{"data":[{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":3,"go_definition":"Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity.","go_depth":4,"go_direction":null,"go_ic":0.86,"go_namespace":"biological_process","go_term_id":"GO:2000310","go_term_name":"regulation of NMDA receptor activity","ke_aop_context":["AOP 12","AOP 13","AOP 522"],"ke_bio_level":"Molecular","ke_id":"KE 195","ke_name":"Inhibition, NMDARs","provenance":{"approved_at":"2026-08-15T12:03:34.590250","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":3.0},"specificity_score":3,"uuid":"79019b1e-03b8-4508-9a55-d0bd2adf7003"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":3,"go_definition":"The directed movement of calcium ions into a cell or organelle.","go_depth":8,"go_direction":null,"go_ic":0.63,"go_namespace":"biological_process","go_term_id":"GO:0070509","go_term_name":"calcium ion import","ke_aop_context":["AOP 12","AOP 13"],"ke_bio_level":"Cellular","ke_id":"KE 52","ke_name":"Decreased, Calcium influx","provenance":{"approved_at":"2026-08-15T12:03:28.384509","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":3.0},"specificity_score":3,"uuid":"689b93ea-31a1-44ce-8d8c-e58378b651fc"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":3,"go_definition":"The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.","go_depth":2,"go_direction":null,"go_ic":0.93,"go_namespace":"biological_process","go_term_id":"GO:0032898","go_term_name":"neurotrophin production","ke_aop_context":["AOP 12","AOP 13","AOP 375","AOP 54","AOP 610"],"ke_bio_level":"Molecular","ke_id":"KE 381","ke_name":"Reduced levels of BDNF","provenance":{"approved_at":"2026-08-15T12:03:22.541049","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.67},"specificity_score":2,"uuid":"97c82084-1137-476c-b0b1-6673bc5faa27"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":3,"go_definition":"The process in which the anatomical structures of a dendrite are generated and organized.","go_depth":4,"go_direction":null,"go_ic":0.61,"go_namespace":"biological_process","go_term_id":"GO:0048813","go_term_name":"dendrite morphogenesis","ke_aop_context":["AOP 13"],"ke_bio_level":"Cellular","ke_id":"KE 382","ke_name":"Aberrant, Dendritic morphology","provenance":{"approved_at":"2026-08-15T12:03:16.746980","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":3.0},"specificity_score":3,"uuid":"35b5a44d-9f09-4029-bb96-bb4878c5a992"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":3,"go_definition":"The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter.","go_depth":5,"go_direction":null,"go_ic":1.0,"go_namespace":"biological_process","go_term_id":"GO:0061535","go_term_name":"glutamate secretion, neurotransmission","ke_aop_context":["AOP 13"],"ke_bio_level":"Molecular","ke_id":"KE 383","ke_name":"Reduced, Presynaptic release of glutamate","provenance":{"approved_at":"2026-08-15T12:03:12.365882","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":3.0},"specificity_score":3,"uuid":"4a94d13a-15a6-40a0-89f0-14e815cfce5d"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":3,"go_definition":"The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).","go_depth":5,"go_direction":null,"go_ic":0.51,"go_namespace":"biological_process","go_term_id":"GO:0007416","go_term_name":"synapse assembly","ke_aop_context":["AOP 13","AOP 533","AOP 54","AOP 610"],"ke_bio_level":"Cellular","ke_id":"KE 385","ke_name":"Decrease of synaptogenesis","provenance":{"approved_at":"2026-08-15T12:03:07.634311","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":3.0},"specificity_score":3,"uuid":"918436f3-3c21-4334-b501-f5bdd6fe60d3"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.","go_depth":7,"go_direction":null,"go_ic":0.39,"go_namespace":"biological_process","go_term_id":"GO:0007268","go_term_name":"chemical