# molAOP Builder GMT export
# resource: KE-REACTOME-CENTRIC
# export-revision: e07468f8ed7dbfde
# source-fingerprint: 13:a7a1ca254da13e94630e2051549c6572|reactome_gene_annotations.json:1185374:1785757638122606378
# confidence: all tiers
# generated: 2026-09-05T04:01:50+00:00
# Lines beginning with # are provenance, not gene sets.
KE55	Increase, Cell injury/death	APPL1	CASP3	CASP8	CASP9	CD14	CFLAR	DAPK1	DAPK2	DAPK3	DCC	FADD	FAS	FASLG	LY96	MAGED1	MC159L	ORF71	RIPK1	TICAM1	TICAM2	TLR4	TNFRSF10A	TNFRSF10B	TNFSF10	TRADD	TRAF2	UNC5A	UNC5B	BIRC2	BIRC3	CYLD	IKBKE	MIB2	OPTN	OTUD1	OTUD7B	RBCK1	RNF31	SHARPIN	SPATA2	TBK1	TNF	TNFAIP3	TNFRSF1A	UL36	USP2	USP21	USP4	XIAP
KE149	Increase, Inflammation	8	ADRM1	AGER	AIP	AKT1	ALOX15	ALOX5	ALPK1	ANXA1	ANXA2	APP	ARF1	ATF1	ATF2	BATF	BCL2	BCL2L1	BCL6	BIRC5	BLNK	BOLA2	BRWD1	BTRC	CA1	CANX	CAPZA1	CASP1	CASP3	CASP8	CBL	CCL11	CCL19	CCL2	CCL20	CCL22	CCL3	CCL3L1	CCL4	CCL5	CCND1	CCR1	CCR2	CCR5	CD36	CD4	CD80	CD86	CDC42	CDKN1A	CEBPD	CFL1	CHUK	CISH	CLCF1	CNN2	CNTF	CNTFR	COL1A2	CREB1	CRK	CRKL	CRLF1	CRLF2	CSF1	CSF1R	CSF2	CSF2RA	CSF2RB	CSF3	CSF3R	CTF1	CTSG	CUL1	CXCL1	CXCL10	CXCL2	CXCL8	DUSP3	DUSP4	DUSP6	DUSP7	EBI3	ELK1	F13A1	FASLG	FBXW11	FCER2	FGF2	FN1	FOS	FOXO1	FOXO3	FPR1	FSCN1	FYN	GAB2	GATA3	GRB2	GSDMD	GSTA2	GSTO1	H3C1	H3C15	HAVCR2	HCK	HGF	HIF1A	HMGB1	HMOX1	HNRNPA2B1	HNRNPDL	HNRNPF	HSP90AA1	HSP90B1	HSPA8	HSPA9	ICAM1	IFNG	IFNL1	IFNL2	IFNL3	IFNLR1	IGHE	IGHG1	IGHG4	IKBIP	IKBKB	IKBKG	IL10	IL10RA	IL10RB	IL11	IL11RA	IL12A	IL12B	IL12RB1	IL12RB2	IL13	IL13RA1	IL13RA2	IL15	IL15RA	IL16	IL17A	IL17C	IL17F	IL17RA	IL17RB	IL17RC	IL17RE	IL18	IL18BP	IL18R1	IL18RAP	IL19	IL1A	IL1B	IL1F10	IL1R1	IL1R2	IL1RAP	IL1RAPL1	IL1RL1	IL1RL2	IL1RN	IL2	IL20	IL20RA	IL20RB	IL21	IL21R	IL22	IL22RA1	IL22RA2	IL23A	IL23R	IL24	IL25	IL26	IL27	IL27RA	IL2RA	IL2RB	IL2RG	IL3	IL31	IL31RA	IL32	IL33	IL34	IL36A	IL36B	IL36G	IL36RN	IL37	IL3RA	IL4	IL4R	IL5	IL5RA	IL6	IL6R	IL6ST	IL7	IL7R	IL9	IL9R	INPP5D	INPPL1	IRAK1	IRAK2	IRAK3	IRAK4	IRF4	IRS1	IRS2	ITGAM	ITGAX	ITGB1	