UQCRH	UQCRHL	UQCRQ
KE1097	Occurrence, renal proximal tubular necrosis	BAK1	BAX	BIRC2	BIRC3	CASP1	CASP3	CASP4	CASP5	CASP8	CDC37	CFLAR	CHMP2A	CHMP2B	CHMP3	CHMP4A	CHMP4B	CHMP4C	CHMP6	CHMP7	CYCS	ELANE	FADD	FAS	FASLG	FLOT1	FLOT2	GSDMD	GSDME	GZMB	HMGB1	HSP90AA1	IL18	IL1A	IL1B	IRF1	IRF2	ITCH	MLKL	NS	OGT	PDCD6IP	PELI1	PRKN	RIPK1	RIPK3	RIR1	RPS27A	SDCBP	STUB1	TNFRSF10A	TNFRSF10B	TNFSF10	TP53	TP63	TRADD	TRAF2	UBA52	UBB	UBC	UBE2L3	XIAP
KE1115	Increase, Reactive oxygen species	AQP8	ATOX1	ATP7A	CAT	CCS	CYBA	CYBB	CYCS	ERO1A	GPX1	GPX2	GPX3	GPX5	GPX6	GPX7	GPX8	GSR	GSTP1	NCF1	NCF2	NCF4	NOX4	NOX5	NUDT2	P4HB	PRDX1	PRDX2	PRDX3	PRDX5	PRDX6	SOD1	SOD2	SOD3	TXN	TXN2	TXNRD1	TXNRD2
KE1194	Increase, DNA damage	ABL1	ABRAXAS1	ACD	ACTB	ACTL6A	ACTR5	ACTR8	ADPRS	ADRM1	ALKBH2	ALKBH3	ALKBH5	APBB1	APEX1	AQR	ASCC1	ASCC2	ASCC3	ATM	ATR	ATRIP	BABAM1	BABAM2	BAP1	BARD1	BAZ1B	BLM	BRCA1	BRCA2	BRCC3	BRIP1	CCNA1	CCNA2	CCNH	CDK2	CDK7	CENPS	CENPX	CETN2	CHD1L	CHEK1	CHEK2	CLSPN	COPS2	COPS3	COPS4	COPS5	COPS6	COPS7A	COPS7B	COPS8	CUL4A	CUL4B	DCAF8L1	DCAF8L2	DCLRE1A	DCLRE1B	DCLRE1C	DDB1	DDB2	DNA2	DTL	ELL	EME1	EME2	ERCC1	ERCC2	ERCC3	ERCC4	ERCC5	ERCC6	ERCC8	EXO1	EYA1	EYA2	EYA3	EYA4	FAAP100	FAAP20	FAAP24	FAN1	FANCA	FANCB	FANCC	FANCD2	FANCE	FANCF	FANCG	FANCI	FANCL	FANCM	FEN1	FIGNL1	FIRRM	FTO	GEN1	GPS1	GTF2H1	GTF2H2	GTF2H3	GTF2H4	GTF2H5	H2AB1	H2AC14	H2AC18	H2AC20	H2AC4	H2AC6	H2AC7	H2AJ	H2AX	H2AZ2	H2BC1	H2BC11	H2BC12	H2BC12L	H2BC13	H2BC14	H2BC15	H2BC17	H2BC21	H2BC26	H2BC3	H2BC4	H2BC5	H2BC9	H3-4	H4C1	HERC2	HUS1	INO80	INO80B	INO80C	INO80D	INO80E	ISG15	ISY1	KAT5	KDM4A	KDM4B	KPNA2	LIG1	LIG3	LIG4	MAD2L2	MAPK8	MBD4	MCRS1	MDC1	MGMT	MLH1	MNAT1	MPG	MRE11	MSH2	MSH3	MSH6	MUS81	MUTYH	NBN	NEIL1	NEIL2	NEIL3	NFRKB	NHEJ1	NPLOC4	NSD2	NTHL1	OGG1	PALB2	PARG	PARP1	PARP2	PAXIP1	PCLAF	PCNA	PHF6	PIAS1	PIAS3	PIAS4	PMS2	PNKP	POLB	POLD1	POLD2	POLD3	POLD4	POLE	POLE2	POLE3	POLE4	POLH	POLI	POLK	POLL	POLM	POLN	POLQ	POLR2A	POLR2B	POLR2C	POLR2D	POLR2E	POLR2F	POLR2G	POLR2H	POLR2I	POLR2J	POLR2K	POLR2L	POT1	PPIE	PPP4C	PPP4R2	PPP5C	PRKDC	PRPF19	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD11	PSMD12	PSMD13	PSMD14	PSMD2	PSMD3	PSMD6	PSMD7	PSMD8	RAD1	RAD17	RAD18	RAD23A	RAD23B	RAD50	RAD51	RAD51AP1	RAD51B	RAD51C	RAD51D	RAD52	RAD9A	RAD9B	RBBP8	RBX1	RCHY1	REV1	REV3L	RFC1	RFC2	RFC3	RFC4	RFC5	RHNO1	RIF1	RMI1	RMI2	RNF111	RNF168	RNF4	RNF8	RPA1	RPA2	RPA3	RPS27A	RTEL1	RUVBL1	SEM1	SIRT6	SLX1A	SLX4	SMARCA5	SMUG1	SPIDR	SPRTN	SUMO1	SUMO2	SUMO3	TCEA1	TDG	TDP1	TDP2	TERF1	TERF2	TERF2IP	TFPT	TIMELESS	TINF2	TIPIN	TOP3A	TOPBP1	TP53	TP53BP1	TRIM25	UBA52	UBA7	UBB	UBC	UBE2B	UBE2I	UBE2L6	UBE2N	UBE2T	UBE2V2	UBXN1	UFD1	UIMC1	UNG	USP1	USP10	USP43	USP45	USP7	UVSSA	VCP	WDR48	WRN	XAB2	XPA	XPC	XRCC1	XRCC2	XRCC3	XRCC4	XRCC5	XRCC6	YY1	ZNF830
KE1287	Glutathione synthesis	CHAC1	CHAC2	CNDP2	GCLC	GCLM	GGCT	GGT1	GGT3P	GGT5	GGT6	GGT7	GSS	OPLAH
KE1392	Oxidative Stress	ATF4	BACH1	CHD6	CREBBP	EP300	GCLC	GCLM	GSR	GSTA1	GSTA3	HMOX1	MAFK	NFE2L2	NQO1	PRDX1	SLC7A11	SOD3	SRXN1	TXN	TXNRD1