synaptic transmission","ke_aop_context":["AOP 13","AOP 17","AOP 405","AOP 429","AOP 475","AOP 501","AOP 522","AOP 533","AOP 54","AOP 610","AOP 636","AOP 78","AOP 90"],"ke_bio_level":"Organ","ke_id":"KE 386","ke_name":"Decrease of neuronal network function","provenance":{"approved_at":"2026-08-15T12:03:04.055037","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"5f888c18-1edc-41d1-838d-20251168a9b3"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":3,"go_definition":"The acquisition and processing of information and/or the storage and retrieval of this information over time.","go_depth":3,"go_direction":null,"go_ic":0.47,"go_namespace":"biological_process","go_term_id":"GO:0007611","go_term_name":"learning or memory","ke_aop_context":["AOP 12","AOP 13","AOP 17","AOP 475","AOP 48","AOP 483","AOP 490","AOP 499","AOP 500","AOP 520","AOP 525","AOP 533","AOP 535","AOP 54","AOP 610","AOP 77","AOP 78","AOP 87","AOP 88","AOP 89","AOP 90","AOP 99"],"ke_bio_level":"Individual","ke_id":"KE 341","ke_name":"Impairment, Learning and memory","provenance":{"approved_at":"2026-08-15T12:02:56.990914","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":3.0},"specificity_score":3,"uuid":"6ec5170e-cbdf-4929-8686-085d9d3c8b19"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":3,"go_definition":"Any process that modulates the frequency, rate or extent of fatty acid transport.","go_depth":6,"go_direction":null,"go_ic":0.67,"go_namespace":"biological_process","go_term_id":"GO:2000191","go_term_name":"regulation of fatty acid transport","ke_aop_context":["AOP 34","AOP 517"],"ke_bio_level":"Cellular","ke_id":"KE 115","ke_name":"Increase, FA Influx","provenance":{"approved_at":"2026-07-29T16:54:19.560035","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.67},"specificity_score":2,"uuid":"ffe9ace7-6ab3-4e80-9345-d2198af48ab2"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"context","evidence_score":2,"go_definition":"A nuclear receptor-mediated signaling pathway initiated by a ligand binding to an intracellular peroxisome proliferator activated receptor (alpha, beta or gamma) of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.","go_depth":6,"go_direction":null,"go_ic":0.78,"go_namespace":"biological_process","go_term_id":"GO:0035357","go_term_name":"peroxisome proliferator activated receptor signaling pathway","ke_aop_context":["AOP 34","AOP 510","AOP 58","AOP 72"],"ke_bio_level":"Molecular","ke_id":"KE 228","ke_name":"peroxisome proliferator activated receptor promoter demethylation","provenance":{"approved_at":"2026-07-29T16:54:09.257778","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"b46ec6d6-4bd8-4a11-bda6-b0fdd16bc3f0"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"related","evidence_score":2,"go_definition":"The disaggregation of an organelle into its constituent components.","go_depth":5,"go_direction":null,"go_ic":0.56,"go_namespace":"biological_process","go_term_id":"GO:1903008","go_term_name":"organelle disassembly","ke_aop_context":["AOP 144","AOP 257","AOP 530"],"ke_bio_level":"Cellular","ke_id":"KE 898","ke_name":"Disruption, Lysosome","provenance":{"approved_at":"2026-07-29T16:53:51.071104","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"c5ed4c20-bd3f-4fee-8b1b-290a823cf9c1"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.","go_depth":4,"go_direction":null,"go_ic":0.73,"go_namespace":"biological_process","go_term_id":"GO:1903409","go_term_name":"reactive oxygen species biosynthetic process","ke_aop_context":["AOP 186","AOP 207","AOP 213","AOP 26","AOP 27","AOP 273","AOP 282","AOP 298","AOP 299","AOP 303","AOP 311","AOP 319","AOP 324","AOP 325","AOP 326","AOP 327","AOP 