ITGB2	JAK1	JAK2	JAK3	JUN	JUNB	LAMA5	LBP	LCK	LCN2	LCP1	LGALS9	LIF	LIFR	LMNB1	LRRC14	LYN	MAOA	MAP2K1	MAP2K3	MAP2K4	MAP2K6	MAP2K7	MAP3K3	MAP3K7	MAP3K8	MAPK1	MAPK10	MAPK11	MAPK14	MAPK3	MAPK7	MAPK8	MAPK9	MAPKAPK2	MAPKAPK3	MCL1	MEF2A	MEF2C	MIF	MMP1	MMP2	MMP3	MMP9	MSN	MTAP	MUC1	MYC	MYD88	N	N4BP1	NANOG	NDN	NFKB1	NFKB2	NFKBIA	NFKBIB	NKIRAS1	NKIRAS2	NLRC5	NLRX1	NOD1	NOD2	NOS2	OPRD1	OPRM1	OSM	OSMR	P4HB	PAK2	PDCD4	PELI1	PELI2	PELI3	PIK3CA	PIK3CB	PIK3CD	PIK3R1	PIK3R2	PIK3R3	PIM1	PITPNA	POMC	POU2F1	PPIA	PPP2CA	PPP2CB	PPP2R1A	PPP2R1B	PPP2R5D	PRKACA	PRTN3	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD11	PSMD12	PSMD13	PSMD14	PSMD2	PSMD3	PSMD6	PSMD7	PSMD8	PSME2	PTAFR	PTGS2	PTK2B	PTPN11	PTPN12	PTPN13	PTPN14	PTPN18	PTPN2	PTPN20	PTPN23	PTPN4	PTPN5	PTPN6	PTPN7	PTPN9	PTPRZ1	RAG1	RAG2	RALA	RAP1B	RAPGEF1	RBX1	RELA	RHOU	RIPK2	RORA	RORC	RPLP0	RPS27A	RPS6KA1	RPS6KA2	RPS6KA3	RPS6KA5	S100A12	S100B	S1PR1	SAA1	SDC1	SEM1	SERPINB2	SHC1	SIGIRR	SKP1	SMAD3	SMARCA4	SNAP25	SNRPA1	SOCS1	SOCS2	SOCS3	SOCS5	SOD1	SOD2	SOS1	SOS2	SOX2	SQSTM1	STAT1	STAT2	STAT3	STAT4	STAT5A	STAT5B	STAT6	STX1A	STX3	STX4	STXBP2	SYK	TAB1	TAB2	TAB3	TALDO1	TBK1	TCP1	TEC	TGFB1	TIFA	TIMP1	TNF	TNFRSF1A	TNFRSF1B	TNIP2	TOLLIP	TP53	TRAF2	TRAF6	TSLP	TWIST1	TXLNA	TYK2	UBA52	UBB	UBC	UBE2N	UBE2V1	USP14	USP18	VAMP2	VAMP7	VAV1	VCAM1	VEGFA	VIM	VRK3	YES1	YWHAZ	ZEB1	AIM2	HSP90AB1	MEFV	NLRC4	NLRP1	NLRP3	P2RX7	PANX1	PSTPIP1	PYCARD	SUGT1	TXN	TXNIP	fliC	fljB	hly	prgJ
KE177	Increase, Mitochondrial dysfunction	ACAD9	BCS1L	CMC1	COA1	COA3	COA5	COQ10A	COQ10B	COX11	COX14	COX15	COX16	COX17	COX18	COX19	COX20	COX4I1	COX4I2	COX5A	COX5B	COX6A1	COX6A2	COX6B1	COX6B2	COX6C	COX7A1	COX7A2	COX7A2L	COX7B	COX7C	COX8A	COX8C	COXFA4	CYC1	CYCS	DMAC1	DMAC2	ECSIT	ETFA	ETFB	ETFDH	FOXRED1	FXN	GOT1	GOT2	HCCS	HIGD1A	HIGD1C	HIGD2A	HSCB	HSPA9	ISCU	LETM1	LYRM2	LYRM4	LYRM7	MDH1	MDH2	MT-CO1	MT-CO2	MT-CO3	MT-CYB	MT-ND1	MT-ND2	MT-ND3	MT-ND4	MT-ND5	MT-ND6	NDUFA1	NDUFA10	NDUFA11	NDUFA12	NDUFA13	NDUFA2	NDUFA3	NDUFA5	NDUFA6	NDUFA7	NDUFA8	NDUFA9	