328","AOP 329","AOP 330","AOP 331","AOP 332","AOP 333","AOP 382","AOP 383","AOP 384","AOP 386","AOP 387","AOP 396","AOP 409","AOP 413","AOP 416","AOP 418","AOP 423","AOP 451","AOP 462","AOP 472","AOP 476","AOP 481","AOP 488","AOP 492","AOP 497","AOP 500","AOP 505","AOP 511","AOP 513","AOP 521","AOP 534","AOP 540","AOP 569","AOP 595","AOP 596","AOP 598","AOP 599","AOP 600","AOP 601","AOP 602","AOP 603","AOP 608","AOP 613","AOP 622","AOP 636","AOP 638"],"ke_bio_level":"Cellular","ke_id":"KE 1115","ke_name":"Increase, Reactive oxygen species","provenance":{"approved_at":"2026-07-29T16:53:40.991621","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"d86c21e0-d05e-4ba8-ab75-30b458ea68f7"},{"assessment_version":"v2","confidence_level":"medium","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.","go_depth":3,"go_direction":null,"go_ic":0.47,"go_namespace":"biological_process","go_term_id":"GO:0002263","go_term_name":"cell activation involved in immune response","ke_aop_context":["AOP 17","AOP 293","AOP 294","AOP 38","AOP 483"],"ke_bio_level":"Cellular","ke_id":"KE 1492","ke_name":"Tissue resident cell activation","provenance":{"approved_at":"2026-07-29T16:53:36.100373","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":2,"uuid":"19c6b67a-536d-472d-ab8d-2f286480ad6a"},{"assessment_version":"v2","confidence_level":"medium","connection_score":3,"connection_type":"involves","evidence_score":2,"go_definition":"Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.","go_depth":5,"go_direction":null,"go_ic":0.57,"go_namespace":"biological_process","go_term_id":"GO:0002526","go_term_name":"acute inflammatory response","ke_aop_context":["AOP 144","AOP 17","AOP 293","AOP 294","AOP 377","AOP 38","AOP 432","AOP 470"],"ke_bio_level":"Tissue","ke_id":"KE 1493","ke_name":"Increased Pro-inflammatory mediators","provenance":{"approved_at":"2026-07-29T16:53:32.718374","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":2,"uuid":"6e435b7b-792d-468f-949e-e8fefe45039a"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission.","go_depth":5,"go_direction":null,"go_ic":0.93,"go_namespace":"biological_process","go_term_id":"GO:0001507","go_term_name":"acetylcholine catabolic process in synaptic cleft","ke_aop_context":["AOP 16","AOP 281","AOP 312","AOP 405","AOP 471"],"ke_bio_level":"Cellular","ke_id":"KE 10","ke_name":"Acetylcholine accumulation in synapses","provenance":{"approved_at":"2026-07-28T16:53:53.860638","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":3,"uuid":"cfe11aee-fb2f-4746-8438-896aeb4f4860"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The regulated release of acetylcholine by a cell.","go_depth":5,"go_direction":null,"go_ic":1.0,"go_namespace":"biological_process","go_term_id":"GO:0061526","go_term_name":"acetylcholine secretion","ke_aop_context":["AOP 16","AOP 281","AOP 312","AOP 405","AOP 471"],"ke_bio_level":"Cellular","ke_id":"KE 10","ke_name":"Acetylcholine accumulation in synapses","provenance":{"approved_at":"2026-07-28T16:53:51.164255","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":3,"uuid":"a91448ea-1d81-45a2-b1a9-1e7db439fe67"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell.","go_depth":5,"go_direction":null,"go_ic":0.47,"go_namespace":"biological_process","go_term_id":"GO:0006874","go_term_name":"intracellular calcium ion homeostasis","ke_aop_context":["AOP 26"],"ke_bio_level":"Cellular","ke_id":"KE 50","ke_name":"Increase, Ca++ (intracellular)","provenance":{"approved_at":"2026-07-28T16:53:47.336149","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"853db91b-fbea-4436-9824-f3a82ee9e347"},{"assessment_version":"v2","confidence_level":"medium","connection_score":1,"connection_type":"context","evidence_score":1,"go_definition":"The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.","go_depth":6,"go_direction":null,"go_ic":0.82,"go_namespace":"biological_process","go_term_id":"GO:0032782","go_term_name":"bile acid secretion","ke_aop_context":["AOP 27"],"ke_bio_level":"Individual","ke_id":"KE 357","ke_name":"Cholestasis, Pathology","provenance":{"approved_at":"2026-07-28T16:53:59.765165","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.33},"specificity_score":2,"uuid":"e7112f59-f8a3-4df7-8c25-94819aada8c2"},{"assessment_version":"v2","confidence_level":"medium","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.","go_depth":3,"go_direction":null,"go_ic":0.5,"go_namespace":"biological_process","go_term_id":"GO:0006805","go_term_name":"xenobiotic metabolic process","ke_aop_context":["AOP 220","AOP 450"],"ke_bio_level":"Molecular","ke_id":"KE 1391","ke_name":"Activation of Cyp2E1","provenance":{"approved_at":"2026-07-28T16:53:18.955016","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":1,"uuid":"8c8989b3-a886-4f75-9c2c-e89ae26ff406"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.","go_depth":5,"go_direction":null,"go_ic":0.53,"go_namespace":"biological_process","go_term_id":"GO:0022904","go_term_name":"respiratory electron transport chain","ke_aop_context":["AOP 437","AOP 447","AOP 479","AOP 480"],"ke_bio_level":"Molecular","ke_id":"KE 105","ke_name":"Inhibition, Mitochondrial Electron Transport Chain Complexes","provenance":{"approved_at":"2026-07-28T16:53:07.053784","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"71cec9d2-c49e-40c4-8729-4254219abddd"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.","go_depth":5,"go_direction":null,"go_ic":0.53,"go_namespace":"biological_process","go_term_id":"GO:0022904","go_term_name":"respiratory electron transport chain","ke_aop_context":["AOP 26","AOP 284","AOP 564","AOP 590"],"ke_bio_level":"Cellular","ke_id":"KE 178","ke_name":"Mitochondrial electron transport chain, disrupted","provenance":{"approved_at":"2026-07-28T16:53:12.634016","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":2,"uuid":"71e97c6f-eb82-4368-b950-1145544dc2d1"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.","go_depth":4,"go_direction":null,"go_ic":0.67,"go_namespace":"biological_process","go_term_id":"GO:0046209","go_term_name":"nitric oxide metabolic process","ke_aop_context":["AOP 26"],"ke_bio_level":"Cellular","ke_id":"KE 193","ke_name":"Decreased, Nitric Oxide","provenance":{"approved_at":"2026-07-28T16:52:40.635133","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"28f0ba58-4a86-4101-ba65-25339b67d583"},{"assessment_version":"v2","confidence_level":"high","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.","go_depth":5,"go_direction":null,"go_ic":0.82,"go_namespace":"biological_process","go_term_id":"GO:0098989","go_term_name":"NMDA selective glutamate receptor signaling pathway","ke_aop_context":["AOP 12","AOP 13"],"ke_bio_level":"Molecular","ke_id":"KE 201","ke_name":"Binding of antagonist, NMDA receptors","provenance":{"approved_at":"2026-07-28T16:53:13.652730","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"56219e0f-d6a3-4ae9-a0d9-abd2c0c59d63"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.","go_depth":5,"go_direction":null,"go_ic":1.0,"go_namespace":"biological_process","go_term_id":"GO:0007296","go_term_name":"vitellogenesis","ke_aop_context":["AOP 29","AOP 53","AOP 536","AOP 537"],"ke_bio_level":"Organ","ke_id":"KE 220","ke_name":"Increase, Plasma vitellogenin concentrations","provenance":{"approved_at":"2026-07-28T16:52:16.502094","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"7234272f-66df-495b-ae7f-accd425c72cd"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.","go_depth":4,"go_direction":null,"go_ic":1.0,"go_namespace":"biological_process","go_term_id":"GO:0030730","go_term_name":"triglyceride