NDUFAB1	NDUFAF1	NDUFAF2	NDUFAF3	NDUFAF4	NDUFAF5	NDUFAF6	NDUFAF7	NDUFAF8	NDUFB1	NDUFB10	NDUFB11	NDUFB2	NDUFB3	NDUFB4	NDUFB5	NDUFB6	NDUFB7	NDUFB8	NDUFB9	NDUFC1	NDUFC2	NDUFS1	NDUFS2	NDUFS3	NDUFS4	NDUFS5	NDUFS6	NDUFS7	NDUFS8	NDUFV1	NDUFV2	NDUFV3	NFS1	NUBPL	OXA1L	PET100	PET117	PNKD	PYURF	RAB5IF	SCO1	SCO2	SDHA	SDHB	SDHC	SDHD	SFXN4	SLC25A11	SLC25A12	SLC25A13	SLC25A18	SLC25A22	SMIM20	SURF1	TACO1	TIMM21	TIMMDC1	TMEM126A	TMEM126B	TMEM177	TMEM186	TMEM223	TRAP1	TTC19	UQCC1	UQCC2	UQCC3	UQCC5	UQCC6	UQCR10	UQCR11	UQCRB	UQCRC1	UQCRC2	UQCRFS1	UQCRH	UQCRHL	UQCRQ	DLAT	DLD	GSTZ1	PDHA1	PDHA2	PDHB	PDHX	PDK1	PDK2	PDK3	PDK4	PDP1	PDP2	PDPR	SIRT4
KE1097	Occurrence, renal proximal tubular necrosis	BAK1	BAX	BIRC2	BIRC3	CASP1	CASP3	CASP4	CASP5	CASP8	CDC37	CFLAR	CHMP2A	CHMP2B	CHMP3	CHMP4A	CHMP4B	CHMP4C	CHMP6	CHMP7	CYCS	ELANE	FADD	FAS	FASLG	FLOT1	FLOT2	GSDMD	GSDME	GZMB	HMGB1	HSP90AA1	IL18	IL1A	IL1B	IRF1	IRF2	ITCH	MLKL	NS	OGT	PDCD6IP	PELI1	PRKN	RIPK1	RIPK3	RIR1	RPS27A	SDCBP	STUB1	TNFRSF10A	TNFRSF10B	TNFSF10	TP53	TP63	TRADD	TRAF2	UBA52	UBB	UBC	UBE2L3	XIAP
KE1115	Increase, Reactive oxygen species	AQP8	ATOX1	ATP7A	CAT	CCS	CYBA	CYBB	CYCS	ERO1A	GPX1	GPX2	GPX3	GPX5	GPX6	GPX7	GPX8	GSR	GSTP1	NCF1	NCF2	NCF4	NOX4	NOX5	NUDT2	P4HB	PRDX1	PRDX2	PRDX3	PRDX5	PRDX6	SOD1	SOD2	SOD3	TXN	TXN2	TXNRD1	TXNRD2
KE1194	Increase, DNA damage	ABL1	ABRAXAS1	ACD	ACTB	ACTL6A	ACTR5	ACTR8	ADPRS	ADRM1	ALKBH2	ALKBH3	ALKBH5	APBB1	APEX1	AQR	ASCC1	ASCC2	ASCC3	ATM	ATR	ATRIP	BABAM1	BABAM2	BAP1	BARD1	BAZ1B	BLM	BRCA1	BRCA2	BRCC3	BRIP1	CCNA1	CCNA2	CCNH	CDK2	CDK7	CENPS	CENPX	CETN2	CHD1L	CHEK1	CHEK2	CLSPN	COPS2	COPS3	COPS4	COPS5	COPS6	COPS7A	COPS7B	COPS8	CUL4A	CUL4B	DCAF8L1	DCAF8L2	DCLRE1A	DCLRE1B	DCLRE1C	DDB1	DDB2	DNA2	DTL	ELL	EME1	EME2	ERCC1	ERCC2	ERCC3	ERCC4	ERCC5	ERCC6	ERCC8	EXO1	EYA1	EYA2	EYA3	EYA4	FAAP100	FAAP20	FAAP24	FAN1	FANCA	FANCB	FANCC	FANCD2	FANCE	FANCF	FANCG	FANCI	FANCL	FANCM	FEN1	FIGNL1	FIRRM	FTO	GEN1	GPS1	GTF2H1	GTF2H2	GTF2H3	GTF2H4	GTF2H5	H2AB1	H2AC14	H2AC18	H2AC20	H2AC4	H2AC6	H2AC7	