storage","ke_aop_context":["AOP 318","AOP 34","AOP 517","AOP 518","AOP 529","AOP 57","AOP 580","AOP 591"],"ke_bio_level":"Cellular","ke_id":"KE 291","ke_name":"Accumulation, Triglyceride","provenance":{"approved_at":"2026-07-28T16:52:10.679763","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"3ac79d2e-b75d-4852-a9b8-02bfd6da1a1e"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":1,"go_definition":"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.","go_depth":5,"go_direction":null,"go_ic":0.42,"go_namespace":"biological_process","go_term_id":"GO:0006631","go_term_name":"fatty acid metabolic process","ke_aop_context":["AOP 36","AOP 529","AOP 57","AOP 58","AOP 60"],"ke_bio_level":"Organ","ke_id":"KE 327","ke_name":"Accumulation, Fatty acid","provenance":{"approved_at":"2026-07-28T16:52:05.704948","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.6600000000000001},"specificity_score":2,"uuid":"ea6d0d06-43ee-478b-8eec-82e420a495b2"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":1,"go_definition":"The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.","go_depth":5,"go_direction":null,"go_ic":0.54,"go_namespace":"biological_process","go_term_id":"GO:0015908","go_term_name":"fatty acid transport","ke_aop_context":["AOP 36","AOP 529","AOP 57","AOP 58","AOP 60"],"ke_bio_level":"Organ","ke_id":"KE 327","ke_name":"Accumulation, Fatty acid","provenance":{"approved_at":"2026-07-28T16:52:01.672981","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.6600000000000001},"specificity_score":2,"uuid":"9039e256-099a-4d49-a3d5-9664064a3b57"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"related","evidence_score":1,"go_definition":"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.","go_depth":3,"go_direction":null,"go_ic":0.63,"go_namespace":"biological_process","go_term_id":"GO:0019915","go_term_name":"lipid storage","ke_aop_context":["AOP 34"],"ke_bio_level":"Organ","ke_id":"KE 345","ke_name":"N/A, Liver Steatosis","provenance":{"approved_at":"2026-07-28T16:51:57.181007","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.6600000000000001},"specificity_score":2,"uuid":"292f5d9a-30ed-480f-b062-8f21e33ba4fe"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The acquisition and processing of information and/or the storage and retrieval of this information over time.","go_depth":3,"go_direction":null,"go_ic":0.47,"go_namespace":"biological_process","go_term_id":"GO:0007611","go_term_name":"learning or memory","ke_aop_context":["AOP 471"],"ke_bio_level":"Individual","ke_id":"KE 637","ke_name":"impaired, Learning and memory","provenance":{"approved_at":"2026-07-28T16:51:52.952531","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"c508d9e7-98ad-4403-9b1e-68687777bbc8"},{"assessment_version":"v2","confidence_level":"medium","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).","go_depth":5,"go_direction":null,"go_ic":0.86,"go_namespace":"biological_process","go_term_id":"GO:0097017","go_term_name":"renal protein absorption","ke_aop_context":["AOP 105"],"ke_bio_level":"Tissue","ke_id":"KE 708","ke_name":"Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)","provenance":{"approved_at":"2026-07-28T16:51:49.930052","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":2,"uuid":"5364da86-7a29-4aac-b0aa-07cbe4dde5a7"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.","go_depth":4,"go_direction":null,"go_ic":0.69,"go_namespace":"biological_process","go_term_id":"GO:0042403","go_term_name":"thyroid hormone metabolic process","ke_aop_context":["AOP 402"],"ke_bio_level":"Tissue","ke_id":"KE 771","ke_name":"Decrease, Serum thyroid hormone (T4/T3)","provenance":{"approved_at":"2026-07-28T16:51:40.861760","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"806fbb88-cba9-4d88-8cd7-de6d56eba70e"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"related","evidence_score":1,"go_definition":"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.","go_depth":4,"go_direction":null,"go_ic":0.34,"go_namespace":"biological_process","go_term_id":"GO:0061024","go_term_name":"membrane organization","ke_aop_context":["AOP 130"],"ke_bio_level":"Cellular","ke_id":"KE 829","ke_name":"Damage, Lipid bilayer","provenance":{"approved_at":"2026-07-28T16:51:33.347012","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.33},"specificity_score":1,"uuid":"78079956-eb7c-49f0-820b-5f3411059d70"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"related","evidence_score":1,"go_definition":"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.","go_depth":7,"go_direction":null,"go_ic":0.56,"go_namespace":"biological_process","go_term_id":"GO:0007040","go_term_name":"lysosome organization","ke_aop_context":["AOP 130","AOP 257"],"ke_bio_level":"Cellular","ke_id":"KE 831","ke_name":"Disturbance, Lysosomal function","provenance":{"approved_at":"2026-07-28T16:50:57.041527","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.6600000000000001},"specificity_score":2,"uuid":"aa9624f1-5655-46c6-9534-ac002bf23584"},{"assessment_version":"v2","confidence_level":"medium","connection_score":1,"connection_type":"context","evidence_score":1,"go_definition":"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.","go_depth":3,"go_direction":null,"go_ic":0.56,"go_namespace":"biological_process","go_term_id":"GO:0007626","go_term_name":"locomotory behavior","ke_aop_context":["AOP 3","AOP 464","AOP 471","AOP 587","AOP 588","AOP 589","AOP 593"],"ke_bio_level":"Individual","ke_id":"KE 896","ke_name":"Parkinsonian motor deficits","provenance":{"approved_at":"2026-07-28T16:51:32.330871","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.0},"specificity_score":1,"uuid":"50c29b76-e968-4595-9387-f9f2d8a0fa91"},{"assessment_version":"v2","confidence_level":"medium","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.","go_depth":5,"go_direction":null,"go_ic":0.75,"go_namespace":"biological_process","go_term_id":"GO:0070327","go_term_name":"thyroid hormone transport","ke_aop_context":["AOP 152"],"ke_bio_level":"Molecular","ke_id":"KE 958","ke_name":"Displacement, Serum thyroxine (T4) from transthyretin","provenance":{"approved_at":"2026-07-28T16:50:43.729192","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":2,"uuid":"4124e998-4a9e-4cfe-a426-b668355e75ee"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"related","evidence_score":1,"go_definition":"The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.","go_depth":5,"go_direction":null,"go_ic":0.75,"go_namespace":"biological_process","go_term_id":"GO:0070327","go_term_name":"thyroid hormone transport","ke_aop_context":["AOP 152","AOP 366","AOP 367"],"ke_bio_level":"Tissue","ke_id":"KE 959","ke_name":"Increased, Free serum thyroxine (T4)","provenance":{"approved_at":"2026-07-28T16:50:39.756128","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.6600000000000001},"specificity_score":2,"uuid":"bc458a90-e8eb-48e4-a5dc-29870cae405d"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary.","go_depth":6,"go_direction":null,"go_ic":1.0,"go_namespace":"biological_process","go_term_id":"GO:0070460","go_term_name":"thyroid-stimulating hormone secretion","ke_aop_context":["AOP 110","AOP 119","AOP 162","AOP 190"],"ke_bio_level":"Tissue","ke_id":"KE 1023","ke_name":"Increased, Thyroid-stimulating hormone (TSH)","provenance":{"approved_at":"2026-07-28T16:50:01.936480","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"2740eab5-9910-434d-9faa-7b8d627d6dda"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals.","go_depth":4,"go_direction":null,"go_ic":0.75,"go_namespace":"biological_process","go_term_id":"GO:0046415","go_term_name":"urate metabolic process","ke_aop_context":["AOP 138","AOP 177"],"ke_bio_level":"Tissue","ke_id":"KE 1096","ke_name":"Increased, blood uric acid concentration","provenance":{"approved_at":"2026-07-28T16:49:59.460156","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"8fa9d0d6-8c1f-43bb-9a7d-4ea65ebf898a"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.","go_depth":5,"go_direction":null,"go_ic":0.76,"go_namespace":"biological_process","go_term_id":"GO:0015747","go_term_name":"urate transport","ke_aop_context":["AOP 138","AOP 177"],"ke_bio_level":"Tissue","ke_id":"KE 1096","ke_name":"Increased, blood uric acid concentration","provenance":{"approved_at":"2026-07-28T16:49:56.621922","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"c5dc2e48-20b5-4910-b2e7-9cd028ab9c36"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.","go_depth":4,"go_direction":null,"go_ic":0.63,"go_namespace":"biological_process","go_term_id":"GO:0055075","go_term_name":"potassium ion homeostasis","ke_aop_context":["AOP 138","AOP 177","AOP 186","AOP 551"],"ke_bio_level":"Tissue","ke_id":"KE 1098","ke_name":"Increased, blood potassium concentration","provenance":{"approved_at":"2026-07-28T16:49:50.161580","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"8e4f61f3-a947-4e14-8592-b23dabc0fa38"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.","go_depth":4,"go_direction":null,"go_ic":0.59,"go_namespace":"biological_process","go_term_id":"GO:0006749","go_term_name":"glutathione metabolic process","ke_aop_context":["AOP 209"],"ke_bio_level":"Cellular","ke_id":"KE 1290","ke_name":"Glutathione homeostasis","provenance":{"approved_at":"2026-07-28T16:51:34.557703","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":2,"uuid":"235d1b46-c67d-43a2-9434-0774ced2bbc8"},{"assessment_version":"v2","confidence_level":"high","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.","go_depth":5,"go_direction":null,"go_ic":0.82,"go_namespace":"biological_process","go_term_id":"GO:0098989","go_term_name":"NMDA selective glutamate receptor signaling pathway","ke_aop_context":["AOP 215","AOP 230"],"ke_bio_level":"Molecular","ke_id":"KE 1351","ke_name":"Activated, NMDA receptor","provenance":{"approved_at":"2026-07-28T16:49:28.404189","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"81d18758-5495-4861-81f2-8c31319a7d2c"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"related","evidence_score":1,"go_definition":"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).","go_depth":2,"go_direction":null,"go_ic":0.31,"go_namespace":"biological_process","go_term_id":"GO:0008219","go_term_name":"cell death","ke_aop_context":["AOP 220"],"ke_bio_level":"Cellular","ke_id":"KE 1393","ke_name":"Hepatocytotoxicity","provenance":{"approved_at":"2026-07-28T16:49:29.770001","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.33},"specificity_score":1,"uuid":"e34b3198-a1f6-4069-8ccc-37fd65a9a5d8"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"Signal transduction in which the initial step occurs in a presynapse.","go_depth":3,"go_direction":null,"go_ic":1.0,"go_namespace":"biological_process","go_term_id":"GO:0098928","go_term_name":"presynaptic signal transduction","ke_aop_context":["AOP 231"],"ke_bio_level":"Cellular","ke_id":"KE 1413","ke_name":"Reduced, presynaptic neuron 2 activity","provenance":{"approved_at":"2026-07-28T16:48:00.949343","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"bd83f4e3-fa12-4a35-a530-a2ea36970462"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.","go_depth":5,"go_direction":null,"go_ic":0.84,"go_namespace":"biological_process","go_term_id":"GO:0009449","go_term_name":"GABA