H2AJ	H2AX	H2AZ2	H2BC1	H2BC11	H2BC12	H2BC12L	H2BC13	H2BC14	H2BC15	H2BC17	H2BC21	H2BC26	H2BC3	H2BC4	H2BC5	H2BC9	H3-4	H4C1	HERC2	HUS1	INO80	INO80B	INO80C	INO80D	INO80E	ISG15	ISY1	KAT5	KDM4A	KDM4B	KPNA2	LIG1	LIG3	LIG4	MAD2L2	MAPK8	MBD4	MCRS1	MDC1	MGMT	MLH1	MNAT1	MPG	MRE11	MSH2	MSH3	MSH6	MUS81	MUTYH	NBN	NEIL1	NEIL2	NEIL3	NFRKB	NHEJ1	NPLOC4	NSD2	NTHL1	OGG1	PALB2	PARG	PARP1	PARP2	PAXIP1	PCLAF	PCNA	PHF6	PIAS1	PIAS3	PIAS4	PMS2	PNKP	POLB	POLD1	POLD2	POLD3	POLD4	POLE	POLE2	POLE3	POLE4	POLH	POLI	POLK	POLL	POLM	POLN	POLQ	POLR2A	POLR2B	POLR2C	POLR2D	POLR2E	POLR2F	POLR2G	POLR2H	POLR2I	POLR2J	POLR2K	POLR2L	POT1	PPIE	PPP4C	PPP4R2	PPP5C	PRKDC	PRPF19	PSMA1	PSMA2	PSMA3	PSMA4	PSMA5	PSMA6	PSMA7	PSMB1	PSMB2	PSMB3	PSMB4	PSMB5	PSMB6	PSMB7	PSMC1	PSMC2	PSMC3	PSMC4	PSMC5	PSMC6	PSMD1	PSMD11	PSMD12	PSMD13	PSMD14	PSMD2	PSMD3	PSMD6	PSMD7	PSMD8	RAD1	RAD17	RAD18	RAD23A	RAD23B	RAD50	RAD51	RAD51AP1	RAD51B	RAD51C	RAD51D	RAD52	RAD9A	RAD9B	RBBP8	RBX1	RCHY1	REV1	REV3L	RFC1	RFC2	RFC3	RFC4	RFC5	RHNO1	RIF1	RMI1	RMI2	RNF111	RNF168	RNF4	RNF8	RPA1	RPA2	RPA3	RPS27A	RTEL1	RUVBL1	SEM1	SIRT6	SLX1A	SLX4	SMARCA5	SMUG1	SPIDR	SPRTN	SUMO1	SUMO2	SUMO3	TCEA1	TDG	TDP1	TDP2	TERF1	TERF2	TERF2IP	TFPT	TIMELESS	TINF2	TIPIN	TOP3A	TOPBP1	TP53	TP53BP1	TRIM25	UBA52	UBA7	UBB	UBC	UBE2B	UBE2I	UBE2L6	UBE2N	UBE2T	UBE2V2	UBXN1	UFD1	UIMC1	UNG	USP1	USP10	USP43	USP45	USP7	UVSSA	VCP	WDR48	WRN	XAB2	XPA	XPC	XRCC1	XRCC2	XRCC3	XRCC4	XRCC5	XRCC6	YY1	ZNF830
KE1287	Glutathione synthesis	CHAC1	CHAC2	CNDP2	GCLC	GCLM	GGCT	GGT1	GGT3P	GGT5	GGT6	GGT7	GSS	OPLAH
KE1392	Oxidative Stress	ATF4	BACH1	CHD6	CREBBP	EP300	GCLC	GCLM	GSR	GSTA1	GSTA3	HMOX1	MAFK	NFE2L2	NQO1	PRDX1	SLC7A11	SOD3	SRXN1	TXN	TXNRD1
KE1825	Increase, Cell death	AIFM2	APAF1	ATM	BAX	BBC3	BCL2L14	BCL6	BID	BIRC5	BNIP3L	CASP1	CASP10	CASP2	CASP6	CHM	CRADD	CREBBP	FAS	IGFBP3	NDRG1	NLRC4	PERP	PIDD1	PMAIP1	PPP1R13B	PRELID1	PRELID3A	RABGGTA	RABGGTB	STEAP3	TMEM219	TNFRSF10A	TNFRSF10B	TNFRSF10C	TNFRSF10D	TP53	TP53AIP1	TP53BP2	TP53I3	TP53INP1	TP63	TP73	TRIAP1	ZNF420