biosynthetic process","ke_aop_context":["AOP 231"],"ke_bio_level":"Cellular","ke_id":"KE 1414","ke_name":"Decreased, GABA","provenance":{"approved_at":"2026-07-28T16:47:50.870991","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":3,"uuid":"8dc13086-6fc9-438c-9151-4d1bf0fae3c2"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues.","go_depth":6,"go_direction":null,"go_ic":0.89,"go_namespace":"biological_process","go_term_id":"GO:0014051","go_term_name":"gamma-aminobutyric acid secretion","ke_aop_context":["AOP 231"],"ke_bio_level":"Cellular","ke_id":"KE 1414","ke_name":"Decreased, GABA","provenance":{"approved_at":"2026-07-28T16:47:45.660540","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.33},"specificity_score":3,"uuid":"075064f7-100d-4873-867b-cbf7453dcdca"},{"assessment_version":"v2","confidence_level":"high","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.","go_depth":4,"go_direction":null,"go_ic":0.67,"go_namespace":"biological_process","go_term_id":"GO:0007214","go_term_name":"gamma-aminobutyric acid signaling pathway","ke_aop_context":["AOP 231"],"ke_bio_level":"Molecular","ke_id":"KE 1415","ke_name":"Reduced, GABA-A receptor activation","provenance":{"approved_at":"2026-07-28T16:48:26.030247","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"29861b83-547c-40fa-be20-87bc6c65e0ac"},{"assessment_version":"v2","confidence_level":"high","connection_score":3,"connection_type":"describes","evidence_score":2,"go_definition":"A homeostatic process involved in the maintenance of a steady state level of chloride ions within a cell.","go_depth":5,"go_direction":null,"go_ic":0.78,"go_namespace":"biological_process","go_term_id":"GO:0030644","go_term_name":"intracellular chloride ion homeostasis","ke_aop_context":["AOP 231"],"ke_bio_level":"Cellular","ke_id":"KE 1416","ke_name":"Decreased, intracellular chloride","provenance":{"approved_at":"2026-07-28T16:46:59.580659","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.66},"specificity_score":3,"uuid":"df63e4be-bc56-41b0-a070-97ac4aeaf956"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"related","evidence_score":1,"go_definition":"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.","go_depth":4,"go_direction":null,"go_ic":0.46,"go_namespace":"biological_process","go_term_id":"GO:0034599","go_term_name":"cellular response to oxidative stress","ke_aop_context":["AOP 232","AOP 507","AOP 508","AOP 509","AOP 615"],"ke_bio_level":"Molecular","ke_id":"KE 1417","ke_name":"NFE2/Nrf2 repression","provenance":{"approved_at":"2026-07-28T16:46:53.689724","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":1.33},"specificity_score":1,"uuid":"e58d6e62-b31e-40e5-a3b1-eb05b5f119fa"},{"assessment_version":"v2","confidence_level":"medium","connection_score":2,"connection_type":"involves","evidence_score":2,"go_definition":"A nuclear receptor-mediated signaling pathway initiated by a bile acid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.","go_depth":4,"go_direction":null,"go_ic":0.93,"go_namespace":"biological_process","go_term_id":"GO:0038185","go_term_name":"nuclear receptor-mediated bile acid signaling pathway","ke_aop_context":[],"ke_bio_level":null,"ke_id":"KE 1419","ke_name":"Reduced, FXR activity","provenance":{"approved_at":"2026-07-28T16:45:32.755715","approved_by":"github:marvinm2","proposed_by":"github:marvinm2","suggestion_score":2.0},"specificity_score":2,"uuid":"46a4479f-c9dd-41de-a4f7-7377dad1850f"}],"pagination":{"next":"https://molaop-builder.vhp4safety.nl/api/v1/go-mappings?page=2&per_page=50","page":1,"per_page":50,"prev":null,"total":355,"total_